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Diabetes And Comorbidities And Pad

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https://www.readbyqxmd.com/read/30088358/medical-resource-consumption-and-quality-of-life-in-peripheral-arterial-disease-in-korea-pad-outcomes-pado-research
#1
Seung Woon Rha, Seung Hyuk Choi, Doo Il Kim, Dong Woon Jeon, Jae Hwan Lee, Kyung Soon Hong, Tae Joon Cha, Jang Hyun Cho, Sang Kon Lee, Yong Hwan Park, Woo Jung Park, Hyun Joo Kim, Young Joo Kim, Juneyoung Lee, Donghoon Choi
BACKGROUND AND OBJECTIVES: We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea. METHODS: This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0...
June 18, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29985264/prevalence-of-peripheral-artery-disease-is-higher-in-persons-living-with-hiv-compared-to-uninfected-controls
#2
Andreas D Knudsen, Marco Gelpi, Shoaib Afzal, Andreas Ronit, Ashley Roen, Amanda Mocroft, Jens Lundgren, Børge Nordestgaard, Henrik Sillesen, Anne-Mette Lebech, Lars Køber, Klaus F Kofoed, Susanne Dam Nielsen
OBJECTIVE: Ankle-brachial index (ABI) is an excellent tool for diagnosing peripheral artery disease (PAD). We aimed to determine the prevalence and risk factors for PAD in people living with HIV (PLWH) compared to uninfected controls. We hypothesized that prevalence of PAD would be higher among PLWH than among controls independent of traditional cardiovascular disease (CVD) risk factors. METHODS: PLWH aged ≥40 were recruited from the Copenhagen comorbidity in HIV infection (COCOMO) study...
July 3, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29898750/disease-specific-and-general-health-related-quality-of-life-in-newly-diagnosed-prostate-cancer-patients-the-pros-it-cnr-study
#3
Angelo Porreca, Marianna Noale, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi
BACKGROUND: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. METHODS: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12)...
June 13, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29848209/neutrophil-lymphocyte-ratio-is-a-marker-of-survival-and-cardiac-complications-rather-than-patency-following-revascularization-of-lower-extremities
#4
Leili Pourafkari, Catherine Choi, Reza Garajehdaghi, Arezou Tajlil, Hasan H Dosluoglu, Nader D Nader
The neutrophil-lymphocyte ratio (NLR), as a marker of inflammation, is associated with the severity of peripheral artery disease (PAD). The role of the NLR on predicting future complications after elective revascularization for patients with PAD remains unknown. We aimed to examine the role of the NLR in the development of major adverse limb events (MALE) and the long-term mortality of these patients. We evaluated 1708 revascularization procedures from May 2001 to December 2015 at the Veterans Affairs Western New York Healthcare System from a prospectively maintained vascular database that included demographics, comorbidities and pre-procedural medications...
May 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29801688/peripheral-vascular-disease-risk-in-diabetic-individuals-without-coronary-heart-disease
#5
Tanya Wilcox, Jonathan D Newman, Thomas S Maldonado, Caron Rockman, Jeffrey S Berger
BACKGROUND AND AIMS: Diabetes mellitus is a coronary heart disease (CHD) risk-equivalent for the outcome of peripheral vascular disease. The impact of diabetes with comorbid risk factors on the outcome of peripheral vascular disease remains unexplored. METHODS: We performed a cross-sectional analysis of participants in Lifeline Vascular Screening Inc. age 40-90 who were screened for peripheral vascular disease, defined as lower extremity peripheral artery disease (PAD, ABI <0...
April 30, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29783031/a-unique-all-payer-rate-setting-system-controls-the-cost-but-not-the-racial-disparity-in-lower-extremity-revascularization-procedures
#6
Besma Nejim, Robert J Beaulieu, Husain Alshaikh, Mohammed Hamouda, Joseph Canner, Mahmoud B Malas
BACKGROUND: Patients with peripheral arterial disease often have high comorbidity burden that may complicate post-interventional course and drive increased health-care expenditures. Racial disparity had been observed in lower extremity revascularization (LER) patterns and outcomes. In 2014, Maryland adopted an all-payer rate-setting system to limit the rising hospitalization costs. This resulted in an aggregate payment system in which hospital compensation takes place as an overall per capita expenditure for hospital services...
May 19, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29745215/peripheral-arterial-disease-in-diabetic-patients-a-long-term-population-based-study-on-occurrence-outcomes-and-cost
#7
MULTICENTER STUDY
Enrico M Marone, Paolo Cozzolino, Roberta Ciampichini, Virginio Chiodini, Roberto Ferraresi, Luigi F Rinaldi, Lorenzo G Mantovani, Giancarlo Cesana
BACKGROUND: Diabetes mellitus (DM) is a highly prevalent disease with severe long-term consequences, and a known risk factor for peripheral artery disease (PAD). These two diseases combined are responsible for high morbidity and mortality. The aim of this study is to investigate the burden of PAD in patients with DM, the effect of revascularization on outcomes, and geographical variation in the access to PAD courses of treatment. METHODS: From the healthcare claims of the Lombardy residents (16% of the Italian population) we identified diabetic patients with PAD as the study population, distinguishing between patients who received revascularization procedures (Revasc) and those who did not (NoRevasc)...
August 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29625727/effectiveness-of-screening-postmenopausal-women-for-cardiovascular-diseases-a-population-based-prospective-parallel-cohort-study
#8
Marie Dahl, Rikke Søgaard, Lars Frost, Annette Høgh, Jes Lindholt
OBJECTIVES: To investigate the effectiveness of systematic screening for multifaceted cardiovascular disease (CVD) in postmenopausal women on all cause mortality and, secondarily, on CVD morbidity. Effectiveness was also evaluated across age strata. METHODS: This was a population based, prospective, parallel cohort study. In total, 107,491 women born in 1936-1951 living in the Central Denmark region were identified in the Danish Civil Registration System. From this population, all women born in 1936, 1941, 1946, and 1951 (n = 1984) living in the Viborg municipality were invited to attend screening...
May 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29588132/epidemiology-of-lower-extremity-peripheral-artery-disease-in-veterans
#9
James Willey, Amgad Mentias, Mary Vaughan-Sarrazin, Kimberly McCoy, Gary Rosenthal, Saket Girotra
OBJECTIVE: The objective of this study was to describe the epidemiology, clinical features, outcomes, and predictors of mortality in veterans with peripheral artery disease (PAD). METHODS: We used national data from the Veterans Health Administration from fiscal years 2009 to 2011 to identify patients with a new diagnosis of PAD. Within this cohort, we describe characteristics of the patients, use of recommended medications, and clinical outcomes during a 3-year follow-up (fiscal year 2014)...
August 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29536628/time-dependent-changes-in-extra-domain-a-fibronectin-concentration-and-relative-amounts-of-fibronectin-fibrin-complexes-in-plasma-of-patients-with-peripheral-arterial-disease-after-endovascular-revascularisation
#10
Małgorzata Pupek, Dorota Krzyżanowska-Gołąb, Daniel Kotschy, Wojciech Witkiewicz, Wiesława Kwiatkowska, Maria Kotschy, Iwona Kątnik-Prastowska
Fibronectin (FN) may be involved in time- and stage-dependent and inter-related controlled processes of inflammation, coagulation, and wound healing accompanying peripheral arterial disease (PAD). In the present study, FN and FN-containing extra-domain A (EDA-FN), macromolecular FN-fibrin complexes, and FN monomer were analysed in the plasma of 142 PAD patients, including 37 patients with restenosis, for 37 months after revascularisation. FN concentration increased significantly in the plasma of PAD patients within 7 to 12 months after revascularisation, whereas the high concentration of EDA-FN was maintained up to 24 months, significantly higher in the group 7 to 12 months after revascularisation with recurrence of stenosis and lower in the PAD groups 1 to 3 months and 4 to 6 months after revascularisation with comorbid diabetes and ulceration, respectively...
March 13, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29536612/long-term-outcomes-of-patients-with-diabetes-mellitus-undergoing-percutaneous-intervention-for-popliteal-and-infrapopliteal-peripheral-arterial-disease
#11
Saroj Neupane, Sushruth Edla, Eesha Maidona, Matthew C Sweet, Susan Szpunar, Thomas Davis, Thomas A LaLonde, Rajendra H Mehta, Howard S Rosman, Hiroshi Yamasaki
OBJECTIVES: To evaluate the association of diabetes mellitus (DM) with clinical and angiographic characteristics and outcomes of patients with popliteal and infrapopliteal peripheral arterial disease (PAD) undergoing peripheral vascular intervention (PVI). BACKGROUND: Clinical features and outcomes in patients with DM and popliteal or infrapopliteal PAD undergoing PVI are not well described. METHODS: Using the data from the laser in popliteal and infrapopliteal stenosis study, we retrospectively examined the association of diabetes with clinical and angiographic characteristics and risk adjusted short- and intermediate term outcomes (all cause death, major adverse events (MAE) [composite of death, ipsilateral major amputation, or repeat revascularization]) in patients with popliteal and infrapopliteal PAD undergoing PVI for critical limb ischemia treated either with laser-assisted balloon angioplasty or balloon angioplasty alone...
March 14, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29492732/surgical-management-of-adult-acquired-buried-penis
#12
REVIEW
Thomas W Fuller, Katherine M Theisen, Anup Shah, Paul J Rusilko
PURPOSE OF REVIEW: Adult acquired buried penis is a morbid condition characterized by complete entrapment of the phallus as a result of morbid obesity, post-surgical cicatrix formation, or primary genital lymphedema. Hygienic voiding is not possible and urinary dribbling is frequent with accompanying inflammation, skin breakdown, and infection from the chronic moisture. The end result is penile skin fibrosis resulting in permanent functional loss. Herein, we describe the etiology of adult acquired buried penis, advances in its surgical management, and quality of life outcomes with treatment...
February 28, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29317447/improving-1-year-outcomes-of-infrainguinal-limb-revascularization-population-based-cohort-study-of-104-000-patients-in-england
#13
Katriina Heikkila, David C Mitchell, Ian M Loftus, Amundeep S Johal, Sam Waton, David A Cromwell
BACKGROUND: The availability and diversity of lower limb revascularization procedures have increased in England in the past decade. We investigated whether these developments in care have translated to improvements in patient pathways and outcomes. METHODS: Individual-patient records from Hospital Episode Statistics were used to identify 103 934 patients who underwent endovascular (angioplasty) or surgical (endarterectomy, profundaplasty, or bypass) lower limb revascularization for infrainguinal peripheral artery disease in England between January 2006 and December 2015...
May 1, 2018: Circulation
https://www.readbyqxmd.com/read/29053020/cardiovascular-outcomes-for-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-in-the-health-improvement-network-thin-in-the-uk
#14
Lucía Cea Soriano, F Gerry R Fowkes, Saga Johansson, Alaster M Allum, Luis A García Rodriguez
Background Few data are available on risk factors and associations with outcomes in symptomatic peripheral artery disease (PAD) populations in primary care. We assessed characteristics and cardiovascular outcomes in patients with and those without symptomatic peripheral artery disease in UK primary care, and quantified risk factors for cardiovascular outcomes in patients with peripheral artery disease. Methods Among patients in The Health Improvement Network (THIN) aged 50-89 years in 2000-2010, a symptomatic peripheral artery disease cohort ( n = 28,484) and a matched comparison cohort without peripheral artery disease ( n = 113,940) were identified using Read codes...
December 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28914527/locally-induced-adipose-tissue-browning-by-microneedle-patch-for-obesity-treatment
#15
Yuqi Zhang, Qiongming Liu, Jicheng Yu, Shuangjiang Yu, Jinqiang Wang, Li Qiang, Zhen Gu
Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer. Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects. In order to enhance treatment efficiency with minimized side effects, we developed a transcutaneous browning agent patch to locally induce adipose tissue transformation...
September 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28844470/high-hemoglobin-a-1c-associated-with-increased-adverse-limb-events-in-peripheral-arterial-disease-patients-undergoing-revascularization
#16
Shipra Arya, Zachary O Binney, Anjali Khakharia, Chandler A Long, Luke P Brewster, Peter W Wilson, William D Jordan, Yazan Duwayri
OBJECTIVE: Diabetes and peripheral arterial disease (PAD) are independently associated with increased risk of amputation. However, the effect of poor glycemic control on adverse limb events has not been studied. We examined the effects of poor glycemic control (high hemoglobin A1c level) on the risk of amputation and modified major adverse limb events (mMALEs) after lower extremity revascularization. METHODS: Patients undergoing PAD revascularization who had hemoglobin A1c (HbA1c ) levels available within 6 months were identified in the Veterans Affairs database of 2003 to 2014 (N = 26,799)...
January 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28765738/baseline-characteristics-of-a-retrospective-patient-cohort-in-the-korean-vascular-intervention-society-endovascular-therapy-in-lower-limb-artery-diseases-k-vis-ella-registry
#17
Young-Guk Ko, Chul-Min Ahn, Pil-Ki Min, Jae-Hwan Lee, Chang-Hwan Yoon, Cheol Woong Yu, Seung Whan Lee, Sang-Rok Lee, Seung Hyuk Choi, Yoon Seok Koh, In-Ho Chae, Donghoon Choi
BACKGROUND AND OBJECTIVES: The Korean Vascular Intervention Society Endovascular Therapy in Lower Limb Artery Diseases (K-VIS ELLA) Registry is a multicenter observational study with retrospective and prospective cohorts of patients with lower extremity peripheral artery disease (PAD) undergoing endovascular treatment. In this study, we report the baseline characteristics of this retrospective cohort. SUBJECTS AND METHODS: In the present study we analyzed datasets of 3073 patients with 3972 target limbs from a retrospective cohort treated with endovascular therapy in 31 Korean hospitals...
July 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28713910/anti-obesity-effects-of-yellow-catfish-protein-hydrolysate-on-mice-fed-a-45-kcal-high-fat-diet
#18
Mi-Ryung Kim, Joo-Wan Kim, Jeong Been Park, Yong-Ki Hong, Sae Kwang Ku, Jae-Suk Choi
Obesity contributes to the etiologies of a variety of comorbid conditions, such as type 2 diabetes, hypertension and cardiovascular disease. In the present study, the anti-obesity effects of yellow catfish protein hydrolysate (YPh) were observed in mice fed a 45% kcal high-fat diet (HFD) compared with those of mice treated with simvastatin. The HFD-fed control mice exhibited noticeable increase in body weight, and whole-body and abdominal fat densities, periovarian and abdominal wall-deposited fat pad weight, as well as in the levels of triglycerides (TG), blood total cholesterol (TC), low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen, and in the fecal TG and TC contents...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28712563/trends-in-comorbidity-in-patients-hospitalised-for-cardiovascular-disease
#19
Josefien Buddeke, Michiel L Bots, Ineke van Dis, Anho Liem, Frank L J Visseren, Ilonca Vaartjes
BACKGROUND: We determined trends over time in cardiovascular and non-cardiovascular comorbidity in patients hospitalised for cardiovascular disease (CVD). METHODS: The Dutch nationwide hospital register was used to identify patients hospitalised for CVD during 2000-2010. Comorbidity was defined as a previous hospital admission for CVD other than the index CVD, cancer, diabetes, musculoskeletal and connective tissue disorders, respiratory disorders, thyroid gland disorders, kidney disorders and dementia in the five years previous to hospital admittance for the index CVD...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28655550/skin-accumulation-of-advanced-glycation-end-products-is-increased-in-patients-with-an-abdominal-aortic-aneurysm
#20
Jeltje Boersema, Lisanne C de Vos, Thera P Links, Douwe J Mulder, Andries J Smit, Clark J Zeebregts, Joop D Lefrandt
OBJECTIVE: Advanced glycation end products (AGEs) are implicated in the pathogenesis of cardiovascular disease. Accumulation of AGEs is driven by oxidative or glycemic stress and can be assessed by skin autofluorescence (SAF). SAF is increased in patients with peripheral artery disease (PAD) and independently associated with mortality and major adverse cardiovascular events in these patients. PAD and abdominal aortic aneurysm (AAA) share several risk factors. Inflammation is an important process in AAA formation and increases levels of oxidative stress...
December 2017: Journal of Vascular Surgery
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