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Ceramide

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https://www.readbyqxmd.com/read/28323975/muscle-sympathetic-nerve-activity-is-associated-with-elements-of-the-plasma-lipidomic-profile-in-young-asian-adults
#1
Nina Eikelis, Elisabeth A Lambert, Sarah Phillips, Carolina Ika Sari, Piyushkumar A Mundra, Jacquelyn M Weir, Kevin Huynh, Mariee T Grima, Nora E Straznicky, John B Dixon, Markus P Schlaich, Peter J Meikle, Gavin W Lambert
Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower BMI compared with Caucasians. Sympathetic nervous system activation and dyslipidaemia, both characteristics of increased adiposity, appear to be related. We therefore analysed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young Asian and Caucasian subjects. Methods: Blood samples were collected from 101 participants of either Asian or Caucasian background, aged 18-30, BMI 28...
March 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319722/bisphenol-s-exposure-modulate-macrophage-phenotype-as-defined-by-cytokines-profiling-global-metabolomics-and-lipidomics-analysis
#2
Chao Zhao, Zhi Tang, Jiacheng Yan, Jing Fang, Hailin Wang, Zongwei Cai
As an important structural analogue of bisphenol A (BPA), bisphenol S (BPS) has been used as alternatives to BPA in industrialized production. However, the immunotoxicity of BPS remains poorly understood. As a critical model in inflammatory responses, macrophages are used to explore the immunotoxic potential and mechanisms of BPS at environmentally relevant concentrations in our study. Here, we are combining molecular toxicology and mass spectrometry (MS)-based global metabolomics and lipidomics study together to estimate the variation of cytokines profiling and metabolism characteristic following BPS exposure...
March 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28317057/synthesis-and-evaluation-of-a-tag-free-photoactive-phospho-ceramide-analogue-1-pcera-1-probe-to-study-immunomodulation-in-macrophages
#3
Rambabu Dandela, Roi Mashiach, Raju Adepu, Rachel Gregor, Muhammad Athamna, Efrat Zecharia, Orna Ernst, Tsaffrir Zor, Michael M Meijler
Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.
March 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28315304/sphingosine-1-phosphate-a-double-edged-sword-in-the-brain
#4
REVIEW
Indulekha Karunakaran, Gerhild van Echten-Deckert
The physiological functions of sphingosine 1-phosphate (S1P) and its pathological roles in various diseases are increasingly being elucidated. Particularly, a growing body of literature has implicated S1P in the pathogenesis of brain related disorders. With the deciphering of more intricate aspects of S1P signalling, there is also a need to reconsider the notion of S1P only as a determinant of cell survival and proliferation. Further the concept of 'S1P-ceramide' balance as the controlling switch of cellular fate and functions needs to be refined...
March 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28314284/altered-levels-of-serum-ceramide-sphingosine-and-sphingomyelin-are-associated-with-colorectal-cancer-a-retrospective-pilot-study
#5
Duska Separovic, Anthony F Shields, Philip A Philip, Jacek Bielawski, Alicja Bielawska, Jason S Pierce, Adi L Tarca
BACKGROUND/AIM: Because patients with cancer of apparently equivalent stage often have different outcomes, it is necessary to gather additional information to complement cancer staging. Dysregulated sphingolipid metabolism contributes to carcinogenesis. In this retrospective pilot study, we tested the hypothesis that changes in serum levels of sphingolipids are associated with stage IV colorectal cancer (CRC). PATIENTS AND METHODS: We used commercially available serum samples from healthy males and patients with CRC (adenocarcinoma of the large intestine, stage IV with metastases)...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28301620/anti-pruritic-efficacy-of-itch-relief-lotion-and-cream-in-patients-with-atopic-history-comparison-with-hydrocortisone-cream
#6
Matthew J Zirwas, Sylvia Barkovic
<p>Objective: To evaluate the speed of onset and duration of relief of two ceramide-containing formulations with 1% pramoxine hydroxide (CeraVe® Itch Relief Lotion and Cream,Valeant Pharmaceuticals North America LLC, Irvine, CA) in patients with atopic history, including those with active flare and the comparative efficacy of CeraVe Itch Relief Cream to hydrocortisone 1% cream and night-time itch relief with continued use. METHODS: Two double-blind, split-body, randomized studies in 66 male and female subjects, ages 11+ years, with history of atopic dermatitis (AD)...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28297799/-a-serum-lipidomic-study-of-patients-with-non-alcoholic-fatty-liver-disease
#7
R X Yang, C X Hu, Y Q Mi, W L Sun, G Y Chen, Q Pan, F Shen, G W Xu, J G Fan
Objective: To investigate the serum lipidomic profile in patients with nonalcoholic fatty liver disease (NAFLD), and to analyze the lipid metabolism characteristics of NAFLD. Methods: The subjects were divided into control group (23 patients) and pathologically confirmed NAFLD group (42 patients), and ultra-high-performance liquid chromatography-tandem mass spectrometry was used to measure serum lipidomic metabolites. The partial least squares-discriminant analysis (PLS-DA) model was established to analyze the differences in lipid metabolism with reference to the univariate analysis...
February 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28297656/the-long-chain-sphingoid-base-of-ceramides-determines-their-propensity-for-lateral-segregation
#8
Md Abdullah Al Sazzad, Tomokazu Yasuda, Michio Murata, J Peter Slotte
We examined how the length of the long-chain base or the N-linked acyl chain of ceramides affected their lateral segregation in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bilayers. Lateral segregation and ceramide-rich phase formation was ascertained by a lifetime analysis of trans-parinaric acid (tPA) fluorescence. The longer the length of the long-chain base (d16:1, d17:1, d18:1, d19:1, and d20:1 in N-palmitoyl ceramide), the less ceramide was needed for the onset of lateral segregation and ceramide-rich phase formation...
March 14, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28297574/bioactive-lipids-and-circulating-progenitor-cells-in-patients-with-cardiovascular-disease
#9
Salim S Hayek, Yuri Klyachkin, Ahmed Asfour, Nima Ghasemzadeh, Mosaab Awad, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Jinhee Kim, Edmund K Waller, Arshed A Quyyumi, Ahmed K Abdel-Latif
Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296891/englerin-a-induces-an-acute-inflammatory-response-and-reveals-lipid-metabolism-and-er-stress-as-targetable-vulnerabilities-in-renal-cell-carcinoma
#10
Ayse Batova, Diego Altomare, Kim E Creek, Robert K Naviaux, Lin Wang, Kefeng Li, Erica Green, Richard Williams, Jane C Naviaux, Mitchell Diccianni, Alice L Yu
Renal cell carcinoma (RCC) is among the top ten most common forms of cancer and is the most common malignancy of the kidney. Clear cell renal carcinoma (cc-RCC), the most common type of RCC, is one of the most refractory cancers with an incidence that is on the rise. Screening of plant extracts in search of new anti-cancer agents resulted in the discovery of englerin A, a guaiane sesquiterpene with potent cytotoxicity against renal cancer cells and a small subset of other cancer cells. Though a few cellular targets have been identified for englerin A, it is still not clear what mechanisms account for the cytotoxicity of englerin A in RCC, which occurs at concentrations well below those used to engage the targets previously identified...
2017: PloS One
https://www.readbyqxmd.com/read/28295641/wash-or-wipe-a-comparative-study-of-skin-physiological-changes-between-water-washing-and-wiping-after-skin-cleaning
#11
K Ogai, M Matsumoto, M Aoki, R Ota, K Hashimoto, R Wada, M Kobayashi, J Sugama
BACKGROUND/PURPOSE: Presently, skin-cleaning agents that claim to be removed by water or wiping alone are commercially available and have been used for the purpose of bed baths. However, there is a lack of knowledge on how water washing and wiping differently affect skin physiological functions or ceramide content. The aim of this study was to compare the effects of water washing and wiping on skin physiological functions and ceramide content. METHODS: Three kinds of the cleaning agents with different removal techniques (ie, water washing and wiping) were used in this study...
March 14, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28295389/proximate-amino-acid-and-lipid-compositions-in-sinonovacula-constricta-lamarck-reared-at-different-salinities
#12
Zhaoshou Ran, Shuang Li, Runtao Zhang, Jilin Xu, Kai Liao, Xuejun Yu, Yingying Zhong, Mengwei Ye, Shanshan Yu, Yun Ran, Wei Huang, Xiaojun Yan
BACKGROUND: Sinonovacula constricta is an economically and nutritionally important bivalve native to the estuaries and mudflats of China, Japan, and Korea. Herein, S. constricta, cultured either under experimental conditions or directly collected from natural coastal areas with different seawater salinities, were investigated for changes in proximates, amino acids and lipids. RESULTS: When culture salinity was increased, levels of moisture, carbohydrate, crude protein and crude lipid were significantly decreased whereas the level of ash was significantly increased...
March 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28292932/crystal-structure-of-the-human-alkaline-sphingomyelinase-provides-insights-into-substrate-recognition
#13
Alexei Gorelik, Fangyu Liu, Katalin Illes, Bhushan Nagar
Absorption of dietary sphingomyelin (SM) requires its initial degradation into ceramide, a process catalyzed by the intestinal enzyme alkaline sphingomyelinase (alk-SMase, NPP7, ENPP7). Alk-SMase belongs to the nucleotide pyrophosphatase / phosphodiesterase family, the members of which hydrolyze nucleoside phosphates, phospholipids and other related molecules. NPP7 is the only paralog that can cleave SM, and its activity requires the presence of bile salts, a class of physiological anionic detergents. To elucidate the mechanism of substrate recognition, we determined the crystal structure of human alk-SMase in complex with phosphocholine, a reaction product...
March 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28288862/autophagy-inhibits-c2-ceramide-mediated-cell-death-by-decreasing-the-reactive-oxygen-species-levels-in-sh-sy5y-cells
#14
Chenghe Fan, Yuanyuan Liu, Mingming Zhao, Rui Zhan, Wei Cui, Haiqiang Jin, Yuming Teng, Pu Lv, Lemin Zheng, Yining Huang
Ceramide has been recognized as a second messenger that regulates several intracellular processes in neuronal cells. However, its role in neuronal autophagy is not fully understood. In this study, we used a human neuroblastoma cell line (SH-SY5Y) to investigate the mechanisms underlying C2-ceramide-mediated cell death and autophagy. C2-ceramide induced caspase-3-independent cell death. In addition, C2-ceramide induced autophagy, decreased the activation of Akt and mTOR, and increased the activation of JNK and ERK1/2...
March 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28287421/in-depth-lipidomic-analysis-of-molecular-species-of-triacylglycerides-diacylglycerides-glycerophospholipids-and-sphingolipids-of-buttermilk-by-gc-ms-fid-hplc-elsd-and-uplc-qtof-ms
#15
Pilar Castro-Gómez, Olimpio Montero, Javier Fontecha
Buttermilk, a byproduct of butter manufacturing, has gained considerable attention due to its high concentration of polar lipids as phospho- and sphingolipids from the milk fat globule membrane (MFGM). These polar lipids (PLs) are essential components of all cellular membranes and exert a variety of indispensable metabolic, neurological, and intracellular signaling processes. Despite its importance, there are few research studies that report a comprehensive characterization of the lipid molecular species of MFGM that could contribute to a better understanding of their putative healthful activities...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28286312/aberrant-ganglioside-composition-in-glioblastoma-multiforme-and-peritumoral-tissue-a-mass-spectrometry-characterization
#16
Dragana Fabris, Marko Rožman, Tomislav Sajko, Željka Vukelić
Tumor cells are characterized by aberrant glycosylation of the cell surface glycoconjugates. Gangliosides are sialylated glycosphingolipids highly abundant in neural tissue and considered as tumor markers and therapeutic targets. In this study, a detailed characterization of native ganglioside mixtures from glioblastoma multiforme, corresponding peritumoral tissue and healthy human brain was performed using mass spectrometry and high performance thin layer chromatography in order to elucidate their roles as tumor-associated antigens...
March 9, 2017: Biochimie
https://www.readbyqxmd.com/read/28284424/soft-coral-cespitularia-stolonifera-new-cytotoxic-ceramides-and-gastroprotective-activity
#17
Abdelsamed I Elshamy, Walaa A El-Kashak, Heba M I Abdallah, Abdelrazik H Farrag, Mahmoud I Nassar
In the present study, a new ceramide, namely 2S, 3R-4E, 8E-2-(heptadecanoylamino)-heptadeca-4, 8-diene-1, 3-diol (1), along with four known steroids, including 24-methylcholesta-5, 24(28)-diene-3β-ol (2), 24-methylcholesta-5, 24(28)-diene-3β-acetate (3), 4-methyl-24-methylcholesta-22-ene-3-ol (4), and cholesterol, was isolated and characterized from CH2Cl2/MeOH extract of Cespitularia stolonifera. A new acetate derivative of compound 1, termed 2S, 3R-4E, 8E-2-(heptadecanoylamino)-heptadeca-4, 8-diene-1, 3-diacetate (1a), was also prepared in the present study...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28283474/acid-sphingomyelinase-mediates-murine-acute-lung-injury-following-transfusion-of-aged-platelets
#18
Mark John McVey, Michael Kim, Arata Tabuchi, Victoria Srbely, Lukasz Japtok, Christoph Arenz, Ori Rotstein, Burkhard Kleuser, John Wesley Semple, Wolfgang Michael Kuebler
Pulmonary complications from stored blood products are the leading cause of mortality related to transfusion. Transfusion related acute lung injury is mediated by antibodies or bioactive mediators, yet, underlying mechanisms are incompletely understood. Sphingolipids such as ceramide regulate lung injury, and their composition changes as a function of time in stored blood. Here, we tested the hypothesis that aged platelets may induce lung injury via a sphingolipid-mediated mechanism. To assess this hypothesis, a two hit mouse model was devised...
March 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28280822/molecular-dynamics-simulation-study-of-translocation-of-fullerene-c60-through-skin-bilayer-effect-of-concentration-on-barrier-properties
#19
Rakesh Gupta, Beena Rai
The molecular level permeation mechanism of fullerenes and its derivatives through human skin could open a vast area for designing novel nanoparticles for cosmetics and drug delivery applications. In this study, we report the permeation mechanism of pristine fullerene C60 for the first time through the skin lipid layer, as determined via prolonged unconstrained and constrained coarse-grained molecular dynamics simulations. The skin layer was modelled as an equimolar ratio of ceramides, cholesterol and free fatty acids...
March 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28277984/neutral-sphingomyelinase-inhibition-alleviates-apoptosis-but-not-er-stress-in-liver-ischemia-reperfusion-injury
#20
Hazal Tuzcu, Betul Unal, Ebru Kırac, Esma Konuk, Filiz Ozcan, Gulsum O Elpek, Necdet Demir, Mutay Aslan
Previous studies have revealed the activation of neutral sphingomyelinase (N-SMase)/ceramide pathway in hepatic tissue following warm liver ischemia reperfusion (IR) injury. Excessive ceramide accumulation is known to potentiate apoptotic stimuli and a link between apoptosis and endoplasmic reticulum (ER) stress has been established in hepatic IR injury. Thus, this study determined the role of selective N-SMase inhibition on ER stress and apoptotic markers in a rat model of liver IR injury. Selective N-SMase inhibitor was administered via intraperitoneal injections...
March 13, 2017: Free Radical Research
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