keyword
MENU ▼
Read by QxMD icon Read
search

Copeptin

keyword
https://www.readbyqxmd.com/read/29665969/copeptin-plasma-levels-are-associated-with-decline-of-renal-function-in-patients-with-type-2-diabetes-mellitus
#1
Maria De La Luz Villela-Torres, Ana Edith Higareda-Mendoza, Anel Gómez-García, Alfonso Rafael Alvarez-Paredes, Elvia García-López, Peter Stenvikel, Harvest F Gu, Abbul Rashid-Qureshi, Bengt Lindholm, Cleto Alvarez-Aguilar
BACKGROUND: Chronic kidney disease (CKD) is a leading complication of type 2 diabetes mellitus (T2DM) and is considered as a public health problem. Copeptin is a surrogate marker of arginine vasopressin (AVP) system and is proposed as a biomarker of decline renal function. OBJECTIVE: Evaluate whether plasma copeptin levels may be used as a biomarker of decline renal function in patients with T2DM. RESEARCH DESIGN AND METHODS: A total of 480 patients with T2DM and different stages of CKD were included...
April 14, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29664160/hyponatremia-and-activation-of-vasopressin-secretion-are-both-independently-associated-with-30-day-mortality-results-of-a-multicenter-observational-study
#2
Andreas Eckart, Pierre Hausfater, Devendra Amin, Adina Amin, Sebastian Haubitz, Maguy Bernard, Annic Baumgartner, Tristan Struja, Alexander Kutz, Mirjam Christ-Crain, Andreas Huber, Beat Mueller, Philipp Schuetz
BACKGROUND: Hyponatremia is a common feature of acute illness and associated with increased mortality. This may be explained by a stress-mediated activation of the vasopressin system with an increase in free-water reabsorption. OBJECTIVES: To investigate whether the association of hyponatremia and mortality could be explained by activation of the vasopressin system. METHODS: We prospectively enrolled adult, medical patients seeking emergency care in three centers in Switzerland, France and the USA...
April 17, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29620422/the-increase-in-copeptin-levels-in-mild-head-trauma-does-not-predict-the-severity-and-the-outcome-of-brain-damage
#3
Luigi M Casello, Livia Salmi, Isabella Zanotti, Clara A Gardino, Marco Baldrighi, Fabio Settanni, Gian C Avanzi
AIM: To investigate the copeptin prognostic role in mild head trauma. METHODS: We enrolled 105 adult patients who entered the emergency room because of recent mild head trauma; we evaluated: clinical picture, imaging and laboratory data (including copeptin). RESULTS: Copeptin resulted higher in mild head trauma patients compared with controls: 29.89 pmol/l versus 7.05 pmol/l; (p = 0.0008). Copeptin failed in identifying patients with or without brain lesions detected by CT scan, and patients with or without adverse events during the 30 days follow-up...
April 5, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29619130/copeptin-as-a-prognostic-marker-in-acute-chest-pain-and-suspected-acute-coronary-syndrome
#4
Beata Morawiec, Damian Kawecki, Brygida Przywara-Chowaniec, Mariusz Opara, Piotr Muzyk, Lam Ho, Lui Chun Tat, Artur Gabrysiak, Olivier Muller, Ewa Nowalany-Kozielska
Background: In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG. Methods: Consecutive patients suspected for an ACS were enrolled prospectively. Copeptin and high-sensitive troponin T (hs-TnT) were measured at admission...
2018: Disease Markers
https://www.readbyqxmd.com/read/29599188/prognostic-impact-of-copeptin-in-pulmonary-embolism-a-multicentre-validation-study
#5
Kristian Hellenkamp, Piotr Pruszczyk, David Jiménez, Anna Wyzgał, Deisy Barrios, Michał Ciurzyński, Raquel Morillo, Lukas Hobohm, Karsten Keller, Katarzyna Kurnicka, Maciej Kostrubiec, Rolf Wachter, Gerd Hasenfuß, Stavros Konstantinides, Mareike Lankeit
To externally validate the prognostic impact of copeptin, either alone or integrated in risk stratification models, in pulmonary embolism (PE), we performed a post-hoc analysis of 843 normotensive PE patients prospectively included in three European cohorts.Within the first 30 days, 21 (2.5;95%CI,1.5-3.8%) patients had an adverse outcome and 12 (1.4;95%CI,0.7-2.5%) died due to PE. Patients with copeptin ≥24 pmol·L-1 had a 6.3-fold increased risk for an adverse outcome (95%CI,2.6-15.5;p<0.001) and a 7...
March 29, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29572679/copeptin-blood-content-as-a-diagnostic-marker-of-chronic-kidney-disease
#6
Stanisław Niemczyk, Longin Niemczyk, Wawrzyniec Żmudzki, Marek Saracyn, Katarzyna Czarzasta, Katarzyna Szamotulska, Agnieszka Cudnoch-Jędrzejewska
Plasma content of copeptin increases with the advancement of chronic kidney disease (CKD). The purpose of this study was to evaluate copeptin content as a potential marker of CKD, as a single pathology or with coexisting heart failure. Seventy-six patients were divided into the following groups: Group 1 (control), without CKD and heart failure; Group 2, CKD stage 3a; Group 3, CKD stage 3b; Group 4, CKD stage 4; Group 5, CKD stage 5; and Group 6, CKD stage 3b and heart failure. For all patients, plasma concentrations of copeptin, creatinine, urea, cystatin C, sodium, C-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and blood pH were assessed...
March 24, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29527508/is-serum-copeptin-a-modifiable-biomarker-in-autosomal-dominant-polycystic-kidney-disease
#7
REVIEW
Moomal Tasneem, Carly Mannix, Annette Wong, Jennifer Zhang, Gopala Rangan
The availability of disease-modifying drugs for the management of autosomal dominant polycystic kidney disease (ADPKD) has accelerated the need to accurately predict renal prognosis and/or treatment response in this condition. Arginine vasopressin (AVP) is a critical determinant of postnatal kidney cyst growth in ADPKD. Copeptin (the C-terminal glycoprotein of the precursor AVP peptide) is an accurate surrogate marker of AVP release that is stable and easily measured by immunoassay. Cohort studies show that serum copeptin is correlated with disease severity in ADPKD, and predicts future renal events [decline in renal function and increase in total kidney volume (TKV)]...
March 6, 2018: World Journal of Nephrology
https://www.readbyqxmd.com/read/29497972/copeptin-in-hyponatremia-is-there-a-role-for-this-biomarker-in-the-diagnostic-workup
#8
Marco Baldrighi, Luigi Mario Castello, Ettore Bartoli
No abstract text is available yet for this article.
March 1, 2018: Endocrine
https://www.readbyqxmd.com/read/29476612/prognostic-performance-of-serial-in-hospital-measurements-of-copeptin-and-multiple-novel-biomarkers-among-patients-with-worsening-heart-failure-results-from-the-molitor-study
#9
Hans-Dirk Düngen, Verena Tscholl, Danilo Obradovic, Sara Radenovic, Dragan Matic, Lindy Musial Bright, Elvis Tahirovic, Almuth Marx, Simone Inkrot, Djawid Hashemi, Jovan Veskovic, Svetlana Apostolovic, Stephan von Haehling, Wolfram Doehner, Natasa Cvetinovic, Mitja Lainscak, Burkert Pieske, Frank Edelmann, Tobias Trippel, Goran Loncar
AIMS: In heart failure, various biomarkers are established for diagnosis and risk stratification; however, little is known about the relevance of serial measurements during an episode worsening heart failure (WHF). This study sought to investigate the trajectory of natriuretic peptides and multiple novel biomarkers during hospitalization for WHF and to determine the best time point to predict outcome. METHODS AND RESULTS: MOLITOR (Impact of Therapy Optimisation on the Level of Biomarkers in Patients with Acute and Decompensated Chronic Heart Failure) was an eight-centre prospective study of 164 patients hospitalized with a primary diagnosis of WHF...
February 24, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29471407/plasma-copeptin-as-a-predictor-of-kidney-disease
#10
Sofia Enhörning, Anders Christensson, Olle Melander
Background: Plasma copeptin, a marker of vasopressin, is associated with renal function decline in the general population. Our aim was to study the links between elevated copeptin and future risk of kidney disease. Methods: Copeptin was measured in a sample of the Malmö Preventive Project (MPP) Reinvestigation (n = 5158) and in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC) (n = 5162). According to national registers, 89 subjects in MPP and 180 in MDC-CC developed chronic kidney disease (CKD) during follow-up (8...
February 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29466220/-head-to-head-comparison-of-suppression-of-tumorogenicity-2-and-copeptin-significance-for-prognosis-of-patients-after-acute-heart-failure-decompensation
#11
O Y Narusov, D E Koshkina, V N Protasov, A A Skvortsov, V P Masenko, S N Tereshchenko, Y F Osmolovskaya, T V Kuznetsova
PURPOSE: To assess the suppression of tumorogenicity 2 (ST2) and copeptin significance for risk stratification of patient (pts) with acute decompensated heart failure (ADHF) during long-term follow-up compared with traditional risk factors. METHODS: We included in a prospective study 159 pts with ADHF. Blood samples to determine copeptin, sST2, NT-proBNP and hsTnT concentration were collected at admission and at discharge from the hospital. Serial determination of biomarker concentration was performed at 3, 6 and 12 months of follow-up...
September 2017: Kardiologiia
https://www.readbyqxmd.com/read/29464737/copeptin-role-in-polyuria-polydipsia-syndrome-differential-diagnosis-and-reference-range-in-paediatric-age
#12
Gerdi Tuli, Daniele Tessaris, Silvia Einaudi, Patrizia Matarazzo, Luisa De Sanctis
OBJECTIVE: Plasma arginine-vasopressin (AVP) analysis can help in the differential diagnosis of the polyuria-polydipsia syndrome (PPS), even if such investigation is hampered by technical difficulties, conversely to its surrogate copeptin. This study aims to enlarge the existing data on normal copeptin levels in childhood, to evaluate the correlation between copeptin, serum sodium and plasma and urine osmolality, and to assess the utility of the copeptin analysis in the diagnostic work-up of PPS in the paediatric age...
February 21, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29426039/prohormones-in-the-early-diagnosis-of-cardiac-syncope
#13
Patrick Badertscher, Thomas Nestelberger, Jeanne du Fay de Lavallaz, Martin Than, Beata Morawiec, Damian Kawecki, Òscar Miró, Beatriz López, F Javier Martin-Sanchez, José Bustamante, Nicolas Geigy, Michael Christ, Salvatore Di Somma, W Frank Peacock, Louise Cullen, François Sarasin, Dayana Flores, Michael Tschuck, Jasper Boeddinghaus, Raphael Twerenbold, Karin Wildi, Zaid Sabti, Christian Puelacher, Maria Rubini Giménez, Nikola Kozhuharov, Samyut Shrestha, Ivo Strebel, Katharina Rentsch, Dagmar I Keller, Imke Poepping, Andreas Buser, Wanda Kloos, Jens Lohrmann, Michael Kuehne, Stefan Osswald, Tobias Reichlin, Christian Mueller
BACKGROUND: The early detection of cardiac syncope is challenging. We aimed to evaluate the diagnostic value of 4 novel prohormones, quantifying different neurohumoral pathways, possibly involved in the pathophysiological features of cardiac syncope: midregional-pro-A-type natriuretic peptide (MRproANP), C-terminal proendothelin 1, copeptin, and midregional-proadrenomedullin. METHODS AND RESULTS: We prospectively enrolled unselected patients presenting with syncope to the emergency department (ED) in a diagnostic multicenter study...
December 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29422070/copeptin-levels-and-commonly-used-laboratory-parameters-in-hospitalised-patients-with-severe-hypernatraemia-the-co-med-study
#14
Nicole Nigro, Bettina Winzeler, Isabelle Suter-Widmer, Philipp Schuetz, Birsen Arici, Martina Bally, Julie Refardt, Matthias Betz, Gani Gashi, Sandrine A Urwyler, Lukas Burget, Claudine A Blum, Andreas Bock, Andreas Huber, Beat Müller, Mirjam Christ-Crain
BACKGROUND: Hypernatraemia is common in inpatients and is associated with substantial morbidity. Its differential diagnosis is challenging, and delayed treatment may have devastating consequences. The most important hormone for the regulation of water homeostasis is arginine vasopressin, and copeptin, the C-terminal portion of the precursor peptide of arginine vasopressin, might be a reliable new parameter with which to assess the underlying cause of hypernatraemia. METHODS: In this prospective, multicentre, observational study conducted in two tertiary referral centres in Switzerland, 92 patients with severe hyperosmolar hypernatraemia (Na+  > 155 mmol/L) were included...
February 9, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29421020/effects-of-hyperoxia-on-myocardial-injury-following-cardioversion-a-randomized-clinical-trial
#15
Kasper Glerup Lauridsen, Anders Sjørslev Schmidt, Kasper Adelborg, Leif Bach, Nete Hornung, Simon Munkesø Jepsen, Charles D Deakin, Hans Rickers, Bo Løfgren
Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. METHODS: Patients undergoing elective biphasic cardioversion for atrial fibrillation or atrial flutter were randomized to receive room air or oxygen (10-15 L/min) during the procedure...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29403357/surge-of-peripheral-arginine-vasopressin-in-a-rat-model-of-birth-asphyxia
#16
Milla Summanen, Susanne Bäck, Juha Voipio, Kai Kaila
Mammalian birth is accompanied by a period of obligatory asphyxia, which consists of hypoxia (drop in blood O2 levels) and hypercapnia (elevation of blood CO2 levels). Prolonged, complicated birth can extend the asphyxic period, leading to a pathophysiological situation, and in humans, to the diagnosis of clinical birth asphyxia, the main cause of hypoxic-ischemic encephalopathy (HIE). The neuroendocrine component of birth asphyxia, in particular the increase in circulating levels of arginine vasopressin (AVP), has been extensively studied in humans...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29371289/elevated-vasopressin-in-pregnant-mice-induces-t-helper-subset-alterations-consistent-with-human-preeclampsia
#17
Sabrina M Scroggins, Donna A Santillan, Jenna M Lund, Jeremy A Sandgren, Lindsay K Krotz, Wendy S Hamilton, Eric J Devor, Heather A Davis, Gary L Pierce, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe, Mark K Santillan
The pathogenesis of preeclampsia (PreE), a hypertensive disorder of pregnancy, involves imbalanced T helper (TH ) cell populations and resultant changes in pro- and anti-inflammatory cytokine release. Elevated copeptin (an inert biomarker of arginine vasopressin (AVP)), secretion precedes the development of symptoms in PreE in humans, and infusion of AVP proximal to and throughout gestation is sufficient to initiate cardiovascular and renal phenotypes of PreE in wild-type C57BL/6J mice. We hypothesize that AVP infusion in wild-type mice is sufficient to induce the immune changes observed in human PreE...
February 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29364700/angiotensin-at-1a-receptors-expressed-in-vasopressin-producing-cells-of-the-supraoptic-nucleus-contribute-to-the-osmotic-control-of-vasopressin
#18
Jeremy A Sandgren, Danny W Linggonegoro, Shao Yang Zhang, Sarah A Sapouckey, Kristin E Claflin, Nicole A Pearson, Mariah R Leidinger, Gary L Pierce, Mark K Santillan, Katherine N Gibson-Corley, Curt D Sigmund, Justin L Grobe
Angiotensin II (ANG) stimulates the release of arginine vasopressin (AVP) from the neurohypophysis through activation of AT1 receptors within the brain, though it remains unclear whether AT1 receptors expressed on AVP-expressing neurons directly mediate this control. We explored the hypothesis that ANG acts through AT1A receptors expressed directly upon AVP-producing cells to regulate AVP secretion. In-situ hybridization and transgenic mice demonstrated localization of AVP and AT1A mRNA in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN), but co-expression of both AVP and AT1A mRNA was only observed in the SON...
January 24, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29359279/hypothalamic-pituitary-adrenocortical-axis-activity-in-alcohol-dependent-patients-during-treatment-with-high-dose-baclofen
#19
Olga Geisel, Ludwig Schlemm, Rainer Hellweg, Klaus Wiedemann, Christian A Müller
AIMS: Activity of the hypothalamic-pituitary-adrenocortical (HPA) axis has been reported to be affected in alcohol use disorder (AUD). It has been suggested that pharmacological relapse prevention in AUD might exert its effects partly by modulation of HPA axis activity. Here, we assessed the effects of high-dose treatment with baclofen on HPA axis activity in alcohol-dependent patients within a 24-week randomized, placebo-controlled trial (BACLAD study). METHODS: Plasma levels of copeptin, adrenocorticotropic hormone (ACTH), and cortisol were measured at 3 timepoints in alcohol-dependent patients during the study...
January 22, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29350536/diagnostic-accuracy-of-functional-imaging-and-biochemical-tests-for-patients-presenting-with-chest-pain-to-the-emergency-department-a-systematic-review-and-meta-analysis
#20
Mario Iannaccone, Sebastiano Gili, Ovidio De Filippo, Salvatore D'Amico, Marco Gagliardi, Maurizio Bertaina, Silvia Mazzilli, Sara Rettegno, Federica Bongiovanni, Paolo Gatti, Fabrizio Ugo, Giacomo G Boccuzzi, Salvatore Colangelo, Silvia Prato, Claudio Moretti, Maurizio D'Amico, Patrizia Noussan, Roberto Garbo, David Hildick-Smith, Fiorenzo Gaita, Fabrizio D'Ascenzo
BACKGROUND: Non-invasive ischaemia tests and biomarkers are widely adopted to rule out acute coronary syndrome in the emergency department. Their diagnostic accuracy has yet to be precisely defined. METHODS: Medline, Cochrane Library CENTRAL, EMBASE and Biomed Central were systematically screened (start date 1 September 2016, end date 1 December 2016). Prospective studies (observational or randomised controlled trial) comparing functional/imaging or biochemical tests for patients presenting with chest pain to the emergency department were included...
January 1, 2018: European Heart Journal. Acute Cardiovascular Care
keyword
keyword
16212
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"