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Arterial hypertension

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https://www.readbyqxmd.com/read/29792748/portal-vein-thrombosis-imaging-the-spectrum-of-disease-with-an-emphasis-on-mri-features
#1
Reena C Jha, Satinderpal Singh Khera, Amit Dinesh Kalaria
OBJECTIVE: The purpose of this article is to review the classic and uncommon imaging findings of portal vein thrombosis (PVT) (acute, chronic, congenital, and septic thrombus) as visualized on multiple modalities, with an emphasis on MRI findings. Additional aims are to understand the imaging of obliterative portal venopathy and its clinical significance, appreciate morphologic changes of the biliary system that may accompany PVT, and recognize changes in liver enhancement patterns seen with PVT related to the hepatic arterial buffer response...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792339/pulmonary-hypertension-in-congenital-heart-disease
#2
Emma Pascall, Robert Mr Tulloh
Pulmonary hypertension is defined as a mean pulmonary arterial pressure ≥25 mmHg. We focus on its relevance in congenital heart disease, reviewing pathophysiology, diagnosis and management. Pulmonary hypertension is a relatively common complication of congenital heart disease, with adult prevalence between 5 and 10%. A multifactorial cause is recognized, relating to the size and nature of cardiac defect as well as environmental and genetic factors. More complex disease is increasingly recognized rather than pure Eisenmenger complex...
May 24, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29792302/blood-pressure-patterns-and-subsequent-coronary-artery-calcification-in-women-who-delivered-preterm-births
#3
Janet M Catov, Gabrielle G Snyder, Abigail Fraser, Cora E Lewis, Kiang Liu, Andrew D Althouse, Marnie Bertolet, Erica P Gunderson
Women who delivered preterm infants have excess cardiovascular disease, but vascular pathways linking these conditions are not understood. We considered that higher blood pressure over 25 years among women with preterm delivery may be associated with coronary artery calcification (CAC). The CARDIA study (Coronary Artery Risk Development in Young Adults) enrolled 1049 black and white women with births between 1985 and 2010 (n=272 ever preterm [<37 weeks]; n=777 all term births [≥37 weeks]). Latent mixture modeling identified blood pressure trajectories across 20 years, and these were related to CAC at years 20 and 25...
May 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29791923/inhaled-treprostinil-prodrug-lipid-nanoparticle-formulations-provide-long-acting-pulmonary-vasodilation
#4
Franziska G Leifer, Donna M Konicek, Kuan-Ju Chen, Adam J Plaunt, Dany Salvail, Charles E Laurent, Michel R Corboz, Zhili Li, Richard W Chapman, Walter R Perkins, Vladimir S Malinin
Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary arterial hypertension, requires continuous infusion or multiple dosing sessions per day for inhaled and oral routes of administration due to its short half-life. The inhaled drug is known to induce adverse systemic and local effects including headache, nausea, cough, and throat irritation which may be due at least in part to transiently high drug concentrations in the lungs and plasma immediately following administration [1]...
May 23, 2018: Drug Research
https://www.readbyqxmd.com/read/29791558/giant-pulmonary-artery-aneurysm-in-a-patient-with-schistosomiasis-associated-pulmonary-arterial-hypertension
#5
Francisca Gavilanes, Bruna Piloto, Caio Julio Cesar Fernandes
No abstract text is available yet for this article.
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29791508/does-arterial-hypertension-influence-the-onset-of-huntington-s-disease
#6
Leire Valcárcel-Ocete, Asier Fullaondo, Gorka Alkorta-Aranburu, María García-Barcina, Raymund A C Roos, Lena E Hjermind, Carsten Saft, Marina Frontali, Ralf Reilmann, Hugh Rickards, Ana M Zubiaga, Ana Aguirre
Huntington's disease (HD) age of onset (AO) is mainly determined by the length of the CAG repeat expansion in the huntingtin gene. The remaining AO variability has been attributed to other little-known factors. A factor that has been associated with other neurodegenerative diseases is arterial hypertension (AHT). The aim of this study is to evaluate the contribution of AHT to the AO of HD. We used data from a cohort of 630 European HD patients with adult onset collected by the REGISTRY project of the European Huntington's Disease Network...
2018: PloS One
https://www.readbyqxmd.com/read/29791321/innovative-multi-site-photoplethysmography-measurement-and-analysis-demonstrating-increased-arterial-stiffness-in-paediatric-heart-transplant-recipients
#7
Emma J Sharkey, Costanzo Di Maria, Annette Klinge, Alan Murray, Dingchang Zheng, John O'Sullivan, John Allen
OBJECTIVE: It has been documented that heart transplantation in children is often complicated by arterial hypertension and increased arterial stiffness. AIM: to use innovative multi-site photoplethysmography (MPPG) pulse measurement and analysis technology to assess arterial stiffness change in paediatric heart transplant recipients (HTR) in comparison with healthy control (HC) children. &#13; &#13; Approach: 20 heart transplant (median age 13.5 years old) (8 male) recipients were compared to an overall age- and gender-matched group of 161 healthy controls (11...
May 23, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29791233/association-of-a-chromosome-locus-9p21-3-cdkn2b-as1-variant-rs4977574-with-hypertension-the-tamrisk-study
#8
Tarja Kunnas, Jaakko Piesanen, Seppo T Nikkari
AIMS: Chromosome locus 9p21.3 CDKN2B antisense RNA 1 (CDKN2B-AS1) has been found to contain multiple genetic markers for coronary artery disease (CAD) by genome-wide association studies (GWAS). Of these, the association of variants rs4977574, rs10757274, and rs2383206 with hypertension was studied in the Tampere adult population cardiovascular risk study (TAMRISK). MATERIALS AND METHODS: A Finnish cohort of 336 subjects diagnosed with hypertension and 444 controls was analyzed...
May 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29791175/-dyslipidemia-and-hypertension-what-to-worry-about-more
#9
Jan Václavík
Dyslipidemia is present in every other patient with arterial hypertension. With increasing blood pressure and cholesterol levels, the risk of cardiovascular events increases proportionally. Treatment of dyslipidemia appears to lower cardiovascular mortality to a greater extent than treatment of hypertension. A significant proportion of patients with dyslipidemia indicated for drug therapy are not treated at all or treated insufficiently and do not reach the target values. Concurrent treatment of hypertension and dyslipidemia reduces the incidence of cardiovascular events significantly more than treating only one of these diseases...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790948/cardioprotection-induced-by-activation-of-gper-in-ovariectomized-rats-with-pulmonary-hypertension
#10
Allan K N Alencar, Guilherme C Montes, Daniele G Costa, Luiza V P Mendes, Ananssa M S Silva, Sabrina T Martinez, Margarete M Trachez, Valéria do M N Cunha, Tadeu L Montagnoli, Aline G M Fraga, Hao Wang, Leanne Groban, Carlos A M Fraga, Roberto T Sudo, Gisele Zapata-Sudo
Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4:1), and is associated with cardiac and skeletal muscle dysfunction. Herein, the activation of a new estrogen receptor (GPER) by the agonist G1 was evaluated in oophorectomized rats with monocrotaline (MCT)-induced PH. Depletion of estrogen was induced by bilateral oophorectomy (OVX) in Wistar rats. Experimental groups included SHAM or OVX rats that received a single intraperitoneal injection of MCT (60 mg/kg) for PH induction. Animals received s...
May 21, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29790793/increased-arterial-stiffness-similar-findings-in-patients-with-inflammatory-bowel-disease-without-prior-hypertension-or-diabetes-and-in-patients-with-well-controlled-hypertension
#11
Radovan Prijić, Vedran Premužić, Marko Brinar, Željko Krznarić, Bojan Jelaković, Silvija Čuković-Čavka
PURPOSE: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. MATERIALS AND METHODS: A total of 89 inflammatory bowel disease patients (60 patients with Crohn's disease and 29 patients with ulcerative colitis, age range 20-64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25-69 years, 41 (56...
May 23, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29790458/relation-of-preoperative-and-postoperative-echocardiographic-parameters-with-rejection-and-mortality-in-liver-transplant-patients
#12
Kerem Can Yilmaz, Orcun Ciftci, Arzu Neslihan Akgun, Haldun Muderrisoglu, Sedat Boyacioglu, Asuman Nihan Haberal, Gokhan Moray, Mehmet Haberal
OBJECTIVES: Survival in liver transplant after end-stage liver disease is associated with major cardiac functions. In a significant number of patients with end-stage liver disease, cardiac dysfunctions may be observed, which can include high-output heart failure, cardiac valve disease, and pulmonary venous and arterial hypertension. All of these affect perioperative survival. The aim of our study was to determine whether preoperative and postoperative echocardiographic parameters, specifically right heart-related tricuspid regurgitation, estimated systolic pulmonary arterial pressure, and tricuspid annular plane systolic excursion, are associated with rejection and mortality in liver transplant patients...
May 23, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29789952/carotid-body-ablation-a-new-target-to-address-central-autonomic-dysfunction
#13
REVIEW
Rodrigo Iturriaga
PURPOSE OF REVIEW: An abnormal heightened carotid body (CB) chemoreflex, which produces autonomic dysfunction and sympathetic overactivation, is the common hallmark of obstructive sleep apnea (OSA), resistant hypertension, systolic heart failure (HF), and cardiometabolic diseases. Accordingly, it has been proposed that the elimination of the CB chemosensory input to the brainstem may reduce the autonomic and cardiorespiratory alterations in sympathetic-associated diseases in humans. RECENT FINDINGS: A growing body of evidence obtained in preclinical animal models support that an enhanced CB discharge produces sympathetic hyperactivity, baroreflex sensitivity and heart rate variability impairment, breathing instability, hypertension, and insulin resistance...
May 22, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29789902/association-of-plasma-pentraxin-3-levels-with-coronary-risk-factors-and-the-lipid-profile-a-cross-sectional-study-in-japanese-patients-with-stable-angina-pectoris
#14
Tetsuji Morishita, Hiroyasu Uzui, Akira Nakano, Yoshitomo Fukuoka, Hiroyuki Ikeda, Naoki Amaya, Kenichi Kaseno, Kentaro Ishida, Jong-Dae Lee, Hiroshi Tada
The aim of this study was to evaluate the relationships among the traditional risk factors, lipid profile, and pentraxin-3 in stable angina (SAP). Plasma pentraxin-3 and serum LDL, HDL, and high-sensitivity CRP levels were measured in 163 SAP and 28 non-coronary artery disease (CAD) patients. Their relationships with five risk factors, hypertension (HT), dyslipidemia (DL), diabetes mellitus (DM), obesity (body mass index: BMI > 25 kg/m2 ), and high age (> 75 years), were evaluated. No significant difference was observed in the pentraxin-3 level between patients in SAP and in non-CAD [2...
May 22, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29789684/dipeptidyl-peptidase-iv-dpp-4-inhibition-alleviates-pulmonary-arterial-remodeling-in-experimental-pulmonary-hypertension
#15
Jian Xu, Jingjing Wang, Mengyu He, Honghao Han, Weiping Xie, Hong Wang, Hui Kong
Dipeptidyl peptidase IV (DPP-4) is well known for its role in glucose homeostasis, and DPP-4 inhibitor (DPP-4i) exhibits multiple actions in cardiovascular diseases. However, the effect of DPP-4i on pulmonary hypertension (PH) remains unclear. Therefore, this study aims to investigate the effect of DPP-4i on pulmonary arterial remodeling in rats with PH and the potential underlying mechanisms. Our results show that DPP-4 was expressed in epithelial cells, endothelial cells, smooth muscle cells, and inflammatory cells in lung...
May 22, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29789348/gestational-low-protein-intake-enhances-whole-kidney-mir-192-and-mir-200-family-expression-and-epithelial-to-mesenchymal-transition-in-rat-adult-male-offspring
#16
Letícia B Sene, Victor Hugo Gonçalves Rizzi, José A R Gontijo, Patricia A Boer
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal transition (EMT) as a common factor...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29789210/should-first-blood-pressure-measurement-be-performed-in-the-newborn
#17
Inês Alves, Tânia Martins, Ana Luísa Neves, Esmeralda Rodrigues, Ana Teixeira, Caldas Afonso, Helena Pinto
Dilated cardiomyopathy is the most common form of cardiomyopathy and the main cause of cardiac transplantation in children and in adults. Infants and children have a wider spectrum of etiologies, hampering their identification. The most frequent initial manifestation of dilated cardiomyopathy is symptomatic heart failure during exercise or at rest (although many patients are asymptomatic). Some causes are potentially reversible, therefore the investigation should be carefully planned and immediately performed after diagnosis...
May 19, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29789083/low-baseline-sympathetic-tone-correlates-to-a-greater-blood-pressure-change-in-the-cold-pressor-test
#18
Marylen Youssef, Azadeh Ghassemi, Catalina Marysol Carvajal Gonczi, Thiffya Arabi Kugathasan, Robert D Kilgour, Peter J Darlington
BACKGROUND: The cold pressor test (CPT) involves acute hand or foot exposure to cold water. CPT hyper-responders have unique traits, including risk of hypertension and a greater vasoconstrictor reserve and g force tolerance compared to hypo-responders. The purpose of this study was to uncover differences in cardiovascular and sympathetic biomarkers between responder types. METHODS: Healthy volunteers (N = 30) submerged one hand into cold water (3.3 ± 0.8°C) for 5 min...
June 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29788800/relationship-between-ykl-40-and-pulmonary-arterial-hypertension-in-systemic-sclerosis
#19
Tetsuya Furukawa, Kiyoshi Matsui, Masayasu Kitano, Yuichi Yokoyama, Masahiro Sekiguchi, Naoto Azuma, Yasutomo Imai, Seiichi Hirota, Kiyofumi Yamanishi, Hajime Sano
OBJECTIVES: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 blood levels in identifying patients with SSc complicated by PAH, as confirmed by immunohistochemistry (IHC) examination. METHODS: We retrospectively analyzed 78 patients with SSc and performed IHC on 7 normal and 7 SSc skin samples in the Japanese population...
May 23, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29788246/hypertension-induced-morphological-and-physiological-changes-in-cells-of-the-arterial-wall
#20
P A Martinez-Quinones, C G McCarthy, S W Watts, N Klee, A Komic, F Calmasini, F Priviero, A Warner, Y Chenghao, C F Wenceslau
Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue, have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, perivascular adipose tissue, and the cell types harbored within each vessel layer...
May 17, 2018: American Journal of Hypertension
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