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Katharina Schütz, Diana Alecsandru, Bodo Grimbacher, Jamanda Haddock, Annemarie Bruining, Gertjan Driessen, Esther de Vries, Peter M van Hagen, Ieneke Hartmann, Francesco Fraioli, Cinzia Milito, Milica Mitrevski, Isabella Quinti, Goffredo Serra, Peter Kelleher, Michael Loebinger, Jiri Litzman, Vera Postranecka, Vojtech Thon, Judith Babar, Alison M Condliffe, Andrew Exley, Dinakantha Kumararatne, Nick Screaton, Alison Jones, Maria P Bondioni, Vassilios Lougaris, Alessandro Plebani, Annarosa Soresina, Cesare Sirignano, Giuseppe Spadaro, Nermeen Galal, Luis I Gonzalez-Granado, Sabine Dettmer, Robert Stirling, Helen Chapel, Mary Lucas, Smita Patel, Claire-Michele Farber, Isabelle Meyts, Arpan K Banerjee, Scott Hackett, John R Hurst, Klaus Warnatz, Benjamin Gathmann, Ulrich Baumann
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency...
December 13, 2018: Journal of Clinical Immunology
Jamie A Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A Gretarsson, Toshihiro Kobayashi, M Azim Surani
Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Göttingen Center for Molecular Biosciences, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany. This has now been corrected in both the PDF and HTML versions of the Article.
December 11, 2018: Nature Communications
Carla De la Fuente Cantó, Joanne Russell, Christine A Hackett, Allan Booth, Siobhan Dancey, Timothy S George, Robbie Waugh
BACKGROUND: Exploring the natural occurring genetic variation of the wild barley genepool has become a major target of barley crop breeding programmes aiming to increase crop productivity and sustainability in global climate change scenarios. However this diversity remains unexploited and effective approaches are required to investigate the benefits that unadapted genomes could bring to crop improved resilience. In the present study, a set of Recombinant Chromosome Substitution Lines (RCSLs) derived from an elite barley cultivar 'Harrington' as the recurrent parent, and a wild barley accession from the Fertile Crescent 'Caesarea 26-24', as the donor parent (Matus et al...
December 7, 2018: BMC Plant Biology
Nonlawat Boonyalai, Christine R Collins, Fiona Hackett, Chrislaine Withers-Martinez, Michael J Blackman
The malaria parasite replicates within erythrocytes. The pathogenesis of clinical malaria is in large part due to the capacity of the parasite to remodel its host cell. To do this, intraerythrocytic stages of Plasmodium falciparum export more than 300 proteins that dramatically alter the morphology of the infected erythrocyte as well as its mechanical and adhesive properties. P. falciparum plasmepsin V (PfPMV) is an aspartic protease that processes proteins for export into the host erythrocyte and is thought to play a key role in parasite virulence and survival...
2018: PloS One
Ryan E Schaub, Krizia M Perez-Medina, Kathleen T Hackett, Daniel L Garcia, Joseph P Dillard
Neisseria gonorrhoeae releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides. These molecules can be released by the actions of lytic transglycosylases or an amidase. However, over 40% of the gonococcal cell wall is crosslinked, where the peptide stem on one peptidoglycan strand is linked to the peptide stem on a neighboring strand, suggesting that endopeptidases may be required for release of many peptidoglycan fragments...
December 3, 2018: Infection and Immunity
Katherine Hackett, Robert Krikorian, Tania Giovannetti, Josefina Melendez-Cabrero, Aneela Rahman, Emily E Caesar, Jaclyn L Chen, Hollie Hristov, Alon Seifan, Lisa Mosconi, Richard S Isaacson
Introduction: The NIH Toolbox Cognition Battery (NIHTB-CB) is a computer-based protocol not yet validated for clinical assessment. Methods: We administered the NIHTB-CB and traditional neuropsychological tests to 247 Memory Disorders and Alzheimer's Prevention Clinic patients with subjective cognitive decline, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition. Principal component analysis, partial correlations, and univariate general linear model tests were performed to assess construct validity...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Lauren E Himmel, Troy A Hackett, Jessica L Moore, Wilson R Adams, Giju Thomas, Tatiana Novitskaya, Richard M Caprioli, Andries Zijlstra, Anita Mahadevan-Jansen, Kelli L Boyd
For decades, histopathology with routine hematoxylin and eosin staining has been and remains the gold standard for reaching a morphologic diagnosis in tissue samples from humans and veterinary species. However, within the past decade, there has been exponential growth in advanced techniques for in situ tissue biomarker imaging that bridge the divide between anatomic and molecular pathology. It is now possible to simultaneously observe localization and expression magnitude of multiple protein, nucleic acid, and molecular targets in tissue sections and apply machine learning to synthesize vast, image-derived datasets...
November 21, 2018: ILAR Journal
Julia Hackett, Lucy Ziegler, Mary Godfrey, Robbie Foy, Michael I Bennett
BACKGROUND: Primary health care teams are key to the delivery of care for patients with advanced cancer during the last year of life. The Gold Standards Framework is proposed as a mechanism for coordinating and guiding identification, assessment, and support. There are still considerable variations in practice despite its introduction. The aim of this qualitative study is to improve understanding of variations in practice through exploring the perspectives and experiences of members of primary health care teams involved in the care of patients with advanced cancer...
November 20, 2018: BMC Family Practice
J Peters-Kennedy, C E Lange, S L Rine, R P Hackett
BACKGROUND: Equus caballus papillomavirus 8, a recently discovered virus, has been reported to cause generalised papillomavirus in horses OBJECTIVES: To describe a case in which multiple viral plaques, viral papillomas, squamous cell carcinoma (SCC) in situ and invasive squamous cell carcinoma (ISCC) were associated with EcPV8 in a horse. STUDY DESIGN: Case report. METHODS: A 16-year-old mixed breed horse presented with dozens of raised crusted papular to nodular lesions over the course of 4 years...
November 19, 2018: Equine Veterinary Journal
A U Arun Kumar, Mohamed E Elsayed, Ahmed Alghali, Alaa A Ali, Husham Mohamed, Wael Hussein, Catriona Hackett, Niamh Leonard, Austin G Stack
Background: Sweet syndrome is a rare skin condition characterised by fever, neutrophilia, and tender erythematous skin lesions and has been reported to occur in association with anti-neutrophil cytoplasmic antibodies (ANCA) as well as complicate treatment with azathioprine therapy. Azathioprine, a relatively safe immunosuppressive, is frequently used to maintain disease remission in the treatment of ANCA-associated vasculitis. The occurrence of Sweet syndrome in a patient with ANCA-positive vasculitis and following treatment with azathioprine prompted us to present this clinical case and share this unusually rare occurrence...
2018: Allergy, Asthma, and Clinical Immunology
Ruth A Hackett, Catherine Moore, Andrew Steptoe, Camille Lassale
Healthy lifestyle is key for type 2 diabetes (T2D) management. It is unclear whether individuals change health behaviours in response to T2D diagnosis. We compared smoking, physical activity, fruit and vegetable intake and alcohol consumption at three times (pre-diagnosis, at diagnosis, 2-4 years post-diagnosis) in individuals who developed T2D and controls. Behaviours were assessed in 6877 individuals at waves 3-7 of the English Longitudinal Study of Ageing. Generalized estimating equations were used to examine differences by group and time and group-by-time interactions...
November 16, 2018: Scientific Reports
Richard S Isaacson, Christine A Ganzer, Hollie Hristov, Katherine Hackett, Emily Caesar, Randy Cohen, Robert Kachko, Josefina Meléndez-Cabrero, Aneela Rahman, Olivia Scheyer, Mu Ji Hwang, Cara Berkowitz, Suzanne Hendrix, Monica Mureb, Matthew W Schelke, Lisa Mosconi, Alon Seifan, Robert Krikorian
Like virtually all age-related chronic diseases, late-onset Alzheimer's disease (AD) develops over an extended preclinical period and is associated with modifiable lifestyle and environmental factors. We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a novel clinical methodology used to evaluate and treat patients at two Alzheimer's Prevention Clinics. The framework applies evidence-based principles of clinical precision medicine to tailor individualized recommendations, follow patients longitudinally to continually refine the interventions, and evaluate N-of-1 effectiveness (trial registered at ClinicalTrials...
November 5, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Youngseok Jee, Yang Yu, Harry W Abernathy, Shiwoo Lee, Thomas L Kalapos, Gregory A Hackett, Paul R Ohodnicki
The demand for real-time sensors in harsh environments at elevated temperature is significant and increasing. In this manuscript, the chemical and temperature sensing using the optical response through the practical fiber platform is demonstrated, and principle component analysis is coupled with targeted experimental film characterization to understand the fundamental sensing layer properties, which dominate measured gas sensing responses in complex gas mixtures. More specifically, tin-doped indium oxide-decorated sensors fabricated with the sol-gel method show stable and stepwise transmission responses varying over a wide range of H2 concentration (5-100%) at 250-350 °C as well as responses to CH4 and CO to a lesser extent...
November 29, 2018: ACS Applied Materials & Interfaces
S McCarthy, M E McMenamin, C C B B Heffron, O Ipadeola, C Hackett, M Lynch
No abstract text is available yet for this article.
November 14, 2018: Clinical and Experimental Dermatology
Patrick Burns, Grant S Lipman, Keiran Warner, Carrie Jurkiewicz, Caleb Phillips, Linda Sanders, Mario Soto, Peter Hackett
BACKGROUND: Acute mountain sickness is a common occurrence for travel to high altitudes. Although previous studies of ibuprofen have shown efficacy for the prevention of acute mountain sickness, recommendations have been limited, as ibuprofen has not been compared directly with acetazolamide until this study. METHODS: Before their ascent to 3810 m on White Mountain in California, adult volunteers were randomized to ibuprofen (600 mg, 3 times daily, started 4 hours before the ascent), or to acetazolamide (125 mg, twice daily, started the night before the ascent)...
November 10, 2018: American Journal of Medicine
Douglas Robinson, Gregory Hand, Jason Ausman, Anthony Hackett
BACKGROUND: Brugada pattern is a well-known pathological finding on electrocardiogram (ECG) which increases the likelihood of cardiac arrest due to ventricular arrhythmia. These cases generally present in younger patients without evidence of an electrolyte abnormality, structural heart disease, or cardiac ischemia. In many instances, this pattern is either hidden on initial presentation or presents as an incidental finding on an EKG. Often times the Brugada syndrome leads to sudden cardiac death or more rarely can be unmasked with a class 1A or 1C anti-arrhythmic agent...
October 23, 2018: American Journal of Emergency Medicine
Andrew M Crawford, Nicole J Sylvain, Huishu Hou, Mark J Hackett, M Jake Pushie, Ingrid J Pickering, Graham N George, Michael E Kelly
Synchrotron X-ray fluorescence imaging enables visualization and quantification of microscopic distributions of elements. This versatile technique has matured to the point where it is used in a wide range of research fields. The method can be used to quantitate the levels of different elements in the image on a pixel-by-pixel basis. Two approaches to X-ray fluorescence image analysis are commonly used, namely, (i) integrative analysis, or window binning, which simply sums the numbers of all photons detected within a specific energy region of interest; and (ii) parametric analysis, or fitting, in which emission spectra are represented by the sum of parameters representing a series of peaks and other contributing factors...
November 1, 2018: Journal of Synchrotron Radiation
M J Hackett, A Hollings, S Caine, B E Bewer, M Alaverdashvili, R Takechi, J C L Mamo, M W M Jones, M D de Jonge, P G Paterson, I J Pickering, G N George
A unique combination of sensitivity, resolution, and penetration make X-ray fluorescence imaging (XFI) ideally suited to investigate trace elemental distributions in the biological context. XFI has gained widespread use as an analytical technique in the biological sciences, and in particular enables exciting new avenues of research in the field of neuroscience. In this study, elemental mapping by XFI was applied to characterise the elemental content within neuronal cell layers of hippocampal sub-regions of mice and rats...
November 6, 2018: Metallomics: Integrated Biometal Science
Mansur A Kutlubaev, Ying Xu, Maree L Hackett, Jon Stone
Comorbid epilepsy and psychogenic nonepileptic seizures (PNES) represent a serious challenge for the clinicians. However, the frequency, associations, and outcomes of dual diagnosis of epilepsy and PNES are unclear. The aim of the review was to determine the frequency, correlates, and outcomes of a dual diagnosis. A systematic review of all published observational studies (from inception to Dec. 2016) was conducted to determine the frequency, correlates, and outcomes of dual diagnosis. We included studies of individuals of any age reporting a dual diagnosis of epilepsy and PNES...
December 2018: Epilepsy & Behavior: E&B
Tania Giovannetti, Takehiko Yamaguchi, Emily Roll, Tetsuya Harada, Sarah Seligman Rycroft, Ross Divers, Jacob Hulswit, Chiu C Tan, Anastasia Matchanova, Lillian Ham, Katherine Hackett, Rachel Mis
BACKGROUND: Efficient, objective measures of mild functional difficulties are lacking. Preliminary data from a novel, non-immersive virtual reality, performance-based task (Virtual Kitchen Challenge; VKC) were obtained to address this gap. METHODS: 14 older and 21 younger adults completed cognitive tests and two everyday tasks (breakfast, lunch) in the VKC with virtual objects and a touch-screen and in the Real Kitchen with real objects (order counterbalanced). Automated performance measures were obtained from the VKC program and human coders scored VKC and Real Kitchen videos for errors...
October 28, 2018: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
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