keyword
https://read.qxmd.com/read/35403483/daylength-shapes-entrainment-patterns-to-artificial-photoperiods-in-a-subterranean-rodent
#21
JOURNAL ARTICLE
Giovane Carreira Improta, Danilo Eugênio França Laurindo Flôres, Gisele Akemi Oda, Verónica Sandra Valentinuzzi
Photoperiodism plays an important role in the synchronization of seasonal phenomena in various organisms. In mammals, photoperiod encoding is mediated by differential entrainment of the circadian system. The limits of daily light entrainment and photoperiodic time measurement can be verified in organisms that inhabit extreme photic environments, such as the subterranean. In this experimental study, we evaluated entrainment of circadian wheel-running rhythms in South American subterranean rodents, the Anillaco tuco-tucos ( Ctenomys aff...
June 2022: Journal of Biological Rhythms
https://read.qxmd.com/read/35360141/understanding-sleep-wake-behavior-in-late-chronotype-adolescents-the-role-of-circadian-phase-sleep-timing-and-sleep-propensity
#22
JOURNAL ARTICLE
Christin Lang, Cele Richardson, Gorica Micic, Michael Gradisar
Background: Adolescents with a late chronotype are at greater risk for mood disorders, risk-taking behaviors, school absenteeism, and lower academic achievement. As there are multiple causes for late chronotype, the field lacks studies on the relationship between mood, circadian phase, and phase angle of entrainment in late chronotype adolescents. Three objectives guide this explorative study: (1) to describe sleep, circadian phase, and phase angle of entrainment in late chronotype adolescents, (2) to explore how different levels of lateness are associated with sleep quality, sleep propensity, and mood, and (3) to investigate the influence of circadian phase on bedtime choice and sleep duration...
2022: Frontiers in Psychiatry
https://read.qxmd.com/read/35137145/diurnal-shift-of-mouse-activity-by-the-deficiency-of-an-ageing-related-gene-lmna
#23
JOURNAL ARTICLE
Satoshi Kawakami, Hikari Yoshitane, Taiki Morimura, Wataru Kimura, Yoshitaka Fukada
Nuclear lamina is a fundamental structure of the cell nucleus and regulates a wide range of molecular pathways. Defects of components of the nuclear lamina cause ageing-like physiological disorders, called laminopathy. Generally, ageing and diseases are often associated with perturbation of various time-of-day-dependent regulations, but it remains elusive whether laminopathy induces any changes of the circadian clock and physiological rhythms. Here, we demonstrated that deficiency of Lmna gene in mice caused an obvious shift of locomotor activities to the daytime...
May 11, 2022: Journal of Biochemistry
https://read.qxmd.com/read/35024497/a-randomized-controlled-trial-on-the-effect-of-blue-blocking-glasses-compared-to-partial-blue-blockers-on-melatonin-profile-among-nulliparous-women-in-third-trimester-of-the-pregnancy
#24
JOURNAL ARTICLE
Randi Liset, Janne Grønli, Roger Ekeberg Henriksen, Tone Elise Gjøtterud Henriksen, Roy Miodini Nilsen, Ståle Pallesen
OBJECTIVE: In pregnancy melatonin regulates circadian rhythms, induce sleep, and has a neuroprotective positive effect on fetal development. Artificial blue light in the evening delays and suppresses melatonin production. Thus, we investigated the effect of blocking blue light on the melatonin profile. METHODS: A randomized controlled trial (n=30 blue-blocking glasses vs. n=30 control glasses with partial blue-blocking effect) including healthy nulliparous pregnant women in the beginning of the third trimester...
May 2022: Neurobiology of Sleep and Circadian Rhythms
https://read.qxmd.com/read/34502541/targeted-disruption-of-the-inhibitor-of-dna-binding-4-id4-gene-alters-photic-entrainment-of-the-circadian-clock
#25
JOURNAL ARTICLE
Giles E Duffield, Maricela Robles-Murguia, Tim Y Hou, Kathleen A McDonald
Inhibitor of DNA binding ( Id ) genes comprise a family of four helix-loop-helix (HLH) transcriptional inhibitors. Our earlier studies revealed a role for ID2 within the circadian system, contributing to input, output, and core clock function through its interaction with CLOCK and BMAL1. Here, we explore the contribution of ID4 to the circadian system using a targeted disruption of the Id4 gene. Attributes of the circadian clock were assessed by monitoring the locomotor activity of Id4 -/- mice, and they revealed disturbances in its operation...
September 6, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34447932/sleep-and-circadian-phenotype-in-people-without-cone-mediated-vision-a-case-series-of-five-cngb3-and-two-cnga3-patients
#26
JOURNAL ARTICLE
Manuel Spitschan, Corrado Garbazza, Susanne Kohl, Christian Cajochen
Light exposure entrains the circadian clock through the intrinsically photosensitive retinal ganglion cells, which sense light in addition to the cone and rod photoreceptors. In congenital achromatopsia (prevalence 1:30-50 000), the cone system is non-functional, resulting in severe light avoidance and photophobia at daytime light levels. How this condition affects circadian and neuroendocrine responses to light is not known. In this case series of genetically confirmed congenital achromatopsia patients ( n  = 7; age 30-72 years; 6 women, 1 male), we examined survey-assessed sleep/circadian phenotype, self-reported visual function, sensitivity to light and use of spectral filters that modify chronic light exposure...
2021: Brain communications
https://read.qxmd.com/read/34211005/the-interindividual-variability-of-sleep-timing-and-circadian-phase-in-humans-is-influenced-by-daytime-and-evening-light-conditions
#27
JOURNAL ARTICLE
C Papatsimpa, L J M Schlangen, K C H J Smolders, J-P M G Linnartz, Y A W de Kort
Human cognitive functioning shows circadian variations throughout the day. However, individuals largely differ in their timing during the day of when they are more capable of performing specific tasks and when they prefer to sleep. These interindividual differences in preferred temporal organization of sleep and daytime activities define the chronotype. Since a late chronotype is associated with adverse mental and physical consequences, it is of vital importance to study how lighting environments affect chronotype...
July 1, 2021: Scientific Reports
https://read.qxmd.com/read/34163535/changes-in-24-h-rhythmicity-of-spontaneous-locomotor-activity-in-the-triple-transgenic-mouse-for-alzheimer-s-disease-3xtg-ad-in-a-jet-lag-protocol-correlations-with-retinal-sensitivity
#28
JOURNAL ARTICLE
Irma Angélica González-Luna, Cinthia Juárez-Tapia, Azucena Aguilar-Vázquez, Edith Arnold, Sofia Díaz-Cintra, Manuel Miranda-Anaya, Mauricio Díaz-Muñoz
The progression of amyloid plaques and neurofibrillary tangles in different brain areas is associated with the effects of Alzheimer's disease (AD). In addition to cognitive impairment, circadian alterations in locomotor activity have also been detected, but they have not been characterized in a jet lag protocol. Therefore, the present study aimed to compare 3xTg-AD and non-transgenic mice in changes of 24 h cycles of spontaneous locomotor activity in a jet lag protocol, in an environment without a running wheel, at 3 different states of neuronal damage: early, intermediate and advanced (3, 8 and 13 months, respectively)...
May 27, 2021: Journal of Circadian Rhythms
https://read.qxmd.com/read/34065211/bioelectrical-impedance-vector-analysis-a-valuable-tool-to-monitor-daily-body-hydration-dynamics-at-altitude
#29
JOURNAL ARTICLE
Ivo B Regli, Rachel Turner, Simon Woyke, Simon Rauch, Hermann Brugger, Hannes Gatterer
Bioelectrical impedance vector analysis (BIVA) is a method used to estimate variation in body hydration. We assessed the potential of BIVA for monitoring daily body hydration fluctuations in nine healthy, normally active males under matching normoxic (NX) and hypobaric hypoxic (HH) experimental conditions. Furthermore, we aimed to investigate whether changes in BIVA may correspond with the development of acute mountain sickness (AMS). Subjects were exposed in a hypobaric chamber to both NX (corresponding to an altitude of 262 m) and HH conditions corresponding to an altitude of 3500 m during two four-day sojourns within which food, water intake and physical activity were controlled...
May 20, 2021: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/34050968/a-classification-approach-to-estimating-human-circadian-phase-under-circadian-alignment-from-actigraphy-and-photometry-data
#30
JOURNAL ARTICLE
Lindsey S Brown, Melissa A St Hilaire, Andrew W McHill, Andrew J K Phillips, Laura K Barger, Akane Sano, Charles A Czeisler, Francis J Doyle, Elizabeth B Klerman
The time of dim light melatonin onset (DLMO) is the gold standard for circadian phase assessment in humans, but collection of samples for DLMO is time and resource-intensive. Numerous studies have attempted to estimate circadian phase from actigraphy data, but most of these studies have involved individuals on controlled and stable sleep-wake schedules, with mean errors reported between 0.5 and 1 hour. We found that such algorithms are less successful in estimating DLMO in a population of college students with more irregular schedules: Mean errors in estimating the time of DLMO are approximately 1...
August 2021: Journal of Pineal Research
https://read.qxmd.com/read/33730443/melatonin-mitigates-disrupted-circadian-rhythms-lowers-intraocular-pressure-and-improves-retinal-ganglion-cells-function-in-glaucoma
#31
JOURNAL ARTICLE
Denis Gubin, Vladimir Neroev, Tatyana Malishevskaya, Germaine Cornelissen, Sergei Y Astakhov, Sergey Kolomeichuk, Natalya Yuzhakova, Yana Kabitskaya, Dietmar Weinert
Glaucoma is a progressive optic neuropathy associated with damage to retinal ganglion cells (RGCs) and disrupted circadian rhythms. Melatonin is a promising substance to ameliorate glaucoma-associated compromised circadian rhythms, sleep, mood, and retinal cells function. However, studies estimating melatonin effects in glaucoma are currently lacking. Therefore, In this study, we investigated the effect of long-term (daily at 10:30 pm for 90 days) oral melatonin administration on systemic (Tb) and local to the organ of vision (IOP) circadian rhythms, pattern electroretinogram (PERG), sleep, and mood, depending on glaucoma stage in patients diagnosed with stable or advanced primary open-angle glaucoma...
March 17, 2021: Journal of Pineal Research
https://read.qxmd.com/read/33545116/sleep-timing-chronotype-and-social-jetlag-impact-on-cognitive-abilities-and-psychiatric-disorders
#32
REVIEW
Jacques Taillard, Patricia Sagaspe, Pierre Philip, Stéphanie Bioulac
Sleep timing is controlled by the subtle interplay between circadian and homeostatic oscillators which, according to their endogenous properties, allow beings to feel spontaneously that it is time to go to bed or wake up in synchrony with the earth's light/dark cycle. In humans, however, social time and nocturnal artificial light modify sleep timing. Our modern lifestyle and artificial nocturnal light delay our bedtime, make us wake up, and lead to a greater intraindividual variability in sleep timing. Depending on the constraints that social time places on us, our sleep timing may be in or out of phase with the internal circadian timing determined by the circadian clock...
September 2021: Biochemical Pharmacology
https://read.qxmd.com/read/33396443/disruption-of-24-hour-rhythm-in-intraocular-pressure-correlates-with-retinal-ganglion-cell-loss-in-glaucoma
#33
JOURNAL ARTICLE
Vladimir Neroev, Tatyana Malishevskaya, Dietmar Weinert, Sergei Astakhov, Sergey Kolomeichuk, Germaine Cornelissen, Yana Kabitskaya, Elena Boiko, Irina Nemtsova, Denis Gubin
Parameters of 24-h rhythm in intraocular pressure (IOP) were assessed in patients with stable or advanced primary open-angle glaucoma (S-POAG/A-POAG) and referenced to the phase of "marker" circadian temperature rhythm of each patient. Body temperature and IOP were measured over a 72-h span in 115 participants (65 S-POAG and 50 A-POAG). Retinal Ganglion Cell (RGC) damage was assessed by high-definition optical coherence tomography. The 24-h IOP rhythm in A-POAG patients peaked during the night, opposite to the daytime phase position in S-POAG patients ( p < 0...
December 31, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/33314496/the-acute-effects-of-sleep-restriction-therapy-for-insomnia-on-circadian-timing-and-vigilance
#34
RANDOMIZED CONTROLLED TRIAL
Leonie F Maurer, Suzanne Ftouni, Colin A Espie, Lampros Bisdounis, Simon D Kyle
Sleep-restriction therapy (SRT) has been shown to improve insomnia symptoms by restricting sleep opportunity. Curtailment of time in bed affects the duration and consolidation of sleep, but also its timing. While recent work suggests that people with insomnia are characterised by misalignment between circadian and behavioural timing of sleep, no study has investigated if SRT modifies this relationship. The primary aim of the present study was to examine change in phase angle after 2 weeks of SRT. As a secondary aim, we also sought to assess the effect of SRT on psychomotor vigilance...
August 2021: Journal of Sleep Research
https://read.qxmd.com/read/33303132/robust-and-sensitive-peptidomics-workflow-for-plasma-based-on-specific-extraction-lipid-removal-capillary-lc-setup-and-multinozzle-esi-emitter
#35
JOURNAL ARTICLE
Bertrand Rochat, Patrice Waridel, Jachen Barblan, Pierre-Edouard Sottas, Manfredo Quadroni
We present a new workflow for the LC-MS determination of native peptides in plasma at picomolar levels. Collected whole blood was quickly diluted with an ice-cold solution in order to stop protease activity. Diluted plasma samples were extracted by protein denaturation followed by solid-phase-extraction with a polymeric stationary phase that removed most proteins and lipids. Using a specific LC-MS setup with 3 pumps, 240 μL of extracts were injected without drying-reconstitution, a step known to cause peptide losses...
February 1, 2021: Talanta
https://read.qxmd.com/read/33144967/resource-competition-shapes-biological-rhythms-and-promotes-temporal-niche-differentiation-in-a-community-simulation
#36
JOURNAL ARTICLE
Vance Difan Gao, Sara Morley-Fletcher, Stefania Maccari, Martha Hotz Vitaterna, Fred W Turek
Competition for resources often contributes strongly to defining an organism's ecological niche. Endogenous biological rhythms are important adaptations to the temporal dimension of niches, but how other organisms influence such temporal niches has not been much studied, and the role of competition in particular has been even less examined. We investigated how interspecific competition and intraspecific competition for resources shape an organism's activity rhythms.To do this, we simulated communities of one or two species in an agent-based model...
October 2020: Ecology and Evolution
https://read.qxmd.com/read/32981454/-inhibitor-of-dna-binding-2-id2-regulates-photic-entrainment-responses-in-mice-differential-responses-of-the-id2-mouse-circadian-system-are-dependent-on-circadian-phase-and-on-duration-and-intensity-of-light
#37
JOURNAL ARTICLE
Giles E Duffield, Sung Han, Tim Y Hou, Horacio O de la Iglesia, Kathleen A McDonald, Kirk L Mecklenburg, Maricela Robles-Murguia
ID2 is a rhythmically expressed helix-loop-helix transcriptional repressor, and its deletion results in abnormal properties of photoentrainment. By examining parametric and nonparametric models of entrainment, we have started to explore the mechanism underlying this circadian phenotype. Id2 -/- mice were exposed to differing photoperiods, and the phase angle of entrainment under short days was delayed 2 h as compared with controls. When exposed to long durations of continuous light, enhanced entrainment responses were observed after a delay of the clock but not with phase advances...
December 2020: Journal of Biological Rhythms
https://read.qxmd.com/read/32979560/chronobiologic-parameter-changes-in-patients-with-major-depressive-disorder-and-sleep-disturbance-treated-with-adjunctive-brexpiprazole-an-open-label-flexible-dose-exploratory-substudy
#38
MULTICENTER STUDY
Andrew D Krystal, Aurélia Mittoux, Annika Lindsten, Ross A Baker
BACKGROUND: Circadian rhythm disturbances have been reported in patients with major depressive disorder (MDD). Among these is an increased phase angle between peak cortisol concentration and dim-light melatonin onset (DLMO). The aim of this study was to evaluate changes in chronobiologic parameters of sleep in patients with MDD receiving adjunctive brexpiprazole. METHODS: This was an interventional, multicenter, open-label, flexible-dose, exploratory study in patients with MDD and inadequate response to antidepressant treatment who were experiencing sleep disturbances...
January 1, 2021: Journal of Affective Disorders
https://read.qxmd.com/read/32785281/the-impact-of-structured-sleep-schedules-prior-to-an-in-laboratory-study-individual-differences-in-sleep-and-circadian-timing
#39
JOURNAL ARTICLE
William R McMahon, Suzanne Ftouni, Andrew J K Phillips, Caroline Beatty, Steven W Lockley, Shanthakumar M W Rajaratnam, Paul Maruff, Sean P A Drummond, Clare Anderson
INTRODUCTION: Many sleep and circadian studies require participants to adhere to structured sleep-wake schedules designed to stabilize sleep outcomes and circadian phase prior to in-laboratory testing. The effectiveness of this approach has not been rigorously evaluated, however. We therefore investigated the differences between participants' unstructured and structured sleep over a three-week interval. METHODS: Twenty-three healthy young adults completed three weeks of sleep monitoring, including one week of unstructured sleep and two weeks of structured sleep with consistent bed and wake times...
2020: PloS One
https://read.qxmd.com/read/32598502/early-chronotype-with-advanced-activity-rhythms-and-dim-light-melatonin-onset-in-a-rural-population
#40
JOURNAL ARTICLE
Francieli S Ruiz, Felipe Beijamini, Andrew D Beale, Bruno da Silva B Gonçalves, Daniel Vartanian, Tâmara P Taporoski, Benita Middleton, José E Krieger, Homero Vallada, Josephine Arendt, Alexandre C Pereira, Kristen L Knutson, Mario Pedrazzoli, Malcolm von Schantz
Studying communities at different stages of urbanisation and industrialisation can teach us how timing and intensity of light affect the circadian clock under real-life conditions. We have previously described a strong tendency towards morningness in the Baependi Heart Study, located in a small rural town in Brazil. Here, we tested the hypothesis that this morningness tendency is associated with early circadian phase based on objective measurements (as determined by dim light melatonin onset, DLMO, and activity) and light exposure...
June 29, 2020: Journal of Pineal Research
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