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https://www.readbyqxmd.com/read/30121435/estimating-and-comparing-the-cancer-risks-from-thms-and-low-level-arsenic-in-drinking-water-based-on-disability-adjusted-life-years
#1
Hui Zhang, Shan Chang, Luobin Wang, Wendong Wang
To determine the priority hazard in drinking water, disability-adjusted life years (DALYs) method was used to evaluate the disease burden induced by trihalomethanes (THMs) and low-level arsenic through multiple exposure routes based on the two-year sampling from drinking water in Xi'an city, Northwest China. The average concentrations of chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), bromoform (TBM) and arsenic were 12.67 μg/L, 1.42 μg/L, 0.60 μg/L, 0.13 μg/L and 1.00 μg/L, respectively, and the total lifetime cancer risks for all THMs and arsenic were 8...
August 7, 2018: Water Research
https://www.readbyqxmd.com/read/30120242/multi-photon-near-infrared-emission-saturation-nanoscopy-using-upconversion-nanoparticles
#2
Chaohao Chen, Fan Wang, Shihui Wen, Qian Peter Su, Mike C L Wu, Yongtao Liu, Baoming Wang, Du Li, Xuchen Shan, Mehran Kianinia, Igor Aharonovich, Milos Toth, Shaun P Jackson, Peng Xi, Dayong Jin
Multiphoton fluorescence microscopy (MPM), using near infrared excitation light, provides increased penetration depth, decreased detection background, and reduced phototoxicity. Using stimulated emission depletion (STED) approach, MPM can bypass the diffraction limitation, but it requires both spatial alignment and temporal synchronization of high power (femtosecond) lasers, which is limited by the inefficiency of the probes. Here, we report that upconversion nanoparticles (UCNPs) can unlock a new mode of near-infrared emission saturation (NIRES) nanoscopy for deep tissue super-resolution imaging with excitation intensity several orders of magnitude lower than that required by conventional MPM dyes...
August 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/30119135/differential-expression-of-micrornas-and-mir-206-mediated-downregulation-of-bdnf-expression-in-the-rat-fetal-brain-following-maternal-hypothyroidism
#3
Qian Xing, Zhongyan Shan, Yun Gao, Jingyuan Mao, Xiu Liu, Jiashu Yu, Huakun Sun, Chenling Fan, Hong Wang, Hongmei Zhang, Weiping Teng
To investigate the mechanism responsible for the neurological alterations, miRNA expression profile and brain-derived neurotrophic factor (BDNF) were evaluated in brain tissues of fetal or neonatal rats and from maternal rats with hypothyroidism. Ninety female Wistar rats were divided into a control and a hypothyroid group, which were mated. Brain samples of the offspring were obtained at maternal embryonic day (E) E13 and E17 as well as postnatal day (P) P0 and P7, and the hippocampus and cortex were separated at P7...
August 17, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/30119030/4-bromodiphenyl-ether-delays-pubertal-leydig-cell-development-in-rats
#4
Xianwu Chen, Yaoyao Dong, Erpo Tian, Lubin Xie, Guimin Wang, Xiaoheng Li, Xiuxiu Chen, Yong Chen, Yao Lv, Chaobo Ni, Yinghui Fang, Ying Zhong, Ren-Shan Ge
Polybrominated diphenyl ethers are a class of brominated flame retardants that are potential endocrine disruptors. 4-Bromodiphenyl ether (BDE-3) is the most abundant photodegradation product of higher polybrominated diphenyl ethers. However, whether BDE-3 affects Leydig cell development during puberty is still unknown. The objective of this study was to explore effects of BDE-3 on the pubertal development of rat Leydig cells. Male Sprague Dawley rats (35 days of age) were gavaged daily with BDE-3 (0, 50, 100, and 200 mg/kg body weight/day) for 21 days...
August 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/30119001/theoretical-studies-on-the-feasibility-of-the-hybrid-nanocomposites-of-graphene-quantum-dot-and-phenoxazine-based-dyes-as-an-efficient-sensitizer-for-dye-sensitized-solar-cells
#5
Feng Gao, Chuan-Lu Yang, Mei-Shan Wang, Xiao-Guang Ma, Wen-Wang Liu
The feasibility of the hybrid nanocomposites of the graphene quantum dot (GQD) and the phenoxazine-based dyes as the efficient sensitizer of the dye-sensitized solar cell (DSSC) is investigated. Based on the first principles density functional theory (DFT), the geometrical structures of the separate GQDs, the phenoxazine-based dyes, and their hybridized nanocomposites are fully optimized. The energy stabilities of the obtained structures are confirmed by harmonic frequency analysis. The optical absorptions of the optimized structures are calculated with the time-dependent DFT (TDDFT)...
August 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30118867/neutrophils-and-neutrophil-lymphocyte-ratio-inflammatory-markers-associated-with-intimal-media-thickness-of-atherosclerosis
#6
Ling-Bing Meng, Ze-Mou Yu, Peng Guo, Qing-Qing Wang, Ruo-Mei Qi, Meng-Jie Shan, Jian Lv, Tao Gong
INTRODUCTION: Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L...
August 3, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/30118287/observation-of-complex-time-structures-in-the-cosmic-ray-electron-and-positron-fluxes-with-the-alpha-magnetic-spectrometer-on-the-international-space-station
#7
M Aguilar, L Ali Cavasonza, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, M Battarbee, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, K F Bindel, V Bindi, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, F Cadoux, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, M J Chae, Y H Chang, A I Chen, G M Chen, H S Chen, Y Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, W Creus, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, D D'Urso, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, G Gallucci, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, T H Hsieh, H Huang, Z C Huang, C Huh, M Incagli, M Ionica, W Y Jang, Yi Jia, H Jinchi, S C Kang, K Kanishev, B Khiali, G N Kim, K S Kim, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, Q Li, T X Li, Z H Li, Z Y Li, S Lim, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, V D Lordello, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, V M Mikuni, D C Mo, P Mott, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, M Palermo, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, F Pilo, C Pizzolotto, V Plyaskin, M Pohl, V Poireau, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, D Son, J W Song, M Tacconi, X W Tang, Z C Tang, D Tescaro, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, C Türkoğlu, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, Z L Weng, K Whitman, H Wu, X Wu, R Q Xiong, W Xu, Q Yan, J Yang, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J Zhang, J H Zhang, S W Zhang, Z Zhang, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
We present high-statistics, precision measurements of the detailed time and energy dependence of the primary cosmic-ray electron flux and positron flux over 79 Bartels rotations from May 2011 to May 2017 in the energy range from 1 to 50 GeV. For the first time, the charge-sign dependent modulation during solar maximum has been investigated in detail by leptons alone. Based on 23.5×10^{6} events, we report the observation of short-term structures on the timescale of months coincident in both the electron flux and the positron flux...
August 3, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30118280/precision-measurement-of-cosmic-ray-nitrogen-and-its-primary-and-secondary-components-with-the-alpha-magnetic-spectrometer-on-the-international-space-station
#8
M Aguilar, L Ali Cavasonza, B Alpat, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, M Battarbee, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, K F Bindel, V Bindi, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, W J Burger, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, Y H Chang, A I Chen, G M Chen, H S Chen, Y Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, W Creus, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, G Gallucci, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, T H Hsieh, H Huang, Z C Huang, M Incagli, Yi Jia, H Jinchi, K Kanishev, B Khiali, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, Q Li, T X Li, Z H Li, Z Y Li, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, Z Liu, V D Lordello, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, V M Mikuni, D C Mo, P Mott, L Mussolin, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, M Palermo, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, F Pilo, V Plyaskin, M Pohl, V Poireau, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, J W Song, M Tacconi, X W Tang, Z C Tang, D Tescaro, J Tian, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, J Wei, Z L Weng, K Whitman, H Wu, R Q Xiong, W Xu, Q Yan, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J Zhang, J H Zhang, S W Zhang, Z Zhang, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
A precision measurement of the nitrogen flux with rigidity (momentum per unit charge) from 2.2 GV to 3.3 TV based on 2.2×10^{6} events is presented. The detailed rigidity dependence of the nitrogen flux spectral index is presented for the first time. The spectral index rapidly hardens at high rigidities and becomes identical to the spectral indices of primary He, C, and O cosmic rays above ∼700  GV. We observed that the nitrogen flux Φ_{N} can be presented as the sum of its primary component Φ_{N}^{P} and secondary component Φ_{N}^{S}, Φ_{N}=Φ_{N}^{P}+Φ_{N}^{S}, and we found Φ_{N} is well described by the weighted sum of the oxygen flux Φ_{O} (primary cosmic rays) and the boron flux Φ_{B} (secondary cosmic rays), with Φ_{N}^{P}=(0...
August 3, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30118264/observation-of-fine-time-structures-in-the-cosmic-proton-and-helium-fluxes-with-the-alpha-magnetic-spectrometer-on-the-international-space-station
#9
M Aguilar, L Ali Cavasonza, B Alpat, G Ambrosi, L Arruda, N Attig, S Aupetit, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, M Battarbee, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, K F Bindel, V Bindi, W de Boer, K Bollweg, V Bonnivard, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, F Cadoux, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, M J Chae, Y H Chang, A I Chen, G M Chen, H S Chen, Y Chen, L Cheng, H Y Chou, E Choumilov, V Choutko, C H Chung, C Clark, R Clavero, G Coignet, C Consolandi, A Contin, C Corti, W Creus, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, D D'Urso, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, G Gallucci, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, A Ghelfi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, J Hoffman, T H Hsieh, H Huang, Z C Huang, C Huh, M Incagli, M Ionica, W Y Jang, Yi Jia, H Jinchi, S C Kang, K Kanishev, B Khiali, G N Kim, K S Kim, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, H S Li, J Q Li, Q Li, T X Li, Z H Li, Z Y Li, C Light, S Lim, C H Lin, P Lipari, T Lippert, D Liu, Hu Liu, V D Lordello, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, X Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, V M Mikuni, D C Mo, P Mott, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, M Palermo, F Palmonari, C Palomares, M Paniccia, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, F Pilo, C Pizzolotto, V Plyaskin, M Pohl, V Poireau, A Popkow, L Quadrani, X M Qi, X Qin, Z Y Qu, T Räihä, P G Rancoita, D Rapin, J S Ricol, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, D Son, J W Song, M Tacconi, X W Tang, Z C Tang, D Tescaro, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, C Türkoğlu, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, C C Wei, Z L Weng, K Whitman, H Wu, X Wu, R Q Xiong, W Xu, Q Yan, J Yang, M Yang, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J Zhang, J H Zhang, S W Zhang, Z Zhang, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
We present the precision measurement from May 2011 to May 2017 (79 Bartels rotations) of the proton fluxes at rigidities from 1 to 60 GV and the helium fluxes from 1.9 to 60 GV based on a total of 1×10^{9} events collected with the Alpha Magnetic Spectrometer aboard the International Space Station. This measurement is in solar cycle 24, which has the solar maximum in April 2014. We observed that, below 40 GV, the proton flux and the helium flux show nearly identical fine structures in both time and relative amplitude...
August 3, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30116925/seasonal-characteristics-of-chemical-compositions-and-sources-identification-of-pm-2-5-in-zhuhai-china
#10
Zuobing Liang, Xinfeng Zhao, Jianyao Chen, Lei Gao, Aiping Zhu, Zhuowei Wang, Shaoheng Li, Jiju Shan, Yuemin Long, Chang Yan, Kai Zhang
Fine particulate matter is associated with adverse health effects, but exactly which characteristics of PM2.5 are responsible for this is still widely debated. We evaluated seasonal dynamics of the composition and chemical characteristics of PM2.5 in Zhuhai, China. PM2.5 characteristics at five selected sites within Zhuhai city were analyzed. Sampling began on January 10, 2015, and was conducted for 1 year. The ambient mass concentration, carbon content (organic and elemental carbon, OC and EC), level of inorganic ions, and major chemical composition of PM2...
August 16, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/30116338/expression-of-bcl-2-and-bad-in-hippocampus-of-status-epileptic-rats-and-molecular-mechanism-of-intervened-recombinant-human-erythropoietin
#11
Jianghua Yu, Zhiqin Shi, Xudong Su, Yi Zhou, Bin Li, Shan Wang, Lijing Jia, Bo Zhao, Mengchu Zhu, Xiaohong Feng, Kuochang Yin, Weiping Wang
Injury of hippocampal neurons in status epilepticus (SE) SD rats kindled by pentylenetetrazol (PTZ) were studied, and the changes of apoptosis neurons, protein expression of Bad and Bcl-2 alone and combined application of phosphatidyl inositol 3-kinase (PI3K) inhibitor LY294002 and recombinant human erythropoietin (rHuEpo) were evaluated for the possible mechanisms of rHuEpo. The SE rats kindled by the PTZ were randomly divided into normal control group [normal saline (NS)], model group (PTZ + NS), rHuEpo treated group (PTZ + rHuEpo), LY294002 treated group (PTZ + LY294002 + rHuEpo) and LY294002 control group (rHuEpo + PTZ + DMSO)...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30116310/dynamic-expression-of-epac-and-rap1-in-mouse-oocytes-and-preimplantation-embryos
#12
Jun-Chao Wang, Ying Geng, Ying Han, Hai-Ning Luo, Yun-Shan Zhang
Cyclic adenosine monophosphate (cAMP) is an important secondary messenger that has long been recognized to control the initiation of meiosis through the activation of protein kinase A (PKA) in mammalian oocytes. However, PKA is not the only target for cAMP. Recent studies on cAMP-dependent and PKA-independent pathways suggest that Ras-related protein-1 (Rap1) is activated through its cAMP-responsive guanine exchange factors (cAMP-GEFs), which comprises the involvement of exchange proteins directly activated by cAMP (Epac) in various cellular processes...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30115949/pregnancy-outcomes-in-women-of-advanced-maternal-age-a-retrospective-cohort-study-from-china
#13
Dan Shan, Pei-Yuan Qiu, Yu-Xia Wu, Qian Chen, Ai-Lin Li, Sivakumar Ramadoss, Ran-Ran Wang, Ya-Yi Hu
This retrospective cohort study attempts to investigate pregnancy complications and adverse pregnancy outcomes in women of advanced maternal age (AMA). Data were extracted from electronic medical records system at West China Second University Hospital of Sichuan University from January 2013 to July 2016. The study cohort consisted 8 subgroups of women on 4 different age levels (20-29 years, 30-34 years, 35-39 years and ≥40 years) and 2 different parities (primiparity and multiparity). In the study period, 38811 women gave birth at our hospital, a randomized block was used to include 2800 women of singleton pregnancy >28 gestational weeks, with 350 patients in each subgroup...
August 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30115258/propofol-compared-with-sevoflurane-general-anaesthesia-is-associated-with-decreased-delayed-neurocognitive-recovery-in-older-adults
#14
Y Zhang, G-J Shan, Y-X Zhang, S-J Cao, S-N Zhu, H-J Li, D Ma, D-X Wang
BACKGROUND: The choice of general anaesthetics may affect postoperative cognitive outcomes. This study was designed to compare the potential impact of propofol-based vs sevoflurane-based general anaesthesia on the development of delayed neurocognitive recovery in older adults early after major cancer surgery. METHODS: Older adults (aged ≥65 and <90 yr) who were scheduled to undergo major cancer surgery (≥2 h) were randomised to receive either propofol- or sevoflurane-based general anaesthesia...
September 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/30114365/measuring-ligand-binding-kinetics-to-membrane-proteins-using-virion-nano-oscillators
#15
Guangzhong Ma, Guan-Da Syu, Xiaonan Shan, Brandon Henson, Shaopeng Wang, Prashant Desai, Heng Zhu, Nongjian Tao
Membrane proteins play vital roles in cellular signaling processes and serve as the most popular drug targets. A key task in studying cellular functions and developing drugs is to measure the binding kinetics of ligands with the membrane proteins. However, this has been a long-standing challenge because one must perform the measurement in a membrane environment to maintain the conformations and functions of the membrane proteins. Here we report a new method to measure ligand binding kinetics to membrane proteins using self-assembled virion-oscillators...
August 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30114351/targeted-therapy-of-atherosclerosis-by-a-broad-spectrum-reactive-oxygen-species-scavenging-nanoparticle-with-intrinsic-anti-inflammatory-activity
#16
Yuquan Wang, Lanlan Li, Weibo Zhao, Yin Dou, Huijie An, Hui Tao, Xiaoqiu Xu, Yi Jia, Shan Lu, Jianxiang Zhang, Houyuan Hu
Atherosclerosis is a leading cause of vascular diseases worldwide. Whereas anti-oxidative therapy has been considered promising for the treatment of atherosclerosis in view of a critical role of reactive oxygen species (ROS) in the pathogenesis of atherosclerosis, currently available antioxidants showed considerably limited clinical outcomes. Herein we hypothesize that a broad-spectrum ROS-scavenging nanoparticle can serve as an effective therapy for atherosclerosis, taking advantages of its anti-oxidative stress activity and targeting effects...
August 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/30113834/metal-organic-frameworks-mediate-cu-coordination-for-selective-co-2-electroreduction
#17
Dae-Hyun Nam, Oleksandr S Bushuyev, Jun Li, Phil De Luna, Ali Seifitokaldani, Cao-Thang Dinh, F Pelayo Garcia de Arquer, Yuhang Wang, Zhiqin Liang, Andrew H Proppe, Chih Shan Tan, Petar Todorovic, Osama Shekhah, Christine M Gabardo, Jea Woong Jo, Jongmin Choi, Min-Jae Choi, Se-Woong Baek, Junghwan Kim, David Sinton, Shana O Kelley, Mohamed Eddaoudi, Edward H Sargent
The electrochemical carbon dioxide reduction reaction (CO2 RR) produces diverse chemical species. Cu clusters with a judiciously-controlled surface coordination number (CN) provide active sites that simultaneously optimize selectivity, activity, and efficiency for CO2 RR. Here we report a strategy involving metal-organic framework (MOF)-regulated Cu cluster formation that shifts CO2 electroreduction toward multiple-carbon product generation. Specifically, we promoted undercoordinated sites during the formation of Cu clusters by controlling the structure of the Cu dimer, the precursor for Cu clusters...
August 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30113133/the-effects-of-work-family-interface-on-domain-specific-satisfaction-and-well-being-across-nations-the-moderating-effects-of-individualistic-culture-and-economic-development
#18
REVIEW
Shan Xu, Yanling Wang, Ren Mu, Jiafei Jin, Feiyi Gao
Work-family conflict (WFC) and work-family enrichment (WFE) have been shown to be important predictors of employees' domain-specific satisfaction and well-being. In this meta-analysis, we consider how the effects of WFC/WFE on various outcomes differ across different national cultures and economic settings. We hypothesized that WFC would have stronger effects on employees' domain-specific satisfaction and well-being in high individualistic nations and economies with higher levels of economic development, whereas WFE would have stronger effects on employees' domain-specific satisfaction and well-being in low individualistic nations and economies with lower levels of economic development...
August 16, 2018: PsyCh Journal
https://www.readbyqxmd.com/read/30112362/a-new-surgical-method-of-u-shaped-myometrial-excavation-and-modified-suture-approach-with-uterus-preservation-for-diffuse-adenomyosis
#19
Xie Jun-Min, Zhu Kun-Peng, Zhao Yin-Kai, Zhang Ya-Qin, Fan Xiao-Fan, Zhu Xiao-Yu, Wei Li, Wang Bin
Objective: To evaluate the feasibility, safety, and efficacy of a new surgical method of U-shaped myometrial excavation and modified suture approach with uterus preservation for diffuse adenomyosis. Methods: From January 2012 to December 2014, 198 patients with diffuse adenomyosis were surgically treated using this novel procedure in Zhengzhou Hua-Shan Hospital. Degree of dysmenorrhea, menstrual blood volume, serum CA 125, and uterine size before and at 1 month, 3 months, 6 months, 12 months, and 24 months after surgery were compared...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30112030/the-clinical-significance-of-mda-7-il-24-and-c-myb-expression-in-tumor-tissues-of-patients-with-diffuse-large-b-cell-lymphoma
#20
Ming Ma, Riyang Zhao, Xingxiao Yang, Lianmei Zhao, Lihua Liu, Cong Zhang, Xuexiao Wang, Baoen Shan
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma in adults. Mda-7/IL-24 had been identified as a differentiation inducer of B phenotype lymphoma cells. Previous studies have revealed that knockdown of C-myb also leads to the terminal differentiation of B cell lymphoma. The aim of the present study was to investigate the association between the expression of Mda-7/IL-24 and C-myb, and their prognostic significance for DLBCL patients. The tumor tissues were collected from 72 cases of DLBCL patients and detected with reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemistry assays...
August 2018: Experimental and Therapeutic Medicine
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