keyword
MENU ▼
Read by QxMD icon Read
search

Pharmaceutical technology

keyword
https://www.readbyqxmd.com/read/30517882/evaluation-of-in-line-particle-measurement-with-an-sft-probe-as-monitoring-tool-for-process-automation-using-a-new-time-based-buffer-approach
#1
Theresa Reimers, Jochen Thies, Stefan Dietrich, Julian Quodbach, Miriam Pein-Hackelbusch
The Process Analytical Technology (PAT) initiative published by the Food and Drug administration (FDA) describes PAT systems as important tools to optimize pharmaceutical processes in order to ensure the final product quality. Real-time particle size measurements provide a promising approach for process automation of fluid bed granulation processes. This work focuses on the introduction and evaluation of a new time-based buffer approach for in-line spatial filtering technique (SFT) in order to provide a minimum time delay of the real-time measurement...
December 2, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30517310/-the-brazilian-market-for-monoclonal-antibodies-used-in-cancer-treatment
#2
Thaís Jeronimo Vidal, Tatiana Aragão Figueiredo, Vera Lúcia Edais Pepe
Monoclonal antibodies (mABs) have been indicated as an innovative technology for the treatment of some types of cancer, since they are capable of targeting and selectively killing tumor cells. However, the high costs of these therapies raise questions as to the sustainability of access. This study aimed to identify the principal characteristics of monoclonal antibodies used in cancer treatment with active marketing authorization in Brazil as of 2016. This was a descriptive retrospective analysis based on consultation of the Brazilian Health Regulatory Agency (Anvisa) website, in which these mABs were characterized according to the target antigen, type of antibody, year of registration, therapeutic indications, and applicant...
November 29, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/30516995/metallaphotoredox-catalyzed-cross-electrophile-csp3-csp3-coupling-of-aliphatic-bromides
#3
Russell T Smith, Xiaheng Zhang, Juan A Rincon, Javier Agejas, Carlos Mateos, Mario Barberis, Susana García-Cerrada, Oscar de Frutos, David W C MacMillan
A strategy for the installation of small alkyl fragments onto pharmaceutically relevant aliphatic structures has been established via metallaphotoredox catalysis. Herein, we report that tris(trimethylsilyl)silanol can be employed as an effective halogen abstraction reagent that, in combination with photoredox and nickel catalysis, allows a generic approach to Csp3-Csp3 cross-electrophile coupling. In this study, we demonstrate that a variety of aliphatic drug-like groups can be successfully coupled with a number of commercially available small alkyl electrophiles, including methyl tosylate and strained cyclic alkyl bromides...
December 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30513888/modeling-of-disintegration-and-dissolution-behavior-of-mefenamic-acid-formulation-using-numeric-solution-of-noyes-whitney-equation-with-cellular-automata-on-microtomographic-and-algorithmically-generated-surfaces
#4
Reiji Yokoyama, Go Kimura, Christian M Schlepütz, Jörg Huwyler, Maxim Puchkov
Manufacturing parameters may have a strong impact on the dissolution and disintegration of solid dosage forms. In line with process analytical technology (PAT) and quality by design approaches, computer-based technologies can be used to design, control, and improve the quality of pharmaceutical compacts and their performance. In view of shortcomings of computationally intensive finite-element or discrete-element methods, we propose a modeling and simulation approach based on numerical solutions of the Noyes-Whitney equation in combination with a cellular automata-supported disintegration model...
December 3, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/30513470/novel-controlled-drug-release-system-engineered-with-inclusion-complexes-based-on-carboxylic-graphene
#5
Yinghong Xiao, Ming Zhang, Yunting Fan, Qicheng Zhang, Yuli Wang, Wenwen Yuan, Ninglin Zhou, Jianfei Che
A novel drug carrier is constructed by compositing hydrophilic hydroxypropyl-β-cyclodextrins (HP-β-CD) and carboxylated graphene nanomaterial (GO-COOH). Fourier transform infrared spectroscopy confirms that the two materials are successfully combined via chemical bonds. Further, a crosslinking agent of glutaraldehyde is applied to fabricate composite GO-COO-HP-β-CD nanospheres, as demonstrated by an atomic force microscope. Dexamethasone (DEX) is selected as the model drug, and the drug loading efficiency and water solubility of the nanospheres greatly increased...
November 28, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30513398/application-of-3d-printing-technology-and-quality-by-design-approach-for-development-of-age-appropriate-pediatric-formulation-of-baclofen
#6
Siddhant Palekar, Pavan Kumar Nukala, Saurabh M Mishra, Thomas Kipping, Ketan Patel
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy and with significant safety concerns. The aim of proposed project was to explore a 3D printing technology for the development of customized minicaplets of baclofen for the pediatric population. Based on results of 3-point bend test, polyvinyl alcohol (PVA) with sorbitol (10% w/w) were selected for preparation of baclofen loaded filaments using hot melt extrusion (HME)...
December 1, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/30513248/uppsala-clinical-research-center-development-of-a-platform-to-promote-national-and-international-clinical-science
#7
Lars Wallentin, Bertil Lindahl
Uppsala Clinical Research Center (UCR) is a non-profit organization that provides service for clinical research aiming for development and improvement of health care in Sweden and worldwide. UCR was started in 2001 with the ambition to shift the focus of clinical research from new medications or devices launched by the industry to problem-based research on issues identified in clinical reality, for example through the national quality registries. In order to accomplish these goals, UCR has established services in: 1) clinical trials of new and old methods in health care; 2) quality development of the health care system supported by internet-based national quality registries; 3) biostatistics, epidemiology, and data management; 4) biobanking of biological materials (Uppsala Biobank); 5) high-throughput biochemical analyses (UCR laboratory); and 6) academic leadership by the members of the UCR research faculty...
December 4, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/30508716/ppcp-degradation-and-dbp-formation-in-the-solar-free-chlorine-system-effects-of-ph-and-dissolved-oxygen
#8
Zhechao Hua, Kaiheng Guo, Xiujuan Kong, Suiki Lin, Zihao Wu, Liping Wang, Huang Huang, Jingyun Fang
The solar/chlorine process produces multiple reactive species by solar photolysis of chlorine, which can be used as an energy-efficient technology for water treatment. This study investigated the effects of pH and dissolved oxygen (DO) on the degradation of pharmaceuticals and personal care products (PPCPs) and on the formation of disinfection byproducts (DBPs) in the solar/chlorine system. The degradation of 24 structurally diverse PPCPs was enhanced appreciably in the solar/chlorine system compared to solar irradiation and dark chlorination...
November 19, 2018: Water Research
https://www.readbyqxmd.com/read/30506453/fumaric-acid-production-and-separation
#9
REVIEW
Roxana-Andreea Ilica, Lenuţa Kloetzer, Anca-Irina Galaction, Dan Caşcaval
Fumaric acid is a valuable compound used in foods, beverages, detergents, animal feed, pharmaceuticals and miscellaneous industrial products. It is produced on a large scale by the petrochemical route but the current tendency is towards implementing "green production" and environmental friendly technologies like biotechnological production of fumaric acid using low-cost raw materials. In this context, numerous studies focus on improving the fermentation process not only by using renewable raw material and genetically modified microorganisms, but also by developing and applying different downstream techniques for easy recovery of fumaric acid from the fermented broth...
December 1, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/30503803/recent-advances-in-pharmaceutical-dosage-forms-and-devices-using-additive-manufacturing-technologies
#10
REVIEW
Christos I Gioumouxouzis, Christina Karavasili, Dimitrios G Fatouros
The era of 'one-size-fits-all' treatment approaches is becoming history for pharmaceutical manufacturing with the future encountering a revolution in drug development through the introduction of additive manufacturing technologies. The innovative elements of this disruptive technology will affect all shareholders of the pharmaceutical chain from the industrial sector to the dispensing facilities and, ultimately, the patient end-user. In this review, we provide an overview of the most recent advances in dosage forms and devices using additive manufacturing technologies, along with the regulatory landscape framing the development and safety requirements for 3D-printed drug products before entering the pharmaceutical market...
November 29, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/30503315/environmentally-related-contaminants-of-high-concern-potential-sources-and-analytical-modalities-for-detection-quantification-and-treatment
#11
REVIEW
Tahir Rasheed, Muhammad Bilal, Faran Nabeel, Muhammad Adeel, Hafiz M N Iqbal
In recent years, emerging contaminants (ECs) of high concern are broadly distributed throughout the environmental matrices because of various industrial practices and anthropogenic inputs, i.e., human-made activities. With ever increasing scientific knowledge, technological advancement, socio-economic awareness, people are now more concern about the widespread distribution of environmentally related ECs of high concern. As, ECs possess serious ecological threats and potential risks to human health and aquatic life, even at minor concentrations...
November 28, 2018: Environment International
https://www.readbyqxmd.com/read/30501785/micronization-of-ibuprofen-particles-using-supercritical-fluid-technology
#12
Tomáš Sosna, Marcel Mikeska, Ondčrej Dutko, Gražyna Simha Martynková, Katečrina Škrlová, Karla Čech Barabaszová, Katečrina Dčedková, Pavlína Peikertová, Daniela Plachá
Most of drugs are only slightly soluble in the circulatory system of the human body. This reduces the efficiency of their use and that is why new ways how to increase their solubility are investigated. One way to improve the solubility of the drug is to reduce its particle size. Conventional techniques such as crushing or grinding usually do not guarantee a narrow particle size distribution, which is required for pharmaceuticals. Application of supercritical fluids, especially of supercritical CO₂, seems to be convenient method for the preparation of pharmaceuticals submicron particles or nanoparticles...
May 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30501624/clinical-and-other-specialty-services-offered-by-pharmacists-in-the-community-the-international-arena-and-israel
#13
Eyal Schwartzberg, Joseph P Nathan, Sivan Avron, Eli Marom
The community pharmacy setting is a venue that is readily accessible to the public. In addition, it is staffed by a pharmacist, who is a healthcare provider, trained and capable of delivering comprehensive pharmaceutical care. As such, community pharmacists have a colossal opportunity to serve as key contributors to patients' health by ensuring appropriate use of medications, preventing medication misadventures, identifying drug-therapy needs, as well as by being involved in disease management, screening, and prevention programs...
December 1, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/30501606/mesoporous-silica-nanoparticles-a-versatile-platform-for-biomedical-applications
#14
Pooja Jain, Nazia Hassan, Zeenat Iqbal, Fahima Dilnawaz
BACKGROUND: Nanotechnology based drug delivery approach has emerged as a promising field, where different kinds of formulations are developed for therapeutic applications. Inflowing of nanomedicine developed through various biomaterials appears to be a game changer in the domain of pharmaceutical and biotechnological industries. Nanomedicines propose to overcome the major constraints of conventional medicine of low solubility and stability, and non-adequate pharmacokinetic profiles and side effects...
December 3, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/30500178/mechanistic-study-on-the-role-of-soluble-microbial-products-in-sulfate-radical%C3%A2-mediated-degradation-of-pharmaceuticals
#15
Lingwei Gao, Daisuke Minakata, Zongsu Wei, Richard Spinney, Dionysios D Dionysiou, Chong-Jian Tang, Liyuan Chai, Ruiyang Xiao
The role of soluble microbial products (SMP), the most important component of effluent organic matter (EfOM) from municipal wastewater treatment plants, in sulfate radical SO4 •- ‒based advanced oxidation technologies (AOTs) remains substantially unclear. In this study, we first utilized a suite of macro and micro analytical techniques to characterize the SMP from a membrane bioreactor for its fundamental molecular, spectroscopic, and reactivity properties. The degradation kinetics of three representative pharmaceuticals (i...
November 30, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/30498677/recent-advances-in-phthalan-and-coumaran-chemistry
#16
REVIEW
Efimov Ilya, Larisa Kulikova, Erik V Van der Eycken, Leonid Voskressensky
Oxygen-containing heterocycles are common in biologically active compounds. In particular, phthalan and coumaran cores are found in pharmaceuticals, organic electronics, and other useful medical and technological applications. Recent research has expanded the methods available for their synthesis. This Minireview presents recent advances in the chemistry of phthalans and coumarans, with the goal of overcoming synthetic challenges and facilitating the applications of phthalans and coumarans.
November 2018: ChemistryOpen
https://www.readbyqxmd.com/read/30488721/strategies-for-modifying-drug-residence-time-and-ocular-bioavailability-to-decrease-treatment-frequency-for-back-of-the-eye-diseases
#17
Whitney Shatz, Jeffrey Aaronson, Stefan Yohe, Robert F Kelley, Yogeshvar N Kalia
Treating posterior eye diseases has become a major area of focus for pharmaceutical and biotechnology companies. Current standard of care for treating posterior eye diseases relies on administration via intravitreal injection. Although effective, this is not without complications and there is great incentive to develop longer-acting therapeutics and/or sustained release delivery systems. Here, we present an overview of emerging technologies for delivery of biologics to the back of the eye. Areas covered: Posterior eye diseases, intravitreal injection, age-related macular degeneration, anti-VEGF, ocular pharmacokinetics, novel technologies to extend half-life, in vivo models, translation to the clinic, hurdles to effective patient care...
November 29, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/30488598/crystal-engineering-an-outlook-for-the-future
#18
Ashwini K Nangia, Gautam R Desiraju
Crystal Engineering has traditionally dealt with molecular crystals. It is the understanding of intermolecular interactions in the context of crystal packing and in the utilization of such understanding in the design of new solids with desired physical and chemical properties. We outline here five areas which come under the umbrella of Crystal Engineering and where we feel that a proper planning of research efforts could lead to higher dividends for science together with greater returns for humankind. We touch on themes and domains where science funding and translation efforts could be directed in the current climate of a society that increasingly expects applications and utility products from science and technology...
November 28, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30486433/preparation-and-characterization-of-water-based-nano-perfumes
#19
Małgorzata Miastkowska, Elwira Lasoń, Elżbieta Sikora, Katarzyna Wolińska-Kennard
The application of nanoemulsions as a novel delivery system for lipophilic materials, such as essential oils, flavors, and fragrances is one of the growing technologies used in cosmetic, pharmaceutical, and food industries. Their characteristic properties, like small droplet size with high interfacial area, transparent or semi-transparent appearance, low viscosity, and high kinetic stability, make them a perfect vehicle for fragrances, in the perfume industry. They could be a great alternative to water-based perfumes, without alcohol, and solve problems related to the oxidation and low bioavailability of fragrances with other non-alcoholic vehicles of perfumes like pomades or gels...
November 27, 2018: Nanomaterials
https://www.readbyqxmd.com/read/30486372/peroxisome-proliferator-activated-receptor-%C3%AE-agonist-and-its-target-nanog-cooperate-to-induce-pluripotency
#20
Jungwoon Lee, Jinhyuk Lee, Yee Sook Cho
The pharmaceutical compounds that modulate pluripotent stem cell (PSC) identity and function are increasingly adopted to generate qualified PSCs and their derivatives, which have promising potential in regenerative medicine, in pursuit of more accuracy and safety and less cost. Here, we demonstrate the peroxisome proliferator-activated receptor α (PPARα) agonist as a novel enhancer of pluripotency acquisition and induced pluripotent stem cell (iPSC) generation. We found that PPARα agonist, examined and selected Food and Drug Administration (FDA) -approved compound libraries, increase the expression of pluripotency-associated genes, such as Nanog, Nr5A2, Oct4, and Rex1, during the reprogramming process and facilitate iPSC generation by enhancing their reprogramming efficiency...
November 27, 2018: Journal of Clinical Medicine
keyword
keyword
162176
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"