Hong-Jai Park, Min Sun Shin, Junghee J Shin, Hyoungsu Kim, Byunghyun Kang, Jennefer Par-Young, Serhan Unlu, Yuliya Afinogenova, Jason Catanzaro, Juan Young, Minhyung Kim, Sang Jin Lee, Sangchoon Jeon, Sungyong You, Michael K Racke, Richard Bucala, Insoo Kang
BACKGROUND: The innate immune cytokine interleukin (IL)-1 can affect T cell immunity, a critical factor in host defense. In a previous study, we identified a subset of human CD4+ T cells which express IL-1 receptor 1 (IL-1R1). However, the expression of such receptor by viral antigen-specific CD4+ T cells and its biological implication remain largely unexplored. This led us to investigate the implication of IL-1R1 in the development of viral antigen-specific CD4+ T cell responses in humans, including healthy individuals and patients with primary antibody deficiency (PAD), and animals...
April 18, 2024: EBioMedicine