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Copeptin

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https://www.readbyqxmd.com/read/29037840/comparison-of-plasma-copeptin-and-multiple-biomarkers-for-assessing-prognosis-of-patients-with-aneurysmal-subarachnoid-hemorrhage
#1
Yong-Ke Zheng, Xiao-Qiao Dong, Quan Du, Hao Wang, Ding-Bo Yang, Qiang Zhu, Zhi-Hao Che, Yong-Feng Shen, Li Jiang, Wei Hu, Ke-Yi Wang, Wen-Hua Yu
BACKGROUND: Increased plasma copeptin concentrations are related to poor prognosis after aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to assess prognostic significance of plasma copeptin detection compared with glial fibrillary astrocyte protein, myelin basic protein, S100B, phosphorylated axonal neurofilament subunit H, neuron-specific enolase, tau and ubiquitin carboxyl-terminal hydrolase L1 in aSAH. METHODS: We detected plasma concentrations of the aforementioned biomarkers in 105 healthy controls using ELISA...
October 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29020337/refining-the-prognostic-impact-of-functional-mitral-regurgitation-in-chronic-heart-failure
#2
Georg Goliasch, Philipp E Bartko, Noemi Pavo, Stephanie Neuhold, Raphael Wurm, Julia Mascherbauer, Irene M Lang, Guido Strunk, Martin Hülsmann
Aims: Significant efforts are currently undertaken to reduce functional mitral regurgitation (FMR) in patients with chronic heart failure in the hope to improve prognosis. We aimed to assess the prognostic impact of FMR in heart failure with reduced ejection fraction (HFrEF) under optimal medical therapy (OMT) and various conditions of HFrEF. We further intended to identify a heart failure phenotype, where FMR is most likely a driving force and not a mere bystander of the disease. Methods and results: We prospectively included 576 consecutive HFrEF patients into our long-term observational study...
July 25, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28982590/copeptin-in-heart-failure-review-and-meta-analysis
#3
REVIEW
Yao Zhong, Rui Wang, Lulu Yan, Man Lin, Xingling Liu, Tianhui You
BACKGROUND: The aim of this study was to explore the prognostic value of copeptin for predicting all-cause mortality in heart failure (HF). METHODS: PubMed, Embase and Cochrane databases were systematically searched to identify if a 2×2 contingency table could be constructed based on both the copeptin level and the all-cause mortality in patients diagnosed with HF. The characteristics of test performance were summarized using forest plots and summary receiver operating characteristic curves (SROC)...
October 2, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28980069/evaluation-of-the-value-of-plasma-concentration-of-copeptin-in-the-first-prenatal-visit-to-diagnose-gestational-diabetes-mellitus
#4
He-Hong Ma, Shuang-Yan Yang, Pei Wang, Jun-Feng Zhang
AIMS: Gestational diabetes mellitus (GDM) is increasing worldwide. The aim of this study was to investigate whether copeptin concentrations, measured at the first prenatal visit, are associated with risk of GDM. METHODS: From July 2015 to June 2016, consecutive women who admitted to the obstetrics center of our hospital were included. Data for fasting plasma glucose and copeptin concentrations at the first prenatal visit and one-step GDM screening with 75-g oral glucose tolerance test performed between 24 and 28 weeks of gestation were collected and analyzed...
October 4, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28967192/the-polyuria-polydipsia-syndrome-a-diagnostic-challenge
#5
REVIEW
Nicole Nigro, Mathis Grossmann, Cherie Chiang, Warrick J Inder
The main determinants for the maintenance of water homeostasis are the hormone arginine-vasopressin (AVP) and thirst. Disturbances in these regulatory mechanisms can lead to the polyuria-polydipsia syndrome, which comprises of three different conditions: central diabetes insipidus (DI) due to insufficient secretion of AVP, nephrogenic DI caused by renal insensitivity to AVP action, and primary polydipsia due to excessive fluid intake and consequent physiologic suppression of AVP. It is crucial to determine the exact diagnosis because treatment strategies vary substantially...
October 2, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28962698/combination-of-copeptin-placental-growth-factor-and-total-annexin-v-microparticles-for-prediction-of-preeclampsia-at-10-14-weeks-of-gestation
#6
Anshul Jadli, Kanjaksha Ghosh, Purnima Satoskar, Kaizad Damania, Vandana Bansal, Shrimati Shetty
INTRODUCTION: Preeclampsia (PE) remains to be an enigmatic puzzle for clinicians and researchers perplexing them for decades. As delivery remains only choice of treatment, early prediction of PE will offer timely therapeutic invention and hence extensive research efforts have been put in identification of biomarkers which will facilitate early prediction of PE. METHODS: Serum levels of CPP, PlGF and plasma total annexin V MPs were assessed in women who subsequently developed PE (n = 33), IUGR (n = 81) and normal pregnancy outcome (n = 112) at 10-14 weeks of gestation...
October 2017: Placenta
https://www.readbyqxmd.com/read/28960777/prognostic-importance-of-emerging-cardiac-inflammatory-and-renal-biomarkers-in-chronic-heart-failure-patients-with-reduced-ejection-fraction-and-anaemia-red-hf-study
#7
Paul Welsh, Lei Kou, Changhong Yu, Inder Anand, Dirk J van Veldhuisen, Aldo P Maggioni, Akshay S Desai, Scott D Solomon, Marc A Pfeffer, Sunfa Cheng, Lars Gullestad, Pål Aukrust, Thor Ueland, Karl Swedberg, James B Young, Michael W Kattan, Naveed Sattar, John J V McMurray
AIMS: To test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED-HF) trial. METHODS AND RESULTS: Circulating cardiac [N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin T (hsTnT)], neurohumoral [mid-regional pro-adrenomedullin (MR-proADM) and copeptin], renal (cystatin C), and inflammatory [high-sensitivity C-reactive protein (hsCRP)] biomarkers were measured at randomization in 1853 participants with complete data...
September 27, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28931055/serum-copeptin-and-neuron-specific-enolase-are-markers-of-neonatal-distress-and-long-term-neurodevelopmental-outcome
#8
RANDOMIZED CONTROLLED TRIAL
Dorottya Kelen, Csilla Andorka, Miklós Szabó, Aleksander Alafuzoff, Kai Kaila, Milla Summanen
The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours after birth are predictive of long-term neurodevelopmental outcome. Copeptin and NSE levels were measured from serum samples collected 6, 12, 24, 48, 72, and 168 hours after birth from 75 term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia for 72 hours...
2017: PloS One
https://www.readbyqxmd.com/read/28924378/vasopressin-mediates-the-renal-damage-induced-by-limited-fructose-rehydration-in-recurrently-dehydrated-rats
#9
Fernando E García-Arroyo, Edilia Tapia, Mónica G Blas-Marron, Guillermo Gonzaga, Octaviano Silverio, Magdalena Cristóbal, Horacio Osorio, Abraham S Arellano-Buendía, Cecilia Zazueta, Omar Emiliano Aparicio-Trejo, Juan G Reyes-García, José Pedraza-Chaverri, Virgilia Soto, Carlos Roncal-Jiménez, Richard J Johnson, Laura G Sánchez-Lozada
Recurrent dehydration and heat stress cause chronic kidney damage in experimental animals. The injury is exacerbated by rehydration with fructose-containing beverages. Fructose may amplify dehydration-induced injury by directly stimulating vasopressin release and also by acting as a substrate for the aldose reductase-fructokinase pathway, as both of these systems are active during dehydration. The role of vasopressin in heat stress associated injury has not to date been explored. Here we show that the amplification of renal damage mediated by fructose in thermal dehydration is mediated by vasopressin...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28894549/predictive-value-of-copeptin-as-a-severity-marker-of-community-acquired-pneumonia
#10
Gamal Baheeg Mohamed, Madeha Abdellah Saed, Abdelhakeem Abdelmohsen Abdelhakeem, Kalid Salah, Abdelrahman Mamdouh Saed
BACKGROUND: Pneumonia is the leading cause of death in children. Few studies have explored the predictive value of copeptin in pediatric pneumonia. AIM: This study aimed to assess the role of copeptin as a marker of severity of community-acquired pneumonia (CAP). METHODS: This prospective case-control study was carried out at Minia University Children's Hospital in Minia (Egypt) from January to December 2016. Eighty children aged from 2 months to 42 months were enrolled in this study and were classified into group 1 (40 children with clinical, laboratory and radiological evidence of pneumonia) and group 2 (40 apparently healthy control)...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28863033/increased-blood-pressure-and-aortic-stiffness-among-abusers-of-anabolic-androgenic-steroids-potential-effect-of-suppressed-natriuretic-peptides-in-plasma
#11
Jon J Rasmussen, Morten Schou, Per L Madsen, Christian Selmer, Marie L Johansen, Peter Hovind, Peter S Ulriksen, Jens Faber, Finn Gustafsson, Caroline Kistorp
BACKGROUND: Abuse of anabolic androgenic steroids (AAS) is prevalent among recreational athletes and adverse effects on blood pressure (BP) and arterial stiffness could be substantial. Testosterone decreases natriuretic peptides which are key components in BP-regulation and may impair BP-homeostasis in AAS abusers. OBJECTIVE: To investigate BP and aortic stiffness in relation to natriuretic peptides among current AAS abusers, former AAS abusers and controls. METHODS: In this cross-sectional study, 37 current AAS abusers, 33 former AAS abusers and 30 controls were included...
August 31, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28856009/the-chronic-kidney-disease-water-intake-trial-protocol-of-a-randomized-controlled-trial
#12
William F Clark, Shih-Han Huang, Amit X Garg, Kerri Gallo, Andrew A House, Louise Moist, Matthew A Weir, Jessica M Sontrop
BACKGROUND: In observational studies, drinking more water associates with a slower rate of kidney function decline; whether the same is true in a randomized controlled trial is unknown. OBJECTIVE: To examine the 1-year effect of a higher vs usual water intake on estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease. DESIGN: Parallel-group randomized controlled trial. SETTING: Nine centers in Ontario, Canada...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28845746/diagnostic-and-prognostic-role-of-resistin-and-copeptin-in-acute-ischemic-stroke
#13
Edi Perovic, Anamarija Mrdjen, Mladen Harapin, Andrea Tesija Kuna, Ana-Maria Simundic
OBJECTIVES: Our aim was to evaluate (i) whether there is a difference in the concentration of resistin and copeptin between acute ischemic stroke patients and stroke-free controls; and (ii) if there is any prognostic value of resistin and copeptin in predicting stroke infarct volume, stroke severity, and outcome. METHODS: Our case-control study has recruited 112 acute ischemic stroke patients admitted within 24 h after the stroke onset. We have also included 63 age and gender matched stroke-free controls...
August 28, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/28834962/artificial-syndrome-of-inappropriate-antidiuresis-model-as-potential-use-for-diagnostic-and-therapeutic-strategies
#14
Julie Refardt, Bettina Winzeler, Fabian Meienberg, Mirjam Christ-Crain
Hyponatremia is the most frequent electrolyte disorder with the syndrome of inappropriate antidiuresis (SIADH) being its predominant cause. Physiological studies in patients with SIADH are difficult to interpret due to usually several comorbidities and polymedication. Therefore, a SIADH model in healthy volunteers would be very helpful to allow insight in this complex disease and to test new therapeutic approaches. The aim of the study was to create a SIADH model with evaluation of subsequent physiological changes...
September 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28814234/biomarkers-of-cardiovascular-risk-in-haemodialysis-patients
#15
Beata Franczyk, Anna Gluba-Brzózka, Jacek Rysz
BACKGROUND: All stages of chronic kidney disease (CKD) are associated with increased risks of atherosclerosis and cardiovascular morbidity and mortality. According to studies, levels of copeptin, growth differentiation factor-15 (GDF-15) and heart fatty-acid binding protein (h-FABP) are increased in dialysis patients. MATERIALS: This study included 50 patients (19 women, 31 men) chronically undergoing haemodialysis. The concentration of markers: copeptin, GDF-15, h-FABP, troponin and serum creatine kinase MB (CKMB) were measured with the use of ELISA tests...
August 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28811392/role-of-sympathetic-cotransmitter-galanin-on-autonomic-balance-in-heart-failure-an-active-player-or-a-bystander
#16
Demet Özkaramanlı Gür, Miray Sağbaş, Aydın Akyüz, Savaş Güzel, Şeref Alpsoy, Niyazi Güler
OBJECTIVE: Galanin, a cotransmitter similar to neuropeptide Y (NPY), aggravates autonomic imbalance in systolic heart failure (HF) by attenuating vagal tonus after burst sympathetic activity. In animal HF models, galanin antagonists have improved cardiac function. To determine whether galanin is a promising therapeutic target in HF, we studied its concentrations in HF patients and evaluated its correlation with NPY, markers of humoral activity such as pro-BNP and copeptin, and echocardiographic parameters of HF severity...
August 11, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28795329/copeptin-as-a-marker-of-an-altered-crh-axis-in-pituitary-disease
#17
Krzysztof C Lewandowski, Andrzej Lewiński, Elżbieta Skowrońska-Jóźwiak, Katarzyna Malicka, Wojciech Horzelski, Georg Brabant
BACKGROUND: Copeptin (pre-proAVP) secreted in equimolar amounts with vasopressin closely reflects vasopressin release. Copeptin has been shown to subtly mirror stress potentially mediated via corticotrophin-releasing hormone. To further test a potential direct interaction of corticotrophin-releasing hormone with copeptin release, which could augment vasopressin effects on pituitary function, we investigated copeptin response to corticotrophin-releasing hormone. PATIENTS AND METHODS: Cortisol, adrenocorticotropin and copeptin were measured in 18 healthy controls and 29 subjects with a history of pituitary disease during standard corticotrophin-releasing hormone test...
August 9, 2017: Endocrine
https://www.readbyqxmd.com/read/28783935/the-relationship-between-ghrelin-and-copeptin-levels-and-anxiety-and-depression-levels-in-suicide-attempts
#18
Metin Atescelik, Mustafa Yilmaz, Sevda Korkmaz, Mehmet Cagri Goktekin, Mehtap Gurger, Nevin Ilhan
Objective: It was aimed to detect acylated ghrelin (AG), unacylated ghrelin (UG) and copeptin levels in patients with suicide attempts and to determine if these biomarkers are risk factors for suicide attempts. Methods: Serum copeptin, AG and GU levels were screened in 128 patients who were admitted to emergency department with suicide attempts and 59 healthy controls. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) were applied simultaneously, and the data were compared statistically...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28765984/-acute-chest-pain
#19
REVIEW
M Möckel, T Störk
Patients presenting with acute chest pain are a challenge for attending physicians in private practice and specialists for emergency and acute medicine in hospitals because a wide spectrum of diagnoses may be the cause, ranging from acute myocardial infarction (AMI) to harmless muscular tension. The evaluation of patients with acute chest pain follows basic principles independent of the setting: A thorough clinical investigation by the responsible physician including medical history and physical examination, followed by a 12-channel electrocardiogram (ECG) and further focused diagnostics...
August 1, 2017: Der Internist
https://www.readbyqxmd.com/read/28716309/arginine-vasopressin-copeptin-and-the-development-of-relative-avp-deficiency-in-hemorrhagic-shock
#20
Carrie A Sims, Yuxia Guan, Meredith Bergey, Rebecca Jaffe, Lilias Holmes-Maguire, Niels Martin, Patrick Reilly
BACKGROUND: Arginine vasopressin (AVP) is critical for maintaining vasomotor tone and low levels have been associated with the development of irreversible shock. We investigated the clinical relationship between AVP, copeptin (the C-terminal fragment of the AVP precursor), and the development of relative AVP deficiency following hemorrhagic shock. METHODS: A prospective, observational study of 21 hypotensive (SBP<90 mmHg X 2) or presumptively bleeding trauma patients was conducted...
October 2017: American Journal of Surgery
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