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https://www.readbyqxmd.com/read/30549220/impact-of-modified-folfox-6-for-patients-with-gastric-cancer-and-a-gastrointestinal-obstruction
#1
Hiroki Yukami, Tetsuji Terazawa, Masahiro Goto, Masahiko Aoki, Ken Asaishi, Toshifumi Yamaguchi, Shin Kuwakado, Takayuki Kii, Kazuhide Higuchi
AIM: Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX-6 for gastric cancer patients with a gastrointestinal obstruction. METHODS: Patients with a poor oral intake because of a gastrointestinal obstruction who received mFOLFOX-6 as systemic chemotherapy were retrospectively analyzed...
December 13, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30543763/role-of-adverse-events-in-unscheduled-hospitalizations-among-patients-with-solid-tumors-who-receive-medical-oncology-treatment
#2
Chris I Wong, Jessica A Zerillo, Sherri O Stuver, Jocelyn H Siegel, Joseph O Jacobson, Kristen K McNiff
PURPOSE: The development of strategies to prevent or mitigate cancer treatment-related adverse events (AEs) is necessary to improve patient experience, safety, and cost containment. To develop a strategy to easily identify and mitigate AEs, we sought to understand the frequency and severity of those that resulted in hospitalizations. METHODS: We retrospectively characterized hospitalizations of ambulatory adult patients with solid tumor cancers within 30 days of chemotherapy administration using medical record data abstraction...
December 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/30543762/practice-patterns-for-older-adult-patients-with-advanced-cancer-physician-office-versus-hospital-outpatient-setting
#3
Allison Lipitz-Snyderman, Coral L Atoria, Stephen M Schleicher, Peter B Bach, Katherine S Panageas
PURPOSE: A shift in outpatient oncology care from the physician's office to hospital outpatient settings has generated interest in the effect of practice setting on outcomes. Our objective was to examine whether medical oncologists' prescribing of drugs and services for older adult patients with advanced cancer is used more in physicians' offices compared with hospital outpatient departments. METHODS: This was a retrospective comparative study. SEER-Medicare data (2004 to 2011) were used to identify Medicare beneficiaries diagnosed with advanced breast, colon, esophagus, non-small-cell lung, pancreatic, or stomach cancer...
December 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/30503265/outpatient-desensitization-of-patients-with-moderate-high-risk-to-severe-platinum-hypersensitivity-reactions
#4
Monica Hagan Vetter, Ambar Khan, Floor J Backes, Kristin Bixel, David E Cohn, Larry J Copeland, Jeffrey M Fowler, Ritu Salani, Quan Li, David M O'Malley
OBJECTIVES: Platinum hypersensitivity reactions (HSR) affect approximately 5% of the general oncologic population. Here we report the efficacy and safety of outpatient platinum desensitization protocol (PD) in gynecologic oncology patients with moderate (high-risk) to severe platinum HSR. METHODS: This is a retrospective report of patients with gynecologic malignancies undergoing an outpatient PD for moderate (high-risk) to severe platinum HSR from 2011 to 2017...
November 29, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30497510/exploring-behaviors-treatment-beliefs-and-barriers-to-oral-chemotherapy-adherence-among-adult-leukemia-patients-in-a-rural-outpatient-setting
#5
C Suzanne Lea, Sulochana Bohra, Tiffanie Moore, Chelsea Passwater, Darla Liles
OBJECTIVE: Adherence to oral chemotherapy is essential for patients with chronic myeloid leukemia (CML) and multiple myeloma (MM) to remain in remission. Few studies have used a Likert-type scale to measure medication adherence in CML and MM patients. We applied a validated treatment adherence tool, the ASK-12 (Adherence Starts with Knowledge® ) survey, which assessed inconvenience and forgetfulness, treatment beliefs, and medication-taking behaviors recorded on a five-point Likert-type scale at two visits...
November 29, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/30484592/clinical-use-of-cardiac-troponin-for-acute-cardiac-care-and-emerging-opportunities-in-the-outpatient-setting
#6
Yader Sandoval, Korosh Sharain, Amy K Saenger, Stephen W Smith, Fred S Apple, Allan S Jaffe
Cardiac troponin (cTn) testing has evolved significantly in recent times. Because of increased sensitivity, its use has shifted from a marker used solely to help diagnose acute myocardial infarction (MI) to a marker than can be used in the outpatient setting, as well as for both detection of myocardial injury and risk-stratification. Its main role remains in the diagnosis of acute MI and the risk-stratification of patients presenting with suspected acute coronary syndrome. The analytical improvements in assays leading to precise high-sensitivity cTn assays have contributed to the development of numerous strategies to identify patients at both low- and high-risk for acute MI within a few hours...
November 27, 2018: Minerva Medica
https://www.readbyqxmd.com/read/30478672/predictive-factors-for-taxane-acute-pain-syndrome-determined-by-ordered-logistic-regression-analysis
#7
Yuko Kanbayashi, Kouichi Sakaguchi, Katsuhiko Nakatsukasa, Yoshimi Ouchi, Yusuke Tabuchi, Tomoko Yoshioka, Takeshi Ishikawa, Koichi Takayama, Tetsuya Taguchi
This retrospective study was undertaken to identify predictive factors for developing taxane acute pain syndrome (TAPS) and to determine new strategies for improving QoL in patients undergoing chemotherapy. Between November 2010 and May 2018, we enrolled 121 breast cancer patients at our outpatient chemotherapy center who were undergoing chemotherapy with nanoparticle albumin-bound paclitaxel (nab-PTX) every 3 weeks. Variables related to the development of TAPS were extracted from the patients' clinical records and used for regression analysis...
November 26, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30477836/effectiveness-of-group-art-therapy-on-quality-of-life-in-paediatric-patients-with-cancer-a-randomized-controlled-trial
#8
Deldar Morad Abdulah, Bayar Mohammed Omar Abdulla
OBJECTIVES: Children with cancer undergoing chemotherapy experience many adverse effects. The effectiveness of painting- and handcrafting-based art therapy on the various dimensions of health-related quality of life in paediatric outpatients previously diagnosed with heterogeneity of malignancy was evaluated in the present study. DESIGN: In an experimental randomized controlled trial, a total of 60 children aged 7-13 years previously diagnosed with malignancy together with their parents were assigned randomly either to an experimental (30 patients) or a control group (30 patients) in 2017 in Iraq...
December 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/30461128/incidence-of-and-risk-factors-for-development-of-oral-mucositis-in-outpatients-undergoing-cancer-chemotherapy
#9
Seher Çakmak, Nesrin Nural
AIM: The aims of the study are to determine the incidence of oral mucositis, the stage of the condition, risk factors, and other oral complications in patients receiving outpatient chemotherapy and to evaluate the factors that have an impact on these. METHODS: The study included 147 patients undergoing outpatient cancer chemotherapy at the Chemotherapy Unit of a University Hospital between February and April 2015. We used a questionnaire and the World Health Organization "Mucositis Grading Scale"...
November 21, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/30452004/monitoring-temperature-knowledge-and-skills-of-outpatients-with-cancer
#10
Teresa Honaker, Alissa Long, Debra Lyons, Reba McCoy, Dana Salters, Susan K MacArthur
BACKGROUND: Elevated temperature can be the first sign of infection; obtaining an accurate temperature in patients undergoing chemotherapy is critical. OBJECTIVES: This study sought to determine outpatients' temperature-monitoring knowledge and skills; whether an educational DVD could increase knowledge; and the level of agreement between a home thermometer and a calibrated hospital thermometer. METHODS: The intervention was an educational DVD...
December 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/30449851/-the-incidence-and-management-of-hypersensitivity-and-infusion-reactions-in-an-outpatient-chemotherapy-center
#11
Hiromi Sekine, Ayumi Akaiwa, Yumiko Onozawa, Taeko Kinjo, Hitomi Nakamura, Rie Nakamura, Mieko Nawa, Shizuka Yoshida, Nobuo Araki, Makoto Iizuka, Hiroaki Shimizu, Noriaki Sunaga, Norifumi Tsukamoto
Hypersensitivity reactions(HSRs)are adverse events that are potentially caused by all anticancer agents. HSRs are unpredictable and can occur at any time, and prompt intervention is needed when symptoms occur. The types of symptoms and their degrees vary with the anticancer agent used and the number of chemotherapy cycles. Here, we evaluated the degree of HSRs and their frequencies in the outpatient chemotherapy center of Gunma University Hospital. Among 55,046 patients, 141 (0.26%)cases of HSRs and 70(0.13%)cases of infusion reactions were identified...
November 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/30444957/from-telling-to-sharing-to-silence-a-longitudinal-ethnography-of-professional-patient-communication-about-oral-chemotherapy-for-colorectal-cancer
#12
Gary Mitchell, Sam Porter, Elizabeth Manias
BACKGROUND: Healthcare professionals are encouraged to promote concordance, a shared agreement about prescription and administration of medications, in their communication with patients. However, there is a paucity of research regarding the impact of communication about self-administered oral chemotherapy. The aim of this study was to examine the changing dynamics of communication through the patient journey from diagnosis of colorectal cancer to posttreatment of chemotherapy. METHODS: Over 60 hours of observational data were digitally recorded from interactions between 15 healthcare professionals, eight patients with colorectal cancer prescribed capecitabine, and 11 family members over a 6-month period in outpatient departments within one hospital in the United Kingdom...
November 16, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/30428872/paraneoplastic-syndrome-as-the-presentation-of-limited-stage-small-cell-carcinoma
#13
Kia Nikoomanesh, Julian Choi, Sarkis Arabian
BACKGROUND: Small cell lung carcinoma (SCLC) is one of the deadliest forms of lung cancer due to its poor prognosis upon diagnosis, rapid doubling time, and affinity for metastasis. As 60-70% of patients with SCLC have disseminated disease upon presentation, it is imperative to determine the extent of disease burden for treatment. As a neuroendocrine carcinoma, clinicians must pay close attention to abnormal findings in a smoker that could lead to earlier diagnosis and better prognostication...
November 14, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/30407350/nivolumab-therapy-for-metastatic-collecting-duct-carcinoma-after-nephrectomy-a-case-report
#14
Shotaro Yasuoka, Tsutomu Hamasaki, Eigo Kuribayashi, Masato Nagasawa, Takanori Kawaguchi, Yoji Nagashima, Yukihiro Kondo
RATIONALE: Collecting duct carcinoma (CDC) is a rare type of nonclear renal cell carcinoma, often presenting at an advanced stage of the disease, and standard treatment guidelines have not been established. PATIENT CONCERNS: A 73-year-old man was admitted to our hospital with complaints of fever and lower right back pain. DIAGNOSES: Computed tomography revealed a poorly defined tumor of the right kidney without metastasis. The patient underwent right radical nephrectomy and was diagnosed with clinical stage T1bN0M0 renal cancer; the pathological findings showed collecting duct carcinoma...
November 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30396959/improvement-of-dysgeusia-by-polaprezinc-a-zinc-l-carnosine-in-outpatients-receiving-cancer-chemotherapy
#15
Hironori Fujii, Chiemi Hirose, Masashi Ishihara, Hirotoshi Iihara, Hisashi Imai, Yoshihiro Tanaka, Nobuhisa Matsuhashi, Takao Takahashi, Kazuya Yamaguchi, Kazuhiro Yoshida, Akio Suzuki
BACKGROUND/AIM: Dysgeusia is one of the adverse events frequently affecting patients undergoing cancer chemotherapy. Dysgeusia-induced anorexia could decrease patient's quality of life. The present study was designed to determine whether the zinc-containing compound polaprezinc improves chemotherapy-induced dysgeusia. PATIENTS AND METHODS: The incidence of grade 2 dysgeusia was assessed in 634 patients receiving cancer chemotherapy in outpatient settings during January 2013 and June 2017...
November 2018: Anticancer Research
https://www.readbyqxmd.com/read/30382054/-a-case-of-long-term-survival-with-multidisciplinary-treatment-in-unresectable-advanced-gastric-cancer-found-with-ovarian-tumor
#16
Suguru Nukada, Toru Aoyama, Mariko Kamiya, Junya Morita, Yukio Maezawa, Shinya Amano, Kazuki Kano, Masakatsu Numata, Sho Sawazaki, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Norio Yukawa, Takashi Oshima, Yasushi Rino, Munetaka Masuda
Although chemotherapy is the standard treatment for unresectable advanced gastric cancer, its prognosis is poor and the median survival time is only around 10 months. With some literature consideration, we report that ovarian metastasis triggered the diagnosis of unresectable advanced gastric cancer with long-term survival through multidisciplinary treatment. This is the case of a 69-year-old woman, who was diagnosed with ovarian tumor and underwent right extracorporectomy and omentum resection in 2011. Pathological diagnosis suspected adenocarcinoma...
October 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/30381649/-survey-of-the-efficacy-of-long-term-and-successive-pharmaceutical-care-in-outpatient-chemotherapy-by-oncology-pharmacy-specialists
#17
Yoshitaka Saito, Sachiko Harada, Masaki Kobayashi, Kosuke Ueda, Kojiro Yamazaki, Masayoshi Kumai, Takenori Miyamoto, Kumiko Kasashi, Takehiro Yamada, Yoshito Komatsu, Ken Iseki
It is important that pharmacists ensure safe chemotherapy implementation. In addition to inspecting chemotherapeutic prescriptions according to patient condition and drug-drug interactions, the management of chemotherapy-induced adverse effects and associated pharmaceutical intervention is one of the most important responsibilities of pharmacists in medical care teams. In May 2016, an oncology pharmacist was set responsible for the specialized, long-term, and successive pharmaceutical care, including instructions about appropriate use of medication at an outpatient chemotherapy center...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/30369763/diffuse-large-b-cell-lymphoma-a-rare-cause-of-lung-consolidation
#18
Aditya Jandial, Kundan Mishra, Pranab Dey, Deepak Goni, Mohd Umair, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Neelam Varma, Pankaj Malhotra
Diffuse large B-cell lymphoma (DLBCL) is the commonest sub-type of non-Hodgkin lymphoma. However, lung consolidation is a rare presentation of DLBCL. Moreover, in view of poor general condition, it poses clinical dilemma of when to start chemotherapy and whether chemotherapy should be given at full dose or truncated doses till improvement in general condition. A 48-years-old lady was admitted with complaints of non-productive cough for 2 months duration. She was febrile and hypoxemic requiring oxygen supplementation...
October 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/30361452/trans-frontal-five-fluorouracil-trafff-a-novel-technique-for-the-application-of-adjuvant-topical-chemotherapeutic-agents-in-sinonasal-adenocarcinoma
#19
Narinder Singh, Eugene Wong, Johnson Huang, Faruque Riffat
Sinonasal adenocarcinoma has traditionally been treated with surgery (craniofacial or endoscopic) and adjuvant radiotherapy. Two large series have demonstrated favourable 5-year survival using surgery with adjuvant topical chemotherapy applied repeatedly over several weeks. The authors describe a novel, transnasal application of topical 5-fluorouracil. However, complete coverage of the frontal region of the anterior skull base can be difficult to achieve with a purely transnasal approach in an outpatient setting...
October 24, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30359714/reduced-recurrence-of-low-grade-papillary-bladder-tumors-associated-with-asymptomatic-bacteriuria
#20
Harry Herr, Machele Donat
OBJECTIVE: To determine tumor recurrence rate of low-grade, papillary, non-muscle-invasive (TaLG) bladder tumors in patients who have asymptomatic bacteriuria (ABU). Microbes in the urine trigger immune responses like intravesical BCG, suggesting that common bacteria may also exert an antitumor effect. METHODS: We investigated recurrence rates in 387 patients with low-grade, papillary non-invasive bladder tumors (TaLG), with or without asymptomatic bacteriuria (ABU)...
October 22, 2018: Urology
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