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https://www.readbyqxmd.com/read/30038921/the-epidemiology-of-ankle-injuries-identified-at-the-national-football-league-combine-2009-2015
#1
Mary K Mulcahey, Andrew S Bernhardson, Colin P Murphy, Angela Chang, Tyler Zajac, George Sanchez, Anthony Sanchez, James M Whalen, Mark D Price, Thomas O Clanton, Matthew T Provencher
Background: American football is a leading cause of sports-related injuries, with the knee, ankle, and shoulder most commonly involved. Purpose/Hypothesis: The purpose of this study was to describe the epidemiology, characteristics, and imaging findings of ankle injuries in football players at the National Football League (NFL) Combine and determine the relationship to player position. We hypothesized that there would be a high relative incidence of ankle injuries in these players compared with other sports and that there would be a direct correlation between the incidence of ankle injuries and player position...
July 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29901435/sex-dependent-responses-to-exertional-heat-stroke-in-mice
#2
Christian K Garcia, Alex J Mattingly, Gerard P Robinson, Orlando Laitano, Michelle A King, Shauna M Dineen, Lisa R Leon, Thomas L Clanton
With increasing participation of females in endurance athletics and active military service, it is important to determine if there are inherent sex-dependent susceptibilities to exertional heat injury or heat stroke. In this study we compared responses of male and female adult mice to exertional heat stroke (EHS). All mice were instrumented for telemetry core temperature measurement and were exercise-trained for 3 weeks prior to EHS. During EHS, environmental temperature was 37.5°C (35% RH) while the mice ran on a forced running wheel, using incremental increases in speed...
June 14, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29753633/does-mesenteric-venous-imaging-assessment-accurately-predict-pathologic-invasion-in-localized-pancreatic-ductal-adenocarcinoma
#3
Jesse Clanton, Stephen Oh, Stephen J Kaplan, Emily Johnson, Andrew Ross, Richard Kozarek, Adnan Alseidi, Thomas Biehl, Vincent J Picozzi, William S Helton, David Coy, Russell Dorer, Flavio G Rocha
BACKGROUND: Accurate prediction of mesenteric venous involvement in pancreatic ductal adenocarcinoma (PDAC) is necessary for adequate staging and treatment. METHODS: A retrospective cohort study was conducted in PDAC patients at a single institution. All patients with resected PDAC and staging CT and EUS between 2003 and 2014 were included and sub-divided into "upfront resected" and "neoadjuvant chemotherapy (NAC)" groups. Independent imaging re-review was correlated to venous resection and venous invasion...
May 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29572055/prospective-evaluation-of-predictors-of-testis-atrophy-after-surgery-for-testis-torsion-in-children
#4
Gwen M Grimsby, Bruce J Schlomer, Vani S Menon, Lauren Ostrov, Melise Keays, Kunj R Sheth, Carlos Villanueva, Candace Granberg, Daniel Dajusta, Martinez Hill, Emma Sanchez, Clanton B Harrison, Micah A Jacobs, Berk Burgu, Halim Hennes, Linda A Baker
OBJECTIVE: To prospectively correlate pain duration, red scrotal skin, ultrasound appearance of testis, and intraoperative testis color to future testis atrophy after acute testicular torsion. METHODS: Patients 2 months-18 years old with unilateral acute scrotum were consecutively enrolled in a National Institutes of Health transcutaneous near-infrared spectroscopy study, with a subgroup analysis of the true torsion group. Presence or absence of red scrotal skin, pain duration, testicular heterogeneity on preoperative ultrasound, and intraoperative testis color based on a novel visual chart 5 minutes after detorsion were recorded...
June 2018: Urology
https://www.readbyqxmd.com/read/29552483/a-percutaneous-knotless-technique-for-acute-achilles-tendon-ruptures
#5
Daniel J Liechti, Gilbert Moatshe, Jonathon D Backus, Daniel Cole Marchetti, Thomas O Clanton
Achilles tendon ruptures are a common tendon injury, usually occurring in middle-aged men during recreational sporting activities. Both nonoperative and operative management are employed to treat these injuries. Several operative treatments are described in the literature, including percutaneous Achilles repair, mini-open repair, and open repair. Open Achilles repair is associated with higher rates of impaired wound healing and infection, whereas minimally invasive techniques have been reported to have an increased risk of iatrogenic sural nerve injury...
February 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29527490/callous-unemotional-traits-and-brain-structure-sex-specific-effects-in-anterior-insula-of-typically-developing-youths
#6
Nora Maria Raschle, Willeke Martine Menks, Lynn Valérie Fehlbaum, Martin Steppan, Areti Smaragdi, Karen Gonzalez-Madruga, Jack Rogers, Roberta Clanton, Gregor Kohls, Anne Martinelli, Anka Bernhard, Kerstin Konrad, Beate Herpertz-Dahlmann, Christine M Freitag, Graeme Fairchild, Stephane A De Brito, Christina Stadler
Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown whether callous-unemotional traits are associated with neuroanatomical correlates within normative populations without clinical levels of aggression or antisocial behavior...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29363200/optogenetically-enhanced-axon-regeneration-motor-versus-sensory-neuron-specific-stimulation
#7
Patricia J Ward, Scott L Clanton, Arthur W English
Brief neuronal activation in injured peripheral nerves is both necessary and sufficient to enhance motor axon regeneration, and this effect is specific to the activated motoneurons. It is less clear whether sensory neurons respond in a similar manner to neuronal activation following peripheral axotomy. Further, it is unknown to what extent enhancement of axon regeneration with increased neuronal activity relies on a reflexive interaction within the spinal circuitry. We used mouse genetics and optical tools to evaluate the precision and selectivity of system-specific neuronal activation to enhance axon regeneration in a mixed nerve...
February 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29350522/chemical-design-of-both-a-glutathione-sensitive-dimeric-drug-guest-and-a-glucose-derived-nanocarrier-host-to-achieve-enhanced-osteosarcoma-lung-metastatic-anticancer-selectivity
#8
Lu Su, Richen Li, Sarosh Khan, Ryan Clanton, Fuwu Zhang, Yen-Nan Lin, Yue Song, Hai Wang, Jingwei Fan, Soleil Hernandez, Andrew S Butters, Gamal Akabani, Ronan MacLoughlin, Justin Smolen, Karen L Wooley
Although nanomedicines have been pursued for nearly 20 years, fundamental chemical strategies that seek to optimize both the drug and drug carrier together in a concerted effort remain uncommon yet may be powerful. In this work, two block polymers and one dimeric prodrug molecule were designed to be coassembled into degradable, functional nanocarriers, where the chemistry of each component was defined to accomplish important tasks. The result is a poly(ethylene glycol) (PEG)-protected redox-responsive dimeric paclitaxel (diPTX)-loaded cationic poly(d-glucose carbonate) micelle (diPTX@CPGC)...
January 31, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29305666/decorated-superparamagnetic-iron-oxide-nanoparticles-with-monoclonal-antibody-and-diethylene-triamine-pentaacetic-acid-labeled-with-thechnetium-99m-and-galium-68-for-breast-cancer-imaging
#9
Marta de Souza Albernaz, Sergio Hiroshi Toma, Jeff Clanton, Koiti Araki, Ralph Santos-Oliveira
PURPOSE: In this study we developed and tested an iron oxide nanoparticle conjugated with DTPA and Trastuzumab, which can efficiently be radiolabeled with 99m-Tc and Ga-68, generating a nanoradiopharmaceutical agent to be used for SPECT and PET imaging. METHODS: The production of iron oxide nanoparticle conjugated with DTPA and Trastuzumab was made using phosphorylethanolamine (PEA) surface modification. Both radiolabeling process was made by the direct radiolabeling of the nanoparticles...
January 5, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29192066/epinephrine-stimulates-cxcl1-il-1-%C3%AE-il-6-secretion-in-isolated-mouse-limb-muscle
#10
Alex J Mattingly, Orlando Laitano, Thomas L Clanton
Catecholamines stimulate interleukin-6 (IL-6) secretion in skeletal muscles. However, whether other cytokines are secreted is currently unknown. Skeletal muscle ex vivo preparations commonly used to study cytokine secretion have dealt with limitations including auto-oxidation of catecholamines. The use of metal chelators could be an alternative to avoid auto-oxidation and allow catecholamines to be used at physiological doses. We exposed isolated soleus muscles to 1 or 100 ng/mL epinephrine (EPI) and collected bath samples at 1 and 2 h for multiplex cytokine analysis...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29182761/sugar-and-aldehyde-content-in-flavored-electronic-cigarette-liquids
#11
Pebbles Fagan, Pallav Pokhrel, Thaddeus A Herzog, Eric T Moolchan, Kevin D Cassel, Adrian A Franke, Xingnan Li, Ian Pagano, Dennis R Trinidad, Kari-Lyn K Sakuma, Kymberle Sterling, Dorothy Jorgensen, Tania Lynch, Crissy Kawamoto, Mignonne C Guy, Ian Lagua, Sarah Hanes, Linda A Alexander, Mark S Clanton, Camonia Graham-Tutt, Thomas Eissenberg
Introduction: Sugars are major constituents and additives in traditional tobacco products, but little is known about their content or related toxins (formaldehyde, acetaldehyde, and acrolein) in electronic cigarette (e-cigarette) liquids. This study quantified levels of sugars and aldehydes in e-cigarette liquids across brands, flavors, and nicotine concentrations (n = 66). Methods: Unheated e-cigarette liquids were analyzed using liquid chromatography mass spectrometry and enzymatic test kits...
July 9, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29181362/erratum-author-s-name-correction
#12
Joerg Mika, Olaf Brinkmann, Thomas O Clanton, Gabor Szalay, Raimund W Kinne
[This corrects the article on p. 5 in vol. 6, PMID: 27299113.].
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29163090/community-violence-exposure-and-conduct-problems-in-children-and-adolescents-with-conduct-disorder-and-healthy-controls
#13
Linda Kersten, Noortje Vriends, Martin Steppan, Nora M Raschle, Martin Praetzlich, Helena Oldenhof, Robert Vermeiren, Lucres Jansen, Katharina Ackermann, Anka Bernhard, Anne Martinelli, Karen Gonzalez-Madruga, Ignazio Puzzo, Amy Wells, Jack C Rogers, Roberta Clanton, Rosalind H Baker, Liam Grisley, Sarah Baumann, Malou Gundlach, Gregor Kohls, Miguel A Gonzalez-Torres, Eva Sesma-Pardo, Roberta Dochnal, Helen Lazaratou, Zacharias Kalogerakis, Aitana Bigorra Gualba, Areti Smaragdi, Réka Siklósi, Dimitris Dikeos, Amaia Hervás, Aranzazu Fernández-Rivas, Stephane A De Brito, Kerstin Konrad, Beate Herpertz-Dahlmann, Graeme Fairchild, Christine M Freitag, Arne Popma, Meinhard Kieser, Christina Stadler
Exposure to community violence through witnessing or being directly victimized has been associated with conduct problems in a range of studies. However, the relationship between community violence exposure (CVE) and conduct problems has never been studied separately in healthy individuals and individuals with conduct disorder (CD). Therefore, it is not clear whether the association between CVE and conduct problems is due to confounding factors, because those with high conduct problems also tend to live in more violent neighborhoods, i...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29156538/combined-effects-of-simulated-microgravity-and-radiation-exposure-on-osteoclast-cell-fusion
#14
Srinivasan Shanmugarajan, Ye Zhang, Maria Moreno-Villanueva, Ryan Clanton, Larry H Rohde, Govindarajan T Ramesh, Jean D Sibonga, Honglu Wu
The loss of bone mass and alteration in bone physiology during space flight are one of the major health risks for astronauts. Although the lack of weight bearing in microgravity is considered a risk factor for bone loss and possible osteoporosis, organisms living in space are also exposed to cosmic radiation and other environmental stress factors. As such, it is still unclear as to whether and by how much radiation exposure contributes to bone loss during space travel, and whether the effects of microgravity and radiation exposure are additive or synergistic...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29121597/rapid-synthesis-of-125-i-integrated-gold-nanoparticles-for-use-in-combined-neoplasm-imaging-and-targeted-radionuclide-therapy
#15
Ryan Clanton, Arnulfo Gonzalez, Sriram Shankar, Gamal Akabani
The selective delivery of radionuclides to tissues of interest remains a problematic task during treatment. The lack of tissue specificity for many therapeutics limit their efficacy by putting healthy organs and tissues at risk (e.g., side effects). Therefore, high specificity therapeutic strategies are needed to overcome these risks. The objective of this study was to use a modified citrate reduction technique to synthesize gold nanoparticles (AuNPs) containing125 I in order to combine their unique therapeutic and diagnostic properties...
January 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28957876/xiphoid-surface-temperature-predicts-mortality-in-a-murine-model-of-septic-shock
#16
Orlando Laitano, David Van Steenbergen, Alex J Mattingly, Christian K Garcia, Gerard P Robinson, Kevin O Murray, Thomas L Clanton, Elizabeth A Nunamaker
Sepsis continues to be a major challenge for modern medicine. Several preclinical models were developed to study sepsis and each has strengths and weaknesses. The cecal slurry (CS) method is a practical alternative because it does not require surgery, and the infection can be dosed. However, one disadvantage is that the dosage must be determined for each CS preparation using survival studies. Our aim was to refine a survival protocol for the CS model by determining a premonitory humane endpoint that would reduce animal suffering...
August 2018: Shock
https://www.readbyqxmd.com/read/28934878/surgical-preparation-for-articular-cartilage-regeneration-in-the-osteoarthritic-knee-joint
#17
Joerg Mika, Thomas O Clanton, Catherine G Ambrose, Raimund W Kinne
PURPOSE: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. HYPOTHESIS: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. METHODS: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non-brute-force debridement for ACI...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28899234/a-youth-leader-program-in-baltimore-city-recreation-centers-lessons-learned-and-applications
#18
Angela C B Trude, Elizabeth Anderson Steeves, Cara Shipley, Pamela J Surkan, Priscila de Morais Sato, Tracey Estep, Stella Clanton, Lisa Lachenmayr, Joel Gittelsohn
Peer-led interventions may be an effective means of addressing the childhood obesity epidemic; however, few studies have looked at the long-term sustainability of such programs. As part of a multilevel obesity prevention intervention, B'More Healthy Communities for Kids, 16 Baltimore college students were trained as youth-leaders (YLs) to deliver a skill-based nutrition curriculum to low-income African American children (10-14 years old). In April 2015, formative research was used to inform sustainability of the YL program in recreation centers...
January 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/28776147/looming-threats-and-animacy-reduced-responsiveness-in-youth-with-disrupted-behavior-disorders
#19
Stuart F White, Laura C Thornton, Joseph Leshin, Roberta Clanton, Stephen Sinclair, Dionne Coker-Appiah, Harma Meffert, Soonjo Hwang, James R Blair
Theoretical models have implicated amygdala dysfunction in the development of Disruptive Behavior Disorders (DBDs; Conduct Disorder/Oppositional Defiant Disorder). Amygdala dysfunction impacts valence evaluation/response selection and emotion attention in youth with DBDs, particularly in those with elevated callous-unemotional (CU) traits. However, amygdala responsiveness during social cognition and the responsiveness of the acute threat circuitry (amygdala/periaqueductal gray) in youth with DBDs have been less well-examined, particularly with reference to CU traits...
May 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28736288/rapid-decay-of-transthoracic-echocardiography-skills-at-1-month-a-prospective-observational-study
#20
Ryo Yamamoto, David Clanton, Ross E Willis, Rachelle Babbitt Jonas, Ramon F Cestero
OBJECTIVE: Focused transthoracic echocardiography (FTTE) is an emerging tool in the management of critically ill patients, but the lack of adequate training models has limited the expansion of this technology. Although basic FTTE training courses have been shown to be sufficient in developing echocardiography skills, limited data exist regarding skill retention. In an effort to develop an adequate FTTE training model, we sought to determine the degree of skill retention after FTTE training...
March 2018: Journal of Surgical Education
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