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https://www.readbyqxmd.com/read/30118861/expression-purification-and-molecular-characterization-of-a-novel-transcription-factor-kccbf3-from-kandelia-candel
#1
Zhaokui Du, Junmin Li
Kandelia candel, a major species of mangrove in the tropical and subtropical area, is susceptible to low temperature in winter. K. candel was introduced into Zhejiang Province (the northern margin of South China) several decades ago, and suffered from low temperature causing growth retardation, in server cases, even death. To explore the molecular mechanisms of cold acclimation in K. candel, a novel C-repeat binding factor gene KcCBF3 (Genbank accession no. KF111715) of 729 bp open reading frame (ORF) encoding a protein of 242 amino acid residues was isolated, expressed, purified and characterized...
August 14, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/30112168/the-role-of-argon-in-stroke
#2
REVIEW
Xiang Li, Zhu-Wei Zhang, Zhong Wang, Jin-Quan Li, Gang Chen
Stroke, also known as "cerebrovascular accident", is an acute cerebrovascular disease that is caused by a sudden rupture of blood vessels in the brain or obstruction of the blood supply by blockage of blood vessels, thus including hemorrhagic and ischemic strokes. The incidence of ischemic stroke is higher than that of hemorrhagic stroke, and accounts for 80% of the total number of strokes. However, the mortality rate of hemorrhagic stroke is relatively high. Internal carotid artery and vertebral artery occlusion and stenosis can cause ischemic stroke, and especially males over 40 years of age are at a high risk of morbidity...
April 2018: Medical Gas Research
https://www.readbyqxmd.com/read/30109841/whole-exome-sequencing-reveals-doubly-novel-heterozygous-myosin-binding-protein-c-and-titin-mutations-in-a-chinese-patient-with-severe-dilated-cardiomyopathy
#3
Liang-Liang Fan, Ya-Qin Chen, Hao Huang, Jie-Yuan Jin, Jing-Jing Li, Zhi-Ping Tan
BACKGROUND: Dilated Cardiomyopathy is a serious heart disorder that may induce sudden cardiac death and heart failure. Significant progress has been made in understanding the molecular basis of dilated cardiomyopathy. In previous studies, mutations in more than fifty genes have been identified in dilated cardiomyopathy patients. The purpose of this study was to detect the genetic lesion in a family from the central south of China affected by severe dilated cardiomyopathy. METHODS: Whole-exome sequencing combined with cardiomyopathy-related genes list were used to analyse the mutations of the proband...
August 15, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30107857/rabies-virus-transmission-via-solid-organs-or-tissue-allotransplantation
#4
REVIEW
Xue-Xin Lu, Wu-Yang Zhu, Gui-Zhen Wu
BACKGROUND: Rabies, for which the mortality rate is almost 100%, is a zoonotic viral disease that can be transmitted via solid organs or tissue allotransplantation. Dozens of deaths from rabies via solid organs or tissues allotransplantation (ROTA) have been documented during the last decades. In 2015 and 2016, two cases of rabies virus transmission via solid organs or tissue allotransplantation were reported in China, which further underscore the risk and importance of this special type of rabies for organ transplant recipients...
August 15, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/30104808/a-study-of-community-acquired-mycoplasma-pneumoniae-in-yantai-china
#5
Hong-Xia Yu, Mao-Mao Zhao, Zeng-Hui Pu, Yuan-Rong Ju, Yan Liu
Introduction: Community-acquired pneumonia (CAP) is a global disease responsible for a large number of deaths, with significant economic impact. As diagnostic tools have increased in sensitivity, understanding of the etiology of CAP has begun to change. Mycoplasma pneumoniae is one of the major pathogens causing CAP. Macrolides and related antibiotics are first-line treatments for M. pneumoniae . Macrolide resistance has been spreading for 15 years and now occurs in worldwide. We undertook the first study on macrolide resistance of M...
June 30, 2018: Colombia Médica: CM
https://www.readbyqxmd.com/read/30103690/using-baidu-index-to-nowcast-hand-foot-mouth-disease-in-china-a-meta-learning-approach
#6
Yang Zhao, Qinneng Xu, Yupeng Chen, Kwok Leung Tsui
BACKGROUND: Hand, foot, and mouth disease (HFMD) has been recognized as one of the leading infectious diseases among children in China, which causes hundreds of annual deaths since 2008. In China, the reports of monthly HFMD cases usually have a delay of 1-2 months due to the time needed for collecting and processing clinical information. This time lag is far from optimal for policymakers making decisions. To alleviate this information gap, this study uses a meta learning framework and combines publicly Internet-based information (Baidu search queries) for real-time estimation of HFMD cases...
August 13, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30100578/association-of-plasma-vitamin-c-concentration-to-total-and-cause-specific-mortality-a-16-year-prospective-study-in-china
#7
Shao-Ming Wang, Jin-Hu Fan, Philip R Taylor, Tram Kim Lam, Sanford M Dawsey, You-Lin Qiao, Christian C Abnet
BACKGROUND: Vitamin C insufficiency occurs across many countries and has been hypothesised to increase risk of various diseases. Few prospective studies with measured circulating vitamin C have related deficiency to disease mortality, particularly in low-income and middle-income countries. METHODS: We randomly selected 948 subjects (473 males and 475 females) aged 53-84 years from a Chinese cohort and measured meta-phosphoric acid-preserved vitamin C concentrations in plasma samples collected in 1999-2000...
August 12, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/30089305/inpatient-cost-of-stroke-in-beijing-a-descriptive-analysis
#8
Xuejun Yin, Lieyu Huang, Xiaowei Man, Yan Jiang, Xuan Zhao, Liying Zhao, Wei Cheng
BACKGROUND: Stroke has been the leading cause of death in China and contributed almost one-third to stroke deaths worldwide. The rising cost of stroke treatment is of great concern, but has not been thoroughly studied. This study aimed to analyze stroke in-hospital charges by subtypes, age, and sex and investigate potential factors associated with the cost of per stay. METHODS: The research was a retrospective observational study based on patients with a primary diagnosis of stroke from 31 hospitals in Beijing...
August 8, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/30087583/cost-effectiveness-analysis-of-folfox4-and-sorafenib-for-the-treatment-of-advanced-hepatocellular-carcinoma-in-china
#9
Shukui Qin, Eliza Kruger, Seng Chuen Tan, Shuqun Cheng, Nanya Wang, Jun Liang
Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally. In China, sorafenib and oxaliplatin plus infusional-fluorouracil/leucovorin (FOLFOX4) are approved for the systemic treatment of advanced HCC. This study compared the cost-effectiveness of these therapies from a healthcare system perspective and a patient perspectives. Methods: A Markov model was constructed using overall and progression-free survival rates and adverse event (AE) rate from two randomized controlled studies of advanced HCC patients from Asia: EACH for FOLFOX4 and ORIENTAL for sorafenib...
2018: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/30085299/enhanced-th1-th2-mixed-immune-responses-elicited-by-polyethyleneimine-adjuvanted-influenza-a-h7n9-antigen-ha1-2-in-chickens
#10
Li Song, Dan Xiong, Maozhi Hu, Xinan Jiao, Zhiming Pan
Influenza A (H7N9) viruses have caused severe human infections and deaths every year in China since 2013. To reduce the risk of human infection and prevent a new influenza pandemic, there is a pressing need to develop safe and effective anti-H7N9 vaccines for poultry. Polyethyleneimine (PEI) is an organic polycation used extensively as a transfection reagent for decades. Although the adjuvant potential of PEI is well studied in mammals, its applicability and immune characteristics to avian species are still very rare...
August 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/30083901/estimating-short-term-mortality-and-economic-benefit-attributable-to-pm-10-exposure-in-china-based-on-benmap
#11
Li Chen, Jian Mao, Mengshuang Shi, Hui Zhang, Yanling Sun, Shuang Gao, Suhuan Li, Miyuan Li, Zhenxing Ma, Zhipeng Bai
With the rapidly booming economy, China has been suffering from serious particulate matter (PM) pollution in recent years. In order to improve the air quality, Chinese government issued a new China National Ambient Air Quality Standard (No. GB3095-2012) in 2012. In this study, PM10 exposure level was simulated based on the data of 912 newly constructed monitoring sites and Voronoi Neighborhood Averaging (VNA) interpolation method. It is widely accepted that PM10 can cause short-term health effects. We calculated the short-term health benefit due to decreasing PM10 concentration to the levels of China National Ambient Air Quality Standard based on Environmental Benefits Mapping and Analysis Program (BenMAP)...
August 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30082621/assessing-effect-modification-of-excess-winter-death-by-causes-of-death-and-individual-characteristics-in-zhejiang-province-china-a-multi-community-case-only-analysis
#12
Yiling He, Xuehai Zhang, Meng Ren, Junzhe Bao, Cunrui Huang, Shakoor Hajat, Adrian G Barnett
Mortality in many parts of the world has a seasonal pattern, with a marked excess of deaths during winter. To date, however, there is very little published evidence on the nature of this wintertime excess in low- and middle-income countries. In this study, we aimed to quantify the extent of the death peak in winter and to assess effect modification on excess winter death (EWD) by individual characteristics and cause of deaths in China. We used a Cosinor model to examine seasonal patterns for specific causes of deaths and a case-only analysis of deaths in winter compared with other seasons to assess effect modification by individual characteristics...
August 6, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30081866/body-mass-index-and-cancer-risk-among-chinese-patients-with-type-2-diabetes-mellitus
#13
Hui-Lin Xu, Min-Lu Zhang, Yu-Jie Yan, Fang Fang, Qi Guo, Dong-Li Xu, Zuo-Feng Zhang, Fen Zhang, Nai-Qing Zhao, Wang-Hong Xu, Guo-You Qin
BACKGROUND: Obesity and diabetes are two risk factors for cancer. To evaluate the association of body mass index (BMI) with cancer risk in diabetic patients may improve current understanding of potential mechanisms. METHODS: A retrospective cohort study was conducted in 51,004 newly diagnosed T2DM patients derived from an electronic health record (EHR) database of Minhang district in Shanghai, China. Incident cancer cases and all-cause deaths occurred before September 30, 2015 were identified by linking with the Shanghai Cancer Registry and the Shanghai Vital Statistics...
August 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30081597/meta-prediction-of-mthfr-gene-polymorphism-and-air-pollution-on-the-risks-of-congenital-heart-defects-worldwide-a-transgenerational-analysis
#14
Hsiao-Ling Yang, Ya-Ling Yang, Chong Ho Yu, S Pamela K Shiao
Congenital heart disease (CHD) is the leading cause of death in children, and is affected by genetic and environmental factors. To investigate the association of air pollution with methylene-tetrahydrofolate reductase ( MTHFR ) polymorphisms and the risk of CHD, we included 58 study groups of children and parents, with 12,347 cases and 18,106 controls worldwide. Both MTHFR C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents...
August 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30081099/tubp1-protein-lead-to-mitochondria-mediated-apoptotic-cell-death-in-verticillium-dahlia
#15
Hong Zeng, Tao Li, Jun Tian, Li-Li Zhang
Verticillium wilt, caused by Verticillium dahliae, is a cancer of cotton which affects cotton quality and yield in China. In our previous study, a novel anti-Verticillium dahliae protein TUBP1 was obtained from Bacillus axarquiensis. Then, we have systematically studied the anti-V. dahliae activity and the pore formation action of TUBP1 protein on V. dahliae membrane. In present study, we provide detailed whether TUBP1 protein induced mitochondrial damaged and mitochondria-mediated apoptotic cell death in V...
August 3, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/30074255/novel-thrb-mutation-analysis-in-congenital-hypothyroidism-with-thyroid-dysgenesis
#16
Zhixia Zhou, Chengyu Yang, Fuyan Lv, Wenmiao Liu, Shengli Yan, Hongwei Zang, Miaomiao Li, Fang Wang, Yucui Zang, Shiguo Liu
Thyroid dysgenesis (TD) accounts for most cases of congenital hypothyroidism. Although mutations in thyroid hormone receptor β (THRB) have been identified in TD, the mutational spectrum of THRB and phenotype-genotype correlations have not been fully elucidated. In this study, we aimed to find mutations of THRB, examine the functions of these mutations, and attempt to elucidate the relationship between THRB and TD. Thus, we screened the exons of THRB in 280 patients with TD and 200 normal subjects in samples collected from China...
August 3, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30064389/construction-of-china-cardiovascular-health-index
#17
Yingying Jiang, Fan Mao, Yichong Li, Jing Liu, Yan Zhang, Yong Jiang, Dong Zhao, Weiwei Chen, Stephen Nicholas, Yong Huo, Junbo Ge, Linhong Wang, Maigeng Zhou
BACKGROUND: Cardiovascular disease (CVD) is not only the primary cause of death in developed western countries, but also its disease burden is increasing in China. The purpose of constructing population cardiovascular health index is to monitor, compare and evaluate disease burden, influencing factors and prevention and control levels of Chinese population cardiovascular disease in order to provide evidence to improve population cardiovascular health. METHODS: This study collected multi-source data and constructed China Cardiovascular Health Index (CHI) using literature review, questionnaire surveys, Delphi method and Analytical Hierarchy Process (AHP) model...
July 31, 2018: BMC Public Health
https://www.readbyqxmd.com/read/30060721/mortality-and-prognostic-factors-in-chinese-patients-with-systemic-lupus-erythematosus
#18
L Mu, Y Hao, Y Fan, H Huang, X Yang, A Xie, X Zhang, L Ji, Y Geng, Z Zhang
Objectives To investigate the mortality and causes of death in Chinese patients with systemic lupus erythematosus. Methods We collected the clinical data of all consecutive adult systemic lupus erythematosus patients at the Rheumatology department of Peking University First Hospital between January 2007 and December 2015. The primary causes of death were identified, the standardized mortality ratio and years of life lost were calculated, and the survival and variables associated with mortality were determined by Kaplan-Meier and Cox regression analysis respectively...
September 2018: Lupus
https://www.readbyqxmd.com/read/30060450/predictions-of-preterm-birth-from-early-pregnancy-characteristics-born-in-guangzhou-cohort-study
#19
Jian-Rong He, Rema Ramakrishnan, Yu-Mian Lai, Wei-Dong Li, Xuan Zhao, Yan Hu, Nian-Nian Chen, Fang Hu, Jin-Hua Lu, Xue-Ling Wei, Ming-Yang Yuan, Song-Ying Shen, Lan Qiu, Qiao-Zhu Chen, Cui-Yue Hu, Kar Keung Cheng, Ben Willem J Mol, Hui-Min Xia, Xiu Qiu
Preterm birth (PTB, <37 weeks) is the leading cause of death in children <5 years of age. Early risk prediction for PTB would enable early monitoring and intervention. However, such prediction models have been rarely reported, especially in low- and middle-income areas. We used data on a number of easily accessible predictors during early pregnancy from 9044 women in Born in Guangzhou Cohort Study, China to generate prediction models for overall PTB and spontaneous, iatrogenic, late (34⁻36 weeks), and early (<34 weeks) PTB...
July 27, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30060304/-a-cohort-study-on-body-mass-index-and-risk-of-all-cause-mortality-among-hypertensive-population
#20
X J Liu, B Y Wang, Y C Ren, Y Zhao, D C Liu, D D Zhang, X Chen, L L Liu, C Cheng, F Y Liu, Q G Zhou, G Z Chen, S H Hong, D Liu, S Q Hu, M Zhang, D S Hu
Objective: To investigate the relationship between body mass index (BMI) and all-cause mortality in hypertensive population. Methods: All participants were selected from a prospective cohort study based on a rural population from Henan province, China. Cox proportional hazards regression models were used to estimate the associations of different levels of BMI stratification with all-cause mortality. Restricted cubic spline models were used to detect the dose-response relation. Results: Among the 5 461 hypertensive patients, a total of 31 048...
July 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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