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https://www.readbyqxmd.com/read/30296381/in-vivo-and-cellular-trafficking-of-acetalated-dextran-microparticles-for-delivery-of-a-host-directed-therapy-for-salmonella-enterica-serovar-typhi-infection
#1
Monica M Johnson, Michael A Collier, Ky V Hoang, Erica N Pino, Elizabeth G Graham-Gurysh, Matthew D Gallovic, Md Shamim Hasan Zahid, Naihan Chen, Larry Schlesinger, John S Gunn, Eric M Bachelder, Kristy M Ainslie
Previously we have encapsulated host-directed therapy AR-12 into acetalated dextran (Ace-DEX) microparticles (MPs) to mitigate drug toxicity and passively target phagocytic host cells. Herein, we have improved upon our initial emulsion-based formulation of Ace-DEX MPs encapsulating AR-12 (AR-12/MPs) by improving the drug encapsulation efficiency, evaluating sterilization processes for manufacturing, and understanding cellular and in vivo trafficking of the MPs. By using an alternative solvent system, ethyl acetate, we report an increased encapsulation efficiency of AR-12 while maintaining the pH-responsive degradation kinetics of Ace-DEX MPs...
October 8, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30285855/salmonella-gallinarum-delivering-m2ecd40l-in-protein-and-dna-formats-acts-as-a-bivalent-vaccine-against-fowl-typhoid-and-h9n2-infection-in-chickens
#2
Irshad Ahmed Hajam, Jehyoung Kim, John Hwa Lee
Fowl typhoid (FT), a septicemic disease caused by Salmonella Gallinarum (SG), and H9N2 influenza infection are two economically important diseases that affect poultry industry worldwide. Herein, we exploited a live attenuated SG mutant (JOL967) to deliver highly conserved extracellular domains of H9N2 M2 (M2e) to induce protective immunity against both H9N2 infection and FT. To increase the immunogenicity of M2e, we physically linked it with CD40L and cloned the fusion gene into either prokaryotic constitutive expression vector pJHL65 or mammalian expression vector pcDNA3...
October 1, 2018: Veterinary Research
https://www.readbyqxmd.com/read/30276212/small-molecule-inhibitor-of-type-three-secretion-system-belonging-to-a-class-2-4-disubstituted-4h-1-3-4-thiadiazine-5-ones-improves-survival-and-decreases-bacterial-loads-in-an-airway-pseudomonas-aeruginosa-infection-in-mice
#3
Anna B Sheremet, Naylia A Zigangirova, Egor S Zayakin, Sergei I Luyksaar, Lydia N Kapotina, Ludmila N Nesterenko, Natalie V Kobets, Alexander L Gintsburg
Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients. High incidence of antibiotic resistance in this pathogen makes the existent therapy inefficient. Type three secretion system (T3SS) is a leading virulence system of P. aeruginosa that actively suppresses host resistance and enhances the severity of infection. Innovative therapeutic strategies aiming at inhibition of type three secretion system of P. aeruginosa are highly attractive, as they may reduce the severity of clinical manifestations and improve antibacterial immune responses...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30268829/in-vitro-and-in-vivo-evaluation-of-the-genotoxicity-of-eriobotrya-japonica-leaf-extract
#4
Myung-Hwan Jeong, Nak-Won Seong, Jong-Yun Lee, Yong-Jae Kim, Na-Rae Shin, Jong-Choon Kim
Eriobotrya japonica leaf is included in the Chinese Pharmacopoeia, and is widely used as a medicinal material in traditional medicine. The present study investigated the potential genotoxic effects of E. japonica leaf extract (EJE) using three standard battery systems. Genotoxicity tests were conducted following the test guidelines of the Organisation for Economic Cooperation and Development (OECD) and Ministry of Food and Drug Safety (MFDS), with application of Good Laboratory Practice. The bacterial reverse mutation test was conducted using the pre-incubation method in the presence or absence of the metabolic activation system (S9 mixture)...
September 27, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/30257571/evaluation-of-genotoxic-potential-of-tert-butylquinone-and-its-derivatives-in-prokaryotic-and-eukaryotic-test-models
#5
Jelena Đorđević, Stoimir Kolarević, Jovana Jovanović, Jovana Kostić-Vuković, Irena Novaković, Marko Jeremić, Dušan Sladić, Branka Vuković-Gačić
Tert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2)...
September 27, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/30240572/increasing-prevalence-and-dissemination-of-invasive-nontyphoidal-salmonella-serotype-typhimurium-with-multidrug-resistance-in-hospitalized-patients-from-southern-brazil
#6
Rafael Oliveira Dos Reis, Margarida Neves Souza, Maria Cristina Piccoli Cecconi, Loeci Timm, Nilo Ikuta, Daniel Simon, Jonas Michel Wolf, Vagner Ricardo Lunge
INTRODUCTION: Nontyphoidal Salmonella serotypes are the main cause of human food-borne infection, including several hospitalization cases in the developing countries. AIM: To detect the main serotypes and to characterize the antibiotic resistance of human non-enteric and enteric nontyphoidal Salmonella from clinical isolates in Brazil. METHODS: Salmonella serotypes were identified by microbiological and molecular methods. Susceptibility testing to antibiotics was performed by agar disk diffusion...
September 18, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30102924/a-novel-multiplex-pcr-electronic-microarray-assay-for-rapid-and-simultaneous-detection-of-bovine-respiratory-and-enteric-pathogens
#7
Niroshan Thanthrige-Don, Oliver Lung, Tara Furukawa-Stoffer, Cody Buchanan, Tomy Joseph, Dale L Godson, John Gilleard, Trevor Alexander, Aruna Ambagala
Respiratory and enteric diseases continue to be two major causes of economic losses to the cattle industry worldwide. Despite their multifactorial etiology, the currently available diagnostic tests for bovine respiratory disease complex (BRDC) and bovine enteric disease (BED) are single-pathogen-tests. DNA microarray when combined with multiplex polymerase chain reaction (PCR) is a powerful tool in detection and differentiation of multiple pathogens in a single sample. This study reports development and initial validation of two independent highly sensitive and specific multiplex PCR-electronic microarray assays, one for the detection and differentiation of pathogens of the BRDC and the other for detection and differentiation of pathogens of the BED...
November 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29992102/biosynthesis-characterization-and-evaluation-of-bioactivities-of-leaf-extract-mediated-biocompatible-gold-nanoparticles-from-alternanthera-bettzickiana
#8
Nagalingam M, Kalpana V N, Devi Rajeswari V, Panneerselvam A
The objective of the study was to synthesize gold nanoparticles (Au NPs) using leaf extract of Alternanthera bettzickiana (A. bettzickiana ). The biosynthesized Au NPs were characterized using UV-vis spectroscopy, X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), Energy dispersive X-ray analysis (EDX), Zeta potential and Transmission electron microscopy (TEM). Morphologically, the Au NPs showed spherical shaped structures. Size distribution of Au NPs calculated using Scherrer's formula, showed an average size of 80-120 nm...
September 2018: Biotechnology Reports
https://www.readbyqxmd.com/read/29991761/cross-feeding-modulates-antibiotic-tolerance-in-bacterial-communities
#9
Elizabeth M Adamowicz, Jeffrey Flynn, Ryan C Hunter, William R Harcombe
Microbes frequently rely on metabolites excreted by other bacterial species, but little is known about how this cross-feeding influences the effect of antibiotics. We hypothesized that when species rely on each other for essential metabolites, the minimum inhibitory concentration (MIC) for all species will drop to that of the "weakest link"-the species least resistant in monoculture. We tested this hypothesis in an obligate cross-feeding system that was engineered between Escherichia coli, Salmonella enterica, and Methylobacterium extorquens...
July 10, 2018: ISME Journal
https://www.readbyqxmd.com/read/29944396/survey-for-bacteria-and-antimicrobial-resistance-in-wild-turkeys-meleagris-gallopavo-in-ontario-canada
#10
Amanda M MacDonald, Claire M Jardine, Leonardo Susta, Durda Slavic, Nicole M Nemeth
Since being successfully reintroduced into Ontario, Canada, wild turkey ( Meleagris gallopavo) populations have undergone robust growth and range expansion. This, along with increases in land use changes from human population growth and subsequent developments in agriculture and livestock production, has heightened opportunities for interactions between wild turkeys, domestic poultry, and humans. As conspecifics, wild and domestic turkeys are susceptible to infection and disease from many of the same pathogens...
June 2018: Avian Diseases
https://www.readbyqxmd.com/read/29929362/vaccination-of-goats-with-a-combination-salmonella-vector-expressing-four-brucella-antigens-bls-prpa-omp19-and-sod-confers-protection-against-brucella-abortus-infection
#11
Mwense Leya, Won Kyong Kim, Jeong Sang Cho, Eun-Chae Yu, Young-Jee Kim, Yoonhwan Yeo, Kwang-Soo Lyoo, Myeon-Sik Yang, Sang-Seop Han, John Hwa Lee, Dongseob Tark, Jin Hur, Bumseok Kim
Salmonella is an intracellular pathogen with a cellular infection mechanism similar to that of Brucella , making it a suitable choice for use in an anti- Brucella immune boost system. This study explores the efficacy of a Salmonella Typhimurium delivery-based combination vaccine for four heterologous Brucella antigens ( Brucella lumazine synthase, proline racemase subunit A, outer-membrane protein 19, and Cu/Zn superoxide dismutase) targeting brucellosis in goats. We inoculated the attenuated Salmonella delivery-based vaccine combination subcutaneously at two different inoculation levels; 5 × 109 colony-forming unit (CFU)/mL (Group B) and 5 × 1010 CFU/mL (Group C) and challenged the inoculations with virulent Brucella abortus at 6 weeks post-immunization...
September 30, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29857512/downregulations-of-akt-mtor-signaling-pathway-for-salmonella-mediated-suppression-of-matrix-metalloproteinases-9-expression-in-mouse-tumor-models
#12
Yu-Tzu Tsao, Chun-Yu Kuo, Shun-Ping Cheng, Che-Hsin Lee
The roles of Matrix MetalloProteinases (MMPs), such as MMP-9, in tumor metastasis are well studied, and this in turns stimulates the development of MMP inhibitors as antitumor agents. Previously, Salmonella accumulation was observed in the metastatic nodules of the lungs after systemic administration. Salmonella significantly enhanced the survival of the pulmonary metastatic tumor-bearing mice. Based on our previous observation, we hypothesized that Salmonella could affect metastasis-related protein expression...
May 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29744941/carvacrol-and-human-health-a-comprehensive-review
#13
REVIEW
Mehdi Sharifi-Rad, Elena Maria Varoni, Marcello Iriti, Miquel Martorell, William N Setzer, María Del Mar Contreras, Bahare Salehi, Azam Soltani-Nejad, Sadegh Rajabi, Mercedeh Tajbakhsh, Javad Sharifi-Rad
Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety...
September 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29719510/-in-vivo-pharmacokinetic-pharmacodynamic-profiles-of-danofloxacin-in-rabbits-infected-with-salmonella-typhimurium-after-oral-administration
#14
Xia Xiao, Lin Pei, Li-Jie Jiang, Wei-Xuan Lan, Jia-Yu Xiao, Yon-Jia Jiang, Zhi-Qiang Wang
Salmonella typhimurium is a highly transmissible pathogen in rabbits that causes significant losses. Danofloxacin shows excellent efficacy against S. typhimurium infections. However, there are few reports of the pharmacokinetic/pharmacodynamic (PK/PD) modeling of danofloxacin against this pathogen. The aim of this study was to evaluate the in vivo PK/PD relationship of danofloxacin in rabbits infected with S. typhimurium. We used the reduction of bacterial burden in the blood, liver, spleen, and lung as the target PD endpoints, and determined the PK/PD indexes that best correlated with the efficacy and its corresponding magnitude...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29692722/the-deletion-of-endothelial-sodium-channel-%C3%AE-%C3%AE-enac-impairs-endothelium-dependent-vasodilation-and-endothelial-barrier-integrity-in-endotoxemia-in-vivo
#15
Magdalena Sternak, Anna Bar, Mateusz G Adamski, Tasnim Mohaissen, Brygida Marczyk, Anna Kieronska, Marta Stojak, Kamil Kus, Antoine Tarjus, Frederic Jaisser, Stefan Chlopicki
The role of epithelial sodium channel (ENaC) activity in the regulation of endothelial function is not clear. Here, we analyze the role of ENaC in the regulation of endothelium-dependent vasodilation and endothelial permeability in vivo in mice with conditional αENaC subunit gene inactivation in the endothelium (endo-αENaCKO mice) using unique MRI-based analysis of acetylcholine-, flow-mediated dilation and vascular permeability. Mice were challenged or not with lipopolysaccharide (LPS, from Salmonella typhosa , 10 mg/kg, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29555556/toxicological-evaluation-of-6-sialyllactose-6-sl-sodium-salt
#16
Rit Bahadur Gurung, Dae Hee Kim, Lila Kim, Albert W Lee, Zhenhua Wang, Yonglin Gao
We performed a series of toxicity studies on the safety of 6'-sialyllactose (6'-SL) sodium salt as a food ingredient. 6'-SL sodium salt, up to a maximum dose of 5000 μg/plate, did not increase the number of revertant colonies in five strains of Salmonella typhimurium in the presence or absence of S9 metabolic activation. A chromosomal aberration assay (using Chinese hamster lung cells) found no clastogenic effects at any concentration of 6'-SL sodium salt in the presence or absence of S9 metabolic activation...
June 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29549001/expression-of-recombinant-human-lysozyme-in-bacterial-artificial-chromosome-transgenic-mice-promotes-the-growth-of-bifidobacterium-and-inhibits-the-growth-of-salmonella-in-the-intestine
#17
Lu Dan, Shen Liu, Shengzhe Shang, Huihua Zhang, Ran Zhang, Ning Li
Targeted gene modification is a novel intervention strategy to increase disease resistance more quickly than traditional animal breeding. Human lysozyme, a natural, non-specific immune factor, participates in innate immunity, exerts a wide range of antimicrobial activities against pathogens, and has immuneregulatory effects. Therefore, it is a candidate gene for improved disease resistance in animals. In this study, we successfully generated a transgenic mouse model by microinjecting a modified bacterial artificial chromosome containing a recombinant human lysozyme (rhLZ) gene into the pronuclei of fertilized mouse embryos...
April 20, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29523766/nucleoside-diphosphate-kinase-3-nme3-enhances-tlr5-induced-nf-%C3%AE%C2%BA-b-activation
#18
Kelly Flentie, Caleb Gonzalez, Brandon Kocher, Yue Wang, Hongtu Zhu, Jayne Marasa, David Piwnica-Worms
Bacterial flagellin is a potent activator of NFκB signaling, inflammation, and host innate immunity, and recent data indicate that flagellin represents a novel antitumor ligand acting through toll-like receptor 5 (TLR5) and the NFκB pathway to induce host immunity and aid in the clearance of tumor xenografts. To identify innate signaling components of TLR5 responsible for these antitumor effects, a loss-of-function high-throughput screen was employed utilizing carcinoma cells expressing a dynamic NFκB bioluminescent reporter stimulated by Salmonella typhimurium expressing flagellin...
June 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29391062/genotoxicity-evaluation-of-so-ochim-tang-gamibang-socg-a-herbal-medicine
#19
Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi, In Chul Jung
BACKGROUND: So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batteries of tests as part of a safety evaluation. METHODS: SOCG was evaluated for potential genotoxic effects using the standard three tests recommended by the Ministry of Food and Drug Safety (MFDS) of Korea. These tests were the bacterial reverse mutation test (Ames test), in vitro mammalian chromosomal aberration test using Chinese hamster lung cells, and in vivo micronucleus test using ICR mice...
February 2, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29374999/tumor-targeting-salmonella-typhimurium-a1-r-combined-with-recombinant-methioninase-and-cisplatinum-eradicates-an-osteosarcoma-cisplatinum-resistant-lung-metastasis-in-a-patient-derived-orthotopic-xenograft-pdox-mouse-model-decoy-trap-and-kill-chemotherapy-moves
#20
Kentaro Igarashi, Kei Kawaguchi, Tasuku Kiyuna, Kentaro Miyake, Masuyo Miyake, Shukuan Li, Qinghong Han, Yuying Tan, Ming Zhao, Yunfeng Li, Scott D Nelson, Sarah M Dry, Arun S Singh, Irmina A Elliott, Tara A Russell, Mark A Eckardt, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya, Fritz C Eilber, Robert M Hoffman
In the present study, a patient-derived orthotopic xenograft (PDOX) model of recurrent cisplatinum (CDDP)-resistant metastatic osteosarcoma was treated with Salmonella typhimurium A1-R (S. typhimurium A1-R), which decoys chemoresistant quiescent cancer cells to cycle, and recombinant methioninase (rMETase), which selectively traps cancer cells in late S/G2 , and chemotherapy. The PDOX models were randomized into the following groups 14 days after implantation: G1, control without treatment; G2, CDDP (6 mg/kg, intraperitoneal (i...
2018: Cell Cycle
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