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outpatient chemotherapy

Paolo Cotogni, Taira Monge, Maurizio Fadda, Antonella De Francesco
BACKGROUND: Home parenteral nutrition (HPN) can improve survival, quality of life, nutritional and functional status in cancer patients. Bioelectrical impedance analysis (BIA) is a non-invasive, validated method to assess body composition. The objective of this prospective single-arm study was to investigate the impact of HPN in advanced cancer patients receiving chemotherapy assessed by BIA, clinical and laboratory measures. METHODS: Adult malnourished cancer outpatients with solid tumors receiving anticancer treatments who were candidates for daily HPN were enrolled...
October 17, 2018: BMC Cancer
A Santaballa, J De Castro, J Maurel, M Lázaro, R Vera, E Alba
PURPOSE: To determine the current management of oral and intravenous chemotherapy (OC and IVC) in outpatient clinics of Oncology Departments in Spain to detect opportunities for improvement. MATERIALS AND METHODS: The Spanish Society of Medical Oncology designed a questionnaire specifically for Heads of Oncology Department: 142 were invited and 52 responded. RESULTS: In most centers, the waiting time (69.7%) and time at the outpatient clinic (84...
October 16, 2018: Clinical & Translational Oncology
Brian H Kushner, Irene Y Cheung, Shakeel Modak, Ellen M Basu, Stephen S Roberts, Nai-Kong Cheung
Importance: Chimeric and murine anti-GD2 antibodies are active against neuroblastoma, but the development of neutralizing antibodies can compromise efficacy. To decrease immunogenicity, hu3F8, a humanized anti-GD2 antibody, was constructed. Objective: To find the maximum-tolerated dose of hu3F8 with granulocyte-macrophage colony-stimulating factor. Design, Setting, and Participants: This phase 1 clinical trial used a 3 + 3 dose-escalation design in a single referral center (Memorial Sloan Kettering Cancer Center, New York, New York)...
September 20, 2018: JAMA Oncology
Jill A Bell, Aaron Galaznik, Marlo Blazer, Huai-Che Shih, Eileen Farrelly, Augustina Ogbonnaya, Michael Eaddy, Robert J Fram, Douglas V Faller
BACKGROUND AND OBJECTIVE: Significant clinical burden is associated with higher-risk myelodysplastic syndromes (HR-MDS); however, the economic burden has not been fully examined. We examined cost of care and healthcare utilization (HCU) in HR-MDS patients engaged in routine care in the United States (US). METHODS: Adult US patients diagnosed with HR-MDS from 1/1/2008 to 10/31/2015 were identified from the Optum database. Patients were followed until death, progression to acute myeloid leukemia (AML), end of enrollment, or end of study (12/31/2015)...
October 15, 2018: PharmacoEconomics Open
Inger Utne, Borghild Løyland, Ellen Karine Grov, Hege Lund Rasmussen, Ann Helen Torstveit, Bruce A Cooper, Judy Mastick, Melissa Mazor, Melisa Wong, Steven M Paul, Yvette P Conley, Thierry Jahan, Christine Ritchie, Jon D Levine, Christine Miaskowski
PURPOSE: While attentional function is an extremely important patient outcome for older adults, research on changes in function in this group is extremely limited. The purposes of this study were to: identify subgroups of older patients (i.e., latent growth classes) based on changes in their level of self-reported attentional function; determine which demographic and clinical characteristics were associated with subgroup membership; and determine if these subgroups differed on quality of life (QOL) outcomes...
October 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Xiao Bin Lai, Shirley Siu Yin Ching, Frances Kam Yuet Wong, Carenx Wai Yee Leung, Lai Ha Lee, Jessica Shuk Yin Wong, Yim Fan Lo
PURPOSE: To evaluate the cost-effectiveness of a nurse-led care program for breast cancer patients receiving outpatient-based chemotherapy. METHOD: An open-label, single-center randomized controlled trial was conducted. Patients receiving the nurse-led care and those receiving the routine care were compared in terms of quality of life, as well as in health service utilizations and total cost of care. A cost-utility analysis was conducted. RESULTS: A total of 124 patients were recruited...
October 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Tina W F Yen, Ann B Nattinger, Emily L McGinley, Nicole Fergestrom, Liliana E Pezzin, Purushottam W Laud
PURPOSE: The effect of advanced practice provider (APP) involvement in oncology care on cancer-specific outcomes is unknown. We examined the association between team-based APP-physician care during chemotherapy and chemotherapy-related adverse events (AEs) among women with breast cancer. METHODS: We performed separate nested case-control analyses in two national cohorts of women who received chemotherapy for incident breast cancer. Cohorts were identified from Medicare (≥ 65 years of age) and MarketScan (18 to 64 years of age) data...
October 10, 2018: Journal of Oncology Practice
Huifang Lu, Anna S Lok, Carla L Warneke, Sairah Ahmed, Harrys A Torres, Fernando Martinez, Maria E Suarez-Almazor, Jessica T Foreman, Alessandra Ferrajoli, Jessica P Hwang
BACKGROUND: Patients previously infected with hepatitis B virus (HBV; indicated by positivity for anti-HBc) can experience HBV reactivation during cancer chemotherapy. Intravenous immunoglobulin infusion, which is frequently used in supportive care, might facilitate passive transfer of anti-HBc. We aimed to estimate the probability of passive transfer of anti-HBc after intravenous immunoglobulin infusion in patients with cancer. METHODS: We reviewed institutional databases to identify adult patients who received outpatient chemotherapy between Jan 1, 2004, and Dec 31, 2011, at the University of Texas MD Anderson Cancer Center, Houston, TX, USA...
October 2018: Lancet Haematology
Satoshi Dote, Shoji Itakura, Kohei Kamei, Daiki Hira, Satoshi Noda, Yuka Kobayashi, Tomohiro Terada
BACKGROUND: Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic drugs in colorectal cancer is unclear. The aim of this study was to investigate the differences in oral mucositis between panitumumab (Pmab) and cetuximab (Cmab) combined with 5-fluorouracil (5-FU). METHODS: We conducted a retrospective cohort study...
October 5, 2018: BMC Cancer
Jochen Hefner, Sara Berberich, Elena Lanvers, Maria Sanning, Ann-Kathrin Steimer, Volker Kunzmann
Purpose: The prescribing of oral chemotherapy agents has introduced the new challenge of ensuring patients' adherence to therapy. Aspects of a close patient-doctor relationship are reported to be correlated with adherence to oral anticancer drugs, but data on capecitabine are scarce. Patients and methods: Sixty-four outpatients with a diagnosis of cancer and prescribed capecitabine were recruited from a German Comprehensive Cancer Center. We used the Patient-Doctor Relationship Questionnaire (PDRQ-9), the Medical Adherence Rating Scale (MARS), the Beliefs about Medicines Questionnaire (BMQ), and the Satisfaction with Information about Medicines Scale (SIMS) to assess patients' perceptions and behavior...
2018: Patient Preference and Adherence
Hajar Dehghan, Ali Keshtkaran, Niloofar Ahmadloo, Zahra Bagheri, Nahid Hatam
In cancer patients, improving the quality of life is a basic goal of treatment, with the patient – physician relationship as a major factor. Therefore the aim of this structural equation modeling study was to analyze the influence of patient involvement in care on quality of life in 411 breast cancer patients undergoing outpatient chemotherapy and radiotherapy. Two questionnaires were used: 1-patient-physician questionnaire, 2-EORTC QLQC-30 (to measure QOL). The structural equation model exhibited an excellent data fit (Chi-Square= 31...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mirjam Renovanz, Dorothea Maurer, Heike Lahr, Elke Weimann, Monika Deininger, Christian Rainer Wirtz, Florian Ringel, Susanne Singer, Jan Coburger
Objective: Supportive care needs in glioma patients often remain unrecognized, and optimization in assessment is required. First, we aimed at assessing the support needed using a simple structured questionnaire. Second, we investigated the psychosocial burden and support requested from caregivers. Methods: Patients were assessed at three centers during their outpatient visits. They completed the Distress Thermometer (DT; score ≥ 6 indicated significant burden in brain tumor patients), the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30+BN20, and the Patients' Perspective Questionnaire (PPQ) that assessed psychosocial distress as well as support requested and received by patients for specific domains (e...
2018: Frontiers in Neurology
Susan Krikorian, Susan Pories, Gary Tataronis, Thomas Caughey, Kirsten Chervinsky, Margaret Lotz, Abra H Shen, Lisa Weissmann
Purpose There is very little data on the effect of combining methods to better predict and improve oral antineoplastic adherence in cancer patients. The goal of this study was to evaluate the effectiveness of an intensive pharmacist intervention at the beginning of oral antineoplastic therapy versus nurse-led control group on adherence. Methods This was a prospective, randomized, open-label controlled trial performed in a single center hematology/oncology outpatient service to compare the effectiveness of repetitive pharmacist educational intervention on adherence rates measured at four and eight weeks after prescribing oral antineoplastic medication compared to a nurse-led control group...
September 26, 2018: Journal of Oncology Pharmacy Practice
Loisa Drozdoff, Evelyn Klein, Marion Kiechle, Daniela Paepke
BACKGROUND: Biologically-based complementary medicines (BB-CAM) including herbs and nutritional supplements are frequently taken by breast- and gynecological cancer patients undergoing systemic therapy. The aim of this study was to analyze the use of these natural CAM methods under systemic therapy. METHODS: From September 2014 to December 2014 and February 2017 to May 2017 all patients (n= 717) undergoing systemic therapy at the day care unit, Department of Gynecology and Obstetrics, Technical University Munich, Germany, with breast- and/or gynecological cancer were included in this survey...
September 24, 2018: BMC Complementary and Alternative Medicine
Julia Quidde, Yiqi Pan, Melanie Salm, Armin Hendi, Sven Nilsson, Karin Oechsle, Alexander Stein, Yvonne Nestoriuc
BACKGROUND: Patients undergoing chemotherapy are highly burdened by side effects. These may be caused by the pharmacodynamics of the drug or be driven by psychological factors such as negative expectations or pre-conditioning, which reflect nocebo effects. As such, negative pre-treatment expectations or prior experiences might exacerbate the burden of chemotherapy side effects. Educating patients about this nocebo effect has been put forward as a potential strategy to optimize patients' pre-treatment expectations...
September 24, 2018: BMC Cancer
Anna Howard, Julia Kerr, Monica McLain, Jessie Modlin
Background Oral chemotherapy agents are being prescribed more frequently in many cancer types. In-office dispensing of oral chemotherapy agents has demonstrated clinical benefits and also shown financial benefit to third-party payers. A previous publication estimated over $200,000 in cost savings annually from in-office dispensing solely from medications returned to stock for credit. However, pharmacists in the in-office setting perform many other interventions that may affect financial outcomes. Objective Assess financial impact of oral chemotherapy in-office dispensing by a clinic-based oral chemotherapy program serving five outpatient cancer centers in Southern Idaho...
September 24, 2018: Journal of Oncology Pharmacy Practice
Emi Aoshima, Marie Mibu, Masaru Kubota, Tohru Hashida
No abstract text is available yet for this article.
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Kenji Mimatsu, Mikiko Kumasaka, Miho Shirato, Ai Hayashi, Tsugutoshi Toma, Hiroko Toda, Yutaka Imai, Yoshihiro Kobayashi, Ayako Okamura, Hirotoshi Fujikawa, Yuichi Kishimoto, Nobutada Fukino, Hajime Suguro
No abstract text is available yet for this article.
September 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Huayan Yuan, Yuanyuan Yang, Wuyi Wang, Yong Cheng
RATIONALE: Rectal neuroendocrine tumor is a rare disease that is difficult to diagnose by clinical and imageological examinations. The treatment of rectal neuroendocrine tumors is still controversial. PATIENT CONCERNS: A 50-year-old woman complained of abdominal pain beneath the xiphoid process for 1 day. Physical checkup revealed tenderness at the right upper abdomen. A fecal occult blood test was positive. MRI showed an occupation lesion in the right lobe of the liver...
September 2018: Medicine (Baltimore)
Diana Comerford, Raakhee Shah
Ambulatory care (AC) is an approach within which inpatient chemotherapy regimens and supportive care are delivered in an outpatient service. Patients receive their treatments and supportive care daily in AC and stay at a nearby hotel or their home, rather than in an inpatient bed. A systematic literature search found a growing amount of literature on AC and the specific regimens used. However, little was found on AC with regard to the patient experience, safety, the benefits and challenges of running an AC service...
September 20, 2018: British Journal of Nursing: BJN
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