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https://www.readbyqxmd.com/read/30343136/effects-of-dissolution-medium-ph-and-simulated-gastrointestinal-contraction-on-drug-release-from-nifedipine-extended-release-tablets
#1
Zongming Gao, Cindy Ngo, Wei Ye, Jason D Rodriguez, David Keire, Dajun Sun, Hong Wen, Wenlei Jiang
In contrast to nifedipine matrix-based extended-release dosage forms, the osmotic pump drug delivery systems have a zero-order drug release independent of external variables such as pH, agitation rate, and dissolution media. The objective of this study focuses on the in vitro evaluation of the mechanical properties of osmotic pump and polymer matrix-based formulations in dissolution media and the potential impacts that media pH and simulated gastrointestinal contraction have on drug release. Two strengths of osmotic pump product A, and polymer matrix-based product B were used in this study...
October 18, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30342405/photocatalytic-degradation-of-ibuprofen-in-water-using-tio-2-uv-and-g-c-3-n-4-visible-light-study-of-intermediate-degradation-products-by-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#2
Marta Jiménez-Salcedo, Miguel Monge, María Teresa Tena
The photocatalytic degradation of ibuprofen with TiO2 nanoparticles (NPs) and UV light and with graphitic carbon nitride (g-C3 N4 ) 2D nanosheets and visible light are proposed and compared as advanced oxidation treatments for the removal of ibuprofen in water. By-products formed with both photocatalytic systems have been tentatively identified based on the results of ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry, using a quadrupole-time of flight mass spectrometer in positive and negative ionization modes, which allowed to obtain the elementary composition of their precursors and fragment ions...
October 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/30340334/a-near-infrared-fluorescent-probe-based-on-a-fret-rhodamine-donor-linked-to-a-cyanine-acceptor-for-sensitive-detection-of-intracellular-ph-alternations
#3
Yibin Zhang, Jianheng Bi, Shuai Xia, Wafa Mazi, Shulin Wan, Logan Mikesell, Rudy L Luck, Haiying Liu
A fluorescence resonance energy transfer (FRET)-based near-infrared fluorescent probe ( B⁺ ) for double-checked sensitive detection of intracellular pH changes has been synthesized by binding a near-infrared rhodamine donor to a near-infrared cyanine acceptor through robust C-N bonds via a nucleophilic substitution reaction. To demonstrate the double-checked advantages of probe B⁺ , a near-infrared probe ( A ) was also prepared by modification of a near-infrared rhodamine dye with ethylenediamine to produce a closed spirolactam residue...
October 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30340310/anaerobic-ammonium-oxidation-coupled-to-iron-reduction-in-constructed-wetland-mesocosms
#4
Weitao Shuai, Peter R Jaffé
Acidimicrobiaceae sp. A6 (referred to as A6) was recently identified as playing a key role in the Feammox process (ammonium oxidation coupled to iron reduction). Two constructed wetlands (CW) were built and bioaugmented with A6 to determine if, under the right conditions, Feammox can be enhanced in CWs by having strata with higher iron content. Hence, the solid stratum in the CWs was sand, and one CW was augmented with ferrihydrite. Vertical ammonium (NH4 + ) concentration profiles in the CW mesocosms were monitored regularly...
January 15, 2019: Science of the Total Environment
https://www.readbyqxmd.com/read/30340278/assessment-of-the-toxic-potential-of-rainwater-precipitation-first-evidence-from-a-case-study-in-three-greek-cities
#5
Dimitris Vlastos, Maria Antonopoulou, Alexia Lavranou, Ioanna Efthimiou, Stefanos Dailianis, Dimitra Hela, Dimitra Lambropoulou, Anastasia K Paschalidou, Pavlos Kassomenos
Considering the necessity to monitor rainwater quality and the limited existing data regarding wet precipitations' toxic potential, the toxic potential of rainwater (RW) samples collected in three cities of Western Greece (Corfu, Agrinion and Patras) during May, October, November, and December of 2014 were investigated. The relationship of the adverse effects obtained, against cytokinesis block micronucleus (CBMN) and Vibrio fischeri bioluminescence (Microtox) assays with the physicochemical characteristics, the heavy metal concentration levels of rainwater samples and the meteorological parameters governing the climatic conditions in each region, were studied in detail...
January 15, 2019: Science of the Total Environment
https://www.readbyqxmd.com/read/30339943/tumor-microenvironment-controlled-nanomicelles-with-aie-property-for-boosting-cancer-therapy-and-apoptosis-monitoring
#6
Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang
Mild acidity matrix, rich blood vessels and special biomarkers constitute the primary tumor microenvironment. Nanoparticles could change their physicochemical characteristics by functionalizing a series of moieties which is responsive towards pH or specific markers. So precise regulation of nanocarrier-based drug delivery systems by the tumor microenvironment has showed great potential for theranostics. Herein, we developed a smart nano delivery system STD-NM, showing tumor microenvironment responsive targeting, efficient drug delivery and precise evaluation of therapeutic effect in vivo...
October 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/30338123/ph-responsive-superstructures-prepared-via-the-assembly-of-fe-3-o-4-amphipathic-janus-nanoparticles
#7
Shuang Cai, Bin Luo, Xiaohui Zhan, Xiaoxi Zhou, Fang Lan, Qiangying Yi, Yao Wu
The strategy of using Fe3 O4 amphiphilic Janus nanoparticles (Fe3 O4 @AJNPs) bearing β-cyclodextrin (β-CD) and aminopyridine (APD) functionalized polymethyl methacrylate (PGMA) to construct pH-stimuli responsive co-assemblies through host-guest interactions between β-CD and APD was proposed. The spherical co-assemblies with an average diameter about 210 nm were excellent magnetic responsive and quite stable even up to 2 months in deionized water. The pH-liable capability of these co-assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion complexes...
October 2018: Regenerative Biomaterials
https://www.readbyqxmd.com/read/30337166/magnetic-solid-phase-extraction-based-on-60-fullerene-functionalization-of-magnetic-nanoparticles-for-the-determination-of-sixteen-polycyclic-aromatic-hydrocarbons-in-tea-samples
#8
Dian-Bing Zhou, Xuan Sheng, Fang Han, Yan-Yun Hu, Lei Ding, Ya-Ling Lv, Wei Song, Ping Zheng
[60]Fullerene functionalized magnetic nanoparticles (Fe3 O4 @SiO2 @C60 ) were prepared and characterized by transmission electron microscope, vibrating sample magnetometer and infrared spectroscopy. The Fe3 O4 @SiO2 @C60 was then applied for the magnetic solid-phase extraction of 16 priority pollutants polycyclic aromatic hydrocarbons (PAHs) in tea samples. The analyses were performed on gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM) mode. Parameters affecting the extraction, including sorbent amount, desorption solvent, salt concentration, pH and extraction time were investigated...
October 10, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/30337130/-patient-safety-in-psychiatric-hospitalization-what-incidents-are-reported-and-managed
#9
A J Cruz Antolin, J M Otin Grasa, R Mir Abellán, A Miñambres Donaire, I Grimal Melendo, M L de la Puente Martorell
INTRODUCTION: Reporting and management systems monitoring patient safety incidents (PSIs) facilitate the understanding of mechanisms of action and allow work on improvement activities to minimise their occurrence. In our country, little is known about the adverse effects of healthcare during psychiatric hospitalisation (PH). The aim of this study is to determine the occurrence and characteristics of the PSIs, as well as the improvement actions resulting from them, in the PH services being offered at the Parc Sanitari Sant Joan de Deu (an institution specialized in mental healthcare)...
October 15, 2018: Journal of healthcare quality research
https://www.readbyqxmd.com/read/30336967/electrocoagulation-of-wastewater-using-aluminum-iron-and-magnesium-electrodes
#10
Tanner Ryan Devlin, Maciej S Kowalski, Efren Pagaduan, Xugang Zhang, Victor Wei, Jan A Oleszkiewicz
Primary influent from a municipal wastewater treatment plant was electrochemically treated with sacrificial aluminum, iron, and magnesium electrodes. The influence of sacrificial anodes on the removal of chemical oxygen demand, total nitrogen, total phosphorus, and orthophosphate during sedimentation was investigated. Nitrification kinetics were assessed on treated supernatant and biogas production was monitored on settled solids. Changes in alkalinity, conductivity, and pH were also recorded. Aluminum and iron electrodes provided high rates of orthophosphate removal (i...
October 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/30328916/preservation-of-the-vagus-nerves-in-subtotal-esophagectomy-without-thoracotomy
#11
Eduardo Crema, Júverson Alves Terra Júnior, Marisa Carvalho Borges, Carlos Alfredo Salci Queiroz, Luciana Arantes Soares, Alex Augusto da Silva
PURPOSE: To evaluate the outcome of transhiatal esophagectomy without thoracotomy and with preservation of the vagal trunks for the treatment of advanced megaesophagus. METHODS: Between March 2006 and September 2017, it was performed 136 transhiatal esophagectomies without thoracotomy by laparoscopy, with preservation of the vagus nerves. All patients were evaluated pre and postoperatively for respiratory and nutritional aspects Post operatively, some surgical aspects were evaluated like radiology and endoscopy of the digestive tract...
September 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30326981/supplementation-of-a-clay-mineral-based-product-modulates-plasma-metabolomic-profile-and-liver-enzymes-in-cattle-fed-grain-rich-diets
#12
E Humer, I Kröger, V Neubauer, N Reisinger, Q Zebeli
Grain-rich diets often lead to subacute ruminal acidosis (SARA) impairing rumen and systemic cattle health. Recent data suggest beneficial effects of a clay mineral (CM)- based product on the rumen microbiome of cattle during SARA. This study sought to investigate whether the CM supplementation can counteract SARA-induced perturbations of the bovine systemic health. The study used an intermittent diet-induced SARA-model with eight dry Holstein cows receiving either no additive as control or CM via concentrates (n=8 per treatment)...
October 17, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/30319582/proteome-response-of-staphylococcus-xylosus-dsm-20266t-to-anaerobiosis-and-nitrite-exposure
#13
Laura Quintieri, Marzia Giribaldi, Maria Gabriella Giuffrida, Teresa Maria Creanza, Nicola Ancona, Laura Cavallarin, Maria De Angelis, Leonardo Caputo
The viability and competitiveness of Staphylococcus xylosus in meat mostly depend on the ability to adapt itself to rapid oxygen and nutrients depletion during meat fermentation. The utilization of nitrite instead of oxygen becomes a successful strategy for this strain to improve its performance in anaerobiosis; however, metabolic pathways of this strain underlying this adaptation, are partially known. The aim of this study was to provide an overview on proteomic changes of S. xylosus DSM 20266T cultured under anaerobiosis and nitrite exposure...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30319177/fluorescent-probes-based-on-%C3%AF-conjugation-modulation-between-hemicyanine-and-coumarin-moieties-for-ratiometric-detection-of-ph-changes-in-live-cells-with-visible-and-near-infrared-channels
#14
Shuai Xia, Jianbo Wang, Jianheng Bi, Xiao Wang, Mingxi Fang, Tyler Phillips, Aslan May, Nathan Conner, Marina Tanasova, Fen-Tair Luo, Haiying Liu
We report two ratiometric fluorescent probes based on π-conjugation modulation between coumarin and hemicyanine moieties for sensitive ratiometric detection of pH alterations in live cells by monitoring visible and near-infrared fluorescence changes. In a π-conjugation modulation strategy, a coumarin dye was conjugated to a near-infrared hemicyanine dye via a vinyl connection while lysosome-targeting morpholine ligand and o-phenylenediamine residue were introduced to the hemicyanine dye to form closed spirolactam ring structures in probes A and B , respectively...
July 15, 2018: Sensors and Actuators. B, Chemical
https://www.readbyqxmd.com/read/30317833/benchmarking-of-a-simple-scintigraphic-test-for-gastro-oesophageal-reflux-disease-that-assesses-oesophageal-disease-and-its-pulmonary-complications
#15
Leticia Burton, Gregory L. Falk, Stephen Parsons, Mel Cusi, Hans Van Der Wall
Objectives: Gastro-oesophageal reflux disease (GORD) is both common and troubling with a prevalence of 20-40%. We assessed the utility of a scintigraphic reflux study to evaluate the oesophageal and extra-oesophageal manifestation of disease compared to the standard tests such as pH monitoring and manometry. Methods: Patients were recruited into a prospective database of referrals to a tertiary referral center for either resistance to maximal medical therapy or extra-oesophageal symptoms of GORD...
October 9, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/30316129/a-highly-sensitive-and-selective-fluorescent-probe-for-determination-of-cu-ii-and-application-in-live-cell-imaging
#16
Ying Fu, Xiao-Xiao Pang, Zhi-Qiang Wang, Qiong Chai, Fei Ye
A highly sensitive fluorescent probe, 2‑butyl‑6‑(2‑ethylidenehydrazinyl)‑1H‑benzo[de]isoquinoline‑1,3(2H)‑dione (P) has been designed and synthesized to detect Cu2+ in CH3 CN-HEPES (4:1, v/v, pH = 7.4) solution. This probe functions via a distinctive hydrolysis mechanism through Cu2+ -promoted accompany by extinction of the fluorescent and other competing metal ions did not showed any interference. The limit of detection toward Cu2+ was calculated of 320 nM. Probe P was not only successfully used for the determination of trace level Cu2+ in the CH3 CN-HEPES (4:1, v/v, pH = 7...
October 8, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30313042/the-relationship-between-adenoid-hypertrophy-and-gastroesophageal-reflux-disease-a-meta-analysis
#17
Xun Niu, Zeng-Hong Wu, Xi-Yue Xiao, Xiong Chen
BACKGROUND: Gastroesophageal reflux disease (GERD) is believed to be associated with various manifestations in the otorhinolaryngology and has been found to be an additional risk factor for adenoid hypertrophy, but the causal relation between them is under controversial. We thus performed a meta-analysis to grade the strength of evidence and systematically explore whether adenoid hypertrophy correlates with GERD in the literature. METHODS: A systematic literature search was performed using Medline via PubMed, Embase, CNKI, and Web of Science...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312795/zirconium-metal-organic-frameworks-based-dgt-technique-for-in-situ-measurement-of-dissolved-reactive-phosphorus-in-waters
#18
Wenxiu Qin, Yue Gu, Guozhong Wang, Tianxing Wu, Haimin Zhang, Xiaoxian Tang, Yunxia Zhang, Huijun Zhao
In an effort to provide early warnings for the occurrence of eutrophication, it is highly desirable to develop an accurate and efficient technique to ensure continuous monitoring of dissolved reactive phosphorus (DRP) in the aquatic environment from the viewpoint of environmental management. Herein, a new diffusive gradient in thin film (DGT) technique was developed and evaluated for in situ measurement of DRP in waters, in which Zr-based metal organic frameworks (MOFs, UiO-66) were utilized as aqueous binding agent (abbreviated as UiO-66 DGT)...
October 5, 2018: Water Research
https://www.readbyqxmd.com/read/30309548/preparation-of-an-intelligent-ph-film-based-on-biodegradable-polymers-and-roselle-anthocyanins-for-monitoring-pork-freshness
#19
Junjun Zhang, Xiaobo Zou, Xiaodong Zhai, XiaoWei Huang, Caiping Jiang, Mel Holmes
This study aims to develop an intelligent indicating film based on biodegradable polymers incorporated with roselle anthocyanins to monitor pork freshness. Three different films were prepared by using two substances of starch, polyvinyl alcohol and chitosan. The UV-vis spectra and color of anthocyanins changed at pH 2-12. SEM photographs showed that the compatibility of films was improved with the addition of anthocyanins. Furthermore, the polyvinyl alcohol/chitosan/roselle anthocyanins film had the highest tensile strength (98...
January 30, 2019: Food Chemistry
https://www.readbyqxmd.com/read/30308374/occurrence-of-emerging-pollutants-in-estuaries-of-the-basque-country-analysis-of-sources-and-distribution-and-assessment-of-the-environmental-risk
#20
Leire Mijangos, Haizea Ziarrusta, Oihana Ros, Leire Kortazar, Luis Angel Fernández, Maitane Olivares, Olatz Zuloaga, Ailette Prieto, Nestor Etxebarria
In this study, the spatial and temporal-distribution of 41-multiclass organic compounds were assessed in three estuaries of the Basque Country, from winter 2016 to winter 2017 by grab (active) sampling methods and an extra campaign combining both, grab and passive sampling methods. Wastewater treatment plant (WWTP) effluents were also evaluated to assess their impact on the estuaries. Moreover, the physicochemical features (phosphate and nitrate concentrations, pH, etc.) of each site were measured and included in the statistical analysis...
September 29, 2018: Water Research
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