keyword
https://read.qxmd.com/read/38222852/clinical-and-laboratory-correlates-of-qtc-duration-in-adult-and-pediatric-sickle-cell-disease
#21
JOURNAL ARTICLE
Xue Yu, Suvankar Majumdar, J Daryl Pollard, Erin Jackson, Jarrod Knudson, Douglas Wolfe, Gregory J Kato, Joseph F Maher
BACKGROUND: Sickle cell disease, a common genetic disorder in African Americans, manifests an increased risk of sudden death, the basis of which is incompletely understood. Prolongation of heart rate-corrected QT (QTc) interval on the electrocardiogram, a standard clinical measure of cardiac repolarization, may contribute to sudden death by predisposing to torsades de pointes ventricular tachycardia. METHODS: We established a cohort study of 293 adult and 121 pediatric sickle cell disease patients drawn from the same geographic region as the Jackson Heart Study (JHS) cohort, in which significant correlates of QT duration have been characterized and quantitatively modeled...
December 2023: Am J Med Open
https://read.qxmd.com/read/38186521/idiopathic-fascicular-ventricular-tachycardia-in-a-pediatric-patient-with-suicidal-ideation-and-self-injurious-behavior
#22
Margaret A Uchefuna, Ruth Y Eletta, Arleen Delgado, Susan Beker
Idiopathic fascicular ventricular tachycardia (IFVT) is an arrhythmia that occurs in a structurally normal heart and may present with sudden onset in a healthy individual. We present the case of a 10-year-old female child, with no pertinent medical history, who complained of palpitations and shortness of breath, which was followed by suicidal ideations. On presentation to the ER, tachycardia was noted with other vital signs within normal limits. Labs were unremarkable. EKG showed wide-complex tachycardia with right bundle branch block and left superior axis, consistent with idiopathic left ventricular fascicular tachycardia...
December 2023: Curēus
https://read.qxmd.com/read/38163385/heart-rate-variability-in-school-age-children-born-moderate-to-late-preterm
#23
JOURNAL ARTICLE
Fabianne M N A Dantas, Paulo A F Magalhães, Emilly C N Hora, Lívia B Andrade, Emanuel S C Sarinho
BACKGROUND: Prematurity is associated with reduced cardiac autonomic function. This study aimed to investigate the heart rate variability (HRV) in school-age children born moderately to late preterm (MLPT). METHODS: This cross-sectional study investigated school-age children, aged 5 to 10 years, born moderate-to-late preterm. Electrocardiograms recordings were performed during fifteen-minutes. Time and frequency domain parameters were calculated, corrected for heart rate and compared between the groups...
December 21, 2023: Early Human Development
https://read.qxmd.com/read/38159808/a-cluster-of-inappropriate-shocks-in-a-pediatric-s-icd-patient-how-to-troubleshoot
#24
Christina Menexi, Mohamed ElRefai, David Farwell, Neil Srinivasan
We present the case of a 16-year-old male pediatric patient diagnosed with hypertrophic cardiomyopathy (HCM, identified as having a high risk of sudden cardiac death (SCD), who underwent a successful subcutaneous implantable cardiac defibrillator (S-ICD) implantation as a primary prevention measure in 2018. His past medical history included ADHD, Autism, and panic attacks. The patient experienced appropriate shocks that successfully terminated VF episodes. However, he also experienced multiple inappropriate shocks from the S-ICD, triggered by anxiety-induced tachycardia during panic episodes...
December 28, 2023: Indian Pacing and Electrophysiology Journal
https://read.qxmd.com/read/38140053/circulating-biomarkers-for-monitoring-chemotherapy-induced-cardiotoxicity-in-children
#25
REVIEW
Luigia Meo, Maria Savarese, Carmen Munno, Peppino Mirabelli, Pia Ragno, Ornella Leone, Mariaevelina Alfieri
Most commonly diagnosed cancer pathologies in the pediatric population comprise leukemias and cancers of the nervous system. The percentage of cancer survivors increased from approximatively 50% to 80% thanks to improvements in medical treatments and the introduction of new chemotherapies. However, as a consequence, heart disease has become the main cause of death in the children due to the cardiotoxicity induced by chemotherapy treatments. The use of different cardiovascular biomarkers, complementing data obtained from electrocardiogram, echocardiography cardiac imaging, and evaluation of clinical symptoms, is considered a routine in clinical diagnosis, prognosis, risk stratification, and differential diagnosis...
November 30, 2023: Pharmaceutics
https://read.qxmd.com/read/38130349/delirium-assessment-treatment-strategies-in-critically-ill-pediatric-patients-a-pediatric-pharmacy-association-practice-based-research-network-survey-study
#26
JOURNAL ARTICLE
Caitlyn V Bradford, Mon-Yee Fung, Alexander Wang, Emily C Benefield, Ferras Bashqoy, Stephen B Neely, Peter N Johnson
OBJECTIVES: The purpose of this study was to describe overall screening, prevention, and treatments for pediatric delirium at various neonatal intensive care units (NICUs), cardiac intensive care units (CICUs), and pediatric intensive care units (PICUs) from the Pediatric Pharmacy Association (PPA) membership. The primary objective was to identify the number of respondents that had a defined delirium-based protocol. The secondary objectives included identification of delirium assessment tools used, first- and second-line delirium treatment options, and monitoring practices for antipsychotics for delirium management...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/38112526/pharmacokinetics-and-cardiac-safety-of-clofazimine-in-children-with-rifampicin-resistant-tuberculosis
#27
JOURNAL ARTICLE
Ali Mohamed Ali, Belén P Solans, Anneke C Hesseling, Jana Winckler, H Simon Schaaf, Heather R Draper, Louvina van der Laan, Jennifer Hughes, Barend Fourie, James Nielsen, Lubbe Wiesner, Anthony J Garcia-Prats, Radojka M Savic
Clofazimine is recommended for the treatment of rifampicin-resistant tuberculosis (RR-TB), but there is currently no verified dosing guideline for its use in children. There is only limited safety and no pharmacokinetic (PK) data available for children. We aimed to characterize clofazimine PK and its relationship with QT-interval prolongation in children. An observational cohort study of South African children <18 years old routinely treated for RR-TB with a clofazimine-containing regimen was analyzed. Clofazimine 100 mg gelatin capsules were given orally once daily (≥20 kg body weight), every second day (10 to <20 kg), or thrice weekly (<10 kg)...
December 19, 2023: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38105780/the-effects-of-methylphenidate-on-ventricular-repolarization-parameters-in-children-with-attention-deficit-hyperactivity-disorder
#28
JOURNAL ARTICLE
Yaşar Tanır, Muhammed Furkan Erbay, Selçuk Özkan, Rahmi Özdemir, Abdurrahman Cahid Örengül
BACKGROUND: Long-acting methylphenidate (MPH), a psychostimulant agent, is widely used in the treatment of attention-deficit hyperactivity disorder (ADHD). Methylphenidate might cause an increment in the risk of lethal arrhythmias by deteriorating ventricular repolarization. QT intervals, the corrected QT (QTc), QT dispersion, T-peak to T-end (TpTe), and the TpTe/QTc ratio are the most utilized indicators of ventricular repolarization in electrocardiogram (ECG). The present study was conducted to examine the effects of long-term MPH use on the ECG in pediatric patients...
September 2023: Alpha Psychiatry
https://read.qxmd.com/read/38103070/utility-of-konar-multifunctional-occluder-in-complex-situations-unconventional-uses-in-rare-situations
#29
JOURNAL ARTICLE
Mirza Mohd Kamran, Arun Gopi, Zeeshan Lakhani, Amira Shaik, Janeel Musthafa, G Raghuram, P P Mohammed Musthafa
KONAR-MFO (multifunctional occluder) [Lifetech, Shenzhen, China] was first used in humans in 2013 and received the CE mark in May 2018. As name suggest, it can be use in various(multifunctional) situations in paediatric as well as adults. This is a versatile device with an improved delivery and flexibility which make this device a better option to be use with more comfort and minimum complications. This paper is regarding few rare and complicated lesions, like anomalous origin of coronary artery from pulmonary artery (ALCAPA) device closure, device closure of ventricular septal rupture (VSR) post myocardial infarction in sick elderly and finally device closure of paravalvar leak (PVL)after mitral valve replacement which were treated with this device with excellent results...
December 16, 2023: Pediatric Cardiology
https://read.qxmd.com/read/38099231/cardioneuroablation-for-successful-treatment-of-symptomatic-bradycardia-in-a-12-year-old-child-after-a-6-month-follow-up
#30
JOURNAL ARTICLE
Xin Xu, Shuang He, Qian Liu, Ruixi Liu, Lei Zhang, Weijie Chen, Yuehui Yin, Tiewei Lu
BACKGROUND: Cardioneuroablation (CNA) is recognized as a promising therapeutic option for adults with severe symptomatic bradycardia caused by excessive vagal tone. However, no pediatric cases have been reported to date. Therefore, the aim of this study is to evaluate the feasibility and efficacy of CNA in children. METHODS: A 12-year-old male patient was hospitalized with symptoms of fatigue, palpitations, and syncope for more than 2 months, and was definitively diagnosed with functional sinoatrial node dysfunction by using a 12-lead electrocardiogram, 24-h Holter monitoring, loading dose of atropine test (0...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38091068/the-diagnosis-and-treatment-of-pediatric-clinical-myocarditis-in-china-a-multicenter-retrospective-study
#31
JOURNAL ARTICLE
Xiaoou Li, Hu Tuo, Yijuan Huang, Yan Li, Naicheng Zhao, Juanli Wang, Ying Liu, Hua Peng, Xinyi Xu, Qian Peng, Xiaoping Hu, Bin Zhang, Zipu Li, Mingwu Chen, Sheng Zhao, Hongfang Jin, Zhenyu Xiong, Xiaoyun Wu, Jinyong Pan, Xiaoning Wang, Yiying Zhang, Shi Lin, Bing He, Junbao Du
UNLABELLED: This study aims to examine the clinical characteristics and outcomes of clinical myocarditis in pediatric patients in China. This is a multicenter retrospective study. Children diagnosed with clinical myocarditis from 20 hospitals in China and admitted between January 1, 2015, and December 30, 2021, were enrolled. The clinical myocarditis was diagnosed based on the "Diagnostic Recommendation for Myocarditis in Children (Version 2018)". The clinical data were collected from their medical records...
December 13, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/38078969/normative-computed-tomography-angiography-values-of-the-main-and-branch-pulmonary-arteries-in-children
#32
JOURNAL ARTICLE
Rakesh Donthula, Wen Li, Harmanpreet Kaur, Dilachew A Adebo, Santosh C Uppu
Non-invasive cardiac imaging like echocardiogram, cardiac magnetic resonance imaging (CMR), and computed tomography angiography (CTA) play a key role in the diagnosis, aid in management and follow-up of congenital heart disease patients. Normative data for intracardiac and extracardiac vascular structures in children are currently available for echocardiogram, CMR, and non-gated CTA. We sought to establish systolic and diastolic normative data for main and branch pulmonary arteries in children using electrocardiogram (ECG)-gated CTA...
December 11, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/38078841/retrospective-analysis-of-the-impact-of-electronic-medical-record-alerts-on-low-value-care-in-a-pediatric-hospital
#33
JOURNAL ARTICLE
Joanna Lawrence, Mike South, Harriet Hiscock, Daniel Capurro, Anurag Sharma, Jemimah Ride
OBJECTIVES: Hospital costs continue to rise unsustainably. Up to 20% of care is wasteful including low value care (LVC). This study aimed to understand whether electronic medical record (EMR) alerts are effective at reducing pediatric LVC and measure the impact on hospital costs. MATERIALS AND METHODS: Using EMR data over a 76-month period, we evaluated changes in 4 LVC practices following the implementation of EMR alerts, using time series analysis to control for underlying time-based trends, in a large pediatric hospital in Australia...
December 11, 2023: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38077179/qt-interval-changes-in-children-with-febrile-convulsion-compared-with-healthy
#34
JOURNAL ARTICLE
Noor Mohammad Noori, Ali Khajeh, Alireza Teimouri
INTRODUCTION: Febrile seizure is a temperature-related seizure that affects the QT interval. The purpose of this study was to evaluate the changes in the QT interval caused by febrile convulsion (FC) compared with healthy children. METHODS: This case-control study examined 180 children equally distributed between patients and controls. The study was conducted at the Ali Ebne Abi Talib Hospital in Zahedan City, Iran. The disease was diagnosed and confirmed based on standard definitions of FC...
2023: Basic and Clinical Neuroscience
https://read.qxmd.com/read/38076810/digital-twinning-of-cardiac-electrophysiology-for-congenital-heart-disease
#35
Matteo Salvador, Fanwei Kong, Mathias Peirlinck, David W Parker, Henry Chubb, Anne M Dubin, Alison Lesley Marsden
In recent years, blending mechanistic knowledge with machine learning has had a major impact in digital healthcare. In this work, we introduce a computational pipeline to build certified digital replicas of cardiac electrophysiology in pediatric patients with congenital heart disease. We construct the patient-specific geometry by means of semi-automatic segmentation and meshing tools. We generate a dataset of electrophysiology simulations covering cell-to-organ level model parameters and utilizing rigorous mathematical models based on differential equations...
November 28, 2023: bioRxiv
https://read.qxmd.com/read/38073952/amiodarone-and-adenosine-for-pediatric-supraventricular-tachycardia-a-systematic-review
#36
REVIEW
Hector I Guerra Toro, Arturo P Jaramillo, Valeria M Caceres, Genesis Pazmino
A review of the literature was made to find and choose research papers, on drugs (amiodarone and adenosine) used for managing supraventricular tachycardia (SVT) in children and infants (one hour to 17 years of age) with no structural heart disease by PRISMA guideline. Our team conducted an exhaustive systematic literature review (SLR), utilizing an extensive search methodology across recognized databases like PubMed, PubMed Central, Google Scholar, Web of Science, and The Cochrane Library. We included 10 scholarly articles that satisfied our rigorous selection criteria including systematic reviews/meta-analysis, and randomized control trials, shedding light on treatment with amiodarone and adenosine for SVT in pediatric patients...
November 2023: Curēus
https://read.qxmd.com/read/38071296/effectiveness-and-safety-of-intracardiac-electrocardiogram-guidance-for-epicutaneo-cava-catheters-via-the-lower-extremity-in-preterm-infants-a-retrospective-study
#37
JOURNAL ARTICLE
Xinying Yu, Li Gai, Xuejun Wang, Chaonan Kong, Na Cao, Ling Fan, Fan Yang, Xiaoyu Yang, Le Sun
INTRODUCTION: In recent years, intracardiac electrocardiogram (IC-ECG) technology has been widely used for epicutaneo-cava catheter (ECC) placement and has shown many potential advantages. However, evidence about the quantitative changes, effectiveness, and safety of IC-ECG for lower extremity ECC is sparse. This study aimed to explore the quantitative changes in IC-ECG for lower extremity ECC and determine its effectiveness and safety. METHODS: A retrospective study was conducted on 303 premature infants who underwent successful IC-ECG-guided lower extremity ECC placement between January 2019 and December 2021...
December 9, 2023: BMC Pediatrics
https://read.qxmd.com/read/38062530/lessons-learnt-in-the-first-year-of-an-australian-pediatric-cardio-oncology-clinic
#38
JOURNAL ARTICLE
Claudia Toro, Ben Felmingham, Mangesh Jhadav, David S Celermajer, Andre La Gerche, John O'Sullivan, Sanjeev Kumar, Marion K Mateos, Joy Fulbright, Dinisha Govender, Lane Collier, Michael Cheung, David D Eisenstat, Peter W Lange, Julian Ayer, David A Elliott, Rachel Conyers
BACKGROUND: Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment. Recommendations for high-risk patients who should be monitored in a pediatric cardio-oncology clinic have previously been developed by expert Delphi consensus by our group. In 2022 we opened our first multidisciplinary pediatric cardio-oncology clinic adhering to these recommendations in surveillance and management...
December 7, 2023: Cardio-Oncology
https://read.qxmd.com/read/38056348/application-of-dual-energy-ct-with-prospective-ecg-gating-in-cardiac-ct-angiography-for-children-radiation-and-contrast-agent-dose
#39
JOURNAL ARTICLE
Mingye Xie, Haoru Wang, Shilong Tang, Mingjing Chen, Ting Li, Ling He
OBJECTIVE: This research aimed to investigate the feasibility of utilizing dual-energy CT virtual monoenergetic images (VMI1 ) with prospective electrocardiogram (ECG2 ) gating for reducing radiation and contrast agent doses in pediatric patients with congenital heart disease (CHD3 ). METHODS: There were 100 pediatric patients with CHD included in this study. Group A (n = 50) underwent dual-energy scanning with prospective ECG-gating, and group B (n = 50) underwent conventional scanning with retrospective ECG-gating...
November 28, 2023: European Journal of Radiology
https://read.qxmd.com/read/38044147/holter-electrocardiographic-approach-to-predicting-outcomes-of-pediatric-patients-with-long-qt-syndrome
#40
JOURNAL ARTICLE
Masao Yoshinaga, Yumiko Ninomiya, Yuji Tanaka, Megumi Fukuyama, Koichi Kato, Seiko Ohno, Minoru Horie, Hiromitsu Ogata
BACKGROUND: This study was performed to clarify the clinical findings of pediatric patients diagnosed with long QT syndrome (LQTS) through electrocardiographic screening programs and to predict their outcome using Holter electrocardiographic approaches.Methods and Results: This retrospective study included pediatric patients with a Schwartz score of ≥3.5 who visited the National Hospital Organization Kagoshima Medical Center between April 2005 and March 2019. Resting 12-lead and Holter electrocardiograms were recorded at every visit...
December 1, 2023: Circulation Journal: Official Journal of the Japanese Circulation Society
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