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Digestive Oncology

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https://www.readbyqxmd.com/read/30076724/new-intraoperative-imaging-technologies-innovating-the-surgeon-s-eye-toward-surgical-precision
#1
REVIEW
Pietro Mascagni, Fabio Longo, Manuel Barberio, Barbara Seeliger, Vincent Agnus, Paola Saccomandi, Alexandre Hostettler, Jacques Marescaux, Michele Diana
Imaging is one of the pillars for the ongoing evolution of surgical oncology toward a precision paradigm. In the present overview, some established or emerging intraoperative imaging technologies are described in light of the vision and experience of our group in image-guided surgery, focusing on digestive surgical oncology.
August 4, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30075908/protocol-digest-of-randomized-phase-ii-study-of-modified-folfirinox-versus-gemcitabine-plus-nab-paclitaxel-combination-therapy-for-locally-advanced-pancreatic-cancer-japan-clinical-oncology-group-study-jcog1407
#2
Junki Mizusawa, Akira Fukutomi, Hiroshi Katayama, Hiroshi Ishii, Tatsuya Ioka, Takuji Okusaka, Hideki Ueno, Makoto Ueno, Masafumi Ikeda, Nobumasa Mizuno, Masato Ozaka, Haruhiko Fukuda, Junji Furuse
Gemcitabine is one of the standard treatments for locally advanced pancreatic cancer. Recent studies on metastatic pancreatic cancer have shown that combination chemotherapy with oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) and gemcitabine plus nab-paclitaxel (GnP) prolonged the overall survival compared with gemcitabine alone. To select the most promising chemotherapy, a randomized phase II selection design trial was started in July 2016 to compare between modified FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer...
July 27, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/30037179/non-anatomical-colonic-resections-splenic-flexure-and-transverse-colectomy-central-vascular-ligation-is-crucial-for-survival
#3
Rossella Reddavid, Laura Esposito, Andrea Evangelista, Silvia Sofia, Maurizio Degiuli
BACKGROUND: Cancers of the transverse colon (TC) and of the splenic flexure (SF) are rather uncommon and their prognosis has been reported significantly poorer as compared to right- and left- sided colon cancers. Several studies tried to investigate which is the optimal surgery for oncological and survival outcomes reporting extended colectomies as more effective than limited resections. METHODS: All consecutive patients with diagnosis of colorectal cancer submitted to surgical resection with anastomosis between January 2005 and December 2016 at University of Turin, Department of Oncology, Division of Surgical Oncology and Digestive Surgery, were included...
July 23, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29951810/extreme-hypomagnesemia-characteristics-of-119-consecutive-inpatients
#4
Geoffrey Cheminet, Gabrielle Clain, Anne-Sophie Jannot, Brigitte Ranque, Amélie Passeron, Adrien Michon, Gonzalo De Luna, Jean-Luc Diehl, Stéphane Oudard, Christophe Cellier, Alexandre Karras, Benoit Vedié, Caroline Prot-Bertoye, Jacques Pouchot, Jean-Benoît Arlet
Extreme hypomagnesemia (hypoMg) can be encountered in many situations, but little data currently exist. Our aim is to describe the epidemiological, clinical, etiological characteristics, and the biological abnormalities of consecutive inpatients with extreme hypomagnesemia. In our observational monocentric study, between 1st July 2000 and April 2015, all inpatients with extreme hypomagnesemia, defined by at least one plasma magnesium concentration (PMg ) below 0.3 mmol/L, were included. Demographic, clinical, biological characteristics and the drugs prescribed before the qualifying PMg measurement were retrospectively collected...
June 27, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29944280/-appendix-tumours-and-their-management
#5
Jeremy Meyer, Alexandre Balaphas, Thibaud Koessler, Philippe Morel, Léo Bühler, Nicolas Buchs, Frédéric Ris
An appendix tumour is found every 100 appendectomies. It can also be incidental discovery during a routine radiological examination and presents as a mucocele of the appendix. Appendix tumours are of varied histological type, and include mainly neuroendocrine tumours as well as epithelial tumours. The latter, when they secrete mucin, can give rise to peritoneal pseudomyxoma, a particular form of carcinosis harbouring serious complications. The management of appendix tumours responds to specific recommendations and, in advanced cases, requires the expertise of a university centre specialized in digestive oncology...
June 13, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29868164/oral-shedding-of-human-herpesviruses-in-patients-undergoing-radiotherapy-chemotherapy-for-head-and-neck-squamous-cell-carcinoma-is-not-affected-by-xerostomia
#6
Michelle Palmieri, Mariana Ornaghi, Victor Adriano de Oliveira Martins, Luciana Correa, Thais Bianca Brandao, Ana Carolina do Prado Ribeiro, Laura Masami Sumita, Tania Regina Tozetto-Mendoza, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva
Background : Xerostomia is a very relevant and frequent complication of radiotherapy, causing the irradiated oral mucosa to be affected by bacterial, fungal and viral infections. Objective : The objective of this study was to evaluate a possible relationship between oral shedding of human herpesviruses and xerostomia in patients with squamous cell carcinoma of head and neck submitted to radio/chemotherapy. Methods : In this study, oral rinse samples were collected weekly from 20 patients during radiotherapy...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29865163/frontiers-in-gastrointestinal-oncology-advances-in-multi-disciplinary-patient-care
#7
Nelson S Yee, Eugene J Lengerich, Kathryn H Schmitz, Jennifer L Maranki, Niraj J Gusani, Leila Tchelebi, Heath B Mackley, Karen L Krok, Maria J Baker, Claire de Boer, Julian D Yee
Cancers of the digestive system remain highly lethal; therefore, the care of patients with malignant diseases of the digestive tract requires the expertise of providers from multiple health disciplines. Progress has been made to advance the understanding of epidemiology and genetics, diagnostic and screening evaluation, treatment modalities, and supportive care for patients with gastrointestinal cancers. At the Multi-Disciplinary Patient Care in Gastrointestinal Oncology conference at the Hershey Country Club in Hershey, Pennsylvania on 29 September 2017, the faculty members of the Penn State Health Milton S...
June 1, 2018: Biomedicines
https://www.readbyqxmd.com/read/29806890/only-in-silence
#8
Daniel Eison
The oncology floor can be a silent place. Unlike the cardiology floor, with its insistent telemetry beeping, or the incessant bustle of the general ward below. Silence can be healing, and the oncology floor reveres all forms of healing it can find. Yet some voices ring loud on this floor. As an intern, I would grimace into my scut list as oncology attendings intoned dire diagnoses and exhorted still-reeling victims to altruistically enroll in clinical trials. I mutely ground my teeth listening to the relentless stream of probabilities and adverse reactions flooding into the shocked silence of a child baffled by his or her metamorphosis into a cancer patient between breakfast and lunch...
May 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29769085/contemporary-enteral-and-parenteral-nutrition-before-surgery-for-gastrointestinal-cancers-a-literature-review
#9
REVIEW
Michal Jankowski, Manuela Las-Jankowska, Massaoud Sousak, Wojciech Zegarski
BACKGROUND: Gastrointestinal cancers are among the most recognised oncological diseases in well-developed countries. Tumours located in the digestive tract may cause the fast occurrence of malnutrition. MAIN TEXT: The perioperative period is a special time for systemic metabolism. Thanks to published guidelines, early universal control nutritional status before treatment, patients may have a chance to get suitable nutritional intervention. Although the first line of the intervention-nutritional consultation as well as the fortification of a diet and oral nutritional support (ONS)-is not debatable, in a case of inability of undergoing an oral feeding, the choice of the way of administration in patients before a surgery may represent a serious clinical obstacle...
May 16, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29741571/struggling-with-nutrition-in-patients-with-advanced-cancer-nutrition-and-nourishment-focusing-on-metabolism-and-supportive-care
#10
J Arends
Patients with advanced cancer are at high risk of losing vital body resources resulting in malnutrition, immunodeficiency, impaired quality of life and worse clinical outcome. Prominent among the diverse factors contributing to this complex condition are metabolic derangements characterized by systemic inflammation, catabolism and accumulating changes in body composition. Because cure in advanced cancer still remains elusive, optimal supportive and integrated palliative care are required to allow patients to tolerate aggressive or long-term anticancer treatments, to maintain an adequate quality of life or to stay the course of advancing disease...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29705564/management-of-malabsorptive-bariatric-surgery-after-cancer-surgery-for-malignancies-of-the-digestive-apparatus
#11
Francesco S Papadia, Giovanni B Camerini, Flavia Carlini, Raffaele De Rosa, Franco De Cian, Nicola Scopinaro
BACKGROUND: Data regarding management of former bariatric operations after onset of a malignancy are still lacking and there is no consensus whether bariatric surgery negatively influences the oncologic management of patients. OBJECTIVES: To investigate the strategy by which patients previously submitted to bariatric surgery were managed after diagnosis of malignancy of the digestive apparatus, whether a revision was performed or not, to assess the incidence of nutritional complications, and the effect of revision versus no revision of bariatric surgery on the outcome of cancer treatment...
July 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29607792/nutritional-strategies-to-prevent-gastrointestinal-toxicity-during-pelvic-radiotherapy
#12
Linda J Wedlake
Radiotherapy-induced damage to non-cancerous gastrointestinal mucosa has effects on secretory and absorptive functions and can interfere with normal gastrointestinal physiology. Nutrient absorption and digestion may be compromised. Dietary manipulation is an attractive option with sound rationale for intervention. The aim of this review was to synthesise published evidence for the use of elemental formulae, low or modified fat diets, fibre, lactose restriction and probiotics, prebiotics and synbiotics to protect the bowel from gastrointestinal side effects during long-course, radical pelvic radiotherapy...
April 2, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29565172/-nutritional-support-and-parenteral-nutrition-in-the-oncological-patient-an-expert-group-consensus-report
#13
Miguel Camblor-Álvarez, María Julia Ocón-Bretón, Luis Miguel Luengo-Pérez, Juan Antonio Viruzuela, María José Sendrós-Maroño, Mercedes Cervera-Peris, Enrique Grande, Julia Álvarez-Hernández, Paula Jiménez-Fonseca
BACKGROUND: Malnutrition is a frequent medical problem of cancer patients that negatively impacts their quality of life. OBJECTIVE: To analyze and respond to different issues related to the nutritional management of cancer patients in the clinical setting. METHODS: A multidisciplinary group of experts in Medical Oncology, Pharmacy, and Nutrition developed a list of topics related to the nutritional status of cancer patients, which were grouped into three blocks: Nutritional support; Parenteral nutrition (PN); and Home PN (HPN) in cancer patients...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29547556/update-in-systemic-and-targeted-therapies-in-gastrointestinal-oncology
#14
Nelson S Yee
Progress has been made in the treatment of gastrointestinal cancers through advances in systemic therapies, surgical interventions, and radiation therapy. At the Multi-Disciplinary Patient Care in Gastrointestinal Oncology conference, the faculty members of the Penn State Health Milton S. Hershey Medical Center presented a variety of topics that focused on this sub-specialty. This conference paper highlights the new development in systemic treatment of various malignant diseases in the digestive system. Results of the recent clinical trials that investigated the clinical efficacy of pegylated hyaluronidase, napabucasin, and L-asparaginase in pancreatic carcinoma are presented...
March 16, 2018: Biomedicines
https://www.readbyqxmd.com/read/29509539/cervical-exenteration-guidelines-and-surgical-technique-principles
#15
Constantin Ciuce, Răzvan Scurtu, Cătălin Ciuce, Raluca Apostu, Horea Bocşe, George Dindelegan
Introduction: Neoplastic invasion of the structures of the cervical region originating from a malignant tumour developed in one of the viscera of the throat may benefit from cervical exenteration. Defined as resection of the hypopharynx, cervical oesophagus, larynx and cervical trachea, exenteration has limited indications and is mandatorily accompanied by digestive tube reconstruction. The aim of this article is to highlight the indication, surgical strategy and important surgical stages illustrated by images from personal professional experience...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29509534/esophageal-reconstruction-with-the-stomach-a-functional-dilemma
#16
Dragoş Predescu, Silviu Constantinoiu
Background: A few decades ago, esophageal substitution was mainly dedicated particularly in postcaustic esophageal stenosis; currently, the reconstruction has expanded its palette of indications to other areas of benign esophageal pathology (severe motor disorders, esophageal achalasia with multiple relapses, peptic stenosis, etc.) but has also become a quasi-obligatory final time in the esophagectomy for cancer whenever it is possible. The techniques of esophageal reconstruction using the stomach, regardless of the indication and the chosen technical option, remain a valuable and effective method...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29481479/a-3-dimensional-biomimetic-platform-to-interrogate-the-safety-of-autologous-fat-transfer-in-the-setting-of-breast-cancer
#17
Yoshiko Toyoda, Karel-Bart Celie, Jonathan T Xu, Justin S Buro, Julia Jin, Alexandra J Lin, Kristy A Brown, Jason A Spector
INTRODUCTION: Obesity is a known risk factor for the development and prognosis of breast cancer. Adipocytes have been identified as a source of exogenous lipids in other cancer types and may similarly provide energy to fuel malignant survival and growth in breast cancer. This relationship is of particular relevance to plastic surgery, because many reconstructions after oncologic mastectomy achieve optimal aesthetics and durability using adjunctive autologous fat transfer (AFT). Despite the increasing ubiquity and promise of AFT, many unanswered questions remain, including safety in the setting of breast cancer...
April 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29426740/-evaluation-of-the-feasibility-of-a-program-of-adapted-physical-activity-in-day-hospital-of-digestive-oncology-from-the-point-of-view-of-patients
#18
Céline Crespel, Cloé Brami, Paul de Boissieu, Camille Mazza, Kevin Chauvet, Amélie Lemoine, Benoit Gavlak, Chloé Léandri, Mathilde Brasseur, Eric Bertin, Olivier Bouché
INTRODUCTION: Adapted physical activity (APA) is recognized as an effective supportive care for asthenia and quality of life in oncology. Before an APA program was organized, the feasibility of such a program was evaluated among the patients. METHODS: Descriptive, prospective, semi-qualitative, single-center study over a 3-month period in patients treated with ambulatory chemotherapy for digestive cancer. A self-questionnaire was offered to all patients to evaluate their practice and knowledge about APA...
March 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29406473/characteristics-of-pediatric-patient-transferred-from-hospital-based-general-emergency-departments-to-acute-care-facilities-an-analysis-of-the-healthcare-cost-and-utilization-project-nationwide-emergency-department-sample
#19
Isabel Araujo Barata, Meredith Akerman, Zayan Mahmooth, Kathryn Bradburn, John DʼAngelo
STUDY OBJECTIVE: The objective of this study was to analyze the characteristics of pediatric patients transferred from a hospital-based general emergency department (ED) to an acute care facility. METHODS: Study data were abstracted from the 2010 Healthcare Cost and Utilization Project Nationwide Emergency Department Sample database. A multivariate logistic regression was constructed for pediatric patients (<18 years old) who require a transfer to an acute care facility from a general ED...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29373207/karakousis-s-abdominoinguinal-approach-for-the-treatment-of-a-primary-retroperitoneal-parasitic-leiomyoma-with-inguinal-extension-a-case-report
#20
Alberto Gomez Portilla, Victor Echenagusía, Iñaki Cendoya, Aintzane Maqueda, Eduardo López de Heredia
INTRODUCTION: Primary retroperitoneal parasitic leiomyoma (PRPL) with inguinal extension is a diagnostic-therapeutic challenge due to its uncertain etiopathogenesis and because it has been considered unresectable according to customary surgical techniques in some instances. The abdominoinguinal incision described by Karakousis in the 1980s allows a safe and radical approach for lower quadrants abdominopelvic tumors. OBJECTIVES: We present the case of a rare PRPL satisfactorily treated through Karakousis's approach...
January 9, 2018: International Journal of Surgery Case Reports
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