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Circadian depression

Elizabeth Cash, C Riley Duck, Courtney Brinkman, Whitney Rebholz, Christy Albert, Mary Worthen, Mia Jusufbegovic, Liz Wilson, Jeffrey M Bumpous
OBJECTIVE: Depressive symptoms have demonstrated prognostic significance among head and neck cancer patients. Depression is associated with circadian disruption, which is prognostic in multiple other cancer types. We hypothesized that depressive symptoms would be associated with circadian disruption in head and neck cancer, that each would be related to poorer two-year overall survival, and that relationships would be mediated by tumor response to treatment. METHODS: Patients (N=55) reported on cognitive/affective and somatic depressive symptoms (PHQ-9) and wore an actigraph for six days to continuously record rest and activity cycles prior to chemoradiation...
August 16, 2018: Psycho-oncology
Mónica M C González
The influence of light on mammalian physiology and behavior is due to the entrainment of circadian rhythms complemented with a direct modulation of light that would be unlikely an outcome of circadian system. In mammals, physiological and behavioral circadian rhythms are regulated by the suprachiasmatic nucleus (SCN) of the hypothalamus. This central control allows organisms to predict and anticipate environmental change, as well as to coordinate different rhythmic modalities within an individual. In adult mammals, direct retinal projections to the SCN are responsible for resetting and synchronizing physiological and behavioral rhythms to the light-dark (LD) cycle...
2018: Frontiers in Neurology
Thomas A Wehr
In bipolar disorder, episodes of depression and mania are associated with dramatic disturbances in sleep, which experiments show are likely to contribute to the pathogenesis of the episodes. A recent finding that 18 patients' manic-depressive cycles oscillated in synchrony with biweekly surges in amplitude of the moon's tides provided a clue to the cause of the sleep-disturbances. Analyses of one of the patients' sleep-wake cycles suggest that his mood cycles arose when a circadian rhythm that normally is entrained to dawn and controls the daily onset of wakefulness became entrained instead to 24...
August 13, 2018: Translational Psychiatry
Heiðdís B Valdimarsdottir, Mariana G Figueiro, William Holden, Susan Lutgendorf, Lisa M Wu, Sonia Ancoli-Israel, Jason Chen, Ariella Hoffman-Peterson, Julia Granski, Nina Prescott, Alejandro Vega, Natalie Stern, Gary Winkel, William H Redd
BACKGROUND: Over a third of multiple myeloma (MM) patients report clinical levels of depression during autologous stem cell transplant (ASCT) hospitalization. We report preliminary results from a randomized clinical trial investigating the effect of Programmed Environmental Illumination (PEI) of hospital rooms on depression. METHODS: Patients (N = 187) scheduled to receive an ASCT were assessed for eligibility. Those who met study eligibility criteria (n = 44) were randomly assigned to one of two PEI conditions involving delivery of either circadian active bright white light (BWL) or circadian inactive dim white light (DWL) throughout the room from 7 to 10 am daily during hospitalization...
August 11, 2018: Cancer Medicine
Kari Grethe Hjorthaug Gallaher, Anastasiya Slyepchenko, Benicio N Frey, Kristin Urstad, Signe K Dørheim
Women often experience sleep disturbances and worsening sleep quality throughout pregnancy and postpartum. Circadian rhythms are closely linked to sleep problems and mood disorders. This systematic review provides a summary of studies of circadian rhythms and associated sleep problems and maternal distress, among postpartum women. Articles were idenitfied through a systematic literature search. Circadian rhythm disturbances were strongly correlated with depression, social factors and mothers`s exposure to light postpartum...
September 2018: Sleep Medicine Clinics
Jean-François Costemale-Lacoste, Romain Colle, Séverine Martin, Khalil El Asmar, Emanuel Loeb, Bruno Feve, Céline Verstuyft, Séverine Trabado, Florian Ferreri, Emmanuel Haffen, Mircea Polosan, Laurent Becquemont, Emmanuelle Corruble
BACKGROUND: 80-90% of patients with Major Depressive Episode (MDE) experience insomnia and up-to 50% severe insomnia. Glycogen Synthase Kinase-3β (GSK3B) is involved both in mood regulation and circadian rhythm. Since GSK3B polymorphisms could affect protein levels or functionality, we investigated the association of GSK3B polymorphisms with insomnia in a sample of depressed patients treated with antidepressants. METHODS: In this 6-month prospective real-world treatment study in psychiatric settings (METADAP), 492 Caucasian patients requiring a new antidepressant treatment were included and genotyped for five GSK3B Single Nucleotide Polymorphisms (SNPs) (rs6808874, rs6782799, rs2319398, rs13321783, rs334558)...
July 24, 2018: Journal of Affective Disorders
Senthil Kumaran Satyanarayanan, Huanxing Su, Yi-Wen Lin, Kuan-Pin Su
BACKGROUND: Circadian rhythm disruption underlies the pathophysiology of psychiatric disorders, especially depression. Both pharmacological and non-pharmacological strategies affecting endogenous circadian rhythms have been developed with specificity to alter the circadian dysfunction. The current management strategy with antidepressants is far from being satisfactory in addressing this issue. In recent years, attempts at discovering new antidepressants focused on a melatonergic system which is known to be altered in depression have led to a potential option for treatment of depression...
August 2, 2018: Current Pharmaceutical Design
Lindsay Melhuish Beaupre, Gregory M Brown, James L Kennedy
BACKGROUND: A core symptom of major depressive disorder (MDD), is sleep disturbance, specifically hypersomnia or insomnia. Sleep is highly regulated by circadian rhythms, controlled by circadian genes, that act through a series of feedback loops to regulate the sleep-wake cycle. OBJECTIVES: To the best of our knowledge, a systematic review regarding the core circadian genes and their role in MDD has not been published recently. More specifically, a review of these genes and their role in sleep disturbances in depressed individuals appears to have never been done...
July 30, 2018: World Journal of Biological Psychiatry
Joseph R Scarpa, Peng Jiang, Vance D Gao, Karrie Fitzpatrick, Joshua Millstein, Christopher Olker, Anthony Gotter, Christopher J Winrow, John J Renger, Andrew Kasarskis, Fred W Turek, Martha H Vitaterna
To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/6J × 129S1/SvImJ) F2 mice by measuring 283 affective and sleep phenotypes and profiling gene expression across four brain regions. We identified converging molecular bases for sleep and affective phenotypes at both the single-gene and gene-network levels. Using publicly available transcriptomic datasets collected from sleep-deprived mice and patients with major depressive disorder (MDD), we identified three cortical gene networks altered by the sleep/wake state and depression...
July 2018: Science Advances
Carina Soares-Cunha, Bárbara Coimbra, Sónia Borges, Ana Verónica Domingues, Deolinda Silva, Nuno Sousa, Ana João Rodrigues
Stress or high levels of glucocorticoids (GCs) during developmental periods is known to induce persistent effects in the neuroendocrine circuits that control stress response, which may underlie individuals' increased risk for developing neuropsychiatric conditions later in life, such as anxiety or depression. We developed a rat model (Wistar han) of mild exposure to unpredictable prenatal stress (PS), which consists in a 4-h stressor administered three times per week on a random basis; stressors include strobe lights, noise and restrain...
2018: Frontiers in Behavioral Neuroscience
Connor Martin, Dennis Fricke, Abisha Vijayashanthar, Courtney Lowinger, Dimitris Koutsomitis, Daniel Popoola, Michael Hadjiargyrou, David E Komatsu, Panayotis K Thanos
Chronic oral methylphenidate (MP) exposure in rats is associated with numerous developmental and behavioral consequences. The present study investigated the persistence of the effects of chronic oral MP exposure after abstinence from MP use. Male and female rats were exposed to daily orally self-administered water, low dose MP (LD), or high dose (HD) MP for 13 weeks, followed by a 4-week abstinence period. Fluid, food consumption and bodyweights were monitored and animals were tested for locomotor activity, anxiety- and depressive-like symptoms, learning and memory, and social behavior during both the treatment and abstinence phases of the experiment...
September 2018: Pharmacology, Biochemistry, and Behavior
Changjiu Zhao, Stephen C Gammie
Nuclear receptor subfamily 1, group D, member 1 (Nr1d1) (also known as Rev-erb alpha) has been linked to circadian rhythm regulation, mood-related behaviour and disorders associated with social deficits. Recent work from our laboratory found striking decreases in Nr1d1 in the nucleus accumbens (NAc) in the maternal condition and indirect evidence that Nr1d1 was interacting with numerous addiction and reward-related genes to modulate social reward. In this study, we applied our insights from the maternal state to nonparental adult mice to determine whether decreases in Nr1d1 expression in the NAc via adeno-associated viral (AAV) vectors and short hairpin RNA (shRNA)-mediated gene knockdown were sufficient to modulate social behaviours and mood-related behaviours...
July 20, 2018: European Journal of Neuroscience
Inken Kirschbaum-Lesch, Stephanie Gest, Tanja Legenbauer, Martin Holtmann
OBJECTIVE: Bright light therapy (BLT) has recently come into increasing focus in the treatment of adolescent depression, whereby light glasses today appear to be more feasible than light therapy boxes. This study investigated the feasibility and efficacy of 4 weeks of BLT with light glasses. It also analyzed whether a treatment duration of 4 weeks of BLT yields larger effects than the 2 weeks of BLT investigated in previous studies. METHODS: This first open-label, single-arm, prospective clinical trial pursued a naturalistic approach: 39 inpatients aged 12-18 years with moderate or severe depression received 4 weeks of morning BLT with light glasses in addition to usual treatment...
July 17, 2018: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
A T Peters, R A Smith, M T Kassel, M Hagan, P Maki, A Van Meter, E M Briceño, K A Ryan, A L Weldon, S L Weisenbach, M N Starkman, S A Langenecker
BACKGROUND: Decreased volume and disrupted function in neural structures essential for memory formation (e.g. medial temporal lobe and prefrontal cortex) are common among individuals with depression. Hypothalamic-pituitary-axis function, as reflected by measurement of cortisol levels, is linked to neural activity during memory encoding in healthy people. However, it is not as well understood whether cortisol is associated with alterations in fronto-temporal recruitment during memory encoding in depression...
July 7, 2018: Journal of Affective Disorders
Esther Rosenkranz, Andrea Thissen, Sonja Siegel, Marc Piroth, Hans Clusmann, Judith Gebauer, Georg Brabant, Ilonka Kreitschmann-Andermahr
OBJECTIVE: Cranial irradiation for brain tumours or leukaemias has been related to cognitive, endocrine and psychosocial late effects as well as sleep disturbances and increased daytime sleepiness. Studies suggest that cranial irradiation might impact on pineal melatonin secretion. Melatonin is an important regulator in human circadian rhythms and the sleep-wake cycle. The objective of this study was to investigate melatonin secretion, subjective sleep parameters and their interplay in a cohort of cranially irradiated head and brain tumour and leukaemia survivors at least 3 years after radiotherapy...
July 13, 2018: Clinical Endocrinology
Marina de Tommaso, Marianna Delussi
BACKGROUND: Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-sectional study aimed to: 1. Assess the circadian rhythm of migraine attacks onset in a large patients' population selected in a headache center and including episodic and chronic migraine 2. Analyze the principal characteristic of the different onset time groups 3. Verify if migraine features, particularly those associated to chronic and disabling migraine, could be discriminant factors for time of onset group...
July 2, 2018: BMC Neurology
Xin Zhao, Chao Yu, Feng Ye, Yan-Gui Wang, Qi-Yong Mei, Qing Ma, Wu-Geng Cui, Wen-Hu Zhou
Chronic itch is clinically correlated with the development of mood disorders such as anxiety and depression. Nonetheless, whether this relevance exists in rodents is unknown, and evidence demonstrating chronic itch can affect mood is lacking. The aim of this study is to characterize the affective consequences of chronic itch, and explore potential mechanisms and interventional strategy. We subjected mice to chronic itch by repetitively cutaneous treatment with acetone and diethylether followed by water (AEW) that models "dry skin"...
June 22, 2018: Pain
Julia Maruani, George Anderson, Bruno Etain, Michel Lejoyeux, Frank Bellivier, Pierre A Geoffroy
Bipolar disorders (BDs) are severe and common psychiatric disorders. BD pathogenesis, clinical manifestations and relapses are associated with numerous circadian rhythm abnormalities. In addition, infradian fluctuations of mood, social activity, weight and sleep patterns are very frequent in BD. Disease course with a seasonal pattern (SP) occurs in approximately 25% of depressive and 15% of manic episodes, which is coupled to a more severe disease symptomatology. The pathophysiological mechanisms of seasonal effects in BD await clarification, with likely important clinical consequences...
June 25, 2018: Chronobiology International
Daisuke Tamada, Tetsuhiro Kitamura, Mitsuyoshi Takahara, Toshihisa Tanaka, Masatoshi Takeda, Michio Otsuki, Iichiro Shimomura
Circadian variations impact thyrotropin (TSH) secretion; in Cushing's syndrome (CS) patients, the nocturnal serum TSH surge is abolished. The aim of this prospective study is to examine whether serum TSH surge may be a useful diagnostic method for CS. This prospective study recruited 136 inpatients for differential diagnosis of CS or subclinical CS (SCS), and 21 inpatients with depression at Osaka University Hospital. Serum TSH surge was assessed by the midnight-to-morning serum TSH ratio (2300-2400 h to 0800-0900 h)...
June 19, 2018: Endocrine Journal
Suliman Khan, Ghulam Nabi, Lunguang Yao, Rabeea Siddique, Wasim Sajjad, Sunjeet Kumar, Pengfei Duan, Hongwei Hou
The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders...
2018: International Journal of Biological Sciences
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