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TBI rat

Jyothsna Chitturi, Ying Li, Vijayalakshmi Santhakumar, Sridhar S Kannurpatti
Pathophysiology of developmental traumatic brain injury (TBI) is unique due to intrinsic differences in the developing brain. Energy metabolic studies of the brain during early development (P13 to P30) have indicated acute oxidative energy metabolic decreases below 24 h after TBI, which generally recovered by 48 h. However, marked neurodegeneration and altered neural functional connectivity have been observed at later stages into adolescence. As secondary neurodegeneration is most prominent during the first week after TBI in the rat model, we hypothesized that the subacute TBI-metabolome may contain predictive markers of neurodegeneration...
August 9, 2018: Neurochemistry International
Wei Gao, Ying-Nan Ju, Jian-Feng Chen, Qiang Zhou, Chun-Yu Song, Yue-Zhen Wang, Hong-Ling Cao, Wan-Chao Yang
OBJECTIVE: Traumatic brain injury (TBI) is a devastating neurological injury, and remains as a major cause of death in the world. Secondary injury after TBI is associated with long-term disability in patients with TBI. The present study evaluated adrenomedullin (AM) on secondary injury and neurological functional outcome in rats after TBI. METHODS: Forty-eight SD rats were randomly assigned into three groups: sham, TBI and TBI+AM groups. TBI was induced by fluid percussion injury (FPI) and AM was intravenously injected...
August 7, 2018: World Neurosurgery
Samuel S Shin, Vijai Krishnan, William Stokes, Courtney Robertson, Pablo Celnik, Yanrong Chen, Xiaolei Song, Hanzhang Lu, Peiying Liu, Galit Pelled
BACKGROUND: Therapeutic strategies for traumatic brain injury (TBI) in the last three decades have failed to show significant benefit in large scale studies. Given the multitude of pathological mechanisms involved in TBI, strategies focusing on multimodality regimen have gained interest as promising future interventions. HYPOTHESIS: We hypothesized that combining noninvasive transcranial magnetic stimulation (TMS) with rehabilitative training in an environmental enrichment (EE) can facilitate post-TBI recovery in rats via cortical excitability and reorganization...
July 25, 2018: Brain Stimulation
Liyan Lu, Mingling Wang, Xiaoer Wei, Wenbin Li
Recent studies have implicated 20-HETE as a vasoconstrictive mediator in trauma, the purpose of this study was to determine whether administration of HET0016, the 20-HETE inhibitor, could protect neurons from trauma and the effect of HET0016 on the blood-brain barrier (BBB) and brain edema in experimental traumatic brain injury (TBI). Rat models with TBI were established. Brain edema was measured according to the wet and dry weight method at 3, 24, and 72 h after injury. The BBB permeability was quantified by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)...
2018: Frontiers in Aging Neuroscience
Hugh H Chan, Connor A Wathen, Nicole D Mathews, Olivia Hogue, James P Modic, Ronak Kundalia, Cara Wyant, Hyun-Joo Park, Imad M Najm, Bruce D Trapp, Andre G Machado, Kenneth B Baker
BACKGROUND: Many traumatic brain injury (TBI) survivors live with persistent disability from chronic motor deficits despite contemporary rehabilitation services, underscoring the need for novel treatment. OBJECTIVE/HYPOTHESIS: We have previously shown that deep brain stimulation (DBS) of the lateral cerebellar nucleus (LCN) can enhance post-stroke motor recovery and increase the expression of markers of long-term potentiation in perilesional cerebral cortex. We hypothesize that a similar beneficial effect will be for motor deficits induced by unilateral fluid percussion injury (FPI) in rodents through long-term potentiation- and anti-inflammatory based mechanisms...
July 25, 2018: Brain Stimulation
Naima Lajud, Arturo Díaz-Chávez, Hannah Radabaugh, Jeffrey P Cheng, Georgina Rojo-Soto, Juan Valdéz-Alarcón, Corina O Bondi, Anthony E Kline
Environmental enrichment (EE) confers motor and cognitive recovery in preclinical models of traumatic brain injury (TBI), and neurogenesis has been attributed to mediating the benefits. Whether that ascription is correct has not been fully investigated. Hence, the goal of the current study is to further clarify the possible role of learning-induced hippocampal neurogenesis on functional recovery after cortical impact or sham injury by utilizing two EE paradigms (i.e., early + continuous; initiated immediately after TBI and presented 24-hr/day, and delayed + abbreviated; initiated 4 days after TBI for 6-hr/day) and comparing them to one another as well as to standard (STD) housed controls...
July 27, 2018: Journal of Neurotrauma
Hui Chen, Yik Lung Chan, Claire Linnane, Yilin Mao, Ayad G Anwer, Arjun Sapkota, Tiara F Annissa, George Herok, Bryce Vissel, Brian G Oliver, Sonia Saad, Catherine A Gorrie
There is a need for pharmaceutical agents that can reduce neuronal loss and improve functional deficits following traumatic brain injury (TBI). Previous research suggests that oxidative stress and mitochondrial dysfunction play a major role in neuronal damage after TBI. Therefore, this study aimed to investigate two drugs known to have antioxidant effects, L-carnitine and exendin-4, in rats with moderate contusive TBI. L-carnitine (1.5 mM in drinking water) or exendin-4 (15 µg/kg/day, ip) were given immediately after the injury for 2 weeks...
July 25, 2018: Scientific Reports
Karthik S Prabhakara, Daniel J Kota, Gregory H Jones, Amit K Srivastava, Charles S Cox, Scott D Olson
Despite intensive research and clinical trials with numerous therapeutic treatments, traumatic brain injury (TBI) is a serious public health problem in the United States. There is no effective FDA-approved treatment to reduce morbidity and mortality associated with TBI. Inflammation plays a pivotal role in the pathogenesis of TBI. We looked to re-purpose existing drugs that reduce immune activation without broad immunosuppression. Teriflunomide, an FDA-approved drug, has been shown to modulate immunological responses outside of its ability to inhibit pyrimidine synthesis in rapidly proliferating cells...
July 5, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Whitney S McDonald, Elizabeth E Jones, Jonathan M Wojciak, Richard R Drake, Roger A Sabbadini, Neil G Harris
Lysophosphatidic acid (LPA) levels increase in the cerebrospinal fluid and blood within 24 hours after traumatic brain injury (TBI), indicating it may be a biomarker for subsequent cellular pathology. However, no data exist that document this association after TBI. We, therefore, acquired matrix-assisted laser desorption ionization imaging mass spectrometry data of LPA, major LPA metabolites, and hemoglobin from adult rat brains at 1 and 3 hours after controlled cortical impact injury. Data were semiquantitatively assessed by signal intensity analysis normalized to naïve rat brains acquired concurrently...
August 2018: American Journal of Pathology
Stephan Missault, Cynthia Anckaerts, Ines Blockx, Steven Deleye, Debby Van Dam, Nora Barriche, Glenn De Pauw, Stephanie Aertgeerts, Femke Valkenburg, Peter Paul De Deyn, Jeroen Verhaeghe, Leonie Wyffels, Annemie Van der Linden, Steven Staelens, Marleen Verhoye, Stefanie Dedeurwaerdere
There is currently a lack of prognostic biomarkers to predict the different sequelae following traumatic brain injury (TBI). The present study investigated the hypothesis that subacute neuroinflammation and microstructural changes correlate with chronic TBI deficits. Rats were subjected to Controlled Cortical Impact (CCI) injury, sham surgery or skin incision (naïve). CCI-injured (n=18) and sham-operated rats (n=6) underwent positron emission tomography (PET) imaging with the translocator protein (TSPO) radioligand [18F]PBR111 and diffusion tensor imaging (DTI) in the subacute phase (≤3 weeks post-injury) to quantify inflammation and microstructural alterations...
July 21, 2018: Journal of Neurotrauma
Haojie Mao, Lihong Lu, Kewei Bian, Fredrik Clausen, Niall Colgan, Michael Gilchrist
Fluid percussion injury (FPI) is a widely used experimental model for studying traumatic brain injury (TBI). However, little is known about how the brain mechanically responds to fluid impacts and how the mechanical pressures/strains of the brain correlate to subsequent brain damage for rodents during FPI. Hence, we developed a numerical approach to simulate FPI experiments on rats and characterize rat brain pressure/strain responses at a high resolution. A previous rat brain model was improved with a new hexahedral elements-based skull model and a new cerebrospinal fluid (CSF) layer...
August 22, 2018: Journal of Biomechanics
Xuefei Shao, Qianxin Hu, Sansong Chen, Qifu Wang, Pengcheng Xu, Xiaochun Jiang
Traumatic brain injury (TBI) is a primary cause of disability and mortality. Ghrelin, a gastrointestinal hormone, has been found to have protective effects for the brain, but the molecular mechanism of these neuroprotective effects of ghrelin remains unclear. In this study, an electronic cortical contusion impactor was used to establish a rat TBI model and we investigated the effect of ghrelin on brain repair by neurological severity score and histological examination. An antibody array was employed to uncover the molecular mechanism of ghrelin's neuroprotective effects by determining the alterations of multiple proteins in the brain cortex...
2018: Frontiers in Neuroscience
Kristen E DeDominicis, Hye Hwang, Casandra M Cartagena, Deborah A Shear, Angela M Boutté
Treatments to improve outcomes following severe traumatic brain injury (TBI) are limited but may benefit from understanding subacute-chronic brain protein profiles and identifying biomarkers suitable for use in this time. Acute alterations in the well-known TBI biomarkers glial fibrillary acidic protein (GFAP), αII-spectrin, and their breakdown products (BDPs) have been well established, but little is known about the subacute-chronic post-injury profiles of these biomarkers. Thus, the current study was designed to determine the extended profile of these TBI-specific biomarkers both in brain tissue and cerebral spinal fluid (CSF)...
2018: Frontiers in Neurology
Joanna K Huttunen, Antti M Airaksinen, Carmen Barba, Gabriella Colicchio, Juha-Pekka Niskanen, Artem Shatillo, Alejandra Sierra Lopez, Xavier Ekolle Ndode-Ekane, Asla Pitkanen, Olli Gröhn
Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a major challenge. As increased neuronal activity in the brain triggers a blood oxygenation level-dependent (BOLD) response in functional magnetic resonance imaging (fMRI), we hypothesized that fMRI could be used to identify the brain area(s) with hyperexcitability during post-injury epileptogenesis. We applied fMRI to detect the onset and spread of BOLD activation after pentylenetetrazol (PTZ)-induced seizures (PTZ, 30 mg/kg, i...
July 18, 2018: Journal of Neurotrauma
Il-Gyu Ko, Sung-Eun Kim, Lakkyong Hwang, Jun-Jang Jin, Chang-Ju Kim, Bo-Kyun Kim, Hong Kim
Traumatic brain injury (TBI) causes deficit in spatial learning and memory function. Physical activity ameliorates neurological dysfunction after TBI. We investigated the effect of late starting treadmill exercise on spatial learning ability in relation with cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway using TBI rats. For this study, radial 8-arm maze test, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) staining, caspase-3 immunohistochemistry, and western blot for Bax, Bcl-2, BDNF, tyrosine kinase B (TrkB), CREB, and phosphorylated CREP (p-CREB) were performed...
June 2018: Journal of Exercise Rehabilitation
Françoise Arnaud, Georgina Pappas, Ye Chen, Eric Maudlin-Jeronimo, Richard McCarron
INTRODUCTION: A stressful environment may contribute to poor outcomes after TBI. The current study evaluates the impact of acute stress in a polytrauma rat model. METHODS: Rats were stressed by a 45-minute immobilization period before instrumentation under ketamine (t1). Polytrauma was produced by blast overpressure and controlled hemorrhage (t2). Rats were euthanized immediately after a 3 h simulated Medevac-transport time (t3) or after 72 h post-trauma (t4)...
July 6, 2018: Neuroscience Letters
Meng-Xian Pan, Jun-Chun Tang, Rui Liu, Yu-Gong Feng, Qi Wan
PURPOSE: To investigate the effects of estrogen G protein-coupled receptor 30 (GPR30) agonist G1 on hippocampal neuronal apoptosis and microglial polarization in rat traumatic brain injury (TBI). METHODS: Male SD rats were randomly divided into sham group, TBI + vehicle group, TBI + G1 group. Experimental moderate TBI was induced using Feeney's weigh-drop method. G1 (100μg/kg) or vehicle was intravenously injected from femoral vein at 30 min post-injury. Rats were sacrificed at 24 h after injury for detection of neuronal apoptosis and microglia polarization...
May 18, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
Derek Ray Verley, Daneil Torolira, Brittany A Hessell, Richard L Sutton, Neil G Harris
Traumatic brain injury results in well-known, significant alterations in structural and functional connectivity. While this is especially likely to occur in areas of pathology, deficits in function to, and from remotely connected brain areas, or diaschisis, also occur as a consequence to local deficits. As a result, consideration of the network wiring of the brain may be required to design the most efficacious rehabilitation therapy to target specific functional networks to improve outcome. In this work, we model remote connections after controlled cortical impact injury in the rat through the effect of callosal deafferentation to the opposite, contralesional cortex...
July 17, 2018: Journal of Neurotrauma
Yanlu Zhang, Michael Chopp, Christopher S Rex, Vincent F Simmon, Stella T Sarraf, Zheng Gang Zhang, Asim Mahmood, Ye Xiong
The tetra (ethylene glycol) derivative of benzothiazole aniline (SPG101) has been shown to improve dendritic spine density and cognitive memory in the triple transgenic mouse model of Alzheimer's disease (AD) when administered intraperitoneally. The present study was designed to investigate the therapeutic effects of SPG101 on dendritic spine density and morphology, and sensorimotor and cognitive functional recovery in a rat model of traumatic brain injury (TBI) induced by controlled cortical impact (CCI). Young adult male Wistar rats with CCI were randomly divided into the following 2 groups (n=7/group): 1) Vehicle, and 2) SPG101...
July 17, 2018: Journal of Neurotrauma
W Brad Hubbard, Margaret Lashof-Sullivan, Shaylen Greenberg, Carly Norris, Joseph Eck, Erin Lavik, Pamela VandeVord
Explosions account for 79% of combat related injuries and often lead to polytrauma, a majority of which include blast-induced traumatic brain injuries (bTBI). These injuries lead to internal bleeding in multiple organs and, in the case of bTBI, long term neurological deficits. Currently, there are no treatments for internal bleeding beyond fluid resuscitation and surgery. There is also a dearth of treatments for TBI. We have developed a novel approach using hemostatic nanoparticles that encapsulate an anti-inflammatory, dexamethasone, to stop the bleeding and reduce inflammation after injury...
July 13, 2018: Scientific Reports
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