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Eosinophilic esophagitis

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https://www.readbyqxmd.com/read/29026590/eosinophilic-esophagitis-what-can-we-learn-from-crohn-s-disease
#1
REVIEW
Javier Molina-Infante, Alain M Schoepfer, Alfredo J Lucendo, Evan S Dellon
Eosinophilic esophagitis (EoE) is an emerging esophageal inflammatory disorder affecting children and young adults. As a relatively new disease, EoE is still burdened by frequent diagnostic and therapeutic pitfalls in clinical practice. This manuscript posits a number of similarities with Crohn's disease, which may help optimize EoE patient management. Commonalities include epidemiologic trends (Westernized diseases, rising incidence, early-life risk factors), diagnostic considerations (symptoms are poor predictors of disease activity, difficulties in disease activity assessment) and therapeutic issues (similar natural history and therapeutic goals, induction and maintenance phases, combination of drug and endoscopic treatment, potential drug interchangeability, long-term unsolved issues)...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29025076/impact-of-smoking-alcohol-consumption-and-nsaid-use-on-risk-for-and-phenotypes-of-eosinophilic-esophagitis
#2
Nathaniel T Koutlas, Swathi Eluri, Spencer Rusin, Irina Perjar, Johnathan Hollyfield, John T Woosley, Nicholas J Shaheen, Evan S Dellon
There are few data exploring modifiable risk factors for eosinophilic esophagitis (EoE). We aimed to determine if smoking, alcohol consumption, and NSAID use were risk factors for EoE, and to assess their impact on EoE phenotypes and treatment outcomes. We performed a case-control study analyzing data collected from a prospective cohort of adults undergoing upper endoscopy for symptoms of esophageal dysfunction. Incident EoE cases were diagnosed via consensus guidelines. Exposure data were collected via standardized patient questionnaire...
August 30, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29022245/prevalence-of-eosinophilic-esophagitis-in-patients-with-gastroesophageal-reflux-symptoms-a-cross-sectional-study-from-a-tertiary-care-hospital-in-north-india
#3
Bhaskarjyoti Baruah, Tarun Kumar, Prasenjit Das, Bhaskar Thakur, Vishnubatla Sreenivas, Vineet Ahuja, Siddhartha Datta Gupta, Govind K Makharia
BACKGROUND: Eosinophilic esophagitis (EoE) is being recognized increasingly all over the globe; Indian data is however sparse. We screened patients with symptoms of gastroesophageal reflux disease (GERD) for presence of EoE in them. METHODS: Consecutive patients with symptoms suggestive of GERD underwent gastroduodenoscopy and esophageal biopsies, obtained from both the upper esophagus (5 cm below the upper esophageal sphincter) and lower esophagus (5 cm above gastroesophageal junction), as well as from any other endoscopically visible abnormal mucosa...
October 12, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29018965/the-role-of-maintenance-therapy-in-eosinophilic-esophagitis-who-why-and-how
#4
REVIEW
Hamish Philpott, Evan S Dellon
In patients with eosinophilic esophagitis (EoE) who do not respond to proton pump inhibitors, initial anti-inflammatory/anti-eosinophilic treatment is with either topical corticosteroids or dietary elimination. A large body of literature supports the efficacy of these approaches, with histologic response rates in the 50-90% range for steroids and 70% range for the six-food elimination diet. However, these studies are almost all short-term and data evaluating long-term safety and efficacy of either treatment are limited...
October 10, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28989006/comparison-of-endoscopy-and-radiographic-imaging-for-detection-of-esophageal-inflammation-and-remodeling-in-adults-with-eosinophilic-esophagitis
#5
Matthew J Nelson, Frank H Miller, Nelson Moy, Angelika Zalewski, Nirmala Gonsalves, Dyanna Gregory, Ikuo Hirano
BACKGROUND AND AIMS: Eosinophil predominant mucosal inflammation is central to the diagnosis and activity assessment of eosinophilic esophagitis (EoE). Esophageal mural remodeling is an important consequence of EoE that is responsible for adverse events of dysphagia, food impaction, and esophageal stenosis. The aim of this study was to compare upper endoscopy (EGD) with barium upper gastrointestinal study (UGI) for the detection of esophageal inflammation and remodeling in adults with EoE...
October 5, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28988919/esophageal-dilation-in-eosinophilic-esophagitis-not-just-for-adults-anymore
#6
Rajitha D Venkatesh, Evan S Dellon
No abstract text is available yet for this article.
October 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28987502/optimal-histologic-cutpoints-for-treatment-response-in-patients-with-eosinophilic-esophagitis-analysis-of-data-from-a-prospective-cohort-study
#7
Craig C Reed, W Asher Wolf, Cary C Cotton, Spencer Rusin, Irina Perjar, Johnathan Hollyfield, John T Woosley, Nicholas J Shaheen, Evan S Dellon
BACKGROUND AND AIMS: No prospective studies substantiate 15 eos/hpf as an appropriate endpoint for treatment of eosinophilic esophagitis (EoE). We aimed to determine a histologic cutpoint that identifies successful treatment of EoE by assessing symptomatic and endoscopic improvement. METHODS: We performed a prospective cohort study of 62 consecutive adult patients undergoing outpatient esophagogastroduodenoscopy at the University of North Carolina from 2009 through 2014...
October 4, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28981449/using-serum-ige-antibodies-to-predict-esophageal-eosinophilia-in-children
#8
Elizabeth A Erwin, Dale A Rhoda, Margaret Redmond, Jean B Ly, John M Russo, Ivor D Hill, Thomas A E Platts-Mills
OBJECTIVES: Symptoms of eosinophilic esophagitis (EoE) are variable and can be nonspecific. Food-specific serum IgE antibodies are frequently found in EoE patients and are obtained using a widely available blood test. Our objective was to evaluate the ability of food-specific IgE antibodies to predict the presence of esophageal eosinophilia. METHODS: We reviewed 144 medical records for pediatric patients having esophageal biopsy and serum analysis for IgE antibodies to food (exploratory group)...
February 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28981080/improvement-in-esophageal-distensibility-in-response-to-medical-and-diet-therapy-in-eosinophilic-esophagitis
#9
Dustin A Carlson, Ikuo Hirano, Angelika Zalewski, Nirmala Gonsalves, Zhiyue Lin, John E Pandolfino
OBJECTIVES: We aimed to evaluate the effect of medical and diet therapies on esophageal distensibility assessed using the functional lumen imaging probe (FLIP) and the association of changes in esophageal distensibility with clinical outcomes in eosinophilic esophagitis (EoE). METHODS: Patients with EoE were evaluated with FLIP during endoscopy at baseline and following therapy without interval dilatation. Evaluation also included a validated patient-reported outcome (PRO; a positive PRO was considered at a 30% score improvement), mucosal biopsies, and scoring of endoscopic features of EoE...
October 5, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28978963/editorial-deep-remission-in-eosinophilic-esophagitis-with-long-term-steroids-difficult-to-attain-and-maintain
#10
Jeffrey Alexander
The study by Greuter et al. entitled "Long-term treatment of eosinophilic esophagitis and swallowed topical corticosteroids: development and evaluation of a therapeutic concept" follows 351 patients over 6 years. This gives considerable insight into long-term topical steroid management of EoE and establishes the concept of deep remission in EoE.
October 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28965008/novel-immunologic-mechanisms-in-eosinophilic-esophagitis
#11
REVIEW
Julie M Caldwell, Misu Paul, Marc E Rothenberg
No abstract text is available yet for this article.
September 28, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28959129/shiitake-like-dermatitis-due-to-tegafur-gimeracil-oteracil-combination-usage
#12
Hiroyuki Goto, Kazunari Sugita, Shigeto Yanagihara, Osamu Yamamoto
S-1 is a combination drug of tegafur, gimeracil and oteracil potassium that is designed on the basis of 5- fluorouracil. We report here for the first time that S-1 is a causative agent of drug eruption mimicking shiitake dermatitis. A 58-year-old Japanese man presented with pruritic erythemas arranged in a linear fashion. He had been treated with S-1 for esophageal cancer. Although differential diagnosis included shiitake dermatitis and dermatomyositis, he had not eaten raw shiitake mushroom, and he did not have other cutaneous lesion such as Gottron's sign and abnormalities of peripheral blood examination including Jo-1 antibody and antinuclear antibody...
September 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28954044/histological-features-of-eosinophilic-esophagitis-in-children-and-adolescents
#13
Adriana Elisabeth Aguiar Benavides Carrasco, Rodrigo Strehl Machado, Francy Reis da Silva Patrício, Elisabete Kawakami
BACKGROUND: Eosinophilic esophagitis is an emerging disease featured by eosinophilic esophageal infiltrate not responsive to proton pump inhibitors. OBJECTIVE: To characterize histological features of children and adolescents with eosinophilic esophagitis. METHODS: Cross-sectional study in a tertiary hospital. Biopsies from each esophageal third from 14 patients (median age 7 years) with eosinophilic esophagitis were evaluated. Histological features evaluated included morphometry of esophageal epithelium, esophageal density (per high power field), extracellular eosinophilic granules, eosinophilic microabscesses, surface disposition of eosinophils, epithelial desquamation, peripapillary eosinophilia, basal layer hyperplasia and papillary elongation...
September 21, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28943560/serum-biomarkers-for-the-diagnosis-of-eosinophilic-esophagitis-and-eosinophilic-gastroenteritis
#14
Shunji Ishihara, Tetsuo Shoda, Norihisa Ishimura, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Eiko Okimoto, Kenji Izuhara, Ichiro Nomura, Kenji Matsumoto, Yoshikazu Kinoshita
Objective Clinically useful serum biomarkers for the diagnosis and monitoring of eosinophilic gastrointestinal diseases are not available. This study was conducted to examine the possible value of eosinophil-related proteins as serum biomarkers. Methods The serum concentrations of 49 cytokines, chemokines, and other proteins were measured in 29 patients with eosinophilic gastrointestinal diseases and 80 controls. Results The levels of interleukin (IL)-5, IL-33, eotaxin-3, and thymic stromal lymphopoietin (TSLP), previously reported as possible biomarkers of eosinophilic esophagitis, were not significantly elevated in the serum...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28937540/herpes-simplex-virus-esophagitis-in-immunocompetent-children-a-harbinger-of-eosinophilic-esophagitis
#15
Julia Fritz, Diana Lerner, Mariko Suchi
Herpes simplex virus (HSV) is a common cause of infectious esophagitis. The aim of this retrospective study is to identify comorbid and predisposing conditions and sequelae of HSV esophagitis in immunocompetent children. We reviewed sixteen cases of HSV esophagitis diagnosed from January, 1982 to March, 2016. Five patients were immunosuppressed, 11 were immunocompetent and included in the study. Three (27%) had no other significant medical history. Five patients (45%) had repeat biopsies following their HSV infection which showed eosinophilic infiltrate consistent with current diagnostic criteria of eosinophilic esophagitis (EoE), one of whom had known EoE...
September 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28917340/esophageal-dilation-for-eosinophilic-esophagitis-it-s-safe-why%C3%A2-aren-t-we-doing-more-dilations
#16
EDITORIAL
Joel E Richter
No abstract text is available yet for this article.
October 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28906318/nutritional-state-and-feeding-behaviors-of-children-with-eosinophilic-esophagitis-and-gastroesophageal-reflux-disease
#17
Pooja Mehta, Glenn T Furuta, Taryn Brennan, Michelle L Henry, Nancy Creskoff Maune, Shikha S Sundaram, Calies Menard-Katcher, Dan Atkins, Faith Takurukura, Sandra Giffen, Zhaoxing Pan, Angela M Haas
OBJECTIVE: Because both gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are associated with malnutrition and feeding dysfunction, this study compares growth, nutrition and feeding behaviors in children with GERD and EoE. METHODS: Subjects aged 1-7 with GERD or EoE were enrolled in a prospective study. Assessments included length/height, weight, 3-day food diary, serum biomarkers of nutrition, and the Behavioral Pediatric Feeding Assessment Scale (BPFAS)...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28895370/eosinophilic-esophagitis-current-evidence-based-diagnosis-and-treatment-in-children-and-adults
#18
Alfredo J Lucendo
Eosinophilic esophagitis (EoE) is a disease caused by an immune response to food antigens in contact with the esophageal mucosa that has arisen as a common disorder in current clinical practice. Its diagnosis is defined by the combination of symptoms of esophageal dysfunction and inflammation of the esophageal mucosa predominantly by eosinophils. Its chronic course and frequent progression to subepithelial fibrosis leading to strictures and narrow-caliber esophagus indicate the need for treatment. Information provided by recent clinical trials and systematic reviews allowed for the development of new clinical guidelines, endorsed by several European scientific societies...
September 11, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28888845/eosinophilic-esophagitis-linked-to-pollen-food-syndrome
#19
Hannah Hunter, Terence Wong, Alison Winstanley, Stephen J Till
No abstract text is available yet for this article.
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28885305/successful-esophageal-dilation-of-eosinophilic-esophagitis-eoe-patients-with-a-previous-postdilation-complication-start-low-and-go-slow
#20
Seth Lipka, Ambuj Kumar, Joel E Richter
INTRODUCTION: Esophageal dilation is an effective and safe treatment option for fibrostenotic eosinophilic esophagitis (EoE). Despite the safety, adverse events occur, yet there is scarce literature on the best treatment postcomplications. METHODS: Patients with diagnosis of EoE (≥15 eosinophils per high-power field) from 2011 to 2015 treated at our center were included. Thirty patients with fibrostenotic disease had records available regarding serial dilation therapy...
September 6, 2017: Journal of Clinical Gastroenterology
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