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https://www.readbyqxmd.com/read/30453162/fabrication-of-mgo-nanostructures-and-its-efficient-photocatalytic-antibacterial-and-anticancer-performance
#1
K Karthik, S Dhanuskodi, C Gobinath, S Prabukumar, S Sivaramakrishnan
Magnesium oxide (MgO) nanostructures were prepared using microwave-assisted (M 1) and hydrothermal (M 2) methods and characterized by XRD, SEM and FT-IR. It exhibits cubic structure with an average crystallite size of 20 nm (M 1) and 14 nm (M 2) and the lattice strain (WH plot) is 0.0017 (M 1), 0.0037 (M 2). It's spherical and rods like structures are confirmed through SEM and TEM. The vibrational stretching mode of MgO is 439 (M 1) and 449 cm-1 (M 2). The optical bandgap is estimated as 5.93 eV (M 1) and 5...
November 12, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30257571/evaluation-of-genotoxic-potential-of-tert-butylquinone-and-its-derivatives-in-prokaryotic-and-eukaryotic-test-models
#2
Jelena Đorđević, Stoimir Kolarević, Jovana Jovanović, Jovana Kostić-Vuković, Irena Novaković, Marko Jeremić, Dušan Sladić, Branka Vuković-Gačić
Tert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2)...
September 27, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29992102/biosynthesis-characterization-and-evaluation-of-bioactivities-of-leaf-extract-mediated-biocompatible-gold-nanoparticles-from-alternanthera-bettzickiana
#3
Nagalingam M, Kalpana V N, Devi Rajeswari V, Panneerselvam A
The objective of the study was to synthesize gold nanoparticles (Au NPs) using leaf extract of Alternanthera bettzickiana (A. bettzickiana ). The biosynthesized Au NPs were characterized using UV-vis spectroscopy, X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Energy dispersive X-ray analysis (EDX), Zeta potential and Transmission electron microscopy (TEM). Morphologically, the Au NPs showed spherical shaped structures. Size distribution of Au NPs calculated using Scherrer's formula, showed an average size of 80-120 nm...
September 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29523766/nucleoside-diphosphate-kinase-3-nme3-enhances-tlr5-induced-nf-%C3%AE%C2%BA-b-activation
#4
Kelly Flentie, Caleb Gonzalez, Brandon Kocher, Yue Wang, Hongtu Zhu, Jayne Marasa, David Piwnica-Worms
Bacterial flagellin is a potent activator of NFκB signaling, inflammation, and host innate immunity, and recent data indicate that flagellin represents a novel antitumor ligand acting through toll-like receptor 5 (TLR5) and the NFκB pathway to induce host immunity and aid in the clearance of tumor xenografts. To identify innate signaling components of TLR5 responsible for these antitumor effects, a loss-of-function high-throughput screen was employed utilizing carcinoma cells expressing a dynamic NFκB bioluminescent reporter stimulated by Salmonella typhimurium expressing flagellin...
June 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29374999/tumor-targeting-salmonella-typhimurium-a1-r-combined-with-recombinant-methioninase-and-cisplatinum-eradicates-an-osteosarcoma-cisplatinum-resistant-lung-metastasis-in-a-patient-derived-orthotopic-xenograft-pdox-mouse-model-decoy-trap-and-kill-chemotherapy-moves
#5
Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Shukuan Li, Qinghong Han, Yuying Tan, Ming Zhao, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Irmina A Elliott, Tara A Russell, Mark A Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
In the present study, a patient-derived orthotopic xenograft (PDOX) model of recurrent cisplatinum (CDDP)-resistant metastatic osteosarcoma was treated with Salmonella typhimurium A1-R (S. typhimurium A1-R), which decoys chemoresistant quiescent cancer cells to cycle, and recombinant methioninase (rMETase), which selectively traps cancer cells in late S/G2 , and chemotherapy. The PDOX models were randomized into the following groups 14 days after implantation: G1, control without treatment; G2, CDDP (6 mg/kg, intraperitoneal (i...
2018: Cell Cycle
https://www.readbyqxmd.com/read/29373863/mutagenicity-and-lung-toxicity-of-smoldering-vs-flaming-emissions-from-various-biomass-fuels-implications-for-health-effects-from-wildland-fires
#6
Yong Ho Kim, Sarah H Warren, Q Todd Krantz, Charly King, Richard Jaskot, William T Preston, Barbara J George, Michael D Hays, Matthew S Landis, Mark Higuchi, David M DeMarini, M Ian Gilmour
BACKGROUND: The increasing size and frequency of wildland fires are leading to greater potential for cardiopulmonary disease and cancer in exposed populations; however, little is known about how the types of fuel and combustion phases affect these adverse outcomes. OBJECTIVES: We evaluated the mutagenicity and lung toxicity of particulate matter (PM) from flaming vs. smoldering phases of five biomass fuels, and compared results by equal mass or emission factors (EFs) derived from amount of fuel consumed...
January 24, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29031407/biomass-burning-particles-in-the-brazilian-amazon-region-mutagenic-effects-of-nitro-and-oxy-pahs-and-assessment-of-health-risks
#7
Marcos Felipe de Oliveira Galvão, Nilmara de Oliveira Alves, Paula Anastácia Ferreira, Sofia Caumo, Pérola de Castro Vasconcellos, Paulo Artaxo, Sandra de Souza Hacon, Deborah Arnsdorff Roubicek, Silvia Regina Batistuzzo de Medeiros
Emissions from burning of biomass in the Amazon region have adverse effects on the environment and human health. Herein, particulate matter (PM) emitted from biomass burning in the Amazon region during two different periods, namely intense and moderate, was investigated. This study focused on: i) organic characterization of nitro- and oxy-polycyclic aromatic hydrocarbons (PAHs); ii) assessment of the excess lifetime cancer risk (LCR); and iii) assessment of the in vitro mutagenic effects of extractable organic matter (EOM)...
February 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29023966/genotoxicity-of-airborne-pm-2-5-assessed-by-salmonella-and-comet-assays-in-five-cities-of-the-emilia-romagna-italy-mutagenicity-monitoring-network
#8
Clara Bocchi, Cristina Bazzini, Federica Fontana, Giancarlo Pinto, Francesca Cassoni
Airborne particulate matter (PM) has long been recognized as a potential health hazard and in 2013 was classified as carcinogenic to humans by the International Agency for Research on Cancer. In this study we evaluate and compare mutagenic and genotoxic potencies of PM2.5 collected in three seasons, from 2012 to 2015, in five Italian cities. Mutagenicity was evaluated through the Ames test on TA98 and TA100 strains and, for the measurement of PM clastogenicity, Comet assay was carried out on cultured human lung cells (A549)...
December 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27692295/characterization-of-urban-aerosol-seasonal-variation-of-mutagenicity-and-genotoxicity-of-pm2-5-pm1-and-semi-volatile-organic-compounds
#9
Clara Bocchi, Cristina Bazzini, Federica Fontana, Giancarlo Pinto, Anna Martino, Francesca Cassoni
Urban particulate matter (PM) is an environmental public health concern as it has been classified by the IARC as carcinogenic to humans (group 1) and it's well known that pollutants are more associated with the finest fractions of PM. In this study we characterize urban aerosol in Bologna, county town of Emilia-Romagna in the north of Italy, collecting PM2.5, PM1 and semi-volatile organic compounds using polyurethane foam. Samples were collected in three different seasons (winter, summer and autumn) and were extracted with acetone...
October 2016: Mutation Research
https://www.readbyqxmd.com/read/27381584/physicochemical-investigations-of-biogenic-chitosan-silver-nanocomposite-as-antimicrobial-and-anticancer-agent
#10
Nithya Arjunan, Henry Linda Jeeva Kumari, Chandra Mohan Singaravelu, Ruckmani Kandasamy, Jothivenkatachalam Kandasamy
Chitosan (CS), a seaweed polysaccharide is a natural macromolecule which is widely being used in medical applications because of its distinctive antimicrobial and anticancer properties. Silver, a noble metal, is also receiving wide attention for its potential usage in antimicrobial and anticancer therapeutics. In this study, an effective way of reduction of silver using chitosan at varying reaction temperatures and an optimised concentration of silver were performed. The optical, structural, spectral, morphological and elemental studies of the biosynthesized chitosan-silver (CS-Ag) nanocomposites were characterized by several techniques...
November 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27371094/enhanced-therapeutic-effect-of-an-antiangiogenesis-peptide-on-lung-cancer-in-vivo-combined-with-salmonella-vnp20009-carrying-a-sox2-shrna-construct
#11
Changhong Zhao, Junjin He, Haoran Cheng, Zhaohao Zhu, Hanmei Xu
BACKGROUND: HM-3 is a polypeptide inhibiting angiogenesis. Recent reports suggest that the antitumor effect of angiogenesis inhibitors administered alone might be limited. Cancer stem cells can survive the lack of oxygen and nutrients. To achieve better anti-tumor effect, HM-3 was administered in combination with the attenuated Salmonella typhimurium VNP20009 transformed with a shRNA construct against sex determining region Y-box 2 (Sox2). METHODS: Cell invasion assay and soft agar colony formation assay were used to assess the migration and growth capability of A549 cells once Sox2 was knocked down with the shRNA construct...
July 2, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27245453/medicinal-attributes-of-major-phenylpropanoids-present-in-cinnamon
#12
Uma Kant Sharma, Amit Kumar Sharma, Abhay K Pandey
BACKGROUND: Excessive production of free radicals has been implicated in many diseases including cancer. They are highly reactive and bring about oxidation of biomolecules i.e., proteins, lipids and nucleic acids which are associated with many degenerative diseases. Natural products acting as antioxidants have ability to neutralize free radicals and their actions and hence they mitigate their harmful effects. The present study was designed to investigate pharmacological properties viz...
May 31, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26923134/overexpression-of-rbm5-induces-autophagy-in-human-lung-adenocarcinoma-cells
#13
Zhenzhong Su, Ke Wang, Ranwei Li, Jinzhi Yin, Yuqiu Hao, Xuejiao Lv, Junyao Li, Lijing Zhao, Yanwei Du, Ping Li, Jie Zhang
BACKGROUND: Dysfunctions in autophagy and apoptosis are closely interacted and play an important role in cancer development. RNA binding motif 5 (RBM5) is a tumor suppressor gene, which inhibits tumor cells' growth and enhances chemosensitivity through inducing apoptosis in our previous studies. In this study, we investigated the relationship between RBM5 overexpression and autophagy in human lung adenocarcinoma cells. METHODS: Human lung adenocarcinoma cancer (A549) cells were cultured in vitro and were transiently transfected with a RBM5 expressing plasmid (GV287-RBM5) or plasmid with scrambled control sequence...
February 29, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26856714/genotoxic-properties-of-xlr-11-a-widely-consumed-synthetic-cannabinoid-and-of-the-benzoyl-indole-rcs-4
#14
Franziska Ferk, Richard Gminski, Halh Al-Serori, Miroslav Mišík, Armen Nersesyan, Verena J Koller, Verena Angerer, Volker Auwärter, Tao Tang, Ali Talib Arif, Siegfried Knasmüller
Aim of this study was the investigation of the genotoxic properties of XLR-11 [1-(5-fluoropentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone, a widely consumed synthetic cannabinoid (SC), and of the benzoyl indole RCS-4 (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone). We characterized the DNA-damaging properties of these drugs in different experimental systems. No evidence for induction of gene mutations was detected in bacterial (Salmonella/microsome) tests, but clear dose-dependent effects were found in in vitro single cell gel electrophoresis (SCGE) assays with human lymphocytes and with buccal- and lung-derived human cell lines (TR-146 and A-549)...
December 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/26846809/methods-for-tumor-targeting-with-salmonella-typhimurium-a1-r
#15
Robert M Hoffman, Ming Zhao
Salmonella typhimurium A1-R (S. typhimurium A1-R) has shown great preclinical promise as a broad-based anti-cancer therapeutic (please see Chapter 1 ). The present chapter describes materials and methods for the preclinical study of S. typhimurium A1-R in clinically-relevant mouse models. Establishment of orthotopic metastatic mouse models of the major cancer types is described, as well as other useful models, for efficacy studies of S. typhimurium A1-R or other tumor-targeting bacteria, as well. Imaging methods are described to visualize GFP-labeled S...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26846797/tumor-targeting-salmonella-typhimurium-a1-r-an-overview
#16
Robert M Hoffman
The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor-targeting strain S. typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ovarian cancer, as well as sarcoma and glioma in orthotopic mouse models is described. Also reviewed is efficacy of S. typhimurium A1-R targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma, breast-cancer brain metastasis, and experimental breast-cancer bone metastasis in orthotopic mouse models...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26799575/in-vitro-antimicrobial-and-anti-proliferative-activities-of-plant-extracts-from-spathodea-campanulata-ficus-bubu-and-carica-papaya
#17
Jean Emmanuel Mbosso Teinkela, Jules Clément Assob Nguedia, Franck Meyer, Erik Vouffo Donfack, Bruno Lenta Ndjakou, Silvère Ngouela, Etienne Tsamo, Dieudonné Adiogo, Anatole Guy Blaise Azebaze, René Wintjens
CONTEXT: African medicinal plants represent a prominent source of new active substances. In this context, three plants were selected for biological investigations based on their traditional uses. OBJECTIVE: The antimicrobial and anti-proliferative features of three plants used for medicinal purpose were evaluated. MATERIALS AND METHODS: The antimicrobial activities of methanol extracts of Ficus bubu Warb. (Moraceae) stem bark and leaves, of Spathodea campanulata P...
2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26476243/cblb502-an-agonist-of-toll-like-receptor-5-has-antioxidant-and-scavenging-free-radicals-activities-in-vitro
#18
Weiguang Li, Changhui Ge, Liu Yang, Ruixue Wang, Yiming Lu, Yan Gao, Zhihui Li, Yonghong Wu, Xiaofei Zheng, Zhaoyan Wang, Chenggang Zhang
The bacterial protein flagellin is the known agonist of Toll-like receptor 5 (TLR5). It has been reported that CBLB502, a novel agonist of TLR5 derived from Salmonella flagellin, could reduce radiation toxicity in mouse and primate models, protect mice from dermatitis and oral mucositis caused by radiation, inhibit acute renal ischemic failure, and inhibit the growth of A549 lung cancer cell. The property of CBLB502 is able to bind to TLR5 and activates NF-κB signaling. In this study, we investigated the antioxidant potential and free radicals scavenging properties of CBLB502 in vitro...
January 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26376999/an-orally-administered-dna-vaccine-targeting-vascular-endothelial-growth-factor-receptor-3-inhibits-lung-carcinoma-growth
#19
Yan Chen, Xin Liu, Cong Guo Jin, Yong Chun Zhou, Roya Navab, Kristine Raaby Jakobsen, Xiao Qun Chen, Jia Li, Ting Ting Li, Lu Luo, Xi Cai Wang
Lung cancer is the leading cause of mortality and 5-year survival rate is very low worldwide. Recent studies show that vascular endothelial growth factor receptor-3 (VEGFR-3) signaling pathway contributes to lung cancer progression. So we hypothesize that an oral DNA vaccine that targets VEGFR-3 carried by attenuated Salmonella enterica serovar typhimurium strain SL3261 has impacts on lung cancer progression. In this study, the oral VEGFR-3-based vaccine-immunized mice showed appreciable inhibition of tumor growth and tumor lymphatic microvessels in lung cancer mice model...
February 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26347489/neoadjuvant-administration-of-semliki-forest-virus-expressing-interleukin-12-combined-with-attenuated-salmonella-eradicates-breast-cancer-metastasis-and-achieves-long-term-survival-in-immunocompetent-mice
#20
M Gabriela Kramer, Martín Masner, Erkuden Casales, María Moreno, Cristian Smerdou, José A Chabalgoity
BACKGROUND: Metastatic breast cancer is a major cause of death among women worldwide; therefore efficient therapeutic strategies are extremely needed. In this work we have developed a gene therapy- and bacteria-based combined neoadjuvant approach and evaluated its antitumor effect in a clinically relevant animal model of metastatic breast cancer. METHODS: 2×10(8) particles of a Semliki Forest virus vector expressing interleukin-12 (SFV-IL-12) and/or 2×10(7) units of an aroC (-) Samonella Typhimurium strain (LVR01) were injected into 4T1 tumor nodules orthotopically implanted in mice...
2015: BMC Cancer
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