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thyroid OR hyperthyroidism OR hypothyroidism

J Paul Banga, Matthias Schott
No abstract text is available yet for this article.
December 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Mette Nygaard Einfeldt, Anne-Marie Schjerning Olsen, Søren Lund Kristensen, Usman Khalid, Jens Faber, Christian Torp-Pedersen, Gunnar H Gislason, Christian Selmer
Context: Hypothyroidism has detrimental effects on the cardiovascular system, but controversy remains concerning the benefits of levothyroxine (L-T4) substitution in patients with heart failure (HF). Objective: Examining the effects of L-T4 in patients with HF. Design: Retrospective cohort study. Setting and Participants: All Danish citizens aged ≥ 18 years diagnosed with HF between 1997 and 2012. L-T4 treatment was identified from nationwide registers...
December 4, 2018: Journal of Clinical Endocrinology and Metabolism
Arjola Bano, Earn Gan, Caroline Addison, Kilimangalam Narayanan, Jolanta U Weaver, Vasileios Tsatlidis, Salman Razvi
Context: Thyrotropin receptor antibodies (TRAbs) play a crucial role in the pathogenesis of Graves' disease (GD). However, factors that influence the association of TRAbs with thyroid hormones and relapse risk in GD remain unclear. Objective: We investigated: (i) the associations of TRAbs at diagnosis with thyroid hormones and relapse risk; (ii) potential factors that can influence these associations in GD. Design and Setting: A prospective study in GD patients from a single endocrine centre in the north-east of England, seen between January 2008 and March 2018...
December 3, 2018: Journal of Clinical Endocrinology and Metabolism
Sijie Fang, Yazhuo Huang, Ningjian Wang, Shuo Zhang, Sisi Zhong, Yinwei Li, Jing Sun, Xingtong Liu, Yang Wang, Ping Gu, Bin Li, Huifang Zhou, Xianqun Fan
Context: Unique features of local immunity in thyroid-associated ophthalmopathy (TAO) may affect disease progression. Objective: To investigate the association between the orbital immune microenvironment and TAO development. Design/Setting/Participants: TAO and control orbital connective tissues were collected. Main Outcome Measures: Single-cell sequencing examined orbital lymphocytic infiltrates. Multi-color flow cytometry explored the phenotypes of different cell subsets and in vitro models for cell functional studies...
December 3, 2018: Journal of Clinical Endocrinology and Metabolism
Antonio Rahal Junior, Priscila Mina Falsarella, Guilherme Falleiros Mendes, Jairo Tabacow Hidal, Danielle Macellaro Andreoni, José Flávio Ferreira Lúcio, Marcos Roberto Gomes de Queiroz, Rodrigo Gobbo Garcia
OBJECTIVE: To evaluate safety and effectiveness of nodule volume reduction and thyroid function after percutaneous laser ablation treatment in patients with benign nonfunctioning thyroid nodules. METHODS: Prospective single-center study, from January 2011 to October 2012, which evaluated 30 euthyroid and thyroid antibodies negative patients with benign solitary or dominant nodule with indication of treatment due to compressive symptoms and aesthetic disturbances...
November 29, 2018: Einstein
Samir Omar Saleh, Flávio Carneiro Hojaij, Ana Maria Itezeroti, Cristina Pires Camargo, Kassem Samir Saleh, Mauro Figueiredo Carvalho de Andrade, Flávia Emi Akamatsu, Alfredo Luiz Jacomo
OBJECTIVE: to describe the presence of lymph nodes and their relationships with demographic and anthropometric characteristics in a specific region, not yet described in anatomy compendiums, called by us Recurrent Carotid Recess (RCR) and located among the right recurrent laryngeal nerve, the right common carotid artery, and the right inferior thyroid artery. METHODS: 32 right cervical regions were harvested from cadavers within 24 hours post-mortem. The fibro-fatty tissue of the RCR was resected and prepared with formalin fixation...
November 29, 2018: Revista do Colégio Brasileiro de Cirurgiões
Paola Anna Erba, Helmut Maecke, Renata Mikołajczak, Clemens Decristoforo, Katja Zaletel, Theodosia Maina-Nock, Petra Kolenc Peitl, Piotr Garnuszek, Alida Froberg, Georg Goebel, Marion de Jong, Agata Jabrocka-Hybel, Mark Konijnenberg, Irena Virgolini, Berthold Nock, Wioletta Lenda-Tracz, Dariusz Pawlak, Christine Rangger, Małgorzata Trofimiuk-Müldner, Anna Sowa-Staszczak, Monika Tomaszuk, Elisabeth von Guggenberg, Lorenza Scarpa, Alicja Hubalewska-Dydejczyk
No abstract text is available yet for this article.
December 5, 2018: Polish Archives of Internal Medicine
Nadia Sawicka-Gutaj, Paulina Ziółkowska, Jerzy Sowiński, Agata Czarnywojtek, Katarzyna Milczarczyk, Paweł Gut, Marek Ruchała
INTRODUCTION Goiter recurrence occurs in a substantial number of patients after thyroid resection. OBJECTIVES We aimed to investigate the prevalence and risk factors of recurrent goiters, influence of goiter recurrence on patient quality of life (QoL) and the efficacy of therapy with radioactive iodine (RAI). PATIENTS AND METHODS This was a case-control study. All thyroidectomized patients admitted within the past year to the outpatient department were included in the study and their medical records were analyzed...
December 5, 2018: Polish Archives of Internal Medicine
Małgorzata Krakowska-Stasiak, Dorota Cibor, Iwon Grys, Tomasz Mach, Danuta Owczarek
No abstract text is available yet for this article.
December 5, 2018: Polish Archives of Internal Medicine
Yilai Chen, Weiwei Zhan, Wei Zhou, Yijie Dong
This research investigates the application of high-frequency ultrasound (US) examination and US-guided fine-needle aspiration (US-FNA) in diagnosing low-volume metastatic lateral lymph nodes (LLNs) from papillary thyroid carcinoma patients. This study reviewed the medical records of 996 LLNs from 858 patients with suspicious thyroid nodules or after thyroidectomy from January 2013 to January 2016. All patients took US-FNA. The US characteristics and the malignancy rate of LLNs classified into group A and group B based on size were analyzed and compared (group A, ≥6 mm; group B, <6 mm)...
December 3, 2018: Ultrasound Quarterly
Lavinia Vija Racaru, Erwan Gabiache, Sebastien Fontaine, Dominique DʼAure, Loic Mourey, Frederic Courbon, Slimane Zerdoud
An 85-year-old man with a 2-year history of prostate cancer, treated with radiotherapy and hormonal therapy, presented increased prostatic-specific antigen levels. F-choline PET/CT showed focal prostatic uptake consistent with known local recurrence, increased uptake of 2 hypodense thyroid nodules and of 2 left cervical lymph nodes, suspected as thyroid cancer. Neck ultrasound confirmed the high risk of malignancy, and a guided biopsy (of a thyroid nodule and cervical lymph node) revealed cellular infiltrates thyroid transcription factor-1 (TTF-1) negative and prostatic-specific antigen positive, confirming intrathyroid and cervical lymph node metastases of prostate cancer...
December 3, 2018: Clinical Nuclear Medicine
Fuqiang Shao, Dan Zhou, Xiaoli Lan
False negative I accumulation in metastatic lesions of thyroid carcinoma could be due to various etiologies. Here we present a 33-year-old woman with a history of papillary thyroid cancer who had increased Tc pertechnetate activity in the mediastinal metastatic lymph nodes, which was not clearly seen on whole body I scan due to adjacent activity from lung metastases.
December 3, 2018: Clinical Nuclear Medicine
M Hrebenyk, L Zelenenka, L Zoria, S Maslii
The clinical experience implies poor prognosis in women with myocardial infarction (MI). We performed a retrospective cohort study of 1395 patients - 987 (70,75%) men and 408 (29,25%) women) aged of 64,63±11,43 years with myocardial infarction and comorbidity hospitalized between 2010-2016. This study shows an increase of mortality in women with myocardial infarction during the last 4 years from 23,1% to 34,2%. We observed more frequent cases of non-STEMI (p=0,014) and recurrent myocardial infarction in females compared with males (р<0,0001)...
October 2018: Georgian Medical News
Mikyung Ryu, Jee-In Hwang
OBJECTIVES: We investigated cancer site differences in the health-related quality of life (HRQOL) of cancer survivors. DESIGN AND SAMPLE: A secondary data analysis was conducted using the sixth Korea National Health and Nutrition Examination Survey (2013-2015). Participants were 15,461 adults (664 cancer survivors) with available EuroQol-5 Dimensions (EQ5D) information. MEASUREMENTS: Constructs from the revised Wilson and Cleary's model were examined...
December 4, 2018: Public Health Nursing
Viswanath Gunda, Benjamin Gigliotti, Tameem Ashry, Dorothy Ndishabandi, Michael McCarthy, Zhiheng Zhou, Salma Amin, Kyu Eun Lee, Tabea Stork, Lori Wirth, Gordon J Freeman, Alessandro Alessandrini, Sareh Parangi
Patients with anaplastic thyroid cancer (ATC) have an extremely poor prognosis despite multimodal therapy with surgery and chemoradiation. Lenvatinib, a multi-targeted tyrosine kinase inhibitor, and checkpoint inhibitors targeting the programmed cell death pathway have proven effective in some patients with advanced thyroid cancer. Combination of these therapies is a potential means to boost effectiveness and minimize treatment resistance in ATC. We utilized our novel immunocompetent murine model of orthotopic ATC to demonstrate that lenvatinib led to significant tumor shrinkage and increased survival, while combination therapy led to dramatic improvements in both...
December 4, 2018: International Journal of Cancer. Journal International du Cancer
Gu Gao, Feng-Fei Li, Yun Hu, Reng-Na Yan, Bing-Li Liu, Xiao-Mei Liu, Xiao-Fei Su, Jian-Hua Ma, Gang Hu
PURPOSE: To observe the glycemic variation (GV) in uncontrolled Graves' disease (GD) patients with normal glucose metabolism measured by continuous glucose monitoring (CGM). METHODS: This was a single-center, open-label, observational study. From January 2017 to October 2017, 20 GD patients with normal glucose metabolism and 24 healthy control subjects were recruited. Serum samples were obtained at 0, 30, and 120 min after oral glucose loading for glucose, insulin, and C-peptide level measurements...
December 4, 2018: Endocrine
Alessandro Sindoni, Carlo Gobitti, Sandro Sulfaro, Vittorio Giacomarra, Eugenio Borsatti
The original version of this article unfortunately contained a mistake. The title of this article was rendered incorrectly; the correct title is as follows: Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination.
December 4, 2018: Hormones: International Journal of Endocrinology and Metabolism
Linjue Shangguan, Shengwei Fang, Peipei Zhang, Suyang Han, Xiaodong Shen, Yawen Geng, Dingcun Luo, Chunlei Zhao
OBJECTIVE: To investigate the impact factors of the outcome of the first 131 I treatment in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy. METHODS: Three hundred and fifty-three patients [256 females, 97 males, average age (43.58 ± 12.33 years)] with PTC after total thyroidectomy who underwent 131 I treatment from July 2014 to August 2017 were retrospectively analyzed. Curative efficacy of 131 I treatment was assessed 6 months afterward...
December 4, 2018: Annals of Nuclear Medicine
Kumutnart Chanprapaph, Wimolsiri Iamsumang, Penpun Wattanakrai, Vasanop Vachiramon
Background: Chronic spontaneous urticaria (CSU) is autoimmune in nature and associated with thyroid autoimmunity (TA), but evidence on autoimmunity in relation to CSU progression and prognosis is limited. We evaluated whether TA and autoimmunity in CSU are correlated with disease severity, therapeutic response, and time to remission and establish an association between CSU characteristics linked to thyroid autoantibody. Methods: Medical records of patients diagnosed with urticaria attending outpatient dermatology clinic at a university-based hospital from 2013 to 2017 were retrospectively reviewed...
2018: BioMed Research International
Luis-Mauricio Hurtado-López, Alejandro Ordoñez-Rueda, Felipe-Rafael Zaldivar-Ramírez, Erich Basurto-Kuba
Background: Optimal neck lymphadenectomy in patients with papillary thyroid cancer (PTC) and microscopic lymph node metastasis needs to be defined in order to aid surgeons in their decision about the best way to proceed in these cases. Methods: Patients who underwent total thyroidectomy and lymphadenectomy at levels IIa to VI were divided into two groups: Group 1 (G1) with macroscopic metastasis detected before surgery and Group 2 (G2) with microscopic metastasis detected in sentinel node during surgery...
2018: Journal of Thyroid Research
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