Jason Y Y Wong, Roel Vermeulen, Yufei Dai, Wei Hu, W Kyle Martin, Sarah H Warren, Hannah K Liberatore, Dianzhi Ren, Huawei Duan, Yong Niu, Jun Xu, Wei Fu, Kees Meliefste, Jufang Yang, Meng Ye, Xiaowei Jia, Tao Meng, Bryan A Bassig, H Dean Hosgood, Jiyeon Choi, Mohammad L Rahman, Douglas I Walker, Yuxin Zheng, Judy Mumford, Debra T Silverman, Nathaniel Rothman, David M DeMarini, Qing Lan
Urinary mutagenicity reflects systemic exposure to complex mixtures of genotoxic/carcinogenic agents and is linked to tumor development. Coal combustion emissions (CCE) and diesel engine exhaust (DEE) are associated with cancers of the lung and other sites, but their influence on urinary mutagenicity is unclear. We investigated associations between exposure to CCE or DEE and urinary mutagenicity. In two separate cross-sectional studies of nonsmokers, organic extracts of urine were evaluated for mutagenicity levels using strain YG1041 in the Salmonella (Ames) mutagenicity assay...
October 2021: Environmental and Molecular Mutagenesis