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Eosinophilic esophagitis

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https://www.readbyqxmd.com/read/27922230/consensus-statement-on-diagnosis-treatment-and-follow-up-of-cow-s-milk-protein-allergy-among-infants-and-children-in-turkey
#1
Aydan Kansu, Aysel Yüce, Buket Dalgıç, Bülent Enis Şekerel, Fügen Çullu-Çokuğraş, Haluk Çokuğraş
The present paper aims to provide experts' consensus on diagnosis and management of cow's milk protein allergy (CMPA) among infants and children in Turkey, based on review of available evidence-based guidelines, publications and experts' clinical experience. The experts agreed that CMPA diagnosis should be based on symptomatic evaluation and diagnostic elimination diet as followed by implementation of an open challenge test after disappearance of symptoms and confirmation of CMPA diagnosis in re-appearance of symptoms...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27921303/eosinophils-from-eosinophilic-oesophagitis-patients-have-t-cell-suppressive-capacity-and-express-foxp3
#2
C Lingblom, J Wallander, M Ingelsten, H Bergquist, M Bove, R Saalman, A Welin, C Wennerås
Eosinophilic esophagitis (EoE) is an antigen-driven T cell-mediated chronic inflammatory disease where food and environmental antigens are thought to have a role. Human eosinophils express the immunoregulatory protein galectin-10 and have T cell suppressive capacity similar to regulatory T cells (Tregs ). We hypothesized that one function of eosinophils in EoE might be to regulate the T cell-driven inflammation in the oesophagus. This was tested by evaluating the suppressive capacity of eosinophils isolated from the blood of adult EoE patients in a mixed lymphocyte reaction...
November 5, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27920662/possible-noninvasive-biomarker-of-eosinophilic-esophagitis-clinical-and-experimental-evidence
#3
Sathisha Upparahalli Venkateshaiah, Murli Manohar, Alok K Verma, Uwe Blecker, Anil Mishra
Eosinophilic esophagitis (EoE) diagnosis and follow-up response to therapy is based on repeated endoscopies and histological examination for eosinophils/HPF. The procedure is invasive and risky in particular for the pediatric population. Presently, there is no highly sensitive and specific noninvasive blood test available to monitor the disease pathogenesis. Reports indicate the expression of PDL1 (CD274) on the eosinophils in allergic patients. Herein, we report that CD274-expressing and -nonexpressing eosinophils were detected in both examined pediatric and adult EoE patients...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27917097/treating-eosinophilic-esophagitis-in-patients-with-a-narrow-caliber-esophagus
#4
Evan S Dellon
No abstract text is available yet for this article.
September 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27917089/allergy-testing-in-patients-with-eosinophilic-esophagitis
#5
Seema S Aceves
No abstract text is available yet for this article.
August 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27906799/diet-and-stress-in-pediatric-eosinophilic-esophagitis
#6
Christine Case, Glenn T Furuta, Dan Atkins, Zhaozing Pan, Jane Robinson
Clinical experiences and recent studies suggest that Eosinophilic Esophagitis (EoE) has the potential to induce caregiver (CG) and child stress. The specific sources of CG EoE-related stress remain uncertain. To address this, we performed a survey of CGs and youth attending an EoE patient education symposium that measured potential stressful elements in their daily life. Our results indicated that CGs experienced most stress associated with purchasing, preparation and completion of meals. We conclude that providers should consider this in choosing therapeutic approaches for children with EoE...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27900765/the-role-of-the-otolaryngologist-in-the-evaluation-and-diagnosis-of-eosinophilic-esophagitis
#7
Mark Kubik, Prasad Thottam, Amber Shaffer, Sukgi Choi
OBJECTIVE: To describe the clinical presentation and role of the otolaryngologist in the evaluation of eosinophilic esophagitis (EoE) at a tertiary pediatric hospital. STUDY DESIGN: Retrospective review. METHODS: Records from pediatric patients with a diagnosis of EoE from 2003 to 2015 were reviewed. Study variables were analyzed to compare patients presenting to different specialties. RESULTS: Two hundred and fifty-one patients with EoE were evaluated...
November 30, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27894141/french-comment-on-article-comparison-of-different-biopsy-forceps-models-for-tissue-sampling-in-eosinophilic-esophagitis
#8
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Endoscopy
https://www.readbyqxmd.com/read/27889574/budesonide-oral-suspension-improves-symptomatic-endoscopic-and-histologic-parameters-compared-with-placebo-in-patients-with-eosinophilic-esophagitis
#9
Evan S Dellon, David A Katzka, Margaret H Collins, Mohamed Hamdani, Sandeep K Gupta, Ikuo Hirano
BACKGROUND & AIMS: Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esophageal eosinophilia in adolescents and adults with EoE. METHODS: In this multicenter, randomized, double-blind, placebo-controlled, parallel-group trial, 93 EoE patients between the ages of 11 and 40 years with dysphagia and active esophageal eosinophilia were randomized to receive either BOS 2 mg or placebo twice daily for 12 weeks...
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27888670/endoscopic-findings-in-eosinophilic-esophagitis-and-esophageal-distensibility-a-proxy-for-transmural-modeling
#10
Bharati Kochar, Evan Dellon
No abstract text is available yet for this article.
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27868307/effects-of-eosinophilic-oesophagitis-on-quality-of-life-in-an-adult-uk-population-a-case-control-study
#11
R Hewett, C Alexakis, A D Farmer, J Ainley, V Chhaya, J O Hayat, A Poullis, J-Y Kang
Eosinophilic oesophagitis (EoE) is a chronic immune-mediated esophageal disease, characterized by symptoms related to esophageal dysfunction and histologically by eosinophil predominant inflammation. Current evidence for an adverse impact on quality of life (QoL) is conflicting and there are no data from a UK population regarding QoL. We conducted a prospective cross-sectional observational study using the Short Form-36 Health Survey, Hospital Dysphagia/Odynophagia Questionnaire, and the EoE Adult Quality of Life Questionnaire to assess QoL and severity of dysphagia in EoE patients, compared to age and gender matched healthy control subjects...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27865717/eosinophilic-esophagitis-as-possible-complication-of-aspirin-treatment-in-patient-with-aspirin-exacerbated-respiratory-disease
#12
Teresa Pelletier, Robert Tamayev, Melissa Iammatteo, Deborah Nautsch, Golda Hudes, Dana Lukin, Elina Jerschow
No abstract text is available yet for this article.
November 16, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27856094/association-of-eosinophilic-esophagitis-and-food-pollen-allergy-syndrome
#13
Mahboobeh Mahdavinia, Faraz Bishehsari, Waqas Hayat, Ahmed Elhassan, Mary C Tobin, Anne M Ditto
No abstract text is available yet for this article.
November 14, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27845336/how-i-approach-the-management-of-eosinophilic-esophagitis-in-adults
#14
Ikuo Hirano
No abstract text is available yet for this article.
November 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27825384/inhibiting-the-proton-pump-mechanisms-benefits-harms-and-questions
#15
Jeffrey K Aronson
Inhibition of the H(+)/K(+)-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syndrome, eosinophilic esophagitis, and prevention of non-steroidal anti-inflammatory drug-induced peptic ulceration...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27825371/effective-and-safe-proton-pump-inhibitor-therapy-in-acid-related-diseases-a-position-paper-addressing-benefits-and-potential-harms-of-acid-suppression
#16
EDITORIAL
Carmelo Scarpignato, Luigi Gatta, Angelo Zullo, Corrado Blandizzi
BACKGROUND: The introduction of proton pump inhibitors (PPIs) into clinical practice has revolutionized the management of acid-related diseases. Studies in primary care and emergency settings suggest that PPIs are frequently prescribed for inappropriate indications or for indications where their use offers little benefit. Inappropriate PPI use is a matter of great concern, especially in the elderly, who are often affected by multiple comorbidities and are taking multiple medications, and are thus at an increased risk of long-term PPI-related adverse outcomes as well as drug-to-drug interactions...
November 9, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27824638/autism-spectrum-disorder-and-avoidant-restrictive-food-intake-disorder
#17
Jennifer Lucarelli, Demetra Pappas, Leah Welchons, Marilyn Augustyn
Kendra is a 4-year-old girl with autism spectrum disorder (ASD) who presents for follow-up of feeding problems to her pediatric clinician. She is an only child in a family where both parents are scientists. Feeding concerns date to infancy, when she was diagnosed with Gastroesophageal Reflux Disease (GERD) associated with persistent bottle refusal and the acceptance of few pureed foods. At 13 months, milk and peanut allergies were diagnosed. Following a feeding clinic evaluation at 24 months, she was prescribed a soy milk supplement and an H2 blocker...
November 4, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27824401/comparison-of-different-biopsy-forceps-models-for-tissue-sampling-in-eosinophilic-esophagitis
#18
Christian Bussmann, Alain M Schoepfer, Ekaterina Safroneeva, Nadine Haas, Sébastien Godat, Christine Sempoux, Hans-Uwe Simon, Alex Straumann
Background and aims: Eosinophilic esophagitis (EoE) is a mixed inflammatory and fibrostenotic disease. Unlike superficial inflammatory changes, subepithelial fibrosis is not routinely sampled in esophageal biopsies. This study aimed to evaluate the efficacy and safety of deep esophageal sampling with four different types of biopsy forceps. Patients and methods: In this cross-sectional study, esophageal biopsies were taken in 30 adult patients by one expert endoscopist. Biopsies sampled from distal esophagus using a static jaw forceps (Olympus, FB-11K-1) were compared with proximal biopsies sampled with static jaw (Olympus, FB-45Q-1), alligator jaw (Olympus, FB-210K), and large-capacity forceps (Boston Scientific, Radial Jaw 4)...
December 2016: Endoscopy
https://www.readbyqxmd.com/read/27821174/eosinophilic-esophagitis-after-congenital-diaphragmatic-hernia
#19
Amelia Licari, Riccardo Castagnoli, Gian Luigi Marseglia
BACKGROUND: Eosinophilic esophagitis (EoE) is an increasingly diagnosed disease, especially in the western world. Although its pathogenesis remains poorly understood, there is strong evidence that the eosinophilic inflammation in EoE is primarily triggered by immune dysregulation secondary to allergic sensitization to dietary or aero-allergens. Recent studies have reported a higher prevalence of EoE in children with congenital gastrointestinal malformations, i.e. esophageal atresia and/or tracheoesophageal fistula...
November 8, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27801733/the-inflammatory-milieu-of-eosinophilic-esophagitis-a-contemporary-review-with-emphasis-in-putative-immunohistochemistry-and-serologic-markers
#20
Marcos Lepe, David O'Connell, Kara A Lombardo, Michael Herzlinger, Shamlal Mangray, Murray B Resnick, Andres Matoso
Eosinophilic esophagitis is a chronic disease characterized by esophageal dysfunction, frequent clinical history of atopy, and eosinophilic inflammation of the esophagus. Within the esophageal mucosa, there is a wide variety of immune mediators, chemotactic factors, mediators of transcription, and markers of epithelial differentiation and integrity that are overexpressed or underexpressed in eosinophilic esophagitis, offering many candidates for biomarkers with diagnostic or prognostic potential. In this review, we summarize the results from studies performed so far to evaluate the detection of these markers by immunohistochemistry on esophageal biopsies...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
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