Jessica van der Weijden, Daan Kremer, Lisa B Westenberg, Jan-Stephan F Sanders, Robert A Pol, Ilja M Nolte, Martin H De Borst, Stefan P Berger, Stephan J L Bakker, Marco van Londen
BACKGROUND AND HYPOTHESIS: Accurate estimation of glomerular filtration rate (GFR) is crucial in living kidney donation. While most eGFR equations are based on plasma creatinine, its levels are strongly influenced by muscle mass. Application of cystatin C (CysC)-based estimates before donation may improve both estimation of current GFR and prediction of post-donation GFR. METHODS: We assessed the performance of CKD-EPI equations based on creatinine (eGFRcreat-2009, eGFRcreat-2021), cystatin C (eGFRCysC-2012), or both (eGFRcombined-2012, eGFRcombined-2021) for estimating pre- and post-donation measured GFR in 486 living kidney donors...
March 13, 2024: Nephrology, Dialysis, Transplantation