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Ying Zhan, Lihua Wang, Guangyang Liu, Xiaohui Zhang, Jingci Yang, Yuxia Pan, Jianmin Luo
Hematological patients who accept chemotherapy always develop secondary tumor or even die of severe infections. As an important central lymphoid organ, the thymus is frequently damaged during chemotherapy. Previous studies showed that the mesenchymal stem cells (MSCs) can promote the proliferation and repair of epithelial cells in thymus. The purpose of our study is to investigate the reparative effects of human adipose-derived mesenchymal stem cells (hADMSCs) for chemotherapy treated damaged thymus. 80 mice were randomly divided into four groups: normal group, model control group, hADMSCs untreated group and hADMSCs treated group...
December 4, 2018: Stem Cells and Development
Kelly M Kenzik, Grant R Williams, Smita Bhatia, Courtney J Balentine
BACKGROUND: Little information is available on the long-term use of post-acute care among older patients with colorectal cancer (CRC), relative to individuals without cancer. This study examines the use of post-acute care among older cancer survivors (>65 y) with CRC and compares it with noncancer patients up to 5 years from surgery. DESIGN: Retrospective cohort. SETTING: SEER-Medicare. PARTICIPANTS: Patients treated for stage I to III CRC between January 1, 2000, and December 31, 2011 (n = 40 812) and noncancer Medicare beneficiaries hospitalized for noncancer treatment matching on age, sex, race, comorbidity, and Medicaid dual eligibility...
December 3, 2018: Journal of the American Geriatrics Society
Daniel Burguete, Ali A Mokdad, Mathew M Augustine, Rebecca Minter, John C Mansour, Michael A Choti, Patricio M Polanco
BACKGROUND: Predictive models for nonhome discharge (NHD) have been proposed in major surgical specialties. The rates and risk factors associated with NHD and prolonged length of stay (PLOS) after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) have not been evaluated. The aim of this study is to identify risk factors for NHD and PLOS after CRS/HIPEC in a national cohort of patients. MATERIALS AND METHODS: CRS/HIPEC cases were identified from the National Surgical Quality Improvement Program 2011-2012 data set...
January 2019: Journal of Surgical Research
Bartosz Grzywacz, Laura Moench, David McKenna, Katelyn M Tessier, Veronika Bachanova, Sarah Cooley, Jeffrey S Miller, Elizabeth L Courville
Cellular immunotherapy using allogeneic natural killer (NK) cells may overcome chemotherapy-refractory acute myeloid leukemia. Our goal was to document NK cell homing/persistence in the bone marrow following adoptive immunotherapy. Our cohort included 109 patients who received NK cell therapy for refractory acute myeloid leukemia following lymphodepleting conditioning +/- denileukin diftitox, +/- low-dose total body irradiation. We evaluated the NK cell density in bone marrow core biopsies performed an average of 14 days after NK cell transfer using a CD56 immunohistochemical stain...
November 27, 2018: Journal of Immunotherapy
András Inotai, Tamás Ágh, Alexei Willem Karpenko, Antal Zemplényi, Zoltán Kaló
INTRODUCTION: Trastuzumab, the standard treatment for HER-2 positive breast cancer, may be associated with access restrictions in countries with severe economic constraints. This study aimed to compare intravenous- (IVT) and subcutaneous trastuzumab (SCT) forms and to explore the transferability of value propositions to Central and Eastern European (CEE) countries. AREAS COVERED: After screening 376 abstracts, 42 articles were included in the final review. Statistical test results were rarely reported, therefore, the similarity of adverse event profiles of SCT and IVT could not be validated...
November 29, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Kajal Gokal, Fehmidah Munir, Samreen Ahmed, Kiran Kancherla, Deborah Wallis
BACKGROUND: Cancer related cognitive impairments have been subjectively reported and objectively detected in breast cancer patients treated with chemotherapy and are known to have a profound negative impact on productivity, psychosocial well-being and overall quality of life. Moderate levels of walking are known to be of benefit to the psychosocial well-being of those affected by breast cancer and for managing cognitive impairment in healthy adults, children, and the elderly. The purpose of this study is to investigate the effects of a home-based, self-managed, moderate intensity walking intervention on subjective and objective cognitive functioning in breast cancer patients undergoing chemotherapy...
2018: PloS One
Lin Cui, Yuli Wang, Meng Liang, Xiaoyang Chu, Shiyao Fu, Chunsheng Gao, Qianqian Liu, Wei Gong, Meiyan Yang, Zhiping Li, Lian Yu, Chunrong Yang, Zhide Su, Xiangyang Xie, Yang Yang, Chunsheng Gao
Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Here we constructed a natural high-density lipoprotein particle (HDL)-based drug delivery system with the dual-modification of T7 and d A7R peptide ligand (T7/d A7R-HDL) to achieve the above goals...
November 2018: Drug Delivery
Clare Warnock, Peter Totterdell, Angela Mary Tod, Rachel Mead, Jamie-Lee Gynn, Barry Hancock
PURPOSE: The primary aim of this study was to examine the value of temperature as a diagnostic and prognostic indicator of infection and sepsis in neutropenic patients. A secondary aim was to gain insight into the presenting symptoms reported by these patients at home or on their initial admission assessment. METHODS: A cohort study was carried out using a case note review of 220 emergency admissions to a regional cancer centre. All participants were neutropenic and were diagnosed with infection on admission...
December 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
Teresa Honaker, Alissa Long, Debra Lyons, Reba McCoy, Dana Salters, Susan K MacArthur
BACKGROUND: Elevated temperature can be the first sign of infection; obtaining an accurate temperature in patients undergoing chemotherapy is critical. OBJECTIVES: This study sought to determine outpatients' temperature-monitoring knowledge and skills; whether an educational DVD could increase knowledge; and the level of agreement between a home thermometer and a calibrated hospital thermometer. METHODS: The intervention was an educational DVD...
December 1, 2018: Clinical Journal of Oncology Nursing
Peter G Jacobs, Peter Hanaway, Joseph Leitschuh, John Condon, Uma Rajhbeharrysingh, Clara Mosquera-Lopez, Carolyn Guidarelli, Kerri Winters-Stone
In this paper, we describe a novel portable test platform that can be used to test peripheral neuropathy either within a clinic or at home. The system, called the PeriVib, is comprised of (1) a small, custom vibration motor designed to apply a vibration stimulus to the toe with constant pressure to test sensation threshold, and (2) a custom smart-phone app that enables a patient to run a series of functional gait and balance tests. Vibration is applied by PeriVib in two separate modes. The first mode, ramp-up, starts at zero amplitude and increases to a maximum level while the patient indicates when they start feeling the pressure by lifting their finger off the touch-screen on the phone...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Asli Nemli, Pinar Tekinsoy Kartin
AIM: To determine the effects of exercise training that was supported with follow-up calls at home on the postoperative level of physical activity and quality of life of women with breast cancer. METHODS: The study was carried out with a quasi-experimental design. Women who had underwent an axillary dissection and mastectomy and who were receiving ongoing chemotherapy treatment in the ambulatory unit of a university hospital were included in the study. Sixty-two women were randomly assigned to an intervention (n = 31) or a control (n = 31) group...
November 14, 2018: Japan Journal of Nursing Science: JJNS
Burkhard Otremba, Carsten Hielscher, Volker Petersen, Christian Petrik
Background: The granulocyte-colony stimulating factor (G-CSF) biosimilar filgrastim (Nivestim™) reduces the duration and severity of neutropenia and the frequency of occurrence of febrile neutropenia (FN). Administration of this biosimilar filgrastim and the patient population receiving it at home have not been sufficiently documented in day-to-day medical practice. Insight into home administration may help optimize the management of FN in this setting, potentially at a reduced cost and patient burden vs hospital administration...
2018: Patient Preference and Adherence
Lena Behrmann, Jasmin Wellbrock, Walter Fiedler
The bone marrow is the home of hematopoiesis and is therefore a hotspot for the development of hematopoietic diseases. Complex interactions between the bone marrow microenvironment and hematopoietic stem cells must find a balance between proliferation, differentiation and homeostasis of the stem cell compartment. Changes in this tightly regulated network can provoke malignant transformation, leading to hematopoietic diseases. Here we focus on acute myeloid leukemia (AML), since this is the most frequent acute leukemia in adulthood with very poor overall survival rates and where relapse after chemotherapy continues to be a major challenge, driving demand for new therapeutic strategies...
2018: Frontiers in Oncology
Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
Nathan H Parker, An Ngo-Huang, Rebecca E Lee, Daniel P O'Connor, Karen M Basen-Engquist, Maria Q B Petzel, Xuemei Wang, Lianchun Xiao, David R Fogelman, Keri L Schadler, Richard J Simpson, Jason B Fleming, Jeffrey E Lee, Gauri R Varadhachary, Sunil K Sahai, Matthew H G Katz
PURPOSE: Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment. We examined differences in weekly self-reported exercise and accelerometer-measured physical activity among participants in a home-based exercise program administered during preoperative treatment for pancreatic cancer. METHODS: Participants were encouraged to perform at least 60 min/week of moderate-intensity aerobic exercise and at least 60 min/week of full-body strengthening exercises concurrent with chemotherapy, chemoradiation therapy or both sequentially and received resistance equipment, program instruction, and biweekly follow-up calls to encourage adherence...
October 17, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Paolo Cotogni, Taira Monge, Maurizio Fadda, Antonella De Francesco
BACKGROUND: Home parenteral nutrition (HPN) can improve survival, quality of life, nutritional and functional status in cancer patients. Bioelectrical impedance analysis (BIA) is a non-invasive, validated method to assess body composition. The objective of this prospective single-arm study was to investigate the impact of HPN in advanced cancer patients receiving chemotherapy assessed by BIA, clinical and laboratory measures. METHODS: Adult malnourished cancer outpatients with solid tumors receiving anticancer treatments who were candidates for daily HPN were enrolled...
October 17, 2018: BMC Cancer
Jordan Doherty, David E Dawe, Gregory R Pond, Peter M Ellis
OBJECTIVES: Small cell lung cancer (SCLC) represents a significant health burden. There is a lack of information about patterns of referral and treatment for older patients over 70 years of age, in comparison to younger patients with SCLC. MATERIALS AND METHODS: A population-based retrospective cohort study was undertaken for patients identified from the Ontario Cancer Registry, Canada. All cases of SCLC diagnosed between January 2000 and December 2010 were eligible...
October 11, 2018: Journal of Geriatric Oncology
K A Nyrop, A M Deal, S K Choi, C W Wagoner, J T Lee, W A Wood, C Anders, L A Carey, E C Dees, T A Jolly, K E Reeder-Hayes, H B Muss
In the original publication, the sixth author name was published incorrectly as A. Wood. The correct author name should read as W. A. Wood.
October 11, 2018: Breast Cancer Research and Treatment
Fabrice Denis, Eric Voog, Yoann Pointreau, Hugues Bourgeois, Valérie Seegers, Katell Le Du
BACKGROUND: We aimed to investigate whether patient self-evaluated symptoms transmitted via Internet is feasible between planned visits to provide an early management of fever and neutropenia induced by chemotherapy, and if it can reduce hospitalizations for severe neutropenia. METHODS: Patients who received a chemotherapy regimen with an overall risk of febrile neutropenia ≥ 20% had to report daily temperature between physician planned visits using a web application...
October 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Nick Gebruers, Melissa Camberlin, Fleur Theunissen, Wiebren Tjalma, Hanne Verbelen, Timia Van Soom, Eric van Breda
OBJECTIVES: The primary purpose of this systematic review is to structure the available evidence concerning physical exercise programs and their effects on (1) physical performance outcomes, (2) experienced fatigue, and (3) quality of life (QoL) in patients during the initial treatment for breast cancer. DATA SOURCES: A systematic literature search, based upon the PRISMA guideline, up to January 1, 2018, was performed using four databases (Web of Science, Cochrane Library for Clinical Trials, PubMed, and Medline)...
October 9, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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