keyword
https://read.qxmd.com/read/38533633/clinical-trial-randomized-controlled-trial-of-linaclotide-in-children-aged-6-17-years-with-functional-constipation
#1
JOURNAL ARTICLE
Carlo Di Lorenzo, Samuel Nurko, Jeffrey S Hyams, Gerardo Rodriguez-Araujo, Cristina Almansa, Valentina Shakhnovich, Miguel Saps, Michael Simon
OBJECTIVES: Linaclotide, a guanylate cyclase-C agonist, was recently approved in the United States for treatment of children 6-17 years old with functional constipation (FC). This study evaluated the safety and efficacy of several linaclotide doses in children 6-17 years old with FC. METHODS: In this multicenter, randomized, double-blind, placebo-controlled phase 2 study, 173 children with FC (based on Rome III criteria) were randomized to once-daily linaclotide (A: 9 or 18 μg, B: 18 or 36 μg, or C: 36 or 72 μg) or placebo in a 1:1:1:1 ratio for 6- to 11-year-olds (dosage determined by weight: 18 to <35 or ≥35 kg) and linaclotide (18, 36, 72, or 145 μg) or placebo in a 1:1:1:1:1 ratio for 12- to 17-year-olds...
March 27, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38527508/-diagnosis-and-treatment-of-arrhythmogenic-cardiomyopathy-in-children
#2
JOURNAL ARTICLE
W Q Ye, Y Y Xiao, X K Jiang, M Jin, X F Wang, W W Ding
Objective: To summarize the clinical manifestations, experiences in diagnosis and treatment of arrhythmogenic cardiomyopathy (ACM) in children. Methods: A retrospective analysis of the clinical manifestations, laboratory tests, radiological features, treatment and follow-up results was conducted in 11 children diagnosed with ACM at the center of congenital heart disease, Beijing anzhen hospital from May 2010 to March 2022. Results: A total of 11 patients aged 2 to 16 years, including 5 males and 6 females were diagnosed with ACM...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38523391/isolated-mitral-valve-aneurysm-in-a-9-year-old-boy
#3
Vehbi Doğan, Kutay Sel
BACKGROUND: Isolated mitral valve aneurysm is rarely reported in children. In most cases it is associated with an underlying disease such as infective endocarditis. MVA can lead to severe complications that needs surgical intervention. CASE: In this report, we present a 9-year old asymptomatic male patient with anterior mitral valve aneurysm and rhythm disturbance diagnosed incidentally during pre-operative evaluation. CONCLUSIONS: Being rare in children, isolated MVA should be kept in mind in the differential diagnosis of mass lesions seen on the atrial side of the mitral valve...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38522866/left-ventricular-outflow-tract-obstruction-in-congenital-heart-disease-the-role-of-cardiovascular-computed-tomography-in-surgical-decision-making
#4
REVIEW
B Kelly Han, Edem Binka, Eric Griffiths, Reilly Hobbs, Aaron Eckhauser, Adil Husain, David Overman
Patients with many forms of congenital heart disease (CHD) and hypertrophic cardiomyopathy undergo surgical intervention to relieve left ventricular outflow tract obstruction (LVOTO). Cardiovascular Computed Tomography (CCT) defines the complex pathway from the ventricle to the outflow tract and can be visualized in 2D, 3D, and 4D (3D in motion) to help define the mechanism and physiologic significance of obstruction. Advanced cardiac visualization may aid in surgical planning to relieve obstruction in the left ventricular outflow tract, aortic or neo-aortic valve and the supravalvular space...
2024: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://read.qxmd.com/read/38520508/limited-relationship-between-echocardiographic-measures-and-electrocardiographic-markers-of-left-ventricular-size-in-healthy-children
#5
JOURNAL ARTICLE
Mark E Alexander, Russell Gongwer, Felicia L Trachtenberg, L LuAnn Minich, John K Triedman, Jonathan R Kaltman, Richard J Czosek, Martin Tristani-Firouzi, Martin J LaPage, Sabrina S Tsao, Andrew E Radbill, Michael P DiLorenzo, Joshua R Kovach, Elizabeth A Stephenson, Christopher Janson, Chad Mao, Jack C Salerno, Bradley C Clark, Joseph Mahgerefteh, Thomas Pilcher, Tiffanie R Johnson, Jeff J Kim, Santiago O Valdes, Nicole Cain, Lanier Jackson, Elizabeth V Saarel
Pediatric ECG standards have been defined without echocardiographic confirmation of normal anatomy. The Pediatric Heart Network Normal Echocardiogram Z-score Project provides a racially diverse group of healthy children with normal echocardiograms. We hypothesized that ECG and echocardiographic measures of left ventricular (LV) dimensions are sufficiently correlated in healthy children to imply a clinically meaningful relationship. This was a secondary analysis of a previously described cohort including 2170 digital ECGs...
March 23, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38497695/diagnosis-and-management-of-paroxysmal-supraventricular-tachycardia
#6
JOURNAL ARTICLE
Gary Peng, Paul C Zei
IMPORTANCE: Paroxysmal supraventricular tachycardia (PSVT), defined as tachyarrhythmias that originate from or conduct through the atria or atrioventricular node with abrupt onset, affects 168 to 332 per 100 000 individuals. Untreated PSVT is associated with adverse outcomes including high symptom burden and tachycardia-mediated cardiomyopathy. OBSERVATIONS: Approximately 50% of patients with PSVT are aged 45 to 64 years and 67.5% are female. Most common symptoms include palpitations (86%), chest discomfort (47%), and dyspnea (38%)...
February 20, 2024: JAMA
https://read.qxmd.com/read/38495921/application-value-of-serum-cardiac-troponin-t-brain-natriuretic-peptide-levels-and-electrocardiogram-changes-in-the-treatment-and-prognosis-evaluation-of-severe-pneumonia-in-children
#7
JOURNAL ARTICLE
Liang Deng, Xiaojun Liu, Wei Liu
OBJECTIVE: To explore the application of serum cardiac troponin T (cTnT), brain natriuretic peptide (BNP) levels, and electrocardiogram changes in the treatment and prognosis evaluation of severe pneumonia in children. METHODS: 120 children with severe pneumonia (severe group) admitted to our hospital from June 2020 to December 2022 were selected as the study subjects with prospective study. They were divided into survival group (n=78) and death group (n=42) based on their survival status; 120 children with mild pneumonia were selected as the control group...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38493473/do-children-with-asymptomatic-ventricular-preexcitation-have-similar-quality-of-life-as-healthy-children
#8
JOURNAL ARTICLE
Emilia Szafran, Michał Bartecki, Anna Bukowska-Posadzy, Artur Baszko, Jarosław Walkowiak, Waldemar Bobkowski
BACKGROUND: To our knowledge, no studies have assessed quality of life (QoL) in asymptomatic children with a preexcitation electrocardiogram pattern. AIM: To evaluate the QoL of children with asymptomatic Wolff-Parkinson-White (WPW) syndrome. METHODS: This study involved QoL assessment of 31 children with asymptomatic preexcitation and 82 healthy children using the WHOQOL-BREF and the Pediatric Arrhythmia Related Score (PARS), a specific questionnaire that we have developed, which is related to patients' feelings and observations concerning arrhythmia...
2024: Kardiologia Polska
https://read.qxmd.com/read/38480035/gated-cardiac-ct-in-infants-what-can-we-expect-from-deep-learning-image-reconstruction-algorithm
#9
JOURNAL ARTICLE
Marianna Gulizia, Leonor Alamo, Yasser Alemán-Gómez, Tyna Cherpillod, Katerina Mandralis, Christine Chevallier, Estelle Tenisch, Anaïs Viry
BACKGROUND: ECG-gated cardiac CT is now widely used in infants with congenital heart disease (CHD). Deep Learning Image Reconstruction (DLIR) could improve image quality while minimizing the radiation dose. OBJECTIVES: To define the potential dose reduction using DLIR with an anthropomorphic phantom. METHOD: An anthropomorphic pediatric phantom was scanned with an ECG-gated cardiac CT at four dose levels. Images were reconstructed with an iterative and a deep-learning reconstruction algorithm (ASIR-V and DLIR)...
March 12, 2024: Journal of Cardiovascular Computed Tomography
https://read.qxmd.com/read/38476099/pharmacokinetics-and-safety-of-erenumab-in-pediatric-patients-with-migraine-a-phase-i-randomized-open-label-multiple-dose-study
#10
JOURNAL ARTICLE
Andrew D Hershey, Gabriel Paiva da Silva Lima, Nicola Pannacciulli, Mia Mackowski, Reija Koukakis, Jennifer Williams McVige
Erenumab, a fully human monoclonal antibody targeting the calcitonin gene-related peptide receptor, is efficacious and safe for prevention of attacks of migraine in adults. This phase I, randomized, open-label, multiple-dose study evaluated the safety, tolerability, and pharmacokinetics (PK) of erenumab in children and adolescents with migraine. The initial treatment phase lasted 12 weeks, followed by an optional 40-week extension phase for adolescents. Primary end points were PK of erenumab, incidence of treatment-emergent adverse events (TEAEs), and changes in clinical and laboratory assessments...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38473000/pediatric-chest-pain-a-review-of-diagnostic-tools-in-the-pediatric-emergency-department
#11
REVIEW
Szu-Wei Huang, Ying-Kuo Liu
Pediatric chest pain is a common chief complaint in the emergency department. Not surprisingly, children with chest pain are usually brought to the emergency department by their parents out of fear of heart disease. However, chest pain in the pediatric population is generally a benign disease. In this review, we have identified musculoskeletal pain as the most prevalent etiology of chest pain in the pediatric population, accounting for 38.7-86.3% of cases, followed by pulmonary (1.8-12.8%), gastrointestinal (0...
March 1, 2024: Diagnostics
https://read.qxmd.com/read/38463516/complete-heart-block-associated-with-hepatitis-a-infection-in-a-female-child-with-fatal-outcome
#12
Mansoor Ahmed, Haseena Naseer, Mohammad Ebad Ur Rehman, Jawad Basit, Abdulqadir J Nashwan, Mateen Arshad, Afnan Ahmad, Muhammad Asad
Hepatitis A virus (HAV) infection can cause extra-hepatic manifestations like myocarditis. An 8-year-old female with HAV infection presented with fever, abdominal pain, vomiting, and icterus. She developed viral myocarditis with complete AV dissociation on ECG and was treated with a temporary pacemaker, but her condition worsened, and she died. Hepatitis A viral infection can be associated with viral myocarditis and complete heart block that can lead to cardiogenic shock and death eventually.
2024: Open Medicine (Warsaw, Poland)
https://read.qxmd.com/read/38459131/can-we-screen-for-heart-disease-in-children-at-public-health-centres-a-multicentre-observational-study-of-screening-for-heart-disease-with-a-risk-of-sudden-death-in-children
#13
JOURNAL ARTICLE
Paula Greciano Calero, Silvia Escribá Bori, Juan Antonio Costa Orvay, Nina González Pons, María Del Carmen Martín Pérez, Dolores Cardona Alfonseca, Cristina Nogales Velázquez, Sergi Verd Vallespir, Alicia Esther Tur Salom, Antonella Chiandetti, Marcos Navarro Noguera, Anna Grau Blanch, María Magdalena Rotger Genestar, Marianna Mambié Meléndez, Mercedes Fernández Hidalgo, Juana María Seguí Llinas, Laura Martorell Bon, Patricia Arestuche Aguilar, Beatriz Garrido Conde, María Del Valle Sánchez Grao, Katia Sarraff Trujillo, Antoni Muntaner Alonso, Catalina Grimalt Ferragut, Andrea Soriano Marco, Viviana Gómez Rojas, Juan Pol Serra
Sudden cardiac death in children is a rare event, but of great social significance. Generally, it is related to heart disease with a risk of sudden cardiac death (SCD), which may occur with cardiovascular symptoms and/or electrocardiographic markers; thus, a primary care paediatrician (PCP) could detect them. Therefore, we proposed a study that assesses how to put into practice and conduct a cardiovascular assessment within the routine healthy-child check-ups at six and twelve years of age; that reflects cardiovascular signs and symptoms, as well as the electrocardiographic alterations that children with a risk of SCD in the selected population present; and that assesses the PCP's skill at electrocardiogram (ECG) interpretation...
March 8, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38454644/a-rare-cause-of-a-continuous-murmur-in-a-newborn
#14
JOURNAL ARTICLE
Alyson R Pierick, Hillary Liken, Michael R Joynt
We describe what we believe to be the first reported case of a neonate with right coronary ostial atresia with the right coronary artery originating from the left circumflex coronary artery, in conjunction with a right coronary artery to right ventricle fistula in a patient with otherwise normal cardiac anatomy. This was found following an evaluation for a continuous murmur at 2 weeks of life with elevated troponin and abnormal electrocardiogram. Thus far the child has required no intervention and is asymptomatic at 17 months of age, but he will require long-term follow-up to monitor the size of the fistula and potential for myocardial insufficiency...
March 7, 2024: World Journal for Pediatric & Congenital Heart Surgery
https://read.qxmd.com/read/38450370/interplay-between-mitochondrial-dysfunction-and-lysosomal-storage-challenges-in-genetic-metabolic-muscle-diseases-with-a-focus-on-infantile-onset-pompe-disease
#15
JOURNAL ARTICLE
Mengjiao Zhang, Jiechao Niu, Mengmeng Xu, Erhu Wei, Peng Liu, Guangyao Sheng
BACKGROUND: Pompe disease (PD) is a rare, progressive autosomal recessive lysosomal storage disorder that directly impacts mitochondrial function, leading to structural abnormalities and potentially culminating in heart failure or cardiogenic shock. The clinical course and molecular mechanisms of the disease remain incompletely understood. METHODS: We performed a retrospective analysis to examine the clinical manifestations, genetic traits, and the relationship between PD and mitochondrial function in a pediatric patient...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38446228/autonomic-cardiac-function-in-children-and-adolescents-with-long-covid-a-case-controlled-study
#16
JOURNAL ARTICLE
A B Delogu, C Aliberti, L Birritella, G De Rosa, C De Rose, R Morello, N Cambise, A G Marino, A Belmusto, L Tinti, A Di Renzo, G A Lanza, D Buonsenso
Although the mechanisms underlying the pathophysiology of long COVID condition are still debated, there is growing evidence that autonomic dysfunction may play a role in the long-term complications or persisting symptoms observed in a significant proportion of patients after SARS-CoV-2 infection. However, studies focused on autonomic dysfunction have primarily been conducted in adults, while autonomic function has not yet been investigated in pediatric subjects. In this study, for the first time, we assessed whether pediatric patients with long COVID present abnormalities in autonomic cardiac function...
March 6, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38431886/cardiac-function-in-pediatric-patients-with-mis-c-using-speckle-tracking-and-conventional-echocardiography-a-longitudinal-single-center-study
#17
JOURNAL ARTICLE
Mohammad Reza Sabri, Alireza Ahmadi, Mahdieh Saviz, Mehdi Ghaderian, Bahar Dehghan, Chehreh Mahdavi, Davood Ramezani Nezhad, Hamid Rahimi, Naseroldin Mostafavi, Zahra Pourmoghaddas
Cardiovascular involvement in Multisystem Inflammatory Syndrome in Children (MIS-C), a potential consequence of coronavirus disease-2019 (COVID-19), is common. Conventional transthoracic echocardiography (TTE) provides primary data on the function of the left and right ventricles, while Speckle Tracking Echocardiography (STE) is more sensitive. This study aims to assess longitudinal cardiac function using STE in these patients. This longitudinal study was conducted from late 2021 to early 2022 at Imam Hossein Children's Hospital, Isfahan...
March 3, 2024: Pediatric Cardiology
https://read.qxmd.com/read/38426635/epidemiology-of-brief-resolved-unexplained-events-and-impact-of-clinical-practice-guidelines-in-general-and-pediatric-emergency-departments
#18
JOURNAL ARTICLE
Nassr Nama, Amy M DeLaroche, Mark I Neuman, Manoj K Mittal, Bruce E Herman, Daniela Hochreiter, Ron L Kaplan, Allayne Stephans, Joel S Tieder
OBJECTIVES: The aim of this study was to describe the incidence of brief resolved unexplained events (BRUEs) and compare the impact of a national clinical practice guideline (CPG) on admission and diagnostic testing practices between general and pediatric emergency departments (EDs). METHODS: Using the Nationwide Emergency Department Sample for 2012-2019, we conducted a cross-sectional study of children <1 year of age with an International Classification of Diseases diagnostic code for BRUE...
March 1, 2024: Academic Emergency Medicine
https://read.qxmd.com/read/38406783/characteristics-of-chest-pain-among-children-presenting-to-the-pediatric-emergency-department
#19
JOURNAL ARTICLE
Abdulrahman Ahmad Alnaim, Hasna Wafi AlGarni, Hussain Adil Al Ghadeer, Muteb Abdulrahman Almulhim, Khalid Ibrahim Al Noaim, Mohammed Ahmad Al Ghamdi, Abdulaziz Abdullah Alahmari, Zainab Hejji Al Alawi, Muneera Abdulrahman Alabdulqader, Manal Mustafa Alghazal, Ohud Yousef Alhamad, Ahmed Eissa AlEissa, Ali Tawfiq AlAmer
Chest pain in pediatric patients is a common concern in pediatric emergency departments (ED). In most cases, benign conditions are related to noncardiac causes, and only a minority of the cases are caused by heart disease. This research aimed to evaluate the causes and characteristics of chest pain among children in a pediatric emergency department. This retrospective study evaluated children younger than 14 years of age who presented to the emergency department of a general pediatric hospital in the Eastern area of Saudi Arabia with non-traumatic chest pain between 2017 and 2022...
November 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38397269/a-survey-of-the-union-of-european-neonatal-and-perinatal-societies-on-neonatal-respiratory-care-in-neonatal-intensive-care-units
#20
JOURNAL ARTICLE
Corrado Moretti, Camilla Gizzi, Luigi Gagliardi, Flavia Petrillo, Maria Luisa Ventura, Daniele Trevisanuto, Gianluca Lista, Raffaele L Dellacà, Artur Beke, Giuseppe Buonocore, Antonia Charitou, Manuela Cucerea, Boris Filipović-Grčić, Nelly Georgieva Jeckova, Esin Koç, Joana Saldanha, Manuel Sanchez-Luna, Dalia Stoniene, Heili Varendi, Giulia Vertecchi, Fabio Mosca
(1) Background: Our survey aimed to gather information on respiratory care in Neonatal Intensive Care Units (NICUs) in the European and Mediterranean region. (2) Methods: Cross-sectional electronic survey. An 89-item questionnaire focusing on the current modes, devices, and strategies employed in neonatal units in the domain of respiratory care was sent to directors/heads of 528 NICUs. The adherence to the "European consensus guidelines on the management of respiratory distress syndrome" was assessed for comparison...
January 26, 2024: Children
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