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https://www.readbyqxmd.com/read/30179626/rates-of-interventions-in-isolated-coarctation-repair-in-neonates-versus-infants-does-age-matter
#1
Rinske Ijsselhof, Hua Liu, Frank Pigula, Kimberlee Gauvreau, John E Mayer, Pedro Del Nido, Meena Nathan
BACKGROUND: In the current era, coarctation repair is usually performed as soon as diagnosis is established. We sought to determine if neonatal isolated coarctation repair had a higher rate of interventions post-discharge when compared to older infants. METHODS: Retrospective review of neonates (≤30 days) and infants(1-6 months) undergoing isolated coarctation repair between 1/1/2000-3/31/2016. Preoperative/postoperative Z scores of arch, aortic valve and isthmus, rates of reintervention and length of stay were compared between groups...
September 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30152422/heat-shock-protein-60-as-a-biomarker-for-acute-kidney-injury-secondary-to-septic-shock-in-pediatric-patients-egyptian-multicenter-experience
#2
Mohamed A El-Gamasy, Akram E El-Sadek, Ahmed R Fakhreldin, Ashraf Kamel, Eman G Elbehery
Acute kidney injury (AKI) is an independent predictor of morbidity and mortality for critically ill children at pediatric Intensive Care Units (PICU). It is proposed that heat shock protein 60 (HSP60) may be either a biomarker or a co-factor of survival in PICU. The aim of this work is to assess plasma levels of HSP60 in critically ill pediatric patients with AKI secondary to septic shock within the first 24 h of admission. This study was carried out on 120 pediatric patients admitted to PICUs of four university hospitals...
July 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/30059476/association-between-transfusion-of-rbcs-and-subsequent-development-of-delirium-in-critically-ill-children
#3
Marianne E Nellis, Ruchika Goel, Sydney Feinstein, Sevini Shahbaz, Savneet Kaur, Chani Traube
OBJECTIVES: To determine the temporal relationship between the transfusion of RBCs and the subsequent development of delirium in a cohort of critically ill children. DESIGN: Nested retrospective cohort study within prospective cohort study. SETTING: Urban academic tertiary care PICU. PATIENTS: All consecutive admissions from September 2014 through August 2015. INTERVENTIONS: Children were screened twice daily for delirium during their PICU admission...
October 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30059475/cognitive-and-behavioral-consequences-of-pediatric-delirium-a-pilot-study
#4
Jochen Meyburg, Markus Ries, Matthias Zielonka, Karin Koch, Anja Sander, Rebecca von Haken, Gitta Reuner
OBJECTIVES: To investigate the long-term impact of postoperative delirium in children. DESIGN: Single-center point prevalence study. SETTING: Twenty-two bed PICU. PATIENTS: Forty-seven patients 1-16 years old. INTERVENTIONS: Standardized neuropsychologic follow-up investigation after a mean time of 17.7 ± 2.9 months after PICU discharge. MEASUREMENTS AND MAIN RESULTS: Pediatric delirium did not have significant long-term impact on global cognition, executive functions, or behavior...
October 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30024571/mitral-annular-plane-systolic-excursion-as-a-predictor-of-mortality-in-children-with-septic-shock
#5
Rania Salah El-Zayat, Awny Gamal Shalaby
OBJECTIVES: Myocardial dysfunction is well recognized in severe sepsis and septic shock. Echocardiography provides rapid, noninvasive, and bedside evaluation of cardiac function in patients with hemodynamic instability. Mitral annular plane systolic excursion is an M-mode-derived echocardiographic variable used to assess longitudinal left ventricular systolic function. No data are available about the uses of mitral annular plane systolic excursion in children with septic shock. Therefore, we aimed to assess the prognostic significance of mitral annular plane systolic excursion in children with septic shock and to correlate it with the most commonly used measures of left ventricular systolic function and myocardial injury...
September 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29990321/influence-of-factor-xiii-activity-on-post-operative-transfusion-in-congenital-cardiac-surgery-a-retrospective-analysis
#6
Fabian B Fahlbusch, Thomas Heinlein, Manfred Rauh, Sven Dittrich, Robert Cesnjevar, Julia Moosmann, Jennifer Nadal, Matthias Schmid, Frank Muench, Michael Schroth, Wolfgang Rascher, Hans-Georg Topf
OBJECTIVES: Coagulation factor XIII (FXIII) plays a key role in fibrin clot stabilization-an essential process for wound healing following cardiothoracic surgery. However, FXIII deficiency as a risk for post-operative bleeding in pediatric cardiac surgery involving cardiopulmonary bypass (CPB) for congenital heart disease (CHD) is controversially discussed. Thus, as primary outcome measures, we analyzed the association of pre-operative FXIII activity and post-operative chest tube drainage (CTD) loss with transfusion requirements post-operatively...
2018: PloS One
https://www.readbyqxmd.com/read/29912812/multicenter-review-of-current-practices-associated-with-venous-thromboembolism-prophylaxis-in-pediatric-patients-after-trauma
#7
Amee M Bigelow, Katherine T Flynn-O'Brien, Pippa M Simpson, Mahua Dasgupta, Sheila J Hanson
OBJECTIVES: Frequency of venous thromboembolism in pediatric trauma patients admitted to PICUs is not insignificant, ranging up to 6%. Risk factors have been identified in this population. However, there is little consensus of actual venous thromboembolism prophylaxis practice. We examined factors associated with venous thromboembolism prophylaxis in PICUs. DESIGN: A retrospective study evaluating associations with mechanical venous thromboembolism prophylaxis, pharmacologic venous thromboembolism prophylaxis, or dual therapy (DUAL) prophylaxis compared with no venous thromboembolism prophylaxis...
September 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29907141/serum-and-urine-fgf23-and-igfbp-7-for-the-prediction-of-acute-kidney-injury-in-critically-ill-children
#8
Zhenjiang Bai, Fang Fang, Zhong Xu, Chunjiu Lu, Xueqin Wang, Jiao Chen, Jian Pan, Jian Wang, Yanhong Li
BACKGROUND: Fibroblast growth factor 23 (FGF23) and insulin-like growth factor binding protein 7 (IGFBP-7) are suggested to be biomarkers for predicting acute kidney injury (AKI). We compared them with proposed AKI biomarker of cystatin C (CysC), and aimed (1) to examine whether concentrations of these biomarkers vary with age, body weight, illness severity assessed by pediatric risk of mortality III score, and kidney function assessed by estimated glomerular filtration rate (eGFR), (2) to determine the association between these biomarkers and AKI, and (3) to evaluate whether these biomarkers could serve as early independent predictors of AKI in critically ill children...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29846315/pas-reduce-rounding-interruptions-in-the-pediatric-intensive-care-unit
#9
Rebecca L Hascall, R Serene Perkins, Lauren Kmiecik, Priya R Gupta, Carolyn F Shelak, Shaban Demirel, Mark T Buchholz
OBJECTIVE: We investigated the proportion of encounters that were interrupted during family-centered rounds in the pediatric intensive care unit (PICU) to determine whether the use of a physician assistant (PA) significantly affected the proportion of interrupted encounters. METHODS: We evaluated 2,657 rounding encounters in our 24-bed regional referral unit. The duration of each rounding encounter and total rounding duration were recorded. The presence or absence of a PA during each rounding encounter, the occurrence of an interruption, and other potential predictors of interruptions were recorded...
June 2018: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/29802651/using-high-flow-nasal-cannulas-for-infants-with-bronchiolitis-admitted-to-paediatric-wards-is-safe-and-feasible
#10
Paula Heikkilä, Paula Sokuri, Minna Mecklin, Kirsi Nuolivirta, Terhi Tapiainen, Outi Peltoniemi, Marjo Renko, Matti Korppi
AIM: Using a high-flow nasal cannula (HFNC) for infant bronchiolitis is increasingly common, but insufficiently studied. In this retrospective study, we examined the outcomes of HFNC and compared infants who did and did not respond to this oxygen delivery method. METHODS: This 2012-2015 study of six Finnish hospitals focused on 88 infants under 12 months who received HFNC: 53 on paediatric wards and 35 in paediatric intensive care units (PICUs). We reviewed patient files for underlying factors, clinical parameters and HFNC treatment...
May 26, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29799613/the-canadian-paediatric-triage-and-acuity-scale-algorithm-for-interfacility-transport
#11
Tanya Holt, Michael Prodanuk, Gregory Hansen
OBJECTIVE: Determining pediatric severity of illness in referring centers may be useful for establishing appropriate patient disposition and interfacility transport. For this retrospective review, the authors evaluated the Canadian Paediatric Triage and Acuity Scale (PaedCTAS) tool in regards to individual patient disposition and outcomes. METHODS: A disposition score using the PaedCTAS algorithm was retrospectively calculated from referring center data at the time our transport team was consulted...
2018: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/29793551/assessment-of-pattern-and-treatment-outcome-of-patients-admitted-to-pediatric-intensive-care-unit-ayder-referral-hospital-tigray-ethiopia-2015
#12
Hansa Haftu, Tedrose Hailu, Araya Medhaniye, Teklit G/Tsadik
OBJECTIVE: To describe admission pattern and outcome with its predictor variable on the mortality of children admitted to pediatric intensive care unit (PICU), Ayder Referral Hospital, Northern Ethiopia, from September 2012 to August 2014. RESULT: From 680 admitted patients, 400 patients were analyzed. Average age at admission was 62.99 ± 60.94 months, with F:M ratio of 1:1.2. Overall (from infectious and non-infectious) the most commonly affected systems were respiratory (90/400 pts...
May 24, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29750895/predictors-and-incidence-of-hospitalization-due-to-respiratory-syncytial-virus-rsv-associated-lower-respiratory-tract-infection-lrti-in-non-prophylaxed-moderate-to-late-preterm-infants-in-bosnia-and-herzegovina
#13
Hajrija Maksić, Suada Heljić, Fahrija Skokić, Darinka Šumanović-Glamuzina, Veroslava Milošević, Almir Zlatanović, Notario Gerard
Prematurity is a risk factor for respiratory syncytial virus (RSV)-associated lower respiratory tract infections (LRTIs), due to immature humoral and cell-mediated immune system in preterm newborns, as well as their incomplete lung development. Palivizumab, a humanized monoclonal antibody against the F glycoprotein of RSV, is licensed for the prevention of severe RSV LRTI in children at high risk for the disease. This study is a part of a larger observational, retrospective-prospective epidemiological study (PONI) conducted at 72 sites across 23 countries in the northern temperate zone...
August 1, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29728467/predictors-of-location-of-death-for-children-with-cancer-enrolled-on-a-palliative-care-service
#14
Erica C Kaye, Samantha DeMarsh, Courtney A Gushue, Jonathan Jerkins, April Sykes, Zhaohua Lu, Jennifer M Snaman, Lindsay J Blazin, Liza-Marie Johnson, Deena R Levine, R Ray Morrison, Justin N Baker
BACKGROUND: In the U.S., more children die from cancer than from any other disease, and more than one third die in the hospital setting. These data have been replicated even in subpopulations of children with cancer enrolled on a palliative care service. Children with cancer who die in high-acuity inpatient settings often experience suffering at the end of life, with increased psychosocial morbidities seen in their bereaved parents. Strategies to preemptively identify children with cancer who are more likely to die in high-acuity inpatient settings have not been explored...
May 4, 2018: Oncologist
https://www.readbyqxmd.com/read/29727363/benzodiazepines-and-development-of-delirium-in-critically-ill-children-estimating-the-causal-effect
#15
Kalgi Mody, Savneet Kaur, Elizabeth A Mauer, Linda M Gerber, Bruce M Greenwald, Gabrielle Silver, Chani Traube
OBJECTIVES: Benzodiazepine use may be associated with delirium in critically ill children. However, benzodiazepines remain the first-line sedative choice in PICUs. Objectives were to determine the temporal relationship between administration of benzodiazepines and delirium development, control for time-varying covariates such as mechanical ventilation and opiates, and evaluate the association between dosage of benzodiazepines and subsequent delirium. DESIGN: Retrospective observational study...
September 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29628400/-prevalence-and-prognostic-value-of-non-thyroidal-illness-syndrome-among-critically-ill-children
#16
Sohair Sayed Abu El-Ella, Muhammad Said El-Mekkawy, Mohamed Abdelrahman El-Dihemey
INTRODUCTION: Alterations in thyroid hormones during critical illness, known as non-thyroidal illness syndrome (NTIS), were suggested to have a prognostic value. However, pediatric data is limited. The aim of this study was to assess prevalence and prognostic value of NTIS among critically ill children. MATERIALS AND METHODS: A prospective observational study conducted on 70 critically ill children admitted into pediatric intensive care unit (PICU). Free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were measured within 24hours of PICU admission...
April 5, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29580966/hand-hygiene-compliance-and-behavioural-determinants-in-a-paediatric-intensive-care-unit-an-observational-study
#17
Aline S C Belela-Anacleto, Denise M Kusahara, Maria Angélica S Peterlini, Mavilde L G Pedreira
BACKGROUND: Hand hygiene is considered the single most effective means of reducing healthcare-associated infections, but improving and sustaining hand hygiene compliance remains a great challenge. OBJECTIVES: To compare hand hygiene compliance before and after interventions to promote adherence in a paediatric intensive care unit (PICU) and to identify predictors of intention to perform the behaviour "hand hygiene during patient care in the PICU". METHODS: A before and after study was conducted in three phases...
March 23, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29574916/determinants-of-change-in-home-participation-among-critically-ill-children
#18
MULTICENTER STUDY
Mary A Khetani, Erin C Albrecht, Jessica M Jarvis, David Pogorzelski, Emmy Cheng, Karen Choong
AIM: To estimate changes in home participation among critically ill children in the first 6 months after discharge from a pediatric intensive care unit (PICU), and to explore the effect of child, service, and environmental factors on change in home participation. METHOD: This was a prospective bi-center, longitudinal cohort study. Caregivers of 180 children, aged 1 to 17 years, who were admitted into the PICU for at least 48 hours were included. Patient-reported outcomes were used to capture caregivers' perspectives of their child's participation and environmental supports for participation in home activities...
August 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29544449/development-and-validation-of-a-diagnostic-model-for-early-differentiation-of-sepsis-and-non-infectious-sirs-in-critically-ill-children-a-data-driven-approach-using-machine-learning-algorithms
#19
RANDOMIZED CONTROLLED TRIAL
Florian Lamping, Thomas Jack, Nicole Rübsamen, Michael Sasse, Philipp Beerbaum, Rafael T Mikolajczyk, Martin Boehne, André Karch
BACKGROUND: Since early antimicrobial therapy is mandatory in septic patients, immediate diagnosis and distinction from non-infectious SIRS is essential but hampered by the similarity of symptoms between both entities. We aimed to develop a diagnostic model for differentiation of sepsis and non-infectious SIRS in critically ill children based on routinely available parameters (baseline characteristics, clinical/laboratory parameters, technical/medical support). METHODS: This is a secondary analysis of a randomized controlled trial conducted at a German tertiary-care pediatric intensive care unit (PICU)...
March 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29504354/outcome-of-traumatic-brain-injury-in-children-by-using-rotterdam-score-on-computed-tomography
#20
Anwarul Haque, Zehra Dhanani, Amin Ali, Basit Salam, Qalab Abbas, Gohar Javed, Humaira Jurair
BACKGROUND: The Rotterdam Score (RS) on CT head is a new evolving clinical tool as a predictor of mortality in Traumatic Brain Injury (TBI). The objective of this study is to assess the outcome of children with TBI admitted in paediatric intensive care unit (PICU) of a tertiary-care, university hospital by using RS. METHODS: This was a prospective observational study conducted on children (age: 1mo -16yr) with TBI admitted in PICU of Aga Khan University Hospital from 2013 to 2016...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
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