keyword
https://read.qxmd.com/read/38536055/predicting-increased-incidence-of-common-antibiotic-resistant-and-antibiotic-associated-pathogens-using-ensemble-species-distribution-modeling
#1
JOURNAL ARTICLE
Siqi C Brough, Luke Caddell, Raymond J Liou, Advait Patil, Giulio De Leo, Joseph D Forrester
The Centers for Disease Control estimates antibiotic-associated pathogens result in 2.8 million infections and 38,000 deaths annually in the United States. This study applies species distribution modeling to elucidate the impact of environmental determinants of human infectious disease in an era of rapid global change. We modeled methicillin-resistant Staphylococcus aureus and Clostridioides difficile using 31 publicly accessible bioclimatic, healthcare, and sociodemographic variables. Ensemble models were created from 8 unique statistical and machine learning algorithms...
March 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38535933/clinical-and-epidemiological-characteristics-of-severe-acute-adult-poisonings-in-french-amazonia-urgent-need-for-a-toxicovigilance-monitoring-framework
#2
JOURNAL ARTICLE
Jean Marc Pujo, Yann Simon, Guy Roger Lontsi Ngoulla, Boubacar Signaté, Rémi Mutricy, Alexis Frémery, Antoine Burin, Bertrand de Toffol, Ibtissem Ben Amara, Stephanie Houcke, Amina Nasri, Dabor Resiere, Hatem Kallel
BACKGROUND: Acute poisonings (AP) are a significant public health problem, accounting for a high number of emergency department visits and thousands of deaths worldwide. This study aimed to assess the epidemiology of AP in an adult population admitted to Cayenne Hospital (French Guiana) and to investigate the clinical and sociodemographic characteristics. METHODS: We conducted a monocentric retrospective study from January 2010 to December 2022, including patients over eighteen years of age who had been admitted to the emergency department of Cayenne Hospital for acute poisoning...
March 5, 2024: Toxics
https://read.qxmd.com/read/38535470/a-review-of-cyclic-imines-in-shellfish-worldwide-occurrence-toxicity-and-assessment-of-the-risk-to-consumers
#3
REVIEW
Sarah C Finch, D Tim Harwood, Michael J Boundy, Andrew I Selwood
Cyclic imines are a class of lipophilic shellfish toxins comprising gymnodimines, spirolides, pinnatoxins, portimines, pteriatoxins, prorocentrolides, spiro-prorocentrimine, symbiomines and kabirimine. They are structurally diverse, but all share an imine moiety as part of a bicyclic ring system. These compounds are produced by marine microalgal species and are characterized by the rapid death that they induce when injected into mice. Cyclic imines have been detected in a range of shellfish species collected from all over the world, which raises the question as to whether they present a food safety risk...
March 11, 2024: Marine Drugs
https://read.qxmd.com/read/38535372/development-and-metabolomic-profiles-of-bactrocera-dorsalis-diptera-tephritidae-larvae-exposed-to-phytosanitary-irradiation-dose-in-hypoxic-environment-using-di-spme-gc-ms
#4
JOURNAL ARTICLE
Changyao Shan, Baishu Li, Li Li, Qun Liu, Hang Zou, Tao Liu
X-ray irradiation and modified atmospheres (MAs) provide eco-friendly, chemical-free methods for pest management. Although a low-oxygen atmospheric treatment improves the performance of some irradiated insects, its influence on the irradiation of quarantine insects and its impacts on pest control efficacy have yet to be investigated. Based on bioassay results, this study employed direct immersion solid-phase microextraction (DI-SPME) combined with gas chromatography-mass spectrometry (GC-MS) to determine metabolic profiles of late third-instar B...
March 6, 2024: Insects
https://read.qxmd.com/read/38535118/cardiac-allograft-vasculopathy-challenges-and-advances-in-invasive-and-non-invasive-diagnostic-modalities
#5
REVIEW
Moaz A Kamel, Isabel G Scalia, Amro T Badr, Nima Baba Ali, Juan M Farina, Milagros Pereyra, Mohammed Tiseer Abbas, Ahmed K Mahmoud, Robert L Scott, David E Steidley, Julie L Rosenthal, Lisa M Lemond, Kristen A Sell-Dottin, Brian W Hardaway, Timothy Barry, Ming Yang, Chieh-Ju Chao, Clinton E Jokerst, Chadi Ayoub, Reza Arsanjani
Cardiac allograft vasculopathy (CAV) is a distinct form of coronary artery disease that represents a major cause of death beyond the first year after heart transplantation. The pathophysiology of CAV is still not completely elucidated; it involves progressive circumferential wall thickening of both the epicardial and intramyocardial coronary arteries. Coronary angiography is still considered the gold-standard test for the diagnosis of CAV, and intravascular ultrasound (IVUS) can detect early intimal thickening with improved sensitivity...
March 21, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535020/merging-two-models-of-one-dimensional-convolutional-neural-networks-to-improve-the-differential-diagnosis-between-acute-asthma-and-bronchitis-in-preschool-children
#6
JOURNAL ARTICLE
Waleed Salih, Hakan Koyuncu
(1) Background: Acute asthma and bronchitis are common infectious diseases in children that affect lower respiratory tract infections (LRTIs), especially in preschool children (below six years). These diseases can be caused by viral or bacterial infections and are considered one of the main reasons for the increase in the number of deaths among children due to the rapid spread of infection, especially in low- and middle-income countries (LMICs). People sometimes confuse acute bronchitis and asthma because there are many overlapping symptoms, such as coughing, runny nose, chills, wheezing, and shortness of breath; therefore, many junior doctors face difficulty differentiating between cases of children in the emergency departments...
March 12, 2024: Diagnostics
https://read.qxmd.com/read/38534957/comparative-effectiveness-and-safety-of-trastuzumab-biosimilars-to-herceptin-for-adjuvant-treatment-of-her2-breast-cancer
#7
JOURNAL ARTICLE
Caroline Muñoz, Xiaochen Tai, Jessica Arias, Andrea Eisen, Munaza Chaudhry, Scott Gavura, Kelvin K W Chan
Background: Ontario publicly funds reference trastuzumab (Herceptin) and four biosimilar trastuzumab products for adjuvant treatment of HER2+ breast cancer. We assessed the real-world safety and effectiveness of biosimilar trastuzumab compared to Herceptin for adjuvant treatment of patients with HER2+ breast cancer. Methods: This was a population-based, retrospective study comparing the safety and effectiveness of biosimilar trastuzumab and Herceptin for neoadjuvant/adjuvant treatment of HER2+ breast cancer from 2016 to 2021...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534938/outpatient-embedded-palliative-care-for-patients-with-advanced-thoracic-malignancy-a-retrospective-cohort-study
#8
JOURNAL ARTICLE
Mary C Boulanger, Margaret D Krasne, Ethan K Gough, Samantha Myers, Ilene S Browner, Josephine L Feliciano
Although cancer care is often contextualized in terms of survival, there are other important cancer care outcomes, such as quality of life and cost of care. The ASCO Value Framework assesses the value of cancer therapies not only in terms of survival but also with consideration of quality of life and financial cost. Early palliative care for patients with advanced cancer is associated with improved quality of life, mood, symptoms, and overall survival for patients, as well as cost savings. While palliative care has been shown to have numerous benefits, the impact of real-world implementation of outpatient embedded palliative care on value-based metrics is not fully understood...
March 7, 2024: Current Oncology
https://read.qxmd.com/read/38534920/sex-based-analysis-of-quality-indicators-of-end-of-life-care-in-gastrointestinal-malignancies
#9
JOURNAL ARTICLE
Caitlin S Lees, Hsien Seow, Kelvin K W Chan, Anastasia Gayowsky, Shaila J Merchant, Aynharan Sinnarajah
Indices of aggressive or supportive end-of-life (EOL) care are used to evaluate health services quality. Disparities according to sex were previously described, with studies showing that male sex is associated with aggressive EOL care. This is a secondary analysis of 69,983 patients who died of a GI malignancy in Ontario between 2006 and 2018. Quality indices from the last 14-30 days of life and aggregate measures for aggressive and supportive EOL care were derived from administrative data. Hospitalizations, emergency department use, intensive care unit admissions, and receipt of chemotherapy were considered indices of aggressive care, while physician house call and palliative home care were considered indices of supportive care...
February 22, 2024: Current Oncology
https://read.qxmd.com/read/38534614/hydrogels-for-cardio-and-vascular-tissue-repair-and-regeneration
#10
REVIEW
Ilenia Motta, Michelina Soccio, Giulia Guidotti, Nadia Lotti, Gianandrea Pasquinelli
Cardiovascular disease (CVD), the leading cause of death globally, affects the heart and arteries with a variety of clinical manifestations, the most dramatic of which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), and intracranial aneurysm (IA) rupture. In MI, necrosis of the myocardium, scar formation, and loss of cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, the arteries that are structurally and functionally connected to the cardiac tissue can undergo pathological dilation, i...
March 13, 2024: Gels
https://read.qxmd.com/read/38534365/tnf-related-apoptosis-inducing-ligand-non-apoptotic-signalling
#11
REVIEW
Abderrahmane Guerrache, Olivier Micheau
TNF-related apoptosis-inducing ligand (TRAIL or Apo2 or TNFSF10) belongs to the TNF superfamily. When bound to its agonistic receptors, TRAIL can induce apoptosis in tumour cells, while sparing healthy cells. Over the last three decades, this tumour selectivity has prompted many studies aiming at evaluating the anti-tumoral potential of TRAIL or its derivatives. Although most of these attempts have failed, so far, novel formulations are still being evaluated. However, emerging evidence indicates that TRAIL can also trigger a non-canonical signal transduction pathway that is likely to be detrimental for its use in oncology...
March 16, 2024: Cells
https://read.qxmd.com/read/38533419/integrating-fall-prevention-strategies-into-ems-services-to-reduce-falls-and-associated-healthcare-costs-for-older-adults
#12
JOURNAL ARTICLE
Kathlene Camp, Sara Murphy, Brandon Pate
PURPOSE: The purpose of this study is to detail the implementation of fall prevention initiatives through emergency medical services (EMS) and associated outcomes. METHODS: Paramedics with MedStar Mobile Healthcare utilized the Stopping Elderly Accidents, Deaths, and Injuries (STEADI) fall prevention model to screen and direct intervention through 9-1-1 emergency response, High Utilization Group (HUG), and 30-day Hospital Readmission Avoidance (HRA) programs. Outcomes from 9-1-1 calls measured the number of older adults screened for falls and identified risk factors...
2024: Clinical Interventions in Aging
https://read.qxmd.com/read/38533302/biomedicines-in-longevity-and-aging-the-quest-to-resist-biological-decline
#13
REVIEW
Raymond D Palmer
Aging is considered part of the natural process of life, however in recent years medical literature has started to show that specific facets of aging are beginning to be understood and those factors may even be considered preventable with various measures. Aging is also considered the number one cause of poor quality of life, disease, disability, and death, so the importance of understanding the aging process and how to control certain aspects of it cannot be underestimated when age related suffering is factored in...
2024: BioMedicine
https://read.qxmd.com/read/38533285/the-hidden-battle-within-shedding-light-on-the-co-existence-of-sarcopenia-and-sarcopenic-obesity-among-participants-with-type-2-diabetes-in-a-tertiary-care-hospital-gujarat
#14
JOURNAL ARTICLE
M Yogesh, Mansi Mody, Naresh Makwana, Samarth Rabadiya, Jenish Patel, Samyak Shah
INTRODUCTION: Type 2 diabetes (T2DM) is characterised by chronic hyperglycaemia due to abnormal insulin secretion and/or utilisation. Currently, sarcopenia has emerged as a new complication of T2DM, which increases the risk of physical disability, and even death. The study aims to estimate the prevalence of sarcopenia and sarcopenic obesity (SO) as well as their association with various other factors related to T2DM. METHODS: The study was an observational hospital-based cross-sectional study conducted among diabetic patients who came to the non-communicable diseases (NCD) clinic of a tertiary care hospital in Gujarat, India, from April 2023 to June 2023...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533137/torsion-in-uterus-an-obstetrical-and-gynaecological-emergency
#15
REVIEW
Sukanya Singh, Surekha Tayade, Drashti Patel
Uterine torsion is defined as torsion of the uterus along its longitudinal axis greater than 45 degrees. It is observed in all age groups of the reproductive period, in all parity groups, and at all stages of pregnancy. Torsion from 60 degrees to 720 degrees has been described. It is not possible to clarify why it occurs, but numerous abnormalities have appeared with uterine torsion. It is a rare complication that can result in placental abruption and intrauterine foetal death. Pregnancy, giant fibroids, and ovarian cysts are among the most common causes...
February 2024: Curēus
https://read.qxmd.com/read/38532939/safety-and-efficacy-of-recombinant-fusion-protein-linking-coagulation-factor-ix-with-albumin-rix-fp-in-previously-untreated-patients-with-hemophilia-b
#16
JOURNAL ARTICLE
Richard Lemons, Michael Wang, Julie Curtin, Lynda Mae Lepatan, Christoph Male, Flora Peyvandi, Mario von Depka Prondzinski, Rongrong Wang, William McKeand, Wilfried Seifert, Johannes Oldenburg
Introduction  Recombinant fusion protein linking coagulation factor IX (FIX) with albumin (rIX-FP) has been shown to be an effective, well-tolerated treatment for patients with severe hemophilia B who had previously received factor replacement therapy. This study investigated the safety and efficacy of rIX-FP in previously untreated patients (PUPs). Methods  Patients with moderately severe/severe hemophilia B (≤2% FIX) previously untreated with FIX replacement products received rIX-FP (25-75 IU/kg) prophylaxis weekly or on-demand treatment over ≥50 exposure days (EDs)...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38532821/lncrna-h19-a-novel-biomarker-in-cardiovascular-disease
#17
REVIEW
Xiaojun Li, Yugui Zhang, Zhaoran Ding, Yijun Chen, Wei Wang
Cardiovascular disease is a major cause of death and disability worldwide. Recently, increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in the pathogenesis of cardiovascular diseases, including atherosclerosis, coronary artery disease, dilated cardiomyopathy, diabetic cardiomyopathy, aortic dissection, and more. LncRNA H19 was the first to be described as a non-protein-coding mRNA-like molecule. A large number of studies have found that lncRNA H19 is related to the pathophysiological processes of cardiovascular diseases, and it is emerging as a potential key regulator of various heart diseases...
March 2024: Acta Cardiologica Sinica
https://read.qxmd.com/read/38532175/overview-of-the-indigenous-health-of-the-yanomami-ethnic-group-in-brazil-a-public-health-emergency
#18
JOURNAL ARTICLE
Nathália Mariana Santos Sansone, Eduarda Vitta, Bianca Aparecida Siqueira, Fernando Augusto Lima Marson
INTRODUCTION: The Indigenous population of the Yanomami ethnic group in Brazil is currently facing a public health emergency due to the high number of deaths, mainly of children. Taking that into consideration, this study aims to analyze this crisis impact on the health of this population in the period between 2018 and 2022. METHODS: The data presented were collected from the report called Yanomami Mission ("Missão Yanomami") published by the Brazilian Ministry of Health and, from it, a descriptive analysis of the Indigenous individuals' health was carried out for (i) the geographical distribution; ii) the number of deaths; (iii) the child death rate; (iv) the deaths of Indigenous individuals from preventable causes; (v) the causes of preventable diseases related to hygiene and basic sanitation, and the distribution of diarrheal diseases according to age groups; (vi) evaluation of the nutritional classification; vii) the percentage (%) of the complete vaccination scheme, and (viii) the coverage of prenatal appointments of Indigenous pregnant women...
March 26, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38531803/analysis-and-investigation-of-bioinformatics-and-epigenetics-reveal-the-underlying-mechanisms-by-which-flot2-modulates-the-progression-of-diffuse-large-b-cell-lymphoma
#19
JOURNAL ARTICLE
Yujing Zhang, Yao Chen, Qiang Guo, Ying Zhang, Aichun Liu
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) poses a significant threat to the quality of life for people worldwide. Regrettably, effective treatment strategies for this disease remain elusive in clinical practice due to the unclear understanding of its molecular mechanisms. Therefore, this study was devised to address these issues and identify novel diagnostic, therapeutic, and prognostic biomarkers for DLBCL. METHODS: Gene expression and clinical data for DLBCL patients were retrieved from The Cancer Genome Atlas (TCGA) database, and relevant clinical data, tumor mutational burden (TMB), and gene expression levels were extracted...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531462/edaravone-counteracts-redox-and-metabolic-disruptions-in-an-emerging-zebrafish-model-of-sporadic-als
#20
JOURNAL ARTICLE
Nuno A S Oliveira, Brígida R Pinho, Joana Pinto, Paula Guedes de Pinho, Jorge M A Oliveira
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the death of motor neurons leads to loss of muscle function. Additionally, cognitive and circadian disruptions are common in ALS patients, contributing to disease progression and burden. Most ALS cases are sporadic, and environmental exposures contribute to their aetiology. However, animal models of these sporadic ALS cases are scarce. The small vertebrate zebrafish is a leading organism to model neurodegenerative diseases; previous studies have proposed bisphenol A (BPA) or β-methylamino-l-alanine (BMAA) exposure to model sporadic ALS in zebrafish, damaging motor neurons and altering motor responses...
March 24, 2024: Free Radical Biology & Medicine
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