keyword
https://read.qxmd.com/read/38220102/treatment-measures-for-seasonal-affective-disorder-a-network-meta-analysis
#21
REVIEW
Zuo-Wei Chen, Xin-Feng Zhang, Zhe-Ming Tu
OBJECTIVE: The purpose of this study was to assess the potential effectiveness of several mainstream therapies, including phototherapy, antidepressants, cognitive-behavioral therapy, and negative ion generators, in the treatment of Seasonal Affective Disorder (SAD). METHODS: A systematic search of PubMed, Embase, Cochrane, and WOS databases was conducted from January 1975 to December 3, 2022. Randomized controlled trials meeting predefined selection criteria for the treatment of SAD using mainstream therapeutic approaches were identified...
January 12, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38216355/the-effects-of-light-therapy-on-sleep-depression-neuropsychiatric-behaviors-and-cognition-among-people-living-with-dementia-a-meta-analysis-of-randomized-controlled-trials
#22
JOURNAL ARTICLE
Nur Aini, Ruey Chen, Hsin Chu, Ching-Yi Chang, Hui-Chen Lin, Hsiu-Ju Jen, Doresses Liu, Tso-Ying Lee, Kuei-Ru Chou
OBJECTIVE: Alterations in the suprachiasmatic nucleus due to underlying pathologies disrupt the circadian rhythms in people living with dementia (PLWD). Circadian rhythms significantly impact sleep, emotional, and cognitive functions, with its synchronization depending on light exposure. We performed a meta-analysis to evaluate the effects of light therapy on sleep, depression, neuropsychiatric behaviors, and cognition among PLWD. METHODS: A systematic search was conducted in Cochrane, ClinicalTrials...
December 23, 2023: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38215991/serum-neurofilament-light-as-a-potential-marker-of-illness-duration-in-bipolar-disorder
#23
JOURNAL ARTICLE
R Queissner, A Buchman, R Demjaha, C Tafrali, P Benkert, J Kuhle, A Jerkovic, N Dalkner, F Fellendorf, A Birner, M Platzer, A Tmava-Berisha, A Maget, T Stross, M Lenger, A Häussl, M Khalil, E Reininghaus
INTRODUCTION: Investigation on specific biomarkers for diagnostic or prognostic usage in mental diseases and especially bipolar disorder BD seems to be one outstanding field in current research. Serum neurofilament light (sNfL), a marker for neuro-axonal injury, is increased in various acute and chronic neurological disorders, but also neuro-psychiatric conditions, including affective disorders. The aim of our study was to determine a potential relation between a neuron-specific marker like sNfL and different clinical states of BD...
January 10, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38187456/blue-light-at-night-produces-stress-evoked-heightened-aggression-by-enhancing-brain-derived-neurotrophic-factor-in-the-basolateral-amygdala
#24
JOURNAL ARTICLE
Zhenlong Li, Chau-Shoun Lee, Si Chen, Benyu He, Xinya Chen, Hsien-Yu Peng, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Dylan Chou
Light is an underappreciated mood manipulator. People are often exposed to electronic equipment, which results in nocturnal blue light exposure in modern society. Light pollution drastically shortens the night phase of the circadian rhythm. Preclinical and clinical studies have reported that nocturnal light exposure can influence mood, such as depressive-like phenotypes. However, the effects of blue light at night (BLAN) on other moods and how it alters mood remain unclear. Here, we explored the impact of BLAN on stress-provoked aggression in male Sprague‒Dawley rats, focusing on its influence on basolateral amygdala (BLA) activity...
January 2024: Neurobiology of Stress
https://read.qxmd.com/read/38171633/chronotherapy-for-patients-with-a-depressive-episode-treated-in-a-public-outpatient-mental-healthcare-clinic-in-norway-protocol-for-a-randomised-controlled-trial
#25
JOURNAL ARTICLE
Lina Stålesen Ramfjord, Nikolaj Kahn, Knut Langsrud, Joar Øveraas Øveraas Halvorsen, Gunnar Morken, Simen Saksvik, Liv Sigrun Sættem Engvik, Stian Lydersen, Håvard Kallestad
INTRODUCTION: Depression is highly prevalent in outpatients receiving treatment for mental disorders. Treatment as usual (TAU) usually consists of either psychotherapy and/or antidepressant medication and often takes several weeks before clinical effect. Chronotherapy, consisting of sleep deprivation, sleep-wake phase advancement and stabilisation, and light therapy, is a possible addition to TAU that may decrease the time to treatment response. This randomised controlled trial will examine the benefits of adding chronotherapy to TAU compared with TAU alone...
January 3, 2024: BMJ Open
https://read.qxmd.com/read/38160889/prospectively-assessed-summer-mood-status-in-major-depression-recurrent-with-seasonal-pattern-evidence-for-sad-s-construct-validity
#26
JOURNAL ARTICLE
Kelly J Rohan, Julia M Terman, Praise Iyiewuare, Jessica Perez, Julia A Camuso, Teodor T Postolache, Michael J DeSarno, Pamela M Vacek
OBJECTIVE: Seasonal patterns are often undetectable in population-based depression studies, calling into question the existence of winter seasonal affective disorder (SAD). If SAD has construct validity, individuals with SAD should show spontaneous depression remission in the summer. Data are sparse on prospectively assessed summer mood status in confirmed SAD patients. METHOD: We conducted prospective summer followup of community adults who, the winter before, were diagnosed with Major Depression, Recurrent with Seasonal Pattern on the Structured Clinical Interview for DSM-IV Axis I Disorders, developed a current SAD episode on the Structured Interview Guide for the Hamilton Rating Scale for Depression-Seasonal Affective Disorder Version (SIGH-SAD), and enrolled in a clinical trial comparing group cognitive-behavioral therapy for SAD and light therapy...
December 29, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/38158049/evaluating-the-impact-of-adjunct-bright-light-therapy-on-subjective-sleep-quality-in-major-depressive-disorder
#27
JOURNAL ARTICLE
Lorenzo Fregna, Francesco Attanasio, Cristina Colombo
BACKGROUND: Sleep disturbances are a fundamental feature of depression, with their persistence after remission serving as a key risk factor for recurrence of depressive episodes, suicide, and hypnotics abuse. Though Adjunct Bright Light Therapy (BLT) has shown efficacy in treating depression by improving sleep duration and timing, its impact on subjective sleep quality remains underexplored. OBJECTIVE: This study investigates the effect of adjunct BLT on the subjective experience of sleep quality of Major Depressive Disorder (MDD) inpatients...
December 28, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/38154586/delivery-of-bright-light-therapy-within-the-veterans-health-administration
#28
JOURNAL ARTICLE
Daniel J Reis, Alexandra L Schneider, Samuel E King, Jeri E Forster, Nazanin H Bahraini
BACKGROUND: Bright light therapy (BLT) is efficacious for seasonal and non-seasonal depression. However, the current state of BLT use in practice is unknown, impeding efforts to identify and address utilization gaps. This study's objective was to investigate BLT delivery in a nationwide U.S. healthcare system. METHODS: This was a retrospective observational study of electronic medical records from all veterans who received outpatient mood disorder-related care in the Veterans Health Administration (VHA) from October 2008 through September 2020...
December 26, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/38146331/dozing-off-with-drosophila-the-effect-of-disrupted-circadian-rhythms-and-sleep-disturbance-on-mortality-mood-and-addiction
#29
JOURNAL ARTICLE
Rania S Lateef, Bibhaw Pokharel, Tasnuva Nuhat Shafin
Many environmental factors can disrupt sleep and circadian rhythms, yet the consequences of such disruptions are poorly understood. The main goals of this project were to study the effects of disrupted circadian rhythms and sleep disturbance on Drosophila melanogaster's : (1) lifespan, (2) depression-like behaviors, and (3) propensity to consume caffeine-containing media. Three experimental groups were used: controls, Circadian Dysfunction (CD), and Sleep Disturbance (SD). Circadian disruption (CD): used flies with Tim 01 mutation, which eliminates circadian behavioral rhythms...
2023: Neuroscience insights
https://read.qxmd.com/read/38128462/eeg-abnormalities-are-not-associated-with-poor-antidepressant-treatment-outcome-a-neuropharm-study
#30
JOURNAL ARTICLE
Kristian H Reveles Jensen, Olalla Urdanibia-Centelles, Vibeke H Dam, Kristin Köhler-Forsberg, Vibe G Frokjaer, Gitte M Knudsen, Martin B Jørgensen, Cheng T Ip
EEG brain abnormalities, such as slowing and isolated epileptiform discharges (IEDs), has previously been associated with non-response to antidepressant treatment with escitalopram and venlafaxine, suggesting a potential need for treatment with anticonvulsant property in some patients. The current study aims to replicate the reported association of EEG abnormality and treatment outcomes in an open-label trial of escitalopram for major depressive disorder (MDD) and explore its relationship to mood and cognition...
December 20, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/38128260/chronic-stress-and-its-effects-on-behavior-rna-expression-of-the-bed-nucleus-of-the-stria-terminalis-and-the-m-current-of-npy-neurons
#31
JOURNAL ARTICLE
Thomas J Degroat, Kimberly Wiersielis, Katherine Denney, Sowmya Kodali, Sierra Daisey, Jessica Tollkuhn, Benjamin A Samuels, Troy A Roepke
Mood disorders, like major depressive disorder, can be precipitated by chronic stress and are more likely to be diagnosed in cisgender women than in cisgender men. This suggests that stress signaling in the brain is sexually dimorphic. We used a chronic variable mild stress paradigm to stress female and male mice for 6 weeks, followed by an assessment of avoidance behavior: the open field test, the elevated plus maze, the light/dark box emergence test, and the novelty suppressed feeding test. Additional cohorts were used for bulk RNA-Sequencing of the anterodorsal bed nucleus of the stria terminalis (adBNST) and whole-cell patch clamp electrophysiology in NPY-expressing neurons of the adBNST to record stress-sensitive M-currents...
December 7, 2023: Psychoneuroendocrinology
https://read.qxmd.com/read/38124413/assessment-of-neuropharmacological-consequences-induced-by-dexamethasone-administration-in-rats-model-of-neurodegenerative-diseases
#32
JOURNAL ARTICLE
Muhammad Farhan, Samia Khan, Ayesha Ahmed Soomro, Shoaib Ahmed, Anila Bibi, Syeda Rabab Zehra, Maria Arshad, Fatima Riaz, Sadia Rehman, Saher Asif
Stress is a well-known and frequently used term among present generation. It has been referred to the response of body to any challenge for a change. It is a natural process and our body is designed to cope with it. However, if stress becomes chronic, it can lead to mental health problems. Stress due to the prolonged administration of glucocorticoid is enabled to produce impressive alterations in rats model shoeing depressive like behavior. In this investigation; purpose was to study the impact of episodic treatment of dexamethasone with respect to behavioral changes in rats...
November 2023: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38109922/blues-stabilizing-mood-and-sleep-with-blue-blocking-eyewear-in-bipolar-disorder-a-randomized-controlled-trial-study-protocol
#33
JOURNAL ARTICLE
Helle Østergaard Madsen, Ida Hageman, Klaus Martiny, Maria Faurholt-Jepsen, Miriam Kolko, Tone E G Henriksen, Lars Vedel Kessing
INTRODUCTION: Chronotherapeutic interventions for bipolar depression and mania are promising interventions associated with rapid response and benign side effect profiles. Filtering of biologically active short wavelength (blue) light by orange tinted eyewear has been shown to induce antimanic and sleep promoting effects in inpatient mania. We here describe a study protocol assessing acute and long-term stabilizing effects of blue blocking (BB) glasses in outpatient treatment of bipolar disorder...
2023: Annals of Medicine
https://read.qxmd.com/read/38094517/psychedelic-drugs-or-hallucinogens-exploring-their-medicinal-potential
#34
REVIEW
Priyanshu Raj, Shyambabu Rauniyar, Bhagyesh Sapkale
Serotonergic hallucinogens also referred to as psychedelics, are psychoactive substances that profoundly alter perception, mood, and cognitive processes. These substances, historically intertwined with religious and cultural rituals, offer profound effects that extend beyond mere hallucinations to profoundly altered states of consciousness. Notable compounds like Lysergic acid diethylamide (LSD) and psilocybin, potent in their action on serotonin receptors, play pivotal roles in influencing brain functions...
November 2023: Curēus
https://read.qxmd.com/read/38007229/socioeconomic-status-and-severe-mental-disorders-a-bidirectional-multivariable-mendelian-randomisation-study
#35
JOURNAL ARTICLE
Álvaro Andreu-Bernabeu, Javier González-Peñas, Celso Arango, Covadonga M Díaz-Caneja
BACKGROUND: Despite the evidence supporting the relationship between socioeconomic status (SES) and severe mental disorders (SMD), the directionality of the associations between income or education and mental disorders is still poorly understood. OBJECTIVE: To investigate the potential bidirectional causal relationships between genetic liability to the two main components of SES (income and educational attainment (EA)) on three SMD: schizophrenia, bipolar disorder (BD) and depression...
November 24, 2023: BMJ Ment Health
https://read.qxmd.com/read/38007104/neuronal-damage-and-inflammatory-biomarkers-are-associated-with-the-affective-and-chronic-fatigue-like-symptoms-due-to-end-stage-renal-disease
#36
JOURNAL ARTICLE
Hussein Kadhem Al-Hakeim, Basim Abd Al-Raheem Twai, Tabarek Hadi Al-Naqeeb, Shatha Rouf Moustafa, Michael Maes
BACKGROUND: Many biochemical, immunological, and neuropsychiatric changes are associated with end-stage renal disease (ESRD). Neuronal damage biomarkers such as glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL), S100 calcium-binding protein B (S100B), ionized calcium-binding adaptor molecule-1 (IBA1), and myelin basic protein (MBP) are among the less-studied biomarkers of ESRD. AIM: We examined the associations between these neuro-axis biomarkers, inflammatory biomarkers, e...
November 23, 2023: Journal of Affective Disorders
https://read.qxmd.com/read/37999209/the-cerebellum-s-role-in-affective-disorders-the-onset-of-its-social-dimension
#37
REVIEW
Stefano Stanca, Martina Rossetti, Paolo Bongioanni
Major Depressive Disorder (MDD) and Bipolar Disorder (BD) are the most frequent mental disorders whose indeterminate etiopathogenesis spurs to explore new aetiologic scenarios. In light of the neuropsychiatric symptoms characterizing Cerebellar Cognitive Affective Syndrome (CCAS), the objective of this narrative review is to analyze the involvement of the cerebellum (Cbm) in the onset of these conditions. It aims at detecting the repercussions of the Cbm activities on mood disorders based on its functional subdivision in vestibulocerebellum (vCbm), pontocerebellum (pCbm) and spinocerebellum (sCbm)...
October 28, 2023: Metabolites
https://read.qxmd.com/read/37998473/a-machine-learning-approach-unveils-the-relationships-between-sickness-behavior-and-interoception-after-vaccination-suggestions-for-psychometric-indices-of-higher-vulnerability
#38
JOURNAL ARTICLE
Gaspare Alfì, Graziella Orrù, Danilo Menicucci, Mario Miccoli, Virginia Casigliani, Michele Totaro, Angelo Baggiani, Angelo Gemignani
OBJECTIVE: Prior research has suggested a possible connection between vaccination and manifestations of Sickness Behavior; however, a need remains to first delve deeper into this association and second examine how Interoceptive Awareness and emotional factors may modulate individuals' perceptions of their health status post vaccination. METHOD: An online retrospective cross-sectional survey of 647 individuals who received a COVID-19 vaccination was conducted. Together with vaccination side effects, socio-demographic characteristics, health status, level of concern about vaccination, and Interoceptive Awareness were collected at the baseline level...
November 18, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37990173/neurophysiological-explorations-across-the-spectrum-of-psychosis-autism-and-depression-during-wakefulness-and-sleep-protocol-of-a-prospective-case-control-transdiagnostic-multimodal-study-demeter
#39
JOURNAL ARTICLE
Valeria Lucarini, Anaëlle Alouit, Delphine Yeh, Jeanne Le Coq, Romane Savatte, Mylène Charre, Cécile Louveau, Meryem Benlaifa Houamri, Sylvain Penaud, Alexandre Gaston-Bellegarde, Stéphane Rio, Laurent Drouet, Maxime Elbaz, Jean Becchio, Sylvain Pourchet, Estelle Pruvost-Robieux, Angela Marchi, Mylène Moyal, Aline Lefebvre, Boris Chaumette, Martine Grice, Påvel G Lindberg, Lucile Dupin, Pascale Piolino, Cédric Lemogne, Damien Léger, Martine Gavaret, Marie-Odile Krebs, Anton Iftimovici
BACKGROUND: Quantitative electroencephalography (EEG) analysis offers the opportunity to study high-level cognitive processes across psychiatric disorders. In particular, EEG microstates translate the temporal dynamics of neuronal networks throughout the brain. Their alteration may reflect transdiagnostic anomalies in neurophysiological functions that are impaired in mood, psychosis, and autism spectrum disorders, such as sensorimotor integration, speech, sleep, and sense of self. The main questions this study aims to answer are as follows: 1) Are EEG microstate anomalies associated with clinical and functional prognosis, both in resting conditions and during sleep, across psychiatric disorders? 2) Are EEG microstate anomalies associated with differences in sensorimotor integration, speech, sense of self, and sleep? 3) Can the dynamic of EEG microstates be modulated by a non-drug intervention such as light hypnosis? METHODS: This prospective cohort will include a population of adolescents and young adults, aged 15 to 30 years old, with ultra-high-risk of psychosis (UHR), first-episode psychosis (FEP), schizophrenia (SCZ), autism spectrum disorder (ASD), and major depressive disorder (MDD), as well as healthy controls (CTRL) (N = 21 × 6), who will be assessed at baseline and after one year of follow-up...
November 21, 2023: BMC Psychiatry
https://read.qxmd.com/read/37975923/effects-of-chronotype-tailored-bright-light-intervention-on-post-treatment-symptoms-and-quality-of-life-in-breast-cancer-survivors
#40
RANDOMIZED CONTROLLED TRIAL
Horng-Shiuann Wu, Feng Gao, Jean E Davis, Charles W Given
PURPOSE: Bright light therapy holds promise for reducing common symptoms, e.g., fatigue, experienced by individuals with cancer. This study aimed to examine the effects of a chronotype-tailored bright light intervention on sleep disturbance, fatigue, depressive mood, cognitive dysfunction, and quality of life among post-treatment breast cancer survivors. METHODS: In this two-group randomized controlled trial (NCT03304587), participants were randomized to receive 30-min daily bright blue-green light (12,000 lx) or dim red light (5 lx) either between 19:00 and 20:00 h or within 30 min of waking in the morning...
November 17, 2023: Supportive Care in Cancer
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