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Light mood depression

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https://www.readbyqxmd.com/read/30537760/effects-of-light-treatment-on-sleep-cognition-mood-and-behavior-in-alzheimer-s-disease-a-systematic-review
#1
REVIEW
Micaela Mitolo, Caterina Tonon, Chiara La Morgia, Claudia Testa, Valerio Carelli, Raffaele Lodi
BACKGROUND: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. SUMMARY: The aim of this review is to provide a critical evaluation of available evidence in this field, highlighting the specific characteristics of effective bright light treatment...
December 11, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/30466205/bright-light-therapy-in-the-morning-or-at-mid-day-in-the-treatment-of-non-seasonal-bipolar-depressive-episodes-lubi-study-protocol-for-a-dose-research-phase-i-ii-trial
#2
Pierre Alexis Geoffroy, El Mountacer Billah El Abbassi, Julia Maruani, Bruno Etain, Michel Lejoyeux, Ali Amad, Philippe Courtet, Caroline Dubertret, Philip Gorwood, Guillaume Vaiva, Frank Bellivier, Sylvie Chevret
Objective: This study protocol aims to determine, using a rigorous approach in patients with bipolar disorder (BD) and non-seasonal major depressive episode (MDE), the characteristics of bright light therapy (BLT) administration (duration, escalation, morning and mid-day exposures) depending on the tolerance (hypomanic symptoms). Methods: Patients with BD I or II and treated by a mood stabilizer are eligible. After 1 week of placebo, patients are randomized between either morning or mid-day exposure for 10 weeks of active BLT with glasses using a dose escalation at 7...
November 26, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/30348255/-psychiatry-and-circadian-rhythms
#3
Klaus Martiny, Carlo Volf, Signe Dunker Svendsen, Mette Kragh, Helle Østergaard Madsen, Ida Hageman
Circadian and seasonal rhythm disturbances are prominent in patients with psychiatric disorders. Properly timed and dosed light of specific spectral composition stabilises mood and sleep through serotonergic mechanisms and through input to the master circadian clock in the hypothalamus. Correctly administered, light can be used as an effective treatment for seasonal and non-seasonal depression and for stabilising the sleep-wake cycle. Blocking blue light in the evening may provide a non-pharmacological anti-manic tool...
September 3, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/30320231/applying-polygenic-risk-scoring-for-psychiatric-disorders-to-a-large-family-with-bipolar-disorder-and-major-depressive-disorder
#4
Simone de Jong, Mateus Jose Abdalla Diniz, Andiara Saloma, Ary Gadelha, Marcos L Santoro, Vanessa K Ota, Cristiano Noto, Charles Curtis, Stephen J Newhouse, Hamel Patel, Lynsey S Hall, Paul F O Reilly, Sintia I Belangero, Rodrigo A Bressan, Gerome Breen
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree ( n  ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations...
2018: Communications biology
https://www.readbyqxmd.com/read/30301878/circadian-rhythms-and-psychiatric-profiles-in-young-adults-with-unipolar-depressive-disorders
#5
Rébecca Robillard, Joanne S Carpenter, Naomi L Rogers, Sarah Fares, Ashlee B Grierson, Daniel F Hermens, Sharon L Naismith, Sharon J Mullin, Kristy-Lee Feilds, Nick Glozier, Elizabeth M Scott, Ian B Hickie
Abnormalities in circadian rhythms have been reported in people with mood disorders, but these abnormalities are marked by considerable inter-individual variability. This study aimed to identify pathophysiological subgroups on the basis of circadian markers and evaluate how these subgroups relate to psychiatric profiles. Thirty-five young adults (18-31 years old) receiving clinical care for unipolar depressive disorders and 15 healthy controls took part to this study. The Hamilton Rating Scale for Depression and the Young Mania rating scale were used to evaluate the severity of mood symptoms in participants with depressive disorders...
October 9, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/30271376/melanopsin-driven-pupil-response-and-light-exposure-in-non-seasonal-major-depressive-disorder
#6
Beatrix Feigl, Govinda Ojha, Leanne Hides, Andrew J Zele
Background: Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation. In seasonal affective disorder, ipRGC dysfunction is thought to cause abberant transmission of the external illumination for photoentrainment. It is not known if patients with non-seasonal depression have abnormal melanospin mediated signaling and/or irregular environmental light exposure...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30218624/illuminated-night-alters-hippocampal-gene-expressions-and-induces-depressive-like-responses-in-diurnal-corvids
#7
S K Tahajjul Taufique, Abhilash Prabhat, Vinod Kumar
Artificial light at night induces circadian disruptions and causes cognitive impairment and mood disorders; yet very little is known about the neural and molecular correlates of these effects in diurnal animals. We manipulated the night environment and examined cellular and molecular changes in hippocampus, the brain region involved in cognition and mood, of Indian house crows (Corvus splendens) exposed to 12 hr light (150 lux): 12 hr darkness (0 lux). Diurnal corvids are an ideal model species with cognitive abilities at par with mammals...
September 15, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/30172213/depressive-mood-and-circadian-rhythms-disturbances-as-outcomes-of-seasonal-affective-disorder-treatment-a-systematic-review
#8
REVIEW
Giulia Menculini, Norma Verdolini, Andrea Murru, Isabella Pacchiarotti, Umberto Volpe, Antonella Cervino, Luca Steardo, Patrizia Moretti, Eduard Vieta, Alfonso Tortorella
BACKGROUND: The present systematic review was aimed at critically summarizing the evidence about interventions focused on circadian rhythms and mood symptoms in seasonal affective disorder (SAD). METHODS: A systematic search of the electronic databases PUBMED, PsycINFO and Web of Science was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Original papers reporting data about the effects of treatments on both mood and circadian rhythms disturbances in SAD patients were considered for inclusion...
December 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/30125565/role-of-inflammation-in-epilepsy-and-neurobehavioral-comorbidities-implication-for-therapy
#9
REVIEW
Yam Nath Paudel, Mohd Farooq Shaikh, Sadia Shah, Yatinesh Kumari, Iekhsan Othman
Epilepsy is a devastating condition affecting around 70 million people worldwide. Moreover, the quality of life of people with epilepsy (PWE) is worsened by a series of comorbidities. The neurobehavioral comorbidities discussed herein share a reciprocal and complex relationship with epilepsy, which ultimately complicates the treatment process in PWE. Understanding the mechanistic pathway by which these comorbidities are associated with epilepsy might be instrumental in developing therapeutic interventions. Inflammatory cytokine signaling in the brain regulates important brain functions including neurotransmitter metabolism, neuroendocrine function, synaptic plasticity, dopaminergic transmission, the kynurenine pathway, and affects neurogenesis as well as the neural circuitry of moods...
October 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30110354/antidepressive-and-anxiolytic-effects-of-ostruthin-a-trek-1-channel-activator
#10
Ancy Joseph, Tran Thi Thu Thuy, Le Tat Thanh, Masayoshi Okada
We screened a library of botanical compounds purified from plants of Vietnam for modulators of the activity of a two-pore domain K+ channel, TREK-1, and we identified a hydroxycoumarin-related compound, ostruthin, as an activator of this channel. Ostruthin increased whole-cell TREK-1 channel currents in 293T cells at a low concentration (EC50 = 5.3 μM), and also activity of the TREK-2 channel (EC50 = 3.7 mM). In contrast, ostruthin inhibited other K+ channels, e.g. human ether-à-go-go-related gene (HERG1), inward-rectifier (Kir2...
2018: PloS One
https://www.readbyqxmd.com/read/30098753/the-role-of-circadian-rhythms-in-postpartum-sleep-and-mood
#11
REVIEW
Kari Grethe Hjorthaug Gallaher, Anastasiya Slyepchenko, Benicio N Frey, Kristin Urstad, Signe K Dørheim
Women often experience sleep disturbances and worsening sleep quality throughout pregnancy and postpartum. Circadian rhythms are closely linked to sleep problems and mood disorders. This systematic review provides a summary of studies of circadian rhythms and associated sleep problems and maternal distress, among postpartum women. Articles were idenitfied through a systematic literature search. Circadian rhythm disturbances were strongly correlated with depression, social factors and mothers`s exposure to light postpartum...
September 2018: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/30093877/disruption-of-inferior-longitudinal-fasciculus-microstructure-in-parkinson-s-disease-a-systematic-review-of-diffusion-tensor-imaging-studies
#12
REVIEW
Maryam Haghshomar, Mahsa Dolatshahi, Farzaneh Ghazi Sherbaf, Hossein Sanjari Moghaddam, Mehdi Shirin Shandiz, Mohammad Hadi Aarabi
Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on our understanding of structural abnormalities underlying PD symptoms or its associations with pathological mechanisms. One of the white matter tracts shown to be disrupted in PD with a possible contribution to some PD symptoms is the inferior longitudinal fasciculus (ILF)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30041620/relationship-between-ambient-light-and-glucose-metabolism-in-healthy-subjects
#13
Hirofumi Hirakawa, Takeshi Terao, Koji Hatano, Kentaro Kohno, Nobuyoshi Ishii
BACKGROUND: Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants of the no intervention group from our previous randomized controlled trial and analyzed the association between ambient light and [18 F]-FDG uptake in the brain. RESULTS: A whole brain analysis revealed a cluster of [18 F]-FDG uptake that was significantly and inversely associated with log-transformed ambient light in the left culmen of the left cerebellum vermis...
July 24, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/30022567/emotionally-aligned-preliminary-results-on-the-effects-of-a-mindfulness-based-intervention-for-depression-on-congruence-between-implicit-and-explicit-mood
#14
Carina Remmers, Johannes Zimmermann, Alice Buxton, Hans-Peter Unger, Sander L Koole, Christine Knaevelsrud, Johannes Michalak
BACKGROUND: Mindfulness-based interventions (MBIs) are effective in treating major depression. Because mindfulness involves monitoring and accepting current experiences, it may lead people resolve incongruencies between emotional responses that would otherwise remain unnoticed. Mindfulness may thus foster congruence between implicit and explicit emotions. The current randomized controlled trial tested this notion. METHODS: N = 39 patients with an acute depressive episode were randomly assigned to an 8-week MBI (n = 24) or a psychopharmacological consultation condition (n = 15)...
July 18, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/30022319/prevalence-of-seasonal-depression-in-a-prospective-cohort-study
#15
Anna Wirz-Justice, Vladeta Ajdacic, Wulf Rössler, Hans-Christoph Steinhausen, Jules Angst
The prevalence of autumn/winter seasonality in depression has been documented in the longitudinal Zurich cohort study by five comprehensive diagnostic interviews at intervals over more than 20 years (N = 499). Repeated winter major depressive episodes (MDE-unipolar + bipolar) showed a prevalence of 3.44% (5× more women than men), whereas MDE with a single winter episode was much higher (9.96%). A total of 7.52% suffered from autumn/winter seasonality in major and minor depressive mood states. The clinical interviews revealed novel findings: high comorbidity of Social Anxiety Disorder and Agoraphobia within the repeated seasonal MDE group, high incidence of classic diurnal variation of mood (with evening improvement), as well as a high rate of oversensitivity to light, noise, or smell...
July 18, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29939958/chronic-itch-impairs-mood-and-hpa-axis-function-in-mice-modulation-by-crfr1-antagonist
#16
Xin Zhao, Chao Yu, Feng Ye, Yan-Gui Wang, Qi-Yong Mei, Qing Ma, Wu-Geng Cui, Wen-Hua Zhou
Chronic itch is clinically correlated with the development of mood disorders such as anxiety and depression. Nonetheless, whether this relevance exists in rodents is unknown, and evidence demonstrating chronic itch can affect mood is lacking. The aim of this study is to characterize the affective consequences of chronic itch, and explore potential mechanisms and interventional strategy. We subjected mice to chronic itch by repetitive cutaneous treatment with acetone and diethylether followed by water (AEW) that models "dry skin...
November 2018: Pain
https://www.readbyqxmd.com/read/29939763/the-neurobiology-of-adaptation-to-seasons-relevance-and-correlations-in-bipolar-disorders
#17
Julia Maruani, George Anderson, Bruno Etain, Michel Lejoyeux, Frank Bellivier, Pierre A Geoffroy
Bipolar disorders (BDs) are severe and common psychiatric disorders. BD pathogenesis, clinical manifestations and relapses are associated with numerous circadian rhythm abnormalities. In addition, infradian fluctuations of mood, social activity, weight and sleep patterns are very frequent in BD. Disease course with a seasonal pattern (SP) occurs in approximately 25% of depressive and 15% of manic episodes, which is coupled to a more severe disease symptomatology. The pathophysiological mechanisms of seasonal effects in BD await clarification, with likely important clinical consequences...
September 2018: Chronobiology International
https://www.readbyqxmd.com/read/29937721/altered-light-conditions-contribute-to-abnormalities-in-emotion-and-cognition-through-hint1-dysfunction-in-c57bl-6-mice
#18
Yuan Zhou, Hao-Kang Zhang, Fei Liu, Gang Lei, Peng Liu, Tong Jiao, Yong-Hui Dang
In recent years, the environmental impact of artificial light at night has been a rapidly growing global problem, affecting 99% of the population in the US and Europe, and 62% of the world population. The present study utilized a mouse model exposed to long-term artificial light and light deprivation to explore the impact of these conditions on emotion and cognition. Based on the potential links between histidine triad nucleotide binding protein 1 (HINT1) and mood disorders, we also examined the expression of HINT1 and related apoptosis factors in the suprachiasmatic nucleus (SCN), prefrontal cortex (PFC), nucleus accumbens (NAc) and hippocampus (Hip)...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29913734/understanding-the-link-between-depression-and-pain
#19
Steven J Linton, Sofia Bergbom
Background and aims Patients seeking care for a pain problem very often also report symptoms of depression.In fact, depression is associated with the development of chronic pain as well as poor treatment results. Yet, the mechanisms by which depression and pain impact upon one another are not clear. This paper provides a critical review of the literature with the aim of shedding light on the relationship between pain and depression. Further, we introduce the Örebro Behavioral Emotion Regulation Model which may stimulate understanding in addition to research...
April 1, 2011: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29848008/postpartum-maternal-mental-health-is-associated-with-cognitive-development-of-hiv-exposed-infants-in-zimbabwe-a-cross-sectional-study
#20
Helen Mebrahtu, Victoria Simms, Rudo Chingono, Zivai Mupambireyi, Helen A Weiss, Patience Ndlovu, Ricky Malaba, Frances M Cowan, Lorraine Sherr
This study examines the cognitive profiles of infants born to HIV positive mothers in Zimbabwe. Caregivers with HIV exposed infants delivered in 30 clinics in two areas of Zimbabwe were recruited to the study. Of the 574 study participants, 562 caregiver-infant dyads with a biological HIV +ve mother and infant aged 0-24 months were interviewed. All infants were tested by a trained administrator for cognitive development on the Mullen Scales of Early Learning (MSEL). The Edinburgh Postnatal Depression Scale and Parental Stress Index-Short Form were completed by the mothers together with infant and caregiver socioeconomic characteristics...
June 2018: AIDS Care
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