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Shan Wang

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https://www.readbyqxmd.com/read/30517796/combination-of-the-searches-for-pair-produced-vectorlike-partners-of-the-third-generation-quarks-at-sqrt-s-13-tev-with-the-atlas-detector
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D'Auria, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R De Asmundis, A De Benedetti, M De Beurs, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, M De Santis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, Y Delabat Diaz, D Delgove, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, L D'Eramo, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, G Di Gregorio, B Di Micco, R Di Nardo, K F Di Petrillo, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias Do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S 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B J Gutelman, P Gutierrez, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A Hamilton, G N Hamity, K Han, L Han, S Han, K Hanagaki, M Hance, D M Handl, B Haney, R Hankache, P Hanke, E Hansen, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, S Harkusha, P F Harrison, N M Hartmann, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, L B Havener, M Havranek, C M Hawkes, R J Hawkings, D Hayden, C Hayes, C P Hays, J M Hays, H S Hayward, S J Haywood, M P Heath, V Hedberg, L Heelan, S Heer, K K Heidegger, J Heilman, S Heim, T Heim, B Heinemann, J J Heinrich, L Heinrich, C Heinz, J Hejbal, L Helary, A Held, S Hellesund, S Hellman, C Helsens, R C W Henderson, Y Heng, S Henkelmann, A M Henriques Correia, G H Herbert, H Herde, V Herget, Y Hernández Jiménez, H Herr, M G Herrmann, T Herrmann, G Herten, R Hertenberger, L Hervas, T C Herwig, G G Hesketh, N P Hessey, S Higashino, E Higón-Rodriguez, K Hildebrand, E Hill, J C Hill, K K Hill, K H Hiller, S J Hillier, M Hils, I Hinchliffe, M Hirose, D Hirschbuehl, B Hiti, O Hladik, D R Hlaluku, X Hoad, J Hobbs, N Hod, M C Hodgkinson, A Hoecker, M R Hoeferkamp, F Hoenig, D Hohn, D Hohov, T R Holmes, M Holzbock, M Homann, S Honda, T Honda, T M Hong, A Hönle, B H Hooberman, W H Hopkins, Y Horii, P Horn, A J Horton, L A Horyn, J-Y Hostachy, A Hostiuc, S Hou, A Hoummada, J Howarth, J Hoya, M Hrabovsky, I Hristova, J Hrivnac, A Hrynevich, T Hryn'ova, P J Hsu, S-C Hsu, Q Hu, S Hu, Y Huang, Z Hubacek, F Hubaut, M Huebner, F Huegging, T B Huffman, M Huhtinen, R F H Hunter, P Huo, A M Hupe, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, Z Idrissi, P Iengo, R Ignazzi, O Igonkina, R Iguchi, T Iizawa, Y Ikegami, M Ikeno, D Iliadis, N Ilic, F Iltzsche, G Introzzi, M Iodice, K Iordanidou, V Ippolito, M F Isacson, N Ishijima, M Ishino, M Ishitsuka, W Islam, C Issever, S Istin, F Ito, J M Iturbe Ponce, R Iuppa, A Ivina, H Iwasaki, J M Izen, V Izzo, P Jacka, P Jackson, R M Jacobs, V Jain, G Jäkel, K B Jakobi, K Jakobs, S Jakobsen, T Jakoubek, D O Jamin, R Jansky, J Janssen, M Janus, P A Janus, G Jarlskog, N Javadov, T Javůrek, M Javurkova, F Jeanneau, L Jeanty, J Jejelava, A Jelinskas, P Jenni, J Jeong, N Jeong, S Jézéquel, H Ji, J Jia, H Jiang, Y Jiang, Z Jiang, S Jiggins, F A Jimenez Morales, J Jimenez Pena, S Jin, A Jinaru, O Jinnouchi, H Jivan, P Johansson, K A Johns, C A Johnson, W J Johnson, K Jon-And, R W L Jones, S D Jones, S Jones, T J Jones, J Jongmanns, P M Jorge, J Jovicevic, X Ju, J J Junggeburth, A Juste Rozas, A Kaczmarska, M Kado, H Kagan, M Kagan, T Kaji, E Kajomovitz, C W Kalderon, A Kaluza, S Kama, A Kamenshchikov, L Kanjir, Y Kano, V A Kantserov, J Kanzaki, B Kaplan, L S Kaplan, D Kar, M J Kareem, E Karentzos, S N Karpov, Z M Karpova, V Kartvelishvili, A N Karyukhin, L Kashif, R D Kass, A Kastanas, Y Kataoka, C Kato, J Katzy, K Kawade, K Kawagoe, T Kawamoto, G Kawamura, E F Kay, V F Kazanin, R Keeler, R Kehoe, J S Keller, E Kellermann, J J Kempster, J Kendrick, O Kepka, S Kersten, B P Kerševan, S Ketabchi Haghighat, R A Keyes, M Khader, F Khalil-Zada, A Khanov, A G Kharlamov, T Kharlamova, E E Khoda, A Khodinov, T J Khoo, E Khramov, J Khubua, S Kido, M Kiehn, C R Kilby, Y K Kim, N Kimura, O M Kind, B T King, D Kirchmeier, J Kirk, A E Kiryunin, T Kishimoto, D Kisielewska, V Kitali, O Kivernyk, E Kladiva, T Klapdor-Kleingrothaus, M H Klein, M Klein, U Klein, K Kleinknecht, P Klimek, A Klimentov, T Klingl, T Klioutchnikova, F F Klitzner, P Kluit, S Kluth, E Kneringer, E B F G Knoops, A Knue, A Kobayashi, D Kobayashi, T Kobayashi, M Kobel, M Kocian, P Kodys, P T Koenig, T Koffas, E Koffeman, N M Köhler, T Koi, M Kolb, I Koletsou, T Kondo, N Kondrashova, K Köneke, A C König, T Kono, R Konoplich, V Konstantinides, N 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Zemaityte, J C Zeng, Q Zeng, O Zenin, D Zerwas, M Zgubič, D F Zhang, D Zhang, F Zhang, G Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, Y Zhao, Z Zhao, A Zhemchugov, Z Zheng, D Zhong, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T→Zt/Wb/Ht, B→Zb/Wt/Hb) is performed using 36.1  fb^{-1} of pp collision data at sqrt[s]=13  TeV with the ATLAS detector at the Large Hadron Collider. The observed data are found to be in good agreement with the standard model background prediction in all individual searches. Therefore, combined 95% confidence-level upper limits are set on the production cross section for a range of vectorlike quark scenarios, significantly improving upon the reach of the individual searches...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517793/observation-of-centrality-dependent-acoplanarity-for-muon-pairs-produced-via-two-photon-scattering-in-pb-pb-collisions-at-sqrt-s_-nn-5-02-tev-with-the-atlas-detector
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Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, P Zhao, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M S Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H L Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
This Letter presents a measurement of γγ→μ^{+}μ^{-} production in Pb+Pb collisions recorded by the ATLAS detector at the Large Hadron Collider at sqrt[s_{NN}]=5.02  TeV with an integrated luminosity of 0.49  nb^{-1}. The azimuthal angle and transverse momentum correlations between the muons are measured as a function of collision centrality. The muon pairs are produced from γγ through the interaction of the large electromagnetic fields of the nuclei. The contribution from background sources of muon pairs is removed using a template fit method...
November 23, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30517786/fluoride-induced-dynamic-surface-self-reconstruction-produces-unexpectedly-efficient-oxygen-evolution-catalyst
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Bowei Zhang, Kun Jiang, Haotian Wang, Shan Hu
Oxygen evolution reaction (OER) is a key process in water splitting systems, fuel cells, and metal-air batteries, but the development of highly active and robust OER catalyst by simple methods is a great challenge. Here, we report an in situ dynamic surface self-reconstruction that can dramatically improve the catalytic activity of electrocatalysts. The fluoride (F-)-incorporated NiFe hydroxide (NiFe-OH-F) nanosheets array was initially grown on Ni foam by a one-step hydrothermal method, which requires a 243 mV overpotential (η) to achieve 10 mA cm-2 current density (j) with a Tafel slope of 42...
December 5, 2018: Nano Letters
https://www.readbyqxmd.com/read/30516836/vdr-rs7975232-apai-genetic-variation-predicts-sustained-hbsag-loss-in-hbeag-positive-chronic-hepatitis-b-patients-treated-with-pegylated-interferon
#4
Shan Ben, Wang Jun Yan, Wang Xia, Fu Juan Juan, Li Li, Pan Xiu Cheng, Li Jian Jun, Tang Xian Tuan
AIM: To evaluate the predictive value of vitamin D and its metabolic pathway gene polymorphisms in response to pegylated interferon (Peg-IFN) in HBeAg-positive CHB patients. METHODS: 119 HBeAg-positive CHB patients who received Peg-IFN monotherapy for 48 weeks and then were followed-up for another 48 weeks were prospectively enrolled; baseline 25-(OH)D and HBV serologic marker levels were detected, 9 critical single nucleotide polymorphisms within vitamin D metabolism were genotyped...
December 5, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/30515782/long-noncoding-rna-nuclear-enriched-abundant-transcript-1-impacts-cell-proliferation-invasion-and-migration-of-glioma-through-regulating-mir-139-5p-cdk6
#5
Dong-Mei Wu, Shan Wang, Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Zi-Feng Zhang, Qun Shan, Jun Lu, Yuan-Lin Zheng
AIMS: We aimed to explore the impact of long noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) on cell proliferation, invasion, and migration of glioma. METHODS: Differentially expressed genes were screened out from Gene Expression Omnibus data set based on the microarray analysis. The expression levels of lncRNA NEAT1, miR-139-5p, and CDK6 in glioma cells and tissues were examined by quantitative reverse transcription polymerase chain reaction, and the protein level of CDK6 in glioma cells was determined by western blot and immunohistochemistry...
December 4, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30514747/night-shift-work-and-abnormal-liver-function-is-non-alcohol-fatty-liver-a-necessary-mediator
#6
Feng Wang, Liuzhuo Zhang, Suyang Wu, Wentao Li, Miaomiao Sun, Wenting Feng, Ding Ding, Samuel Yeung-Shan Wong, Peng Zhu, Greg J Evans, Yun Kwok Wing, Jihui Zhang, Jelle J Vlaanderen, Roel C H Vermeulen, Yanfang Zhang, Emily Ying-Yang Chan, Zhimin Li, Lap Ah Tse
OBJECTIVES: Accumulated evidence implies that night shift work may trigger liver dysfunction. Non-alcoholic fatty liver (NAFL) is suggested to be a necessary mediator in this process. This study aimed to examine the relationship between night shift work and elevated level of alanine transaminase (e-ALT) of workers and investigate the potential mediation effect of NAFL. METHODS: This study included all male workers from the baseline survey of a cohort of night shift workers...
December 4, 2018: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/30513776/elevated-serum-interleukin-8-level-correlates-with-cancer-related-cachexia-and-sarcopenia-an-indicator-for-pancreatic-cancer-outcomes
#7
Ya-Chin Hou, Chih-Jung Wang, Ying-Jui Chao, Hao-Yun Chen, Hao-Chen Wang, Hui-Ling Tung, Jung-Ting Lin, Yan-Shen Shan
Cancer cachexia (CC), characterized by body weight loss and sarcopenia, contributes to over 20% of all cancer-related death. Approximately 80% of pancreatic cancer (PC) patients develop CC during disease progression. Pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α, have been correlated with CC; however, its prognostic significance remains unclear. In this study, serum levels of the CC-related cytokines were determined in normal donors and PC patients...
December 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30513637/%C3%AE-melanocyte-stimulating-hormone-attenuates-neovascularization-by-inducing-nitric-oxide-deficiency-via-mc-rs-pka-nf-%C3%AE%C2%BAb-signaling
#8
Wen-Tsan Weng, Chieh-Shan Wu, Feng-Sheng Wang, Chang-Yi Wu, Yi-Ling Ma, Hoi-Hung Chan, Den-Chiung Wu, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ming-Hong Tai
α-melanocyte-stimulating hormone (α-MSH) has been characterized as a novel angiogenesis inhibitor. The homeostasis of nitric oxide (NO) plays an important role in neovascularization. However, it remains unclear whether α-MSH mitigates angiogenesis through modulation of NO and its signaling pathway. The present study elucidated the function and mechanism of NO signaling in α-MSH-induced angiogenesis inhibition using cultured human umbilical vein endothelial cells (HUVECs), rat aorta rings, and transgenic zebrafish...
November 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30513480/photocatalytic-hydrogen-production-from-water-splitting-with-n-doped-%C3%AE-ga-2-o-3-and-visible-light
#9
Ze-Cheng Zhao, Chuan-Lu Yang, Qing-Tian Meng, Mei-Shan Wang, Xiao-Guang Ma
Based on the first principles calculations, the feasibility of the photocatalytic hydrogen production from water splitting driven by N-doped β-Ga2 O3 in the visible light is investigated. The formation energy and dynamics properties are used to examine the stability of the doped structures. The absolute positions of the band energy edges are obtained and compared to the redox potentials of the hydrogen production reaction. Moreover, we calculate the carrier lifetime and mobility for both electron and hole of all the considered structures...
November 16, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30511872/impact-of-a-single-hydrogen-substitution-by-fluorine-on-the-molecular-interaction-and-miscibility-between-sorafenib-and-polymers
#10
Chengyu Liu, Cong-Qiao Xu, Junguang Yu, Yipshu Pui, Huijun Chen, Shan Wang, Alan Donghua Zhu, Jun Li, Feng Qian
We aim to understand the potential impact of a modest chemical modification of a drug molecule on the downstream design of its amorphous solid dispersion (ASD) formulation. To this end, we used sorafenib (SOR) and its fluorinated form, regorafenib (REG), as model drugs, to assess the impact of a single hydrogen substitution by fluorine on the molecular interaction and miscibility between drug and PVP or PVP-VA, two commonly used polymers for ASDs. In this study, we observed that the Tg values of PVP or PVP-VA based SOR ASDs deviated positively from Gordon-Taylor prediction that assumes ideal mixing, yet the Tg of REG ASDs deviated negatively from or matched well with this ideal mixing model, suggesting much stronger drug-polymer interactions in SOR ASDs compared with the REG ones...
December 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30511395/il-6-yap1-%C3%AE-catenin-signaling-is-involved-in-intervertebral-disc-degeneration
#11
Jian Chen, Zhengfeng Mei, Bao Huang, Xuyang Zhang, Junhui Liu, Zhi Shan, Jiasheng Wang, Xianjun Wang, Fengdong Zhao
Yes-associated protein 1 (YAP1) is a transcriptional coactivator and negative regulator of the Hippo pathway. It regulates diverse cellular processes, such as cell proliferation, contact inhibition, and tissue size. However, the role of YAP1 in intervertebral disc degeneration (IDD) remains elusive. Here, we demonstrated that YAP1 was activated by Interleukin 6 (IL-6) through tyrosine phosphorylation in nucleus pulposus cells (NP cells). Overexpression of YAP1 decreased Sox-9, Col-II, aggrecan expression, whereas increased matrix metalloproteinases 13 level...
December 3, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30510361/anatomical-variation-of-infra-pyloric-artery-origination-a-prospective-multicenter-observational-study-ipa-origin
#12
Rulin Miao, Jianjun Qu, Zhengrong Li, Daguang Wang, Jiang Yu, Weidong Zang, Yong Li, Fenglin Liu, Jian Zhang, Wu Song, Kai Ye, Su Yan, Wei Wang, Shuangyi Ren, Lu Zang, Changqing Jing, Li Zhang, Kuan Wang, Weihua Fu, Lin Fan, Bin Liang, Gang Zhao, Jun Cai, Li Yang, Jiaming Zhu, Jun You, Kun Yang, Qingxing Huang, Zhaojian Niu, Ning Ning, Xingfeng Qiu, Gang Ji, Feng Liang, Hua Huang, Chao Gao, Fei Shan, Shuangxi Li, Yongning Jia, Lianhai Zhang, Xiangji Ying, Yan Zhang, Zhaode Bu, Xiangqian Su, Gang Zhao, Ziyu Li, Jiafu Ji
Objective: Infra-pyloric artery (IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA. Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of 34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned...
October 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30510222/g3bp1-promotes-dna-binding-and-activation-of-cgas
#13
Zhao-Shan Liu, Hong Cai, Wen Xue, Miao Wang, Tian Xia, Wan-Jin Li, Jia-Qing Xing, Ming Zhao, Yi-Jiao Huang, Shuai Chen, Sheng-Ming Wu, Xinzheng Wang, Xin Liu, Xue Pang, Zi-Yu Zhang, Tingting Li, Jiang Dai, Fangting Dong, Qing Xia, Ai-Ling Li, Tao Zhou, Zheng-Gang Liu, Xue-Min Zhang, Tao Li
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection. Here we report that GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. G3BP1 enhanced DNA binding of cGAS by promoting the formation of large cGAS complexes. G3BP1 deficiency led to inefficient DNA binding by cGAS and inhibited cGAS-dependent interferon (IFN) production. The G3BP1 inhibitor epigallocatechin gallate (EGCG) disrupted existing G3BP1-cGAS complexes and inhibited DNA-triggered cGAS activation, thereby blocking DNA-induced IFN production both in vivo and in vitro...
December 3, 2018: Nature Immunology
https://www.readbyqxmd.com/read/30509838/response-of-phytoplankton-assemblages-to-nitrogen-reduction-in-the-laizhou-bay-china
#14
Huichao Jiang, Dongyan Liu, Xiukai Song, Yuanqing Ma, Yujue Wang, Aiying Liu, Ling Cheng, Jianlong He, Shan Sun
The response of phytoplankton assemblages to decreases in nitrogen loading is an essential index to assess the recovery of aquatic ecosystems from eutrophic status. However, a positive signal is hard to observe from short-term operations considering ecosystem complexity. Here, we used decadal data from the Laizhou Bay, China to track the seasonal and annual variations in phytoplankton assemblages after ammonia reduction in the Xiaoqing and Yellow Rivers. Annual trends show reduced phytoplankton abundance and a decline in harmful algal blooms, indicating the positive recovery of phytoplankton assemblages...
November 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/30509596/co-disposal-of-mswi-fly-ash-and-electrolytic-manganese-residue-based-on-geopolymeric-system
#15
Xinyuan Zhan, Li'ao Wang, Chaochao Hu, Jian Gong, Tengtun Xu, Jiaxiang Li, Lu Yang, Jisong Bai, Shan Zhong
MSWI fly ash (MSWI FA) and electrolytic manganese residue (EMR) were successfully co-disposed by use of a geopolymeric system. Alkaline products of MSWI FA and NaOH were used to elicit chemical reactions to promote solidification. The best performing formulation of EMR-based geopolymer for immobilization of heavy metals was composed of 75 wt% MSWI FA and 25 wt% EMR with NaOH solution (7.5 M)/solid of 0.5. Solidification was most effective for the heavy metals: Pb > Cu > Cr > Zn > Mn, respectively...
December 2018: Waste Management
https://www.readbyqxmd.com/read/30508783/exploring-the-reason-for-increased-activity-of-shp2-caused-by-d61y-mutation-through-molecular-dynamics
#16
Rui-Rui Wang, Ying Ma, Shan Du, Wei-Ya Li, Ying-Zhan Sun, Hui Zhou, Run-Ling Wang
Juvenile myelomonocytic leukaemia, an aggressive myeloproliferative neoplasm, is characterized by thrombocytopenia, splenomegaly, fever and excess myelomonocytic cells. Approximately 35% of patients with JMML occur D61Y mutation in PTPN11, and it increases the activity of the protein. However, the effect of the D61Y mutation on SHP2 conformations in molecular basis is poorly understood. Therefore, the molecular dynamics simulations on SHP2-D61Y and SHP2-WT were performed to explore the effect of D61Y mutation on SHP2 and explain the reason for high activity of SHP2-D61Y mutant...
October 29, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30506739/cold-exposure-induces-nuclear-translocation-of-crtc3-in-brown-adipose-tissue
#17
Ziye Xu, Jiaqi Liu, Wenjing You, Yizhen Wang, Tizhong Shan
In mammals, cold stress activates the cAMP-protein kinase A (PKA) signaling pathway, increases brown adipose tissue (BAT) activity, and induces thermogenesis to maintain body temperature. The cAMP responsive element binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) plays important role in adipose development and energy metabolism. However, the effect of cold exposure on the intracellular localization of CRTC3 in BAT is unclear. Here, we report that cold-treated mice have higher expression of uncoupling protein 1 (UCP1) in adipose tissues and lower body weights and fat masses...
December 2, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30506714/comparison-of-2-d-shear-wave-elastography-with-clinical-score-in-localized-scleroderma-a-new-method-to-increase-the-diagnostic-accuracy
#18
Ying Wang, Jie-Ling Shan, Hu-Yan Chen, Zhi-Feng Wu
There is no established diagnostic criteria or widely accepted severity classification of localized scleroderma (LS) by imaging. Acoustic radiation force impulse (ARFI) technology by normalized mean shear wave velocity (SWV) may be as a probing tool for diagnosing and staging LS accurately and objectively. Fifty-six patients with LS of inflammatory (n = 21), sclerotic (n = 24) and atrophic (n = 11) stage and 30 healthy controls were evaluated on the basis of pathological results. Dermal thickness, ARFI quality (elastography score) and quantity (mean SWV) were measured by ultrasonography (US), diagnosis and stage performances of LS using the dermal thickness, elastography score and mean SWV compared with modified localized scleroderma skin severity index (mLoSSI) were evaluated...
December 3, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30505627/an-intravascular-magnetic-wire-for-the-high-throughput-retrieval-of-circulating-tumour-cells-in-vivo
#19
Ophir Vermesh, Amin Aalipour, T Jessie Ge, Yamil Saenz, Yue Guo, Israt S Alam, Seung-Min Park, Charlie N Adelson, Yoshiaki Mitsutake, Jose Vilches-Moure, Elias Godoy, Michael H Bachmann, Chin Chun Ooi, Jennifer K Lyons, Kerstin Mueller, Hamed Arami, Alfredo Green, Edward I Solomon, Shan X Wang, Sanjiv S Gambhir
The detection and analysis of rare blood biomarkers is necessary for early diagnosis of cancer and to facilitate the development of tailored therapies. However, current methods for the isolation of circulating tumour cells (CTCs) or nucleic acids present in a standard clinical sample of only 5-10 ml of blood provide inadequate yields for early cancer detection and comprehensive molecular profiling. Here, we report the development of a flexible magnetic wire that can retrieve rare biomarkers from the subject's blood in vivo at a much higher yield...
September 2018: Nature Biomedical Engineering
https://www.readbyqxmd.com/read/30503582/strain-differences-between-cd-1-and-c57bl-6-mice-in-expression-of-metabolic-enzymes-and-dna-methylation-modifications-of-the-primary-hepatocytes
#20
Shan Wang, Liping Chen, Qing Wang, Zhini He, Shen Chen, Haiyan Zhang, Huiyao Li, Ping Guo, Qiong Li, Rui Zhang, Xiumei Xing, Xiaowen Zeng, Weiwei Lin, Yongmei Xiao, Guanghui Dong, Lu Ma, Namratha Gurram, Aihua Zhang, Wen Chen, Daochuan Li
Primary mouse hepatocyte cultures are widely used in toxicological and pharmacological studies. However, the strain differences in alterations of metabolic enzymes and the regulation of gene expression in response to different stimuli remains unclear. To address this issue, we examined the expression of metabolic enzymes and the regulatory role of DNA methylation in the primary hepatocytes of two mouse strains, CD-1 and C57BL/6. Primary culture of mouse hepatocytes was established using collagen sandwich configuration...
November 29, 2018: Toxicology
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