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https://www.readbyqxmd.com/read/30098489/evaluation-of-free-thyroxine-determination-based-on-one-step-fluorometric-immunoassay-technique-and-the-suboptimal-concordance-with-two-step-immunoassay
#1
Radhouene Doggui, Rahma Mahjoub, Wassef Lotfi Aissa, Imen Tounsi, Zeineb Allagui, Zmorda Cherif, Sihem Haj Sassi, Sinda Ennigrou, Dhiaeddine Edriss, Jalila El Ati, Amina Bibi
Free thyroxine (FT4) quantification is continuing to be a concern. The purpose of the following study was to evaluate the analytical performance of Tosoh AIA900 based on a one-step technique and its comparison to Access 2 (two-step technique) over different clinical contexts (euthyroid, thyroid disorders, uncontrolled diabetes, renal failure and pregnancy). The protocol established by the French society of Clinical Biology was used to evaluate: imprecision, limit of detection, trueness, linearity, interferences and method comparisons...
July 26, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30098239/-clinical-and-genetic-features-of-five-patients-with-allan-herndon-dudley-syndrome
#2
Jiaping Wang, Qingping Zhang, Xinhua Bao, Yan Chen, Shujie Yu
OBJECTIVE: To delineate the clinical and genetic characteristics of patients with Allan-Herndon-Dudley syndrome (AHDS). METHODS: Genetic testing was carried out by next generation sequencing on 117 patients featuring intellectual disability and developmental delay. Clinical information including clinical manifestation, brain magnetic resonance imaging(MRI), thyroid hormone levels, and electrocardiogram was collected for those with SLC16A2 mutations. RESULTS: Five male patients with SLC16A2 gene mutations were identified, including 2 affected brothers and 3 sporadic cases...
August 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/30098100/the-arabidopsis-thada-homolog-modulates-tor-activity-and-cold-acclimation
#3
Yihan Dong, Aurelio Teleman, Christoph Jedmowski, Markus Wirtz, Ruediger Hell
Low temperature is one of the most important environmental factors that affects global survival of humans and animals and equally importantly the distribution of plants and crop productivity. Survival of metazoan cells under cold stress requires regulation of the sensor-kinase Target Of Rapamycin (TOR). TOR controls growth of eukaryotic cells by adjusting anabolic and catabolic metabolism. Previous studies identified the Thyroid Adenoma Associated (THADA) gene as the major effect locus by positive selection in the evolution of modern human adapted to cold...
August 11, 2018: Plant Biology
https://www.readbyqxmd.com/read/30097670/influence-of-lanreotide-on-uptake-of-68-ga-dotatate-in-patients-with-neuroendocrine-tumours-a-prospective-intra-patient-evaluation
#4
E A Aalbersberg, B J de Wit-van der Veen, M W J Versleijen, L J Saveur, G D Valk, M E T Tesselaar, M P M Stokkel
INTRODUCTION: Somatostatin receptor imaging with PET is the standard of care for patients with a neuroendocrine tumour (NET). Since therapy and imaging with somatostatin analogues utilize the same receptor, current guidelines recommend withdrawing long-acting somatostatin analogues for 3-4 weeks prior to somatostatin receptor PET imaging. The aim of this study is to prospectively assess the effect of lanreotide use on the uptake of 68 Ga-DOTATATE intra-individually 1 day prior to and 1 day post injection of lanreotide...
August 10, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/30097501/risk-stratification-of-thyroid-nodules-using-thyroid-imaging-reporting-and-data-system-tirads-the-omission-of-thyroid-scintigraphy-increases-the-rate-of-falsely-suspected-lesions
#5
Simone Schenke, Philipp Seifert, Michael Zimny, Thomas Winkens, Ina Binse, Rainer Goerges
Background: Thyroid nodules are a common finding, especially in iodine-deficient regions. Ultrasonographic scoring systems such as Thyroid Imaging Reporting And Data System (TIRADS) are helpful in differentiating between benign and malignant thyroid nodules by offering a risk stratification model. Depending on the constellation or number of suspicious ultrasound features, a fine needle biopsy (FNB) is recommended. However, none of the previously published TIRADS considered the functional status of the nodules...
August 10, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30097393/spontaneous-coronary-artery-dissection-and-hypothyroidism
#6
Santiago Jesús Camacho Freire, José Francisco Díaz Fernández, Livia Luciana Gheorghe, Antonio Enrique Gómez Menchero, Javier León Jiménez, Jessica Roa Garrido, Rosa Cardenal Piris, Miguel Pedregal González, Teresa Bastante, Marcos García Guimaraes, Alberto Vera, Javier Cuesta, Fernando Rivero, Fernando Alfonso
INTRODUCTION AND OBJECTIVES: Thyroid hormone affects the metabolism of all tissues in the body. The aim of this study was to analyze the prevalence and implications of thyroid disorders in a cohort of consecutive patients with spontaneous coronary artery dissection (SCAD). METHODS: A total of 73 patients with SCAD were analyzed. Baseline characteristics and clinical outcomes were compared between euthyroid and hypothyroid patients. Subsequently, the prevalence of thyroid function abnormalities and the clinical characteristics of SCAD patients were compared with those in 73 patients with acute coronary syndrome but without SCAD, matched by age, sex, and presentation...
August 7, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/30096720/mechanistic-pathways-of-selenium-in-the-treatment-of-graves-disease-and-graves-orbitopathy
#7
Michele Marinò, Giovanna Rotondo Dottore, Marenza Leo, Claudio Marcocci
Based on the role of oxidative stress in the pathogenesis of Graves' hyperthyroidism and Graves' orbitopathy, the use of the antioxidant agent selenium has been proposed and several studies on the subject have been conducted, both in vitro and in vivo. Whereas a true benefit related to the use of selenium in patients with Graves' hyperthyroidism has been questioned, its use in patients with mild Graves' orbitopathy is generally believed to be beneficial because of which selenium has entered in the clinical practice for this eye condition...
August 10, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30096503/a-rare-case-of-thyrotropin-secreting-pituitary-adenoma-coexisting-with-papillary-thyroid-carcinoma-presenting-with-visual-disturbance-without-hyperthyroidism
#8
Hirotaka Inoue, Naoki Shinojima, Ryuta Ueda, Shigetoshi Yano, Keizo Yamamoto, Norio Ishii, Motoyuki Igata, Junji Kawashima, Eiichi Araki, Hirotaka Iwase, Yoshiki Mikami, Akitake Mukasa
BACKGROUND: Thyroid-stimulating hormone (TSH)-secreting pituitary adenomas (TSHomas) are uncommon, and majority of the patients present with symptoms of hyperthyroidism. Herein, we report the first case of TSHoma with DTC that presented with visual disturbance without any clinical feature of hyperthyroidism. CASE DESCRIPTION: A 57-year-old man presented with left temporal hemianopsia of his left eye without any sign of hyperthyroidism. A mass lesion in the sellar and suprasellar region compressing the optic nerves was identified via magnetic resonance imaging...
August 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30096378/cardiac-sparing-whole-lung-imrt-in-children-with-wilms-tumor-final-report-on-technique-and-abdominal-field-matching-to-maximize-normal-tissue-protection
#9
John A Kalapurakal, Bryan Lee, Jonathan Bautista, Cynthia Rigsby, Irene Helenowski, Mahesh Gopalakrishnan
PURPOSE: Cardiac sparing whole lung (WL IMRT) has been shown to improve cardiac protection and lung volume dose coverage compared to standard anteroposterior techniques. This dosimetry study had 2 aims: 1). To determine the dosimetric advantages of a modified WL IMRT (M-WL IMRT) technique designed to reduce radiation exposure to the thyroid gland and breast tissues compared to the standard WL IMRT (S-WL IMRT) and 2). To determine the dosimetric advantages of M-WL IMRT and dosimetrically matched abdomen/flank RT fields designed to reduce normal tissue exposure compared to standard field matching techniques...
August 7, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/30095669/effectiveness-of-early-identification-and-electronic-interventions-for-teens-with-risk-factors-for-the-development-of-heart-disease-and-diabetes-phase-ii-findings
#10
Lorena Jung, Elizabeth Courts, Pam Webber, Qiuping Pearl Zhou
BACKGROUND AND PURPOSE: Serum and physical risk factors for the development of heart disease and diabetes are detectable long before adulthood. The purpose of this two-part study was to assess the prevalence and associations of these risk factors in teens and determine the effectiveness of a customizable two-part electronic education program on minimizing identified risks. METHODS: Data were collected from teens (n = 168) from two high schools (one urban and one rural) in the mid-Atlantic region...
August 6, 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/30095634/the-function-of-carbon-nanoparticles-to-improve-lymph-node-dissection-and-identification-of-parathyroid-glands-during-thyroid-reoperation-for-carcinoma
#11
Bin Wang, An-Ping Su, Teng-Fei Xing, Han Luo, Wan-Jun Zhao, Jing-Qiang Zhu
To evaluate the function of carbon nanoparticles during the thyroid reoperation for carcinoma, we conducted this study by retrospectively analyzing the data of patients who underwent at least completion thyroidectomy with bilateral central lymph nodes dissection for thyroid carcinoma from January 2009 to June 2016. The clinicopathologic characteristics and surgical details were compared between the patient who accepted intraoperative carbon nanoparticles injection and those who accepted nothing injection during the surgery...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30095478/research-ethics-dilemmas-in-thyroid-disease
#12
M Sara Rosenthal, Peter Angelos, Rebecca E Schweppe
PURPOSE OF REVIEW: Since research ethics dilemmas frequently fall outside the purview of the Institutional Review Board (IRB), we present three unique recent research ethics cases in thyroidology that demonstrate research ethics dilemmas. RECENT FINDINGS: The cases presented raise questions surrounding epistemic/scientific integrity, publication ethics, and professional, and personal integrity. SUMMARY: Research ethics dilemmas that fall outside the purview of the IRB are appropriate for a Research Ethics Consultation, a common service in many large academic medical centers...
August 7, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/30095458/beneficial-effect-of-heat-induced-antigen-retrieval-in-immunocytochemical-detection-of-intracellular-antigens-in-alcohol-fixed-cell-samples
#13
Katerina Cizkova, Pavla Flodrova, Romana Baranova, Jakub Malohlava, Matthew Lacey, Zdenek Tauber
Immunohistochemistry and immunocytochemistry (ICC) play an irreplaceable role in research and diagnostics. It is well known that antigen retrieval (AR) can, as a technique, have beneficial outcomes on immunohistochemistry results when using formalin-fixed, paraffin-embedded tissue samples. The main purpose of AR is to break protein crosslinks which are formed during formalin fixation. Although AR was originally designed for formalin-fixed, paraffin-embedded samples, the usefulness of AR in ICC has been described in previous studies...
August 8, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/30095445/use-of-dexmedetomidine-in-a-parturient-with-multiple-endocrine-neoplasia-type-2a-undergoing-adrenalectomy-and-thyroidectomy-a-case-report
#14
Amanda L Faulkner, Eric Swanson, Thomas L McLarney, Cortney Y Lee, Annette Rebel
Dexmedetomidine is a selective α2-agonist, frequently used in perioperative medicine as anesthesia adjunct. The medication carries a Food and Drug Administration pregnancy category C designation and is therefore rarely used for parturients undergoing nonobstetric surgery. We are reporting the use of dexmedetomidine in the anesthetic management of a parturient undergoing minimally invasive unilateral adrenalectomy for pheochromocytoma during the second trimester of pregnancy. Additionally, because of the multiple endocrine neoplasia type 2A constellation with diagnosis of medullary thyroid cancer, the patient underwent a total thyroidectomy 1 week after the adrenalectomy...
August 7, 2018: A&A practice
https://www.readbyqxmd.com/read/30094711/clinical-pharmacokinetics-and-pharmacodynamics-of-dabrafenib
#15
REVIEW
Alicja Puszkiel, Gaëlle Noé, Audrey Bellesoeur, Nora Kramkimel, Marie-Noëlle Paludetto, Audrey Thomas-Schoemann, Michel Vidal, François Goldwasser, Etienne Chatelut, Benoit Blanchet
Dabrafenib is a potent and selective inhibitor of BRAF-mutant kinase that is approved, as monotherapy or in combination with trametinib (mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor), for unresectable or metastatic BRAF-mutated melanoma, advanced non-small cell lung cancer and anaplastic thyroid cancer harbouring the BRAFV600E mutation. The recommended dose of dabrafenib is 150 mg twice daily (bid) under fasted conditions. After single oral administration of the recommended dose, the absolute oral bioavailability (F) of dabrafenib is 95%...
August 9, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/30094410/does-sex-bias-play-a-role-for-dissatisfied-patients-with-hypothyroidism
#16
REVIEW
Elizabeth A McAninch, Jennifer S Glueck, Antonio C Bianco
The current state of the diagnosis and management of thyroid disease cannot be separated from the larger context of women's health for the following reasons: (1) the disproportionate incidence and prevalence of functional and structural thyroid diseases among women vs men; (2) the role of thyroid health on fertility, pregnancy, and postpartum; and (3) the challenge posed in managing the nonspecific symptoms of functional thyroid disease in the context of menopause. Here, we explore the hypothesis that sex bias has played a role in the management of thyroid diseases historically and has extended into the modern medical era...
August 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/30094379/pias-family-proteins-negatively-regulate-glis3-transactivation-function-through-sumo-modification-in-pancreatic-%C3%AE-cells
#17
Tyler M Hoard, Xiao Ping Yang, Anton M Jetten, Gary T ZeRuth
Gli-similar 3 (Glis3) is Krüppel-like transcription factor associated with the transcriptional regulation of insulin. Mutations within the Glis3 locus have been implicated in a number of pathologies including diabetes mellitus and hypothyroidism. Despite its clinical significance, little is known about the proteins and posttranslational modifications that regulate Glis3 transcriptional activity. In this report, we demonstrate that the SUMO-pathway associated proteins, PIASy and Ubc9 are capable of regulating Glis3 transactivation function through a SUMO-dependent mechanism...
July 2018: Heliyon
https://www.readbyqxmd.com/read/30094153/isolated-colonic-metastasis-two-years-after-resection-of-stage-ia-primary-adenocarcinoma-of-the-lung-a-case-report
#18
Stylianos Vittorakis, Georgia Giannakopoulou, Konstantinos Konstantinides, Anna Daskalaki, Konstantinos Samitas
Colonic metastasis from lung cancer is rare, generally asymptomatic and usually develop at advanced cancer stages. Here, we report a case with a resected stage IA lung adenocarcinoma in a 51yo male patient that presented two years later with mild abdominal pain due to intestinal obstruction caused by a metastatic colon tumor. The patient underwent colonoscopy followed by surgical resection and the pathologic report was adenocarcinoma which was the same as that from a lung nodule that was excised two years earlier...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/30094023/hyponatremia-in-kidney-transplant-patients-its-pathophysiologic-mechanisms
#19
Carlos G Musso, Alejandrina Castañeda, María Giordani, Cesar Mombelli, Silvia Groppa, Nora Imperiali, Guillermo Rosa Diez
Kidney transplant patients (KTPs), and particularly those with advanced chronic kidney rejection, may be affected by opportunistic infections, metabolic alterations and vascular and oncologic diseases that promote clinical conditions that require a variety of treatments, the combinations of which may predispose them to hyponatremia. Salt and water imbalance can induce abnormalities in volemia and/or serum sodium depending on the nature of this alteration (increase or decrease), its absolute magnitude (mild or severe) and its relative magnitude (body sodium:water ratio)...
August 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/30093988/thyroid-paraganglioma-a-case-series-of-a-rare-head-and-neck-tumor
#20
Andreas Kiriakopoulos, Dimitrios Linos
Thyroid paragangliomas are rare neuroendocrine tumors. We present two cases analyzing their clinical presentation and pathology findings. A 44-year-old woman presented with a 33 mm left thyroid lobe mass. A 27-year-old male presented with a 27-mm right thyroid lobe mass and a FNA biopsy suggesting a follicular thyroid tumor. Both patients underwent total thyroidectomy. Vigorous bleeding was noted on the first case. Histologic sections revealed encapsulated tumors, whereas immunochemical stains were positive for chromogranin A, synaptophysin and NSE and negative for thyroglobulin, calcitonin, CEA and S-100...
August 2018: Journal of Surgical Case Reports
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