Valeria Lucarini, Anaëlle Alouit, Delphine Yeh, Jeanne Le Coq, Romane Savatte, Mylène Charre, Cécile Louveau, Meryem Benlaifa Houamri, Sylvain Penaud, Alexandre Gaston-Bellegarde, Stéphane Rio, Laurent Drouet, Maxime Elbaz, Jean Becchio, Sylvain Pourchet, Estelle Pruvost-Robieux, Angela Marchi, Mylène Moyal, Aline Lefebvre, Boris Chaumette, Martine Grice, Påvel G Lindberg, Lucile Dupin, Pascale Piolino, Cédric Lemogne, Damien Léger, Martine Gavaret, Marie-Odile Krebs, Anton Iftimovici
BACKGROUND: Quantitative electroencephalography (EEG) analysis offers the opportunity to study high-level cognitive processes across psychiatric disorders. In particular, EEG microstates translate the temporal dynamics of neuronal networks throughout the brain. Their alteration may reflect transdiagnostic anomalies in neurophysiological functions that are impaired in mood, psychosis, and autism spectrum disorders, such as sensorimotor integration, speech, sleep, and sense of self. The main questions this study aims to answer are as follows: 1) Are EEG microstate anomalies associated with clinical and functional prognosis, both in resting conditions and during sleep, across psychiatric disorders? 2) Are EEG microstate anomalies associated with differences in sensorimotor integration, speech, sense of self, and sleep? 3) Can the dynamic of EEG microstates be modulated by a non-drug intervention such as light hypnosis? METHODS: This prospective cohort will include a population of adolescents and young adults, aged 15 to 30 years old, with ultra-high-risk of psychosis (UHR), first-episode psychosis (FEP), schizophrenia (SCZ), autism spectrum disorder (ASD), and major depressive disorder (MDD), as well as healthy controls (CTRL) (N = 21 × 6), who will be assessed at baseline and after one year of follow-up...
November 21, 2023: BMC Psychiatry