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Digestive Oncology

Aziz Zaanan, Julien Taieb
The MSI phenotype in colon cancer is a good prognostic factor, with an impact probably more pronounced for stage II than stage III tumor. This survival advantage may be related to the tumor-infiltrating lymphocytes observed in MSI tumors, thus explaining the existence of a probably more effective anti-tumor immune response. In addition, the MSI status would also be a biomarker able to predict the lack of efficacy of adjuvant 5-fluorouracil (5FU) chemotherapy. In contrast, as observed in MSS colon cancer, the MSI tumors would have a survival benefit with the addition of oxaliplatin to adjuvant 5FU chemotherapy...
December 4, 2018: Bulletin du Cancer
Hanaa Amrani Hassani Joutei, Nabila Marchoudi, Wafaa Mahfoud, Ilham Sadaoui, Taoufiq Fechtali, Hakima Benomar
BACKGROUND AND STUDY AIMS: Targeted therapies have an increasing importance in digestive oncology. To our knowledge, we are the first to report the distribution of PI3KCA and BRAF mutations in Moroccan HER2 overexpressed patients, in order to introduce targeted therapy in the arsenal of therapeutic modalities for management in Morocco. PATIENTS AND METHODS: 98 gastric adenocarcinoma tissue samples were collected. Further histological and immunohistochemical examinations were carried out at the Laboratory of Anatomy Pathology in Pasteur Institute-Morocco, in order to select HER2 positive cases...
November 28, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
Bojoura Schouten, Dominiek De Jonckheere, Marc Aerts, Jochen Decaestecker, Daan Walgraeve, Patrick Vankrunkelsven, Johan Hellings
PURPOSE: Systematic assessment of QOL and care needs was applied in two gastroenterology departments to support "Cancer Care for the Whole Patient." METHODS: Patients with digestive cancer were asked to complete the Cancer Rehabilitation Evaluation System-Short Form (CARES-SF) at the start of treatment and 3 months later. Both times CARES data were processed, and summary reports on the retained insights were sent to the reference nurse for use in further follow-up of the patient...
November 29, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
T Jínek, L Adamčík, R Vrba, M Duda, M Škrovina
INTRODUCTION: Gastric resections due to carcinoma belong to the most demanding procedures in visceral surgery. This is due to the requirements for the extent of resection and lymphadenectomy, coupled with the need for functional reconstruction of the digestive tract. The procedure is associated with 18-46% morbidity, which delays administration of adjuvant therapy and worsens oncological results. Identification of risk factors for potential complications may play an important role in the indication and perioperative care...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Evelyne Liuu, Nicolas Guyot, Simon Valero, Amelie Jamet, Houria El Ouazzani, Patrick Bouchaert, Jean-Marc Tourani, Virginie Migeot, Marc Paccalin
This study aimed to determine cancer prevalence occurring after the age of 75 in 45 French nursing homes (NH), as well as residents' characteristics and parameters associated with cancer-specific management. Descriptive retrospective study including 214 residents (mean age, 89.7 years) with cancer diagnosed after age 75. The studied parameters were sociodemographic, functional, nutritional and cognitive data; comorbidity assessment; date of tumoral diagnosis; cancer type; tumoral stage; treatment plan; multidisciplinary staff decision and oncologic follow-up...
October 29, 2018: European Journal of Cancer Care
Deepak B Vangala, Estelle Cauchin, Judith Balmaña, Lucian Wyrwicz, Eric van Cutsem, Ulrich Güller, Antoni Castells, Fatima Carneiro, Pascal Hammel, Michel Ducreux, Jean-Luc van Laethem, Tamara Matysiak-Budnik, Wolff Schmiegel
Patients with hereditary gastrointestinal (GI) cancers represent a substantial fraction of the overall affected population. Although awareness for hereditary GI cancer syndromes is on the rise, identification of patients and measures of surveillance are often unclear in everyday clinical routine. Therefore, the European Society of Digestive Oncology expert discussion 2018 at the World Congress on Gastrointestinal Cancer focussed on screening and surveillance of hereditary colorectal, gastric and pancreatic cancers...
October 17, 2018: European Journal of Cancer
J M Rosa-Rosa, T Caniego-Casas, S Leskela, G Muñoz, F Del Castillo, P Garrido, J Palacios
Background: Personalised medicine is nowadays a major objective in oncology. Molecular characterization of tumours through NGS offers the possibility to find possible therapeutic targets in a time- and cost-effective way. However, the low quality and complexity of FFPE DNA samples bring a series of disadvantages for massive parallel sequencing techniques compared to high-quality DNA samples (from blood cells, cell cultures, etc.). Results: We performed several experiments to understand the behaviour of FFPE DNA samples during the construction of SureSelectQXT libraries...
2018: Biological Procedures Online
Thomas Vermeulin, Mélodie Lucas, Hélène Marini, Frédéric Di Fiore, Agnès Loeb, Marion Lottin, Hervé Daubert, Christian Gray, Florian Guisier, David Sefrioui, Pierre Michel, Rémy de Mil, Pierre Czernichow, Véronique Merle
INTRODUCTION: During the last decade, most studies on totally implanted venous access-associated adverse events (TIVA-AE) were conducted retrospectively and/or were based on a limited sample size. The aim of our survey was two-fold: to estimate the incidence of TIVA-AE and to identify risk factors in patients with cancer. METHODS: Data from our routine surveillance of TIVA-AE were collected prospectively between October 2009 and January 2011 in two oncology referral centers in Northern France...
November 2018: Bulletin du Cancer
Thomas J Vogl, Philippe L Pereira, Andreas G Schreyer, Wolff Schmiegel, Sebastian Fischer, Christoph Herzog
The updated German S3 guidelines "Colorectal Carcinoma" were created as part of the oncology program of the Association of the Scientific Medical Societies (AWMF), German Cancer Society and the German Cancer Aid under the auspices of the German Society for Digestive and Metabolic Disorders (DGVS) and they replace the previous guidelines from 2013. The main changes in the updated guidelines include the latest recommendations regarding endoscopy and adjuvant/neoadjuvant therapies as well as a complete restructuring of the section regarding therapeutic approach in metastases and in the palliative situation...
September 24, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
L M Canseco-Ávila, F Y Zamudio-Castellanos, R A Sánchez-González, M G Trujillo-Vizuet, S Domínguez-Arrevillaga, C A López-López
INTRODUCTION AND AIM: Gastic cancer is the most frequent neoplasia of the digestive tract worldwide. Incidence rates vary according to the region or country analyzed. Variation in the different regions of Mexico is attributed to very specific dietary, environmental, and genetic patterns. The aim of the present work was to carry out an epidemiologic analysis of the cases of gastric cancer treated at the Hospital Regional de Alta Especialidad 'Ciudad Salud', located in Chiapas, Mexico. MATERIAL AND METHODS: A descriptive, ambispective, longitudinal study was conducted...
September 19, 2018: Revista de Gastroenterología de México
Simran Grewal, Rianne Korthouwer, Marijn Bögels, Rens Braster, Niels Heemskerk, Andries E Budding, Stephan M Pouw, Jack van Horssen, Marjolein Ankersmit, Jeroen Meijerink, Petrousjka van den Tol, Steven Oosterling, Jaap Bonjer, Nuray Gül, Marjolein van Egmond
Surgical resection of the primary tumor provides the best chance of cure for patients with colorectal carcinoma (CRC). However, bacterial translocation during intestinal surgery has been correlated with poor long-term oncological outcome. Therefore, we investigated the influence of bacterial contamination during colon surgery on CRC liver metastases development. Blood and liver samples of patients undergoing resection of primary CRC or liver metastases were collected. Cell numbers, activation markers and inflammatory mediators were determined...
2018: Oncoimmunology
Hongwu Wang, Mingyao Ke, Wen Li, Zikai Wang, Hui Li, Minghua Cong, Yiming Zeng, Liangan Chen, Guoxiang Lai, Baosong Xie, Nan Zhang, Wangping Li, Hongmei Zhou, Xiaoping Wang, Dianjie Lin, Yunzhi Zhou, Huaping Zhang, Dongmei Li, Xiaolian Song, Juan Wang, Shiman Wu, Meimei Tao, Zhengbu Sha, Qiang Tan, Xinwei Han, Lingfei Luo, Hongming Ma, Zhiqiang Wang
Acquired respiratory-digestive tract fistulas occur with abnormal communication between the airways and digestive tract, causing the interflow of gas and liquid. Despite advances in surgical methods and the development of multimodal therapy in recent years, patients with acquired respiratory-digestive tract fistulas continue to exhibit unfavorable clinical outcomes. Therefore, in order to guide clinical practice in China, the Respiratory and Cancer Intervention Alliance of the Beijing Health Promotion Association organized a group of experienced experts in the field to develop this consensus document...
November 2018: Thoracic Cancer
Ayush Naik, Virendra Bhandari, R Y Saadvik, K L Gupta, Mehlam Kausar, Manika Batra
Background: Advancement in diagnostic and therapeutic modalities lead to increased cancer survivors who have 20% higher risk of developing second primary malignancy (SPM). Aim: To look for the incidence, epidemiological factors, treatment-related factors, and common risk factors responsible for the development of the SPM in Malwa region. Materials and Methods: Records of 7709 patients who visited the Department of Oncology between May 2008 and August 2015 were analyzed and looked for the presence of SPM based on Warren and Gates criteria for head and neck and International Agency for Research on Cancer definition for other sites...
July 2018: Journal of Cancer Research and Therapeutics
J Bollo, P Salas, M C Martinez, P Hernandez, A Rabal, E Carrillo, E Targarona
BACKGROUND: Colorectal cancer (CRC) is the third most frequent cancer diagnosed in men and the second in women. Laparoscopic surgery has been a technical revolution in colorectal surgery, facilitating a better recovery of patients with lower morbidity and better esthetic results, compared to traditional surgery via laparotomy, without compromising safety and long-term oncological results. PURPOSE: The trial is a randomized controlled trial indented to evaluate the two interventions with thorough measurements of the postoperative variables and complications to improve the evaluation of the surgical technique...
November 2018: International Journal of Colorectal Disease
Jaume Capdevila, Lisa Bodei, Philippa Davies, Vera Gorbounova, Robert T Jensen, Ulrich Knigge, Guenter J, Eric Krenning, Juan O''Connor, Marc Peeters, Guido Rindi, R Salazar, Marie Pierre Vullierme, Marianne Pavel
<br>Unmet medical needs are not infrequent in oncology and these needs are usually of higher magnitude in rare cancers. The field of neuroendocrine neoplasms (NENs) has evolved rapidly during the last decade and currently a new WHO classification is being implemented and several treatment options are available in metastatic setting after the results of prospective phase III clinical trials. However, several questions are still unanswered and decisions in our daily clinical practice should be made with limited evidence...
August 28, 2018: Neuroendocrinology
Larry C Cheng, Zhen Li, Thomas G Graeber, Nicholas A Graham, Justin M Drake
Phosphoproteomics involves the large-scale study of phosphorylated proteins. Protein phosphorylation is a critical step in many signal transduction pathways and is tightly regulated by kinases and phosphatases. Therefore, characterizing the phosphoproteome may provide insights into identifying novel targets and biomarkers for oncologic therapy. Mass spectrometry provides a way to globally detect and quantify thousands of unique phosphorylation events. However, phosphopeptides are much less abundant than non-phosphopeptides, making biochemical analysis more challenging...
August 2, 2018: Journal of Visualized Experiments: JoVE
Pietro Mascagni, Fabio Longo, Manuel Barberio, Barbara Seeliger, Vincent Agnus, Paola Saccomandi, Alexandre Hostettler, Jacques Marescaux, Michele Diana
Imaging is one of the pillars for the ongoing evolution of surgical oncology toward a precision paradigm. In the present overview, some established or emerging intraoperative imaging technologies are described in light of the vision and experience of our group in image-guided surgery, focusing on digestive surgical oncology.
August 2018: Journal of Surgical Oncology
Junki Mizusawa, Akira Fukutomi, Hiroshi Katayama, Hiroshi Ishii, Tatsuya Ioka, Takuji Okusaka, Hideki Ueno, Makoto Ueno, Masafumi Ikeda, Nobumasa Mizuno, Masato Ozaka, Haruhiko Fukuda, Junji Furuse
Gemcitabine is one of the standard treatments for locally advanced pancreatic cancer. Recent studies on metastatic pancreatic cancer have shown that combination chemotherapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine plus nab-paclitaxel (GnP) prolonged the overall survival compared with gemcitabine alone. To select the most promising chemotherapy, a randomized phase II selection design trial was started in July 2016 to compare between modified FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer...
October 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Rossella Reddavid, Laura Esposito, Andrea Evangelista, Silvia Sofia, Maurizio Degiuli
BACKGROUND: Cancers of the transverse colon (TC) and of the splenic flexure (SF) are rather uncommon and their prognosis has been reported significantly poorer as compared to right- and left- sided colon cancers. Several studies tried to investigate which is the optimal surgery for oncological and survival outcomes reporting extended colectomies as more effective than limited resections. METHODS: All consecutive patients with diagnosis of colorectal cancer submitted to surgical resection with anastomosis between January 2005 and December 2016 at University of Turin, Department of Oncology, Division of Surgical Oncology and Digestive Surgery, were included...
July 23, 2018: Minerva Chirurgica
Geoffrey Cheminet, Gabrielle Clain, Anne-Sophie Jannot, Brigitte Ranque, Amélie Passeron, Adrien Michon, Gonzalo De Luna, Jean-Luc Diehl, Stéphane Oudard, Christophe Cellier, Alexandre Karras, Benoit Vedié, Caroline Prot-Bertoye, Jacques Pouchot, Jean-Benoît Arlet
Extreme hypomagnesemia (hypoMg) can be encountered in many situations, but little data currently exist. Our aim is to describe the epidemiological, clinical, etiological characteristics, and the biological abnormalities of consecutive inpatients with extreme hypomagnesemia. In our observational monocentric study, between 1st July 2000 and April 2015, all inpatients with extreme hypomagnesemia, defined by at least one plasma magnesium concentration (PMg ) below 0.3 mmol/L, were included. Demographic, clinical, biological characteristics and the drugs prescribed before the qualifying PMg measurement were retrospectively collected...
December 2018: Internal and Emergency Medicine
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