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https://www.readbyqxmd.com/read/30536181/correction-to-an-open-label-single-dose-study-to-evaluate-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-cinacalcet-in-pediatric-subjects-aged-28-days-to-6-years-with-chronic-kidney-disease-receiving-dialysis
#1
Winnie Y Sohn, Anthony A Portale, Isidro B Salusky, Hao Zhang, Lucy L Yan, Bella Ertik, Shahnaz Shahinfar, Edward Lee, Bastian Dehmel, Bradley A Warady
The original version of this article unfortunately contained three mistakes. In Table 1, the last line under "Key Inclusion Criteria" should read "Normal or clinically acceptable ECGs at screening and at day - 1." In addition, the abbreviation "IP" in the legend to Table 1 stands for "investigational product."
December 7, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/30516532/can-flecainide-totally-eliminate-bidirectional-ventricular-tachycardia-in-pediatric-patients-with-andersen-tawil-syndrome
#2
Yakup Ergül, Senem Özgür, Sertaç Hanedan Onan, Volkan Tuzcu
Andersen-Tawil syndrome (ATS) is a disorder that causes episodes of muscle weakness (periodic paralysis), changes in heart rhythm, and developmental abnormalities. QT prolongation and ventricular arrhythmias, including bidirectional ventricular tachycardia (VT) and polymorphic VT, may occur. About 60% of all cases of the disorder arecaused by mutations in the KCNJ2 gene. A 13-year-old female patient was referred for frequent premature ventricular contractions. Suspicion of ATS due to dysmorphic findings, electrocardiogram changes, and periodic muscle weakness was genetically confirmed...
December 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/30472138/image-quality-of-ecg-triggered-high-pitch-dual-source-computed-tomography-angiography-for-cardiovascular-assessment-in-children
#3
Christian A Barrera, Hansel J Otero, Ammie M White, David Saul, David M Biko
PURPOSE: Evaluate the feasibility and determinants of image quality of ECG-triggered High-Pitch Dual-Source Computed Tomography Angiography (CTA) for cardiovascular assessment in Children. MATERIAL AND METHODS: All children that underwent ECG-triggered High-Pitch Dual-Source CTA between August 2014 and September 2017 were identified. Scanner parameters and patients' information were retrieved. Objective image quality was evaluated measuring the Hounsfield units (HU) and standard deviation of regions of interests in the left ventricle, ascending and descending aorta...
October 29, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/30447383/attitudes-beliefs-and-practices-of-pediatric-palliative-care-physicians-regarding-the-use-of-methadone-in-children-with-advanced-cancer
#4
Kevin Madden, Diane Liu, Eduardo Bruera
CONTEXT: Methadone is a long-acting opioid known for its unique pharmacokinetic and pharmacodynamic properties. Most research on methadone in children is limited to its effect on the prolongation of the corrected QT (QTc) interval. OBJECTIVES: To better understand the attitudes, beliefs, and practices of pediatric palliative care physicians regarding the use of methadone in children with advanced cancer. METHODS: A survey was sent to The American Academy of Pediatrics Section of Hospice and Palliative Medicine LISTSERV®...
November 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/30428270/detection-of-pediatric-pulmonary-arterial-hypertension-by-school-electrocardiography-mass-screening
#5
Hirofumi Sawada, Yoshihide Mitani, Tomotaka Nakayama, Hiroyuki Fukushima, Shigetoyo Kogaki, Takehiro Igarashi, Fukiko Ichida, Yasuo Ono, Toshio Nakanishi, Shozaburo Doi, Shiro Ishikawa, Masaki Matsushima, Osamu Yamada, Tsutomu Saji
RATIONALE: To detect pulmonary arterial hypertension (PAH) at any early stages is a promising approach to optimize the outcome. OBJECTIVES: To investigate the impact of school electrocardiography(ECG)-based screening on detecting idiopathic or heritable (I/H)-PAH in general pediatric population. METHODS: A nationwide survey of I/H-PAH patients newly diagnosed at 3 months-18years of age in Japan during 2005-12. MEASUREMENTS AND MAIN RESULTS: Eighty-seven eligible patients (age range: 1-16 years) were recruited...
November 14, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/30386135/image-quality-and-radiation-dose-of-high-pitch-dual-source-spiral-cardiothoracic-computed-tomography-in-young-children-with-congenital-heart-disease-comparison-of-non-electrocardiography-synchronization-and-prospective-electrocardiography-triggering
#6
Hyun Woo Goo
Objective: To compare image quality and radiation dose of high-pitch dual-source spiral cardiothoracic computed tomography (CT) between non-electrocardiography (ECG)-synchronized and prospectively ECG-triggered data acquisitions in young children with congenital heart disease. Materials and Methods: Eighty-six children (≤ 3 years) with congenital heart disease who underwent high-pitch dual-source spiral cardiothoracic CT were included in this retrospective study...
November 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/30371107/lack-of-utility-in-performing-blood-glucose-measurement-and-electrocardiogram-in-the-outpatient-evaluation-of-benign-pediatric-syncope
#7
Ayush Gupta, William Bonadio
We aimed to determine the frequency of blood glucose and electrocardiogram (EKG) abnormalities in previously healthy children who present to an emergency department (ED) with a diagnosis of benign syncope. Chart review of consecutive children aged 5 to 18 years presenting to the pediatric ED from 2004 to 2014 with a discharge diagnosis of benign syncope was done. Of 969 patients, hypoglycemia (serum glucose <60 mg/dL) was present in only 3 cases (0.3%). Of 754 patients with EKG performed, only 4 cases (0...
October 29, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/30351471/application-of-pediatric-appropriate-use-criteria-for-initial-outpatient-evaluation-of-asymptomatic-patients-with-abnormal-electrocardiograms
#8
Soham Dasgupta, Shae Anderson, Michael Kelleman, Ritu Sachdeva
INTRODUCTION: In the pediatric Appropriate Use Criteria (AUC), abnormal electrocardiogram (ECG) in an asymptomatic patient has been rated as an "Appropriate" indication for transthoracic echocardiogram (TTE). We hypothesized that the yield of abnormal findings on TTE for this indication will be low. METHODS: All asymptomatic patients (≤ 18 years) from January 1, 2015 to December 31, 2017 who underwent initial outpatient evaluation at our center and had a TTE ordered for an abnormal ECG, were included...
October 23, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/30335689/seizures-meds-and-vtach-a-journey-to-a-brugada-diagnosis
#9
David P Fitzgerald, Srikant Das, Matthew P Malone, B Shane Holland, Stephen M Schexnayder
Sudden cardiac arrest of cardiac etiology is rare in children and adolescents and most often occurs with exertion. Conversely, syncope is a common pediatric emergency department complaint but rarely is associated with a serious underlying cardiac disorder. This report describes a case of the channelopathy Brugada syndrome (BrS) as a cause of sudden cardiac arrest in a febrile preadolescent child taking medications known to affect cardiac conduction. The patient received cardiopulmonary resuscitation and was successfully defibrillated...
October 17, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/30333292/echocardiography-guided-percutaneous-closure-of-patent-ductus-arteriosus-without-arterial-access-feasibility-and-safety-for-a-new-strategy
#10
Weizhi Zhang, Lei Gao, Wancun Jin, Qin Wu, Shijun Hu, Yifeng Yang, Tianli Zhao
To evaluate the feasibility and safety of device closure of patent ductus arteriosus (PDA) using only venous access under echocardiography guidance alone.
 Methods: A total of 102 consecutive pediatric patients underwent transcatheter PDA closure without arterial access, under the guidance of only echocardiography. The patients were followed up by clinical examination, electrocardiogram, and echocardiogram at 1, 3, 6 12, and 24 months.
 Results: Transvenous PDA closure under echocardiographic guidance was successful in 99 (97...
September 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/30327703/age-makes-a-difference-symptoms-in-pediatric-supraventricular-tachycardia
#11
Amanda Quattrocelli, Janet Lang, Andrew Davis, Andreas Pflaumer
Background: Supraventricular tachycardia is a group of rhythm disturbances that affect 1 in 300-1200 Australian children annually. The differentiation of supraventricular tachycardia (SVT) symptoms and age of onset according to their subtype is not well understood in the pediatric population. Most studies rely on ECG criteria only to characterize the subtype of the SVT, which is not applicable to all subtypes. The purpose of this study was to identify the symptoms and ages of onset of SVT subtypes, and to analyze whether ethnicity or severity correlated with the SVT subtype confirmed in an invasive Electrophysiology (EP) study...
October 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/30271014/predictors-of-abnormal-electrocardiograms-in-the-pediatric-emergency-department
#12
Shiv Gandhi, Miranda Lin, Sharon R Smith, Jesse J Sturm
Background: Electrocardiograms (ECGs) are ordered in the pediatric emergency room for a wide variety of chief complaints. Objectives: Criteria are lacking as to when physicians should obtain ECGs. This study uses a large retrospective cohort of 880 pediatric emergency department (ED) patients to highlight objective criteria including significant medical history and specific vital sign abnormalities to guide clinicians as to which patients might have an abnormal ECG...
September 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/30260996/can-smartphone-wireless-ecgs-be-used-to-accurately-assess-ecg-intervals-in-pediatrics-a-comparison-of-mobile-health-monitoring-to-standard-12-lead-ecg
#13
Melanie R F Gropler, Aarti S Dalal, George F Van Hare, Jennifer N Avari Silva
BACKGROUND: Arrhythmias in children are often paroxysmal, complicating the ability to capture the abnormal rhythm on routine ECG during an outpatient visit. The Alivecor Kardia Mobile (KM) device is a wireless mobile health (mHealth) device that generates a single lead ECG tracing with a FDA-approved algorithm for detection of atrial fibrillation in adults. OBJECTIVE: The goal of this study is to assess the accuracy of interval measurements on KM tracings by directly comparing to standard 12-lead ECGs in pediatric patients...
2018: PloS One
https://www.readbyqxmd.com/read/30254039/brugada-syndrome-associated-with-adolescent-loperamide-abuse
#14
Bryan Stefek, L Timothy Wolfe, Mark Cohen
We present the case of a 14-year-old boy with obesity, hypertension, and chronic loperamide abuse who presented to our facility with symptoms of opioid withdrawal and type 1 Brugada pattern on an electrocardiogram. He was treated for anxiety and withdrawal. There were no documented dysrhythmias. His Brugada pattern resolved by hospital day 5 and remained resolved 12 days postadmission. Genetic testing revealed a heterozygous missense mutation in the SCN5A gene (c. 5038G>A, p. Ala1680Thr), which has been reported in association with Brugada syndrome...
October 2018: Pediatrics
https://www.readbyqxmd.com/read/30214250/rupatadine-oral-solution-for-2-5-year-old-children-with-allergic-rhinitis-a-safety-open-label-prospective-study
#15
Eva Santamaría, Iñaki Izquierdo, Marta Valle, Jan Vermeulen, Paul Potter
Background: There are few clinical trials that assess the efficacy of antihistamines in very young children. Rupatadine is a second-generation antihistamine indicated for the treatment of allergic rhinitis (AR) and urticaria. In this study, AR symptoms were evaluated before and after daily 1 mg/mL rupatadine oral solution administration in 2-5-year-old children. Methods: A multicenter open-label study was carried out in 2-5-year-old children with AR. Safety assessments were collected during the study including spontaneous adverse events, vital signs, and electrocardiogram (QTc interval)...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/30188452/evaluation-of-a-magnetic-tracking-and-electrocardiogram-based-tip-confirmation-system-for-peripherally-inserted-central-catheters-in-pediatric-patients
#16
Nina Rosche, Wolfgang Stehr
The purpose of this study was to investigate whether a magnetic tracking and electrocardiogram-based tip confirmation system (TCS) (Sherlock 3CG Tip Confirmation System; Bard, Covington, GA) permits safe and correct placement of a peripherally inserted central catheter (PICC) in the pediatric population. A total of 144 PICCs were placed using the TCS. After excluding participants for various reasons, 112/121 (92.56%) of PICCs were appropriately placed using the TCS. The TCS confirmed tip location an average of 7 to 18 minutes faster than radiographic imaging...
September 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/30152133/pediatric-noncompaction-patients-with-high-spatial-qrs-t-angles-are-at-increased-risk-for-ventricular-tachycardia
#17
Daniel Cortez, Nandita Sharma, Jason R Imundo
INTRODUCTION: Noncompaction cardiomyopathy (NCCM) patients may develop sustained ventricular arrhythmias (VA). Currently no known electrocardiogram (ECG) parameter has demonstrated predictive value for VA development. The spatial QRS-T angle has demonstrated ability to identify VA in other cardiomyopathy populations. METHODS: A total of 39 patients with NCCM, defined by compact to non-compact ratio of >2.3 by magnetic resonance imaging, were assessed. The first ECG taken at time of MRI was assessed utilizing the heart rate, the QRS duration (QRSd), the corrected QT interval (QTc), and the spatial QRS-T angle (SPQRS-T angle, three-dimensional angle between the QRS and T-wave vectors) were assessed...
August 27, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/30142610/depiction-of-the-native-coronary-arteries-during-ecg-triggered-high-pitch-dual-source-coronary-computed-tomography-angiography-in-children-determinants-of-image-quality
#18
Christian A Barrera, Hansel J Otero, Ammie M White, David Saul, David M Biko
OBJECTIVE: Assess the image quality of ECG-triggered High-Pitch Dual-Source CTA for the evaluation of native coronaries in children. MATERIALS AND METHODS: Between August 2014 and September 2017, 45 children with morphologically normal cardiac chambers had cardiac prospective ECG-triggered High-Pitch Dual-Source CTA. Two pediatric radiologists blinded to clinical data, independently reviewed each case. The coronary arteries were evaluated using a four-point scale quality score according to the coronary segment...
August 18, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/30131047/-key-points-of-the-2017-acc-aha-hrs-guideline-for-the-evaluation-and-management-of-patients-with-syncope
#19
G A Golovina, D V Duplyakov
The article presents key points of published in March 2017, Guideline for the Evaluation and Management of Patients With Syncope (A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society). This document contains summary and analysis of evidence base and accumulated experience in this field and reflect further development of the problem of the management of adult and pediatric patients with suspected syncope. Traditionally, the basis of diagnostic algorithm of these patients has been primary examination, and in the present guideline one can find strengthening of the importance of anamnestic criteria, and supplementation of ECG criteria of arrhythmic syncope...
August 2018: Kardiologiia
https://www.readbyqxmd.com/read/30056397/clinical-course-and-treatment-of-children-and-adolescents-with-the-preexcitation-syndrome-own-studies
#20
Aleksandra Stasiak, Katarzyna Niewiadomska-Jarosik, Piotr Kędziora
INTRODUCTION: Essentially, preexcitation syndrome is the presence of an accessory pathway in the heart, which can lead to serious consequences, ranging from atrioventricular reentrant tachycardia to sudden cardiac death. Wolff-Parkinson-White syndrome is the most common preexcitation syndrome. AIM OF THE STUDY: The aim of the study was to evaluate the clinical course of the disease, as well as the treatment of children and adolescents hospitalized in the Department of Pediatric Cardiology in the years 2008-2015...
2018: Developmental Period Medicine
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