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Eosinophilic esophagitis

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https://www.readbyqxmd.com/read/29672471/activated-eosinophils-are-present-in-esophageal-muscle-in-patients-with-achalasia-of-the-esophagus
#1
Hong Jin, Bin Wang, Li-Li Zhang, Wei Zhao
BACKGROUND The aim of this study was to undertake a histological evaluation of the presence of eosinophils in esophageal muscle in patients with achalasia before treatment with peroral endoscopic myotomy (POEM), with clinical follow-up at one year. MATERIAL AND METHODS Before treatment, esophageal biopsies including mucosa and esophageal muscle were obtained from 28 patients with achalasia. Nine patients who had undergone esophagectomy for esophageal carcinoma were included in the control group. The Eckardt Score was used to evaluate the clinical symptoms of achalasia...
April 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29669943/whole-exome-sequencing-uncovers-oxidoreductases-dhtkd1-and-ogdhl-as-linkers-between-mitochondrial-dysfunction-and-eosinophilic-esophagitis
#2
Joseph D Sherrill, Kiran Kc, Xinjian Wang, Ting Wen, Adam Chamberlin, Emily M Stucke, Margaret H Collins, J Pablo Abonia, Yanyan Peng, Qiang Wu, Philip E Putnam, Phillip J Dexheimer, Bruce J Aronow, Leah C Kottyan, Kenneth M Kaufman, John B Harley, Taosheng Huang, Marc E Rothenberg
Eosinophilic esophagitis (EoE) is an allergic inflammatory esophageal disorder with a complex underlying genetic etiology often associated with other comorbidities. Using whole-exome sequencing (WES) of 63 patients with EoE and 60 unaffected family members and family-based trio analysis, we sought to uncover rare coding variants. WES analysis identified 5 rare, damaging variants in dehydrogenase E1 and transketolase domain-containing 1 (DHTKD1). Rare variant burden analysis revealed an overabundance of putative, potentially damaging DHTKD1 mutations in EoE (P = 0...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29628359/gene-expression-phenotype-associations-in-adults-with-eosinophilic-esophagitis
#3
Evan S Dellon, Sara R Selitsky, Robert M Genta, Richard H Lash, Joel S Parker
BACKGROUND: Gene expression patterns have not been extensively examined in the context of clinical features of eosinophilic esophagitis (EoE). AIMS: To assess whether gene expression is associated with clinically defined phenotypes in adults with EoE. METHODS: This was an analysis of prospectively collected esophageal biopsies in newly diagnosed EoE patients. We determined differential gene expression with a 94 gene panel in relation to clinical features and phenotypes...
March 27, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29620602/a-new-paradigm-in-the-treatment-of-eosinophilic-esophagitis-proton-pump-inhibitors-are-safe-aim-for-deep-remission
#4
Samuel Ellison, Hamish Philpott
No abstract text is available yet for this article.
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29617744/natural-history-of-eosinophilic-esophagitis-a-systematic-review-of-epidemiology-and-disease-course
#5
N J Shaheen, V Mukkada, C S Eichinger, H Schofield, L Todorova, G W Falk
Eosinophilic esophagitis is a chronic immune-mediated esophageal disorder. For its timely diagnosis, clinicians must recognize common symptoms, and understand differences in symptoms across patient groups. The aim of this study is to systematically review the epidemiology and natural history of eosinophilic esophagitis. The MEDLINE, Embase, and Cochrane databases were searched from 1974 to February 2017 for studies describing the epidemiology and natural history of eosinophilic esophagitis. Congress abstracts from 2014 to 2016 were also searched...
March 31, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29616839/the-cultivable-bacterial-flora-of-the-esophagus-in-subjects-with-esophagitis
#6
Elisabeth Norder Grusell, Gunnar Dahlén, Magnus Ruth, Henrik Bergquist, Mogens Bove
BACKGROUND: The healthy human esophagus is colonized by bacteria similar to that of the oral mucosa. However, little is known about the microbiome of the esophagus in esophagitis or the possible role of bacteria in the inflammatory response. AIM: To survey bacterial diversity and compare the microbiome of the esophagus in subjects with gastro-esophageal reflux disease (GERD) and eosinophilic esophagitis (EoE). MATERIAL AND METHODS: Seventeen subjects diagnosed with GERD and 10 with EoE underwent endoscopic examination with brush sampling and biopsies from the oral cavity, upper and lower esophagus...
April 4, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29614304/decreased-esophageal-distensibility-in-children-with-eosinophilic-esophagitis-is-fibrosis-inevitable
#7
Jennifer L Horsley-Silva, Evan S Dellon
No abstract text is available yet for this article.
April 1, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29611440/new-biologics-for-allergic-diseases
#8
Laurie A Manka, Michael E Wechsler
Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas Covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation...
April 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29611207/immunological-and-hematological-effects-of-il-5-r%C3%AE-targeted-therapy-an-overview
#9
REVIEW
M Hassani, L Koenderman
IL-5 is an important cytokine for priming and survival of mature eosinophils, and for proliferation and maturation of their progenitors. Hence, IL-5(Rα) targeting will be increasingly used in diseases where eosinophils are the key immune effector cells such as eosinophilic asthma (EA), hyper eosinophilic syndrome (HES), eosinophilic esophagitis (EE) and eosinophilic granulomatosis with polyangitis (EGPA). Therefore, several neutralizing monoclonal antibodies directed against IL-5 (mepolizumab and reslizumab) and its receptor IL-5Rα (benralizumab) have found or will find their way to the clinic...
April 3, 2018: Allergy
https://www.readbyqxmd.com/read/29611076/assessing-adherence-and-barriers-to-long-term-elimination-diet-therapy-in-adults-with-eosinophilic-esophagitis
#10
Ryan Wang, Ikuo Hirano, Bethany Doerfler, Angelika Zalewski, Nirmala Gonsalves, Tiffany Taft
BACKGROUND: The six-food elimination diet (SFED) is an effective treatment approach for eosinophilic esophagitis (EoE), but it can be challenging and affect patients' quality of life. AIM: Assess patients' long-term adherence to SFED and potential factors influencing adherence. METHODS: EoE patients were recruited online via multiple platforms. Patients were classified as reaching the maintenance stage if they responded to SFED and identified specific trigger foods by reintroduction...
April 2, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29608467/how-to-cope-with-food-allergy-symptoms
#11
Antoine Deschildre, Stéphanie Lejeune
PURPOSE OF REVIEW: Food allergy symptoms may involve a wide variety of organs (skin, gastrointestinal tract, and eyes) and systems (respiratory, circulatory, and neurological). They are often associated. Their severity ranges from mild to potentially life-threatening reactions and the presentation from acute to chronic. RECENT FINDINGS: Food allergies have been the focus of multiple studies, position papers, and guidelines in recent years. They have defined an approach in classifying symptoms as mild to anaphylactic, distinguishing objective from subjective symptoms, and describing their heterogeneity, specific phenotypes or syndromes (e...
March 31, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29608193/compounded-oral-viscous-budesonide-is-effective-and-provides-a-durable-response-in-eosinophilic-esophagitis
#12
Craig C Reed, Claire Fan, Nathaniel Koutlas, Zoe Stefanadis, Swathi Eluri, Nicholas J Shaheen, Evan S Dellon
Aim: Because no approved medications exist for eosinophilic esophagitis (EoE), patients must use off-label drugs or create their own formulations. We assessed the efficacy of a standardized compounded budesonide suspension for treatment of EoE. Materials and methods: We conducted a retrospective cohort study of EoE patients at the University of North Carolina treated with compounded budesonide dispensed by a specialty compounding pharmacy. Outcomes (symptomatic global response [yes/no], endoscopic response [% with individual findings], and histologic response [absolute eosinophil count; % with <15 eos/hpf])were assessed after the initial and last treatment in our system...
2018: HSOA journal of gastroenterology & hepatology research
https://www.readbyqxmd.com/read/29605980/diagnostic-trends-and-clinical-characteristics-of-eosinophilic-esophagitis-a-korean-single-center-database-study
#13
Ga Hee Kim, Kee Wook Jung, Hwoon-Yong Jung, Kee Don Choi, JungBok Lee, Young Soo Park, So-Woon Kim, Jeong Hoon Lee, Do Hoon Kim, Ji Yong Ahn, Ho June Song, Gin Hyug Lee, Jin-Ho Kim
Background/Aims: The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods: Using an endoscopic database maintained at a tertiary care center, we retrospectively reviewed the biopsy reports regarding 18 399 biopsy specimens collected from all patients who underwent esophagogastroduodenoscopy and esophageal biopsy at this facility between 2006 and 2014...
April 30, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29604997/clinical-characteristics-of-spirocerca-lupi-migration-in-the-spinal-cord
#14
Orit Chai, Einat Yas, Ori Brenner, Alicia Rojas, Lilach Konstantin, Sigal Klainbart, Merav H Shamir
Spirocerca lupi is a nematode infecting dogs mostly in tropical and subtropical areas. Although its typical target is the esophageal wall, aberrant migration is not uncommon, including migration of unknown incidence into the spinal cord. While successful treatment of intraspinal S. lupi (ISSL) infection depends on early diagnosis, tools for definitive ante-mortem diagnosis are unavailable. We therefore aimed at characterizing clinical signs and clinical pathology findings of ISSL in dogs. For that, we analyzed medical records of dogs hospitalized in 2005-2016 presenting with neurological signs consistent with ISSL, which were diagnosed definitively post-mortem...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29594977/low-prevalence-of-biopsy-proven-eosinophilic-esophagitis-in-patients-with-esophageal-food-impaction-in-mexican-population
#15
Diego García-Compeán, José A González-González, José J Duran-Castro, Gilberto Herrera-Quiñones, Omar D Borjas-Almaguer, Héctor J Maldonado-Garza
BACKGROUND: Eosinophilic esophagitis (EoE) is the most common cause of dysphagia and esophageal food impaction (EFI) in the USA, Western Europe, and Australia. In Mexico, the uncomplicated form of this disease is infrequent, and prevalence in patients with EFI is unknown. AIMS: To determine the prevalence and causes of EFI, endoscopic and therapeutic aspects, and establish the prevalence of biopsy-proven EoE in patients with EFI. METHODS: Diagnostic upper gastrointestinal endoscopy reports from January 2011 to December 2016 were retrospectively reviewed...
March 29, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29571780/how-do-we-assess-what-lies-beneath-in-eosinophilic-esophagitis
#16
EDITORIAL
David A Katzka
No abstract text is available yet for this article.
April 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29571547/eosinophilic-esophagitis
#17
Amanda B Muir
Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus that effects children and adults. Typical symptoms of EoE typically involve failure to thrive and vomiting in small children, and dysphagia and food impaction in adolescents and adults. However, throat clearing, choking, gagging, and hoarseness have also been observed and these issues often bring patients to first seek otolaryngology and pulmonary evaluation. Diagnosis is only made by esophogastroduodenoscopy with biopsy, so clinicians must have a low threshold for considering eosinophilic esophagitis even in the absence of frank gastrointestinal symptoms...
March 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29568038/frequency-of-esophageal-eosinophilia-in-a-pediatric-population-from-central-brazil
#18
Daniel Strozzi, Marco Aurélio Silveira Botacin, Marilia Adriano Mekdessi, Luciana Ximenes Salustiano, Pedro H de Paula Silva, Lysa Bernardes Minasi, Gesmar Rodrigues Silva Segundo, Aparecido Divino da Cruz
Here we report a retrospective cross-sectional study on Esophageal eosinophilia (EsEo) frequency in Brazil, for 2, 425 pediatric patients with symptoms associated with gastroesophageal diseases in 2012. EsEo is defined by ≥15 eosinophils per high power field (400x) and confirmed through histological analyses of esophageal biopsies. Overall, 126 patients had EsEo equating to a frequency of 5.2%. There was a significant difference between the endoscopic features of patients with EsEo, where 10.7% had erosive esophagitis, 3...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29560665/esophagitis-dissecans-superficialis-a-case-series-of-7-patients-and-review-of-the-literature
#19
Elias Fiani, François Guisset, Quitterie Fontanges, Jacques Devière, Arnaud Lemmers
INTRODUCTION : Esophagitis dissecans superficialis (EDS) is a rare desquamative disorder of the eso-phagus, characterized by sloughing of the superficial mucosa. It is a benign entity of uncertain etiology. Most cases of EDS are idiopathic but can be caused by medications, hot beverages, chemical irritants, celiac disease and many skin conditions. AIM: Knowing that few case series have described this entity, we decided to review all the cases diagnosed in our center to characterize them...
July 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29552622/the-esophageal-organoid-system-reveals-functional-interplay-between-notch-and-cytokines-in-reactive-epithelial-changes
#20
Yuta Kasagi, Prasanna M Chandramouleeswaran, Kelly A Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J Benitez, Maureen DeMarshall, John W Tobias, Kathryn E Hamilton, Gary W Falk, Jonathan M Spergel, Andres J Klein-Szanto, Anil K Rustgi, Amanda B Muir, Hiroshi Nakagawa
Background & Aims: Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to study esophageal epithelial homeostasis under physiological and pathologic conditions. Methods: We modified keratinocyte-serum free medium to grow 3D organoids from endoscopic esophageal biopsies, immortalized human esophageal epithelial cells, and murine esophagi...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
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