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Digestive Oncology

Thomas J Vogl, Philippe L Pereira, Andreas G Schreyer, Wolff Schmiegel, Sebastian Fischer, Christoph Herzog
The updated German S3 guidelines "Colorectal Carcinoma" were created as part of the oncology program of the Association of the Scientific Medical Societies (AWMF), German Cancer Society and the German Cancer Aid under the auspices of the German Society for Digestive and Metabolic Disorders (DGVS) and they replace the previous guidelines from 2013. The main changes in the updated guidelines include the latest recommendations regarding endoscopy and adjuvant/neoadjuvant therapies as well as a complete restructuring of the section regarding therapeutic approach in metastases and in the palliative situation...
September 24, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
L M Canseco-Ávila, F Y Zamudio-Castellanos, R A Sánchez-González, M G Trujillo-Vizuet, S Domínguez-Arrevillaga, C A López-López
INTRODUCTION AND AIM: Gastic cancer is the most frequent neoplasia of the digestive tract worldwide. Incidence rates vary according to the region or country analyzed. Variation in the different regions of Mexico is attributed to very specific dietary, environmental, and genetic patterns. The aim of the present work was to carry out an epidemiologic analysis of the cases of gastric cancer treated at the Hospital Regional de Alta Especialidad 'Ciudad Salud', located in Chiapas, Mexico. MATERIAL AND METHODS: A descriptive, ambispective, longitudinal study was conducted...
September 19, 2018: Revista de Gastroenterología de México
Simran Grewal, Rianne Korthouwer, Marijn Bögels, Rens Braster, Niels Heemskerk, Andries E Budding, Stephan M Pouw, Jack van Horssen, Marjolein Ankersmit, Jeroen Meijerink, Petrousjka van den Tol, Steven Oosterling, Jaap Bonjer, Nuray Gül, Marjolein van Egmond
Surgical resection of the primary tumor provides the best chance of cure for patients with colorectal carcinoma (CRC). However, bacterial translocation during intestinal surgery has been correlated with poor long-term oncological outcome. Therefore, we investigated the influence of bacterial contamination during colon surgery on CRC liver metastases development. Blood and liver samples of patients undergoing resection of primary CRC or liver metastases were collected. Cell numbers, activation markers and inflammatory mediators were determined...
2018: Oncoimmunology
Hongwu Wang, Mingyao Ke, Wen Li, Zikai Wang, Hui Li, Minghua Cong, Yiming Zeng, Liangan Chen, Guoxiang Lai, Baosong Xie, Nan Zhang, Wangping Li, Hongmei Zhou, Xiaoping Wang, Dianjie Lin, Yunzhi Zhou, Huaping Zhang, Dongmei Li, Xiaolian Song, Juan Wang, Shiman Wu, Meimei Tao, Zhengbu Sha, Qiang Tan, Xinwei Han, Lingfei Luo, Hongming Ma, Zhiqiang Wang
Acquired respiratory-digestive tract fistulas occur with abnormal communication between the airways and digestive tract, causing the interflow of gas and liquid. Despite advances in surgical methods and the development of multimodal therapy in recent years, patients with acquired respiratory-digestive tract fistulas continue to exhibit unfavorable clinical outcomes. Therefore, in order to guide clinical practice in China, the Respiratory and Cancer Intervention Alliance of the Beijing Health Promotion Association organized a group of experienced experts in the field to develop this consensus document...
September 17, 2018: Thoracic Cancer
Ayush Naik, Virendra Bhandari, R Y Saadvik, K L Gupta, Mehlam Kausar, Manika Batra
Background: Advancement in diagnostic and therapeutic modalities lead to increased cancer survivors who have 20% higher risk of developing second primary malignancy (SPM). Aim: To look for the incidence, epidemiological factors, treatment-related factors, and common risk factors responsible for the development of the SPM in Malwa region. Materials and Methods: Records of 7709 patients who visited the Department of Oncology between May 2008 and August 2015 were analyzed and looked for the presence of SPM based on Warren and Gates criteria for head and neck and International Agency for Research on Cancer definition for other sites...
July 2018: Journal of Cancer Research and Therapeutics
J Bollo, P Salas, M C Martinez, P Hernandez, A Rabal, E Carrillo, E Targarona
BACKGROUND: Colorectal cancer (CRC) is the third most frequent cancer diagnosed in men and the second in women. Laparoscopic surgery has been a technical revolution in colorectal surgery, facilitating a better recovery of patients with lower morbidity and better esthetic results, compared to traditional surgery via laparotomy, without compromising safety and long-term oncological results. PURPOSE: The trial is a randomized controlled trial indented to evaluate the two interventions with thorough measurements of the postoperative variables and complications to improve the evaluation of the surgical technique...
September 6, 2018: International Journal of Colorectal Disease
Jaume Capdevila, Lisa Bodei, Philippa Davies, Vera Gorbounova, Robert T Jensen, Ulrich Knigge, Guenter J, Eric Krenning, Juan O''Connor, Marc Peeters, Guido Rindi, R Salazar, Marie Pierre Vullierme, Marianne Pavel
<br>Unmet medical needs are not infrequent in oncology and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade and currently a new WHO classification is being implemented and several treatment options are available in metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered and decisions in our daily clinical practice should be made with limited evidence...
August 28, 2018: Neuroendocrinology
Larry C Cheng, Zhen Li, Thomas G Graeber, Nicholas A Graham, Justin M Drake
Phosphoproteomics involves the large-scale study of phosphorylated proteins. Protein phosphorylation is a critical step in many signal transduction pathways and is tightly regulated by kinases and phosphatases. Therefore, characterizing the phosphoproteome may provide insights into identifying novel targets and biomarkers for oncologic therapy. Mass spectrometry provides a way to globally detect and quantify thousands of unique phosphorylation events. However, phosphopeptides are much less abundant than non-phosphopeptides, making biochemical analysis more challenging...
August 2, 2018: Journal of Visualized Experiments: JoVE
Pietro Mascagni, Fabio Longo, Manuel Barberio, Barbara Seeliger, Vincent Agnus, Paola Saccomandi, Alexandre Hostettler, Jacques Marescaux, Michele Diana
Imaging is one of the pillars for the ongoing evolution of surgical oncology toward a precision paradigm. In the present overview, some established or emerging intraoperative imaging technologies are described in light of the vision and experience of our group in image-guided surgery, focusing on digestive surgical oncology.
August 2018: Journal of Surgical Oncology
Junki Mizusawa, Akira Fukutomi, Hiroshi Katayama, Hiroshi Ishii, Tatsuya Ioka, Takuji Okusaka, Hideki Ueno, Makoto Ueno, Masafumi Ikeda, Nobumasa Mizuno, Masato Ozaka, Haruhiko Fukuda, Junji Furuse
Gemcitabine is one of the standard treatments for locally advanced pancreatic cancer. Recent studies on metastatic pancreatic cancer have shown that combination chemotherapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine plus nab-paclitaxel (GnP) prolonged the overall survival compared with gemcitabine alone. To select the most promising chemotherapy, a randomized phase II selection design trial was started in July 2016 to compare between modified FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer...
October 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Rossella Reddavid, Laura Esposito, Andrea Evangelista, Silvia Sofia, Maurizio Degiuli
BACKGROUND: Cancers of the transverse colon (TC) and of the splenic flexure (SF) are rather uncommon and their prognosis has been reported significantly poorer as compared to right- and left- sided colon cancers. Several studies tried to investigate which is the optimal surgery for oncological and survival outcomes reporting extended colectomies as more effective than limited resections. METHODS: All consecutive patients with diagnosis of colorectal cancer submitted to surgical resection with anastomosis between January 2005 and December 2016 at University of Turin, Department of Oncology, Division of Surgical Oncology and Digestive Surgery, were included...
July 23, 2018: Minerva Chirurgica
Geoffrey Cheminet, Gabrielle Clain, Anne-Sophie Jannot, Brigitte Ranque, Amélie Passeron, Adrien Michon, Gonzalo De Luna, Jean-Luc Diehl, Stéphane Oudard, Christophe Cellier, Alexandre Karras, Benoit Vedié, Caroline Prot-Bertoye, Jacques Pouchot, Jean-Benoît Arlet
Extreme hypomagnesemia (hypoMg) can be encountered in many situations, but little data currently exist. Our aim is to describe the epidemiological, clinical, etiological characteristics, and the biological abnormalities of consecutive inpatients with extreme hypomagnesemia. In our observational monocentric study, between 1st July 2000 and April 2015, all inpatients with extreme hypomagnesemia, defined by at least one plasma magnesium concentration (PMg ) below 0.3 mmol/L, were included. Demographic, clinical, biological characteristics and the drugs prescribed before the qualifying PMg measurement were retrospectively collected...
June 27, 2018: Internal and Emergency Medicine
Jeremy Meyer, Alexandre Balaphas, Thibaud Koessler, Philippe Morel, Léo Bühler, Nicolas Buchs, Frédéric Ris
An appendix tumour is found every 100 appendectomies. It can also be incidental discovery during a routine radiological examination and presents as a mucocele of the appendix. Appendix tumours are of varied histological type, and include mainly neuroendocrine tumours as well as epithelial tumours. The latter, when they secrete mucin, can give rise to peritoneal pseudomyxoma, a particular form of carcinosis harbouring serious complications. The management of appendix tumours responds to specific recommendations and, in advanced cases, requires the expertise of a university centre specialized in digestive oncology...
June 13, 2018: Revue Médicale Suisse
Michelle Palmieri, Mariana Ornaghi, Victor Adriano de Oliveira Martins, Luciana Correa, Thais Bianca Brandao, Ana Carolina do Prado Ribeiro, Laura Masami Sumita, Tania Regina Tozetto-Mendoza, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva
Background : Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective : The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods : In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy...
2018: Journal of Oral Microbiology
Nelson S Yee, Eugene J Lengerich, Kathryn H Schmitz, Jennifer L Maranki, Niraj J Gusani, Leila Tchelebi, Heath B Mackley, Karen L Krok, Maria J Baker, Claire de Boer, Julian D Yee
Cancers of the digestive system remain highly lethal; therefore, the care of patients with malignant diseases of the digestive tract requires the expertise of providers from multiple health disciplines. Progress has been made to advance the understanding of epidemiology and genetics, diagnostic and screening evaluation, treatment modalities, and supportive care for patients with gastrointestinal cancers. At the Multi-Disciplinary Patient Care in Gastrointestinal Oncology conference at the Hershey Country Club in Hershey, Pennsylvania on 29 September 2017, the faculty members of the Penn State Health Milton S...
June 1, 2018: Biomedicines
Daniel Eison
The oncology floor can be a silent place. Unlike the cardiology floor, with its insistent telemetry beeping, or the incessant bustle of the general ward below. Silence can be healing, and the oncology floor reveres all forms of healing it can find. Yet some voices ring loud on this floor. As an intern, I would grimace into my scut list as oncology attendings intoned dire diagnoses and exhorted still-reeling victims to altruistically enroll in clinical trials. I mutely ground my teeth listening to the relentless stream of probabilities and adverse reactions flooding into the shocked silence of a child baffled by his or her metamorphosis into a cancer patient between breakfast and lunch...
May 2018: Hastings Center Report
Michal Jankowski, Manuela Las-Jankowska, Massaoud Sousak, Wojciech Zegarski
BACKGROUND: Gastrointestinal cancers are among the most recognised oncological diseases in well-developed countries. Tumours located in the digestive tract may cause the fast occurrence of malnutrition. MAIN TEXT: The perioperative period is a special time for systemic metabolism. Thanks to published guidelines, early universal control nutritional status before treatment, patients may have a chance to get suitable nutritional intervention. Although the first line of the intervention-nutritional consultation as well as the fortification of a diet and oral nutritional support (ONS)-is not debatable, in a case of inability of undergoing an oral feeding, the choice of the way of administration in patients before a surgery may represent a serious clinical obstacle...
May 16, 2018: World Journal of Surgical Oncology
J Arends
Patients with advanced cancer are at high risk of losing vital body resources resulting in malnutrition, immunodeficiency, impaired quality of life and worse clinical outcome. Prominent among the diverse factors contributing to this complex condition are metabolic derangements characterized by systemic inflammation, catabolism and accumulating changes in body composition. Because cure in advanced cancer still remains elusive, optimal supportive and integrated palliative care are required to allow patients to tolerate aggressive or long-term anticancer treatments, to maintain an adequate quality of life or to stay the course of advancing disease...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Francesco S Papadia, Giovanni B Camerini, Flavia Carlini, Raffaele De Rosa, Franco De Cian, Nicola Scopinaro
BACKGROUND: Data regarding management of former bariatric operations after onset of a malignancy are still lacking and there is no consensus whether bariatric surgery negatively influences the oncologic management of patients. OBJECTIVES: To investigate the strategy by which patients previously submitted to bariatric surgery were managed after diagnosis of malignancy of the digestive apparatus, whether a revision was performed or not, to assess the incidence of nutritional complications, and the effect of revision versus no revision of bariatric surgery on the outcome of cancer treatment...
July 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Linda J Wedlake
Radiotherapy-induced damage to non-cancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option with sound rationale for intervention. The aim of this review was to synthesise published evidence for the use of elemental formulae, low or modified fat diets, fibre, lactose restriction and probiotics, prebiotics and synbiotics to protect the bowel from gastrointestinal side effects during long-course, radical pelvic radiotherapy...
April 2, 2018: Proceedings of the Nutrition Society
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