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premature rupture membranes

Natnael Etsay Assefa, Hailemariam Berhe, Fiseha Girma, Kidanemariam Berhe, Yodit Zewdie Berhe, Gidiom Gebreheat, Weldu Mamu Werid, Almaz Berhe, Hagos B Rufae, Guesh Welu
Following publication of the original article [1], the author reported that his name was misspelled. The original article has been corrected.Incorrect name: Gidiom GebrehetCorrect name: Gdiom Gebreheat.
October 16, 2018: BMC Pregnancy and Childbirth
Jose R Duncan, Ana M Tobiasz, Katherine M Dorsett, Michael M Aziz, Rebecca E Thompson, Zoran Bursac, Ajay J Talati, Giancarlo Mari M D Mba, Mauro H Schenone
OBJECTIVE: To determine the prognostic accuracy of the fetal pulmonary artery acceleration time/ejection time (PATET) for the prediction of neonatal respiratory complications (NRC) in pregnancies with preterm premature rupture of membranes (PPROM). METHODS: This is a prospective cohort of singleton pregnancies complicated by PPROM managed in our institution from October 2015 to April 2018. Inclusion criteria included mothers from 13-46 years of age and singleton pregnancies with PATET measurements < 7 days prior to delivery...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Devin D Smith, Deepika Sagaram, Russell Miller, Cynthia Gyamfi-Bannerman
OBJECTIVE: Our objective was to describe cerebral palsy (CP) incidence stratified by gestational age (GA) groups within a group at risk for spontaneous preterm birth (sPTB). STUDY DESIGN: This is a secondary analysis of a large study of magnesium for neuroprotection. Nonanomalous, singleton gestations complicated by preterm premature rupture of membranes (PPROM) or preterm labor (PTL) were included. Infants that developed CP were compared to controls that did not...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Rossana Di Sarno, Antonio Raffone, Gabriele Saccone
Different strategies have been adopted for prevention of spontaneous preterm birth, including use of progestogens. So far, five randomized trials have been published evaluating the efficacy of progestogens in women with PPROM, including a total of 425 partipants. All the five trials enrolled pregnant women with singleton pregnancies randomized between 20 and 34 weeks of gestation. In four trials women were randomized to either weekly intramuscular 250 mg 17α-hydroxyprogesterone-caproate or placebo, while Mirzaei et al...
October 11, 2018: Minerva Ginecologica
Mauro Cozzolino, Francesca Basile, Giovanni Pontrelli
INTRODUCTION: Several studies investigated the correlation between adenomyosis and adverse pregnancy outcomes. However, the role of adenomyosis as a risk factor for adverse outcomes in has yet to be established. The aim of this systematic review is to clarify the possible association between uterine adenomyosis and poor obstetrical outcomes. EVIDENCE ACQUISITION: Numerous studies have demonstrated that adenomyosis increased miscarriage rate, preterm birth and preterm premature rupture of membranes...
October 11, 2018: Minerva Ginecologica
Ayesha Husain, Aliya Naseem, Sagheera Anjum, Sajida Imran, Muhammad Arifuzzaman, Syed Omair Adil
OBJECTIVE: To determine the relationship between the colour of liquor and the trace of cardiotocography to see whether it is reactive or non-reactive.. METHODS: This cross-sectional study was conducted at Obstetrics and Gynaecology department, Dar-ul-Sehat Hospital, Karachi from June 2015 to March 2016, and comprised women in labour who delivered singleton babies and had >37 weeks of gestation. Intrapartum monitoring by cardiotocography was conducted. The status of the amniotic membranes, colour and amount of liquor observed were recorded...
July 2018: JPMA. the Journal of the Pakistan Medical Association
Yves Ville, Patrick Rozenberg
Cervical length (CL) measured by transvaginal ultrasound examination (TVUE) best identifies the risk for preterm birth (PTB). It identifies women at risk who can benefit from corticosteroids or in utero transfer. Early screening improves effectiveness of tocolysis. It reduces iatrogenicity and cost. In preterm premature rupture of membranes (PPROM), CL is devoid of infectious risk and predicts duration of the latency phase but not the risk of perinatal sepsis. Asymptomatic women at risk should be screened at a 2-week interval starting from 16 to 18 weeks, up to 24 weeks...
July 7, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Sule Ozel, Selen Yaman, Hatice Kansu-Celik, Necati Hancerliogullari, Nurgul Balci, Yaprak Engin-Ustun
OBJECTIVE:  The aim of this study was to analyze and compare obstetric and neonatal outcomes between Syrian refugees and ethnic Turkish women. METHODS:  Retrospective, observational study. A total of 576 Syrian refugees and 576 ethnic Turkish women were included in this study, which was conducted between January 2015 and December 2015 at a tertiary maternity training hospital in Ankara, Turkey. The demographic characteristics, obstetric and neonatal outcomes were compared...
October 11, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Emilia Holmström, Tarja Myntti, Timo Sorsa, Heidi Kruit, Juuso Juhila, Jorma Paavonen, Leena Rahkonen, Vedran Stefanovic
INTRODUCTION: Intra-amniotic inflammation is defined by elevated inflammatory biomarkers in the amniotic fluid (AF), either due to microbial invasion of the amniotic cavity (MIAC) or sterile inflammation. Amniocentesis being an invasive procedure, we wanted to investigate whether elevated matrix metalloproteinase-8 (MMP-8) or interleukin-6 (IL-6) concentrations could be detected from cervical fluid samples. MATERIALS AND METHODS: This prospective study included 67 women with singleton nondiabetic pregnancies with or without preterm premature rupture of membranes (PPROM) between 22+0 and 37+0 weeks of gestation...
October 11, 2018: Fetal Diagnosis and Therapy
Lu-Yao Wang, Wang-Sheng Wang, Ya-Wei Wang, Jiang-Wen Lu, Yi Lu, Chu-Yue Zhang, Wen-Jiao Li, Kang Sun, Hao Ying
Preterm premature rupture of fetal membranes precedes 30-40% of preterm births. Activation of matrix metalloproteases (MMPs) is the one of the major causes of extracellular matrix (ECM) degradation in membrane rupture. Increased cortisol, regenerated by 11β-hydroxysteroid dehydrogenase 1 in the amnion at parturition, is known to participate in a number of parturition-pertinent events. However, whether cortisol has a role in the regulation of MMPs in the membranes is not known. Here, we addressed this issue using human amnion tissue, the most tensile layer of the membranes...
October 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Felix Boria, Maria de la Calle, Marcos Cuerva, Angela Sainz, Jose Luis Bartha
AIM: To evaluate obstetric and perinatal outcomes of twin pregnancies obtained after in vitro fertilization with donated oocytes. METHODS: This is a case-control study comparing 50 women with twin pregnancies after oocyte donation and 50 women after in vitro fertilization with autologous oocytes. Clinical records were reviewed and obstetric and perinatal outcome variables including rates of preeclampsia, gestational diabetes, pregnancy induced hypertension, preterm delivery, premature rupture of membranes, cesarean delivery, birth weight, Apgar score, pH test were compared...
October 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
Bhavi P Modi, Hardik I Parikh, Maria E Teves, Rewa Kulkarni, Jiang Liyu, Roberto Romero, Timothy P York, Jerome F Strauss
BACKGROUND: Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth, a complication that is more common in African Americans. Attempts to identify genetic loci associated with preterm birth using genome-wide association studies (GWAS) have only been successful with large numbers of cases and controls, and there has yet to be a convincing genetic association to explain racial/ethnic disparities. Indeed, the search for ancestry-specific variants associated with preterm birth has led to the conclusion that spontaneous preterm birth could be the consequence of multiple rare variants...
October 5, 2018: BMC Medical Genetics
Mohammed Abaraya, Sheka Shemsi Seid, Shemsedin Amme Ibro
Background: Preterm birth is the second leading cause of death next to pneumonia in children aged <5 years and the single-most important cause of death in the first month of life. Research examining determinants of preterm birth in Ethiopia is limited. Therefore, this study aimed to determine risk factors associated with preterm births at Jimma University Medical Center in southwest Ethiopia. Methods: This unmatched case-control study was conducted from March 15 to April 1, 2017 from medical records of mothers and newborns delivered at Jimma University Medical Center from January 1 to December 30, 2016...
2018: Pediatric Health, Medicine and Therapeutics
Lone Nikoline Nørgaard, Ulrikka Nygaard, Julie Agner Damm, Barbara Hoff Esbjørn, Mette Marie Agner Pedersen, Amanda Rottbøll, Connie Jørgensen, Karin Sundberg
BACKGROUND: The treatment options for fetal chylothorax include thoracocentesis, thoracoamniotic shunting, and pleurodesis using OK-432. Knowledge on the long-term outcomes after treatment with OK-432 is limited. OBJECTIVE: The aim of this study was to assess the long-term outcomes of children treated in utero with OK-432. METHODS: We performed follow-up on pregnancies and children treated in utero with OK-432 between 2003 and 2009 at Copenhagen University Hospital Rigshospitalet for pleural effusions at gestational age (GA) 16+0-21+6 weeks...
October 3, 2018: Fetal Diagnosis and Therapy
Annick Moens, Karen van Hoeve, Evelien Humblet, Jean-François Rahier, Peter Bossuyt, Sophie Dewit, Denis Franchimont, Elisabeth Macken, Jochen Nijs, Annelies Posen, Beatrijs Strubbe, Anneleen Van Hootegem, Wouter Van Moerkercke, Séverine Vermeire, Marc Ferrante
Background and Aims: Vedolizumab is an IgG1 anti-α4β7 integrin antibody approved for the treatment of inflammatory bowel diseases [IBD], but without clear safety data during conception, pregnancy and nursing. Animal studies showed that mucosal vascular addressin cell adhesion molecule 1 [MAdCAM-1] is expressed by maternal vessels in the placenta and recruits α4β7-expressing cells that are considered important for maternal/fetal tolerance. Blocking this interaction by vedolizumab might affect this process...
October 3, 2018: Journal of Crohn's & Colitis
Natnael Etsay Assefa, Hailemariam Berhe, Fiseha Girma, Kidanemariam Berhe, Yodit Zewdie Berhe, Gidiom Gebreheat, Weldu Mamu Werid, Almaz Berhe, Hagos B Rufae, Guesh Welu
BACKGROUND: The incidence of premature rupture of membranes ranges from about 5% to 10% of all deliveries. A woman with premature rupture of membranes is at risk of intra-amniotic infection, postpartum infection, endometritis, and death. A neonate born from premature rupture of membranes mother is at high risk of respiratory distress syndrome, sepsis, intraventricular hemorrhage and death. Little is known regarding the risk factors in Ethiopia. Therefore, this study was conducted to identify risk factors of premature rupture of membranes among pregnant women admitted to public hospitals in Mekelle city, Tigray, Ethiopia...
September 29, 2018: BMC Pregnancy and Childbirth
Lynne Sykes, Phillip R Bennett
Preterm birth (PTB) occurs in 5-18% of pregnancies and is the leading cause of neonatal morbidity, mortality and infant death. Up to 30% of PTBs are due to iatrogenic reasons, but the remainder are due to the spontaneous onset of labour or pre-labour premature rupture of membranes (P-PROM). During pregnancy, the uterus remains quiescent and the cervix remains long and closed. Although the exact mechanisms that lead to spontaneous PTB (sPTB) are not fully understood, it is likely that the terminal pathways that are common to term labour are activated prematurely...
September 8, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Katherine Kohari, Krista Mehlhaff, Audrey Merriam, Sonya Abdel-Razeq, Olga Grechukhina, Daisy Leon-Martinez, Mert Ozan Bahtiyar
Prelabor rupture of the membranes (PROM) near the limit of viability is associated with significant risks for both mother and fetus. Preterm labor, intra-amniotic infection, and placental abruption are the immediate risks to the pregnancy; however, the fetus incurs additional risks related to the sequela of persistent oligohydramnios. Transabdominal intra-amniotic infusions have been studied. Results, suggesting that this intervention may prolong the latency period, and potentially, decrease pulmonary hypoplasia in surviving neonates without evidence of increasing risk of intra-amniotic infection...
July 2018: American Journal of Perinatology Reports
Alfonsus Adrian Hadikusumo Harsono, Achmadi Achmadi, Muhammad Ilham Aldika Akbar, Hermanto Tri Joewono
BACKGROUND Recurrent seizure in patients with magnesium sulfate-treated eclampsia is very rare and requires meticulous management due to poor prognosis. The development of eclamptic convulsions is considered a preventable obstetric situation. Magnesium sulfate has been the drug of choice in such cases. However, some cases are persistent and need more aggressive treatment. CASE REPORT First case: A 20-year-old, nulliparous woman was referred from a private midwifery practice with history of convulsion, 40 weeks of gestational age (GA), and in the active phase of labor...
September 25, 2018: American Journal of Case Reports
Z Q Zhao, J Zhai
Objective: To evaluate the prognosis and complications after reduction of monochorionic multifetal pregnancies using bipolar umbilical cord coagulation (BCC) or radiofrequency ablation (RFA). Methods: A literature search were performed by using online databases including PubMed, Embase, and COCHRANE.The publications that described prognosis and complications after selective reduction of monochorionic twin pregnancies using either BCC or RFA for studies with clear outcome data were identified. Results: We identified five retrospective cohort studies for the meta-analysis and 231 cases of BCC and 174 cases of RFA...
September 18, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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