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Ismail Altintop, Mehmet Tatli
AIM: Elderly physical abuse (EPA) is defined as injury or assault to or the restriction of an elderly person. Although EPA is an important social problem, its diagnosis is difficult because of tendency to cover up the event. In this study, patients aged 65 years and over who presented at the emergency department (ED) for forensic reasons and in whom physical abuse was suspected were examined. The aim of this study was to raise ED awareness of EPA and thereby to contribute to treatment plans for these patients in the ED...
August 13, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
C Hjalmarsson, J-A Liljeqvist, M Lindh, K Karason, E Bollano, A Oldfors, B Andersson
BACKGROUND: Parvovirus B19 (PVB19) has emerged as one of the viruses possibly inducing chronic myocarditis and subsequent IDCM. AIM: to investigate the presence and the long-term consequences of PVB19-DNA within myocardial biopsies in patients with IDCM and to compare the findings with those of donor hearts (control group). METHODS AND RESULTS: 40 hospitalized IDCM patients (age 47 ±12y) with LVEF 27 ±12% were included. The presence of PVB19-DNA in myocardial biopsies, and of IgG and IgM antibodies in patient sera was analysed...
August 10, 2018: Journal of Cardiac Failure
Hsiao-Shan Tseng, Zi-Hao Chao, Song-Kong Huang, Tao-Hsin Tung, Ching-Wen Chien
This retrospective follow-up study explored the status of patients with myocardial infarction with regard to the likelihood of being readmitted to the hospital within 30 days after undergoing coronary artery bypass surgery (CABG) and their survival status within one year of the procedure.The rate of readmission within 30 days was 10.7% (167/1,575), primarily due to surgical wound infection (11.3% of readmission cases), ischemic heart disease (10.3%), and heart failure (8.7%). The readmission group consisted mainly of older males with a high comorbidity index...
August 11, 2018: International Heart Journal
Rosanne Beuthin
Accessing medical assistance in dying (MAiD) became legal in Canada in June, 2016. This marks a unique time in our history, as eligible persons can now opt for an assisted death and health care professionals can be involved without criminal repercussion. I used an autoethnographic approach to explore and describe my experience of implementing and coordinating a new MAiD program in a local health authority. Part I is a self-reflexive narrative based on journal entries about my immersion in this practice role over a 6 month period...
September 2018: Qualitative Health Research
Giovanni Ribaudo, Enrico Zanforlin, Giuseppe Zagotto
The introduction of tyrosine kinase inhibitors (TKIs) in the clinical management of oncological patients spread the light on the use of selective, rationally designed small molecules for the treatment of cancer. First-generation TKIs bared high response against these malignancies, although the unavoidable shadow of resistance limits their long-term efficacy. Non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancer cases, and it is the first cause of cancer deaths worldwide for men and women. Traditional chemotherapy is marginally effective against this form, and erlotinib and gefitinib were introduced as first-line treatments based on the observation that the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), is mutated in several cases and, thus, represents a druggable target...
August 12, 2018: Archiv der Pharmazie
Chiara Oltolini, Marco Ripa, Andrea Andolina, Elena Brioschi, Marta Cilla, Giovanna Petrella, Vanesa Gregorc, Barbara Castiglioni, Chiara Tassan Din, Paolo Scarpellini
The widespread use of T lymphocyte-associated antigen-4 (CTLA-4) and programmed death (PD)-1 and PD ligand-1 (PDL1)-targeted agents in cancer patients as immunotherapy has raised some issues on their safety profile. Regarding infectious complications, it has emerged that these compounds do not intrinsically increase susceptibility to opportunistic infections, which mainly correlate with the co-administration of systemic immunosuppressive therapy (high-dose corticosteroids and anti-tumor necrosis factors inhibitors) to cure immune-related adverse events (colitis, hepatitis, pneumonitis and pancreatitis), well-known complications of these targeted drugs...
August 13, 2018: Mycopathologia
Erlinda M Gordon, Joshua R Ravicz, Seiya Liu, Sant P Chawla, Frederick L Hall
Basic research in genetics, biochemistry and cell biology has identified the executive enzymes and protein kinase activities that regulate the cell division cycle of all eukaryotic organisms, thereby elucidating the importance of site-specific protein phosphorylation events that govern cell cycle progression. Research in cancer genomics and virology has provided meaningful links to mammalian checkpoint control elements with the characterization of growth-promoting proto-oncogenes encoding c-Myc, Mdm2, cyclins A, D1 and G1, and opposing tumor suppressor proteins, such as p53, pRb, p16INK4A and p21WAF1 , which are commonly dysregulated in cancer...
August 2018: Molecular and Clinical Oncology
Benjamin Anathory Kamala, Andrew Hans Mgaya, Matilda Michael Ngarina, Hussein Lesio Kidanto
Introduction: The global prevalence of low birth weight (LBW) is 16%, representing more than 20 million infants worldwide, of which 96% are born in low-income countries. This study aimed to determine the prevalence, predictors and perinatal outcomes of LBW newborns. Methods: We conducted a retrospective analysis of data obtained from the hospital's obstetric and neonatal database. Descriptive statistics and multivariate logistic regression were performed with 95% confidence intervals (CI)...
2018: Pan African Medical Journal
Laura P Gelfman, Yolanda Barrón, Stanley Moore, Christopher M Murtaugh, Anuradha Lala, Melissa D Aldridge, Nathan E Goldstein
OBJECTIVES: This study sought to: 1) identify the predictors of hospice enrollment for patients with heart failure (HF); and 2) determine the impact of hospice enrollment on health care use. BACKGROUND: Patients with HF rarely enroll in hospice. Little is known about how hospice affects this group's health care use. METHODS: Using a propensity score-matched sample of Medicare decedents with ≥2 HF discharges within 6 months, an Outcome and Assessment Information Set (OASIS) assessment, and subsequent death, we used Medicare administrative, claims, and patient assessment data to compare hospitalizations, intensive care unit stays, and emergency department visits for those beneficiaries who enrolled in hospice and those who did not...
August 7, 2018: JACC. Heart Failure
Abhinav Sharma, Lauren B Cooper, Mona Fiuzat, Robert J Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O'Connor, Faiez Zannad
There is increasing recognition of the relationship between diabetes and heart failure (HF). Comorbid diabetes is associated with worse outcomes in patients with HF, and death from HF forms a large burden of mortality among patients with diabetes and atherosclerotic cardiovascular disease. However, there is evidence of harm relating to the risk of HF outcomes from several antihyperglycemic therapies. The absence of well-powered randomized controlled studies has resulted in significant treatment variations in the glycemic management in patients with coexisting diabetes and HF...
August 7, 2018: JACC. Heart Failure
Milos Brankovic, K Martijn Akkerhuis, Henk Mouthaan, Alina Constantinescu, Kadir Caliskan, Jan van Ramshorst, Tjeerd Germans, Victor Umans, Isabella Kardys
BACKGROUND: Our aim was to explore potential use of temporal profiles of seven emerging cardio-renal and two pulmonary candidate biomarkers for predicting future adverse clinical outcome in stable patients with chronic heart failure (CHF). METHODS: In 263 CHF patients, we determined the risk of a composite endpoint of HF-hospitalization, cardiac death, LVAD-placement and heart transplantation in relation to repeatedly assessed (567 samples in total) blood biomarker levels, and slopes of their temporal trajectories (i...
August 3, 2018: International Journal of Cardiology
Min-Ho Shin, Gi-Won Song, Sung-Gyu Lee, Shin Hwang, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Dong-Hwan Jung, Gil-Chun Park, Young-In Yun, Wan-Jun Kim, Woo-Hyoung Kang, Seok-Hwan Kim, Hongsi Jiang, Sungmin Lee, Eun-Young Tak
Randomized, open-label, comparative, single-center, Phase 4, 24-week study comparing pharmacokinetics (PK), safety, and efficacy of once-daily, prolonged-release tacrolimus (PR-T) with twice-daily, immediate-release tacrolimus (IR-T) in adult de novo living-donor liver transplant (LDLT) recipients in Korea. All patients received intravenous tacrolimus from Day 0 (transplantation) for 4 days and were randomized (1:1) to receive oral PR-T or IR-T from Day 5. PK profiles taken on Days 6 and 21. Primary endpoint: area-under-the-concentration-time curve over 24h (AUC0-24 )...
August 11, 2018: Clinical Transplantation
Shuxin Shen, Ying Li, Yunbin Xiao, Zonglei Zhao, Chuanxi Zhang, Junfen Wang, Hairui Li, Feng Liu, Nvqin He, Ye Yuan, Yongkang Lu, Shengcun Guo, Yan Wang, Wangjun Liao, Yulin Liao, Yanmei Chen, Jianping Bin
With the rapid development of cancer-targeted nanotechnology, a variety of nanoparticle-based drug delivery systems have clinically been employed in cancer therapy. However, multidrug resistance significantly impacts the therapeutic efficacy. Physical non-drug therapy has emerged as a new and promising strategy. This study aimed to determine whether novel folate-nanobubbles (F-NBs), combined with therapeutic ultrasound (US), could act as a safe and effective physical targeted cancer therapy. Using folate-conjugated N-palmitoyl chitosan (F-PLCS), we developed novel F-NBs and characterised their physicochemical properties, internalization mechanism, targeting ability, therapeutic effects, and killing mechanism...
July 30, 2018: Biomaterials
Luis Lowe, Stephanie A Dopson, Alicia P Budd
Laboratory and epidemiologic data are vital to identify a novel influenza A virus and inform the public health response, whether it be to a localized outbreak or pandemic. The Centers for Disease Control and Prevention (CDC) developed the Pandemic Influenza Readiness Assessment (PIRA) to evaluate the state of the nation's preparedness for the next influenza pandemic. Representatives from all 62 Public Health Emergency Preparedness (PHEP) awardee jurisdictions were requested to complete the web-based questionnaire in July 2015...
August 10, 2018: Health Security
Pedro Melgar-Lesmes, Aureli Luquero, Marina Parra-Robert, Adriana Mora, Jordi Ribera, Elazer R Edelman, Wladimiro Jiménez
Fibrosis contributes to ~45% of all deaths in industrialized nations but no direct anti-fibrotic therapeutic interventions exist to date. Graphene-based nanomaterials exhibit excellent versatility in electronics, and emerging trends exploit their properties for biomedical applications, especially for drug and gene delivery. We designed constructs of graphene nanostars linked to PAMAM-G5 dendrimer for selective targeting and delivery of a plasmid expressing the collagenase metalloproteinase 9 under CD11b promoter into inflammatory macrophages in cirrhotic livers...
August 10, 2018: Nano Letters
Nina Buchtele, Christian Schörgenhofer, Alexander O Spiel, Bernd Jilma, Michael Schwameis
OBJECTIVES: Recent data suggest that early increased fibrinolysis may be associated with unfavorable prognosis in cardiac arrest. The current study aimed to assess whether there is an optimal fibrinolysis cutoff value as determined by thrombelastometry at hospital admission to predict poor outcome in a cohort of adult patients with out-of-hospital cardiac arrest. DESIGN: Prospective observational cohort study. SETTING: Emergency department of a 2...
August 9, 2018: Critical Care Medicine
M T Ndiaye Diop, F Ly, A Diop, B Seck, S Diadie, A Kane
to assess : the frequency of emergencies among patients admitted to dermatology departments in Dakar, their most common causes, mortality rate, and the most frequent dermatoses. This one-year prospective study took place in the two reference departments for the treatment of dermatological diseases in Dakar. We have included all patients with a dermatological emergency, regardless of age and gender, as determined by the doctor receiving the patient. The data were entered in Excel and analyzed with R software, version 3...
August 6, 2018: Médecine et Santé Tropicales
Penny Vlahos, Stephen L Schensul, Nishantha Nanayakkara, Rohana Chandrajith, Lalarukh Haider, Shuchi Anand, Kalinga Tudor Silva, Jean J Schensul
Over the last two decades, a global epidemic of chronic kidney disease of unknown etiology (CKDu) has emerged in rural, arid, agricultural, lowland areas. Endemic regions have reported 15 to 20% prevalence among residents aged 30-60 years. CKDu is a progressive and irreversible disease resulting in renal failure and death in the absence of dialysis or a kidney transplant. While much of the research has focused on identifying etiology, this project seeks to ascertain factors associated with the rapidity of kidney disease progression in one of Sri Lanka's CKDu endemic areas...
August 10, 2018: Global Public Health
Mathew J Summers, Innocenzo Rainero, Alessandro E Vercelli, Georg Aumayr, Helios de Rosario, Michaela Mönter, Ryuta Kawashima
Introduction: Frailty increases the risk of poor health outcomes, disability, hospitalization, and death in older adults and affects 7%-12% of the aging population. Secondary impacts of frailty on psychological health and socialization are significant negative contributors to poor outcomes for frail older adults. Method: The My Active and Healthy Aging (My-AHA) consortium has developed an information and communications technology-based platform to support active and healthy aging through early detection of prefrailty and provision of individually tailored interventions, targeting multidomain risks for frailty across physical activity, cognitive activity, diet and nutrition, sleep, and psychosocial activities...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Vesper H Chisumpa, Clifford O Odimegwu
In the context of high adult mortality and an immense impact on the health burden of Zambia, a decomposition analysis of age- and cause-specific mortality in age group 15-59 was performed to determine the contributions to the gap in life expectancy at birth between males and females. Previous studies on decomposition have examined income groups, ethnicity, and regional differences' contributions to gaps in life expectancy, but not the adult mortality age group 15-59. These studies focus on developed countries and few on developing countries...
August 2018: SSM—Population Health
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