Takuma Ide, Kumi Izawa, Wahyu Diono, Anna Kamei, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Akihisa Yoshikawa, Risa Yamamoto, Shino Uchida, Hexing Wang, Mayuki Kojima, Keiko Maeda, Nobuhiro Nakano, Masahiro Nakamura, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Fumihiko Matsumoto, Katsuhisa Ikeda, Motonobu Goto, Jiro Kitaura
Allergic rhinitis (AR) is caused by type I hypersensitivity reaction in the nasal tissues. The interaction between CD300f and its ligand ceramide suppresses immunoglobulin E (IgE)-mediated mast cell activation. However, whether CD300f inhibits the development of allergic rhinitis (AR) remains elusive. We aimed to investigate the roles of CD300f in the development of AR and the effectiveness of intranasal administration of ceramide liposomes on AR in murine models. We used ragweed pollen-induced AR models in mice...
April 10, 2024: Scientific Reports