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https://www.readbyqxmd.com/read/30537150/incidence-and-risk-factors-of-preterm-premature-rupture-of-membranes-in-singleton-pregnancies-at-siriraj-hospital
#1
Phatsorn Sae-Lin, Prapat Wanitpongpan
AIM: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies. METHODS: This study was a retrospective case-control study. The institutional ethical committee has approved the study. The medical records of eligible cases were reviewed. To assess the risk factors of PPROM, the data of the cases with PPROM in 2016 were compared with the data of pregnant women who did not have PPROM and delivered at term...
December 11, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30536821/quantitative-proteomics-by-swath-ms-suggest-an-association-between-circulating-exosomes-and-maternal-metabolic-changes-in-gestational-diabetes-mellitus
#2
Nanthini Jayabalan, Andrew Lai, Soumyalekshmi Nair, Dominic Guanzon, Katherin Scholz-Romero, Carlos Palma, Harold David McIntyre, Martha Lappas, Carlos Salomon
Several factors including placental hormones (PH) released from the human placenta have been associated with the development of insulin resistance and gestational diabetes mellitus (GDM). However, circulating levels of PH do not correlate well with maternal insulin sensitivity across gestation, suggesting that other, previously unrecognized, mechanisms may be involved. The levels of circulating exosomes are higher in GDM compared to normal. GDM derived exosomes produce greater release of pro-inflammatory cytokines from endothelial cells compared to exosomes from normal, suggesting that their contents may differ compared to normal pregnancies...
December 7, 2018: Proteomics
https://www.readbyqxmd.com/read/30535412/growth-factor-modulation-of-equine-trophoblast-mitosis-and-prostaglandin-gene-expression
#3
Susana Bonometti, Bruno Carvalho Menarim, Brad M Reinholt, Alan D Ealy, Sally E Johnson
To provide insight into maternal recognition of pregnancy control in equids, the mitogenic and developmental effects of endometrium-expressed growth factors (epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), hepatocyte growth factor (HGF), insulin-like growth factor 1 (IGF-1)) were examined in equine iTr cells, an equine trophectoderm cell line. Initial Western blots revealed that HGF and IGF-1 stimulate phosphorylation of AKT serine/threonine kinase 1 (AKT1) and EGF, FGF2 or HGF resulted in phosphorylation of both extracellular signal-regulated kinase 1 (ERK1) and ERK2...
December 11, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30535232/metastasis-related-methyltransferase-1-merm1-represses-the-methyltransferase-activity-of-dnmt3a-and-facilitates-rna-polymerase-i-transcriptional-elongation
#4
Guoliang Lyu, Le Zong, Chao Zhang, Xiaoke Huang, Wenbing Xie, Junnan Fang, Yiting Guan, Lijun Zhang, Ting Ni, Jun Gu, Wei Tao
Stimulatory regulators for DNA methyltransferase activity, such as Dnmt3L and some Dnmt3b isoforms, affect DNA methylation patterns, thereby maintaining gene body methylation and maternal methylation imprinting, as well as the methylation landscape of pluripotent cells. Here we show that metastasis-related methyltransferase 1 (Merm1), a protein deleted in individuals with Williams-Beuren syndrome, acts as a repressive regulator of Dnmt3a. Merm1 interacts with Dnmt3a and represses its methyltransferase activity with the requirement of the binding motif for S-adenosyl-L-methionine...
March 21, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/30535156/sibling-recurrence-risk-and-cross-aggregation-of-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorder
#5
Meghan Miller, Erica D Musser, Gregory S Young, Brent Olson, Robert D Steiner, Joel T Nigg
Importance: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are believed to partially share genetic factors and biological influences. As the number of children with these diagnoses rises, so does the number of younger siblings at presumed risk for ADHD and ASD; reliable recurrence risk estimates within and across diagnoses may aid screening and early detection efforts and enhance understanding of potential shared causes. Objective: To examine within-diagnosis sibling recurrence risk and sibling cross-aggregation of ADHD and ASD among later-born siblings of children with either disorder...
December 10, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/30534359/the-roles-of-lncrna-in-hepatic-fibrosis
#6
REVIEW
Hu Peng, Lin-Yan Wan, Jia-Jie Liang, Yan-Qiong Zhang, Wen-Bing Ai, Jiang-Feng Wu
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear. Hepatic fibrosis is a continuous wound-healing process caused by numerous chronic hepatic diseases, and the activation of hepatic stellate cells (HSCs) is generally considered to be a pivotal step in hepatic fibrosis. In the process of hepatic fibrosis, some lncRNAs regulates diverse cellular processes. Here are several examples: the lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and liver fibrosis-associated lncRNA1 (lnc-LFAR1) promote HSC activation in the progression of hepatic fibrosis via the transforming growth factor-β signaling pathway; the lncRNA HIF 1 alpha-antisense RNA 1 (HIF1A-AS1) and Maternally expressed gene 3 reduce HSC activation which are associated with DNA methylation; the lncRNA plasmacytoma variant translocation 1, Homeobox (HOX) transcript antisense RNA and MALAT1 promote HSC activation as competing endogenous RNAs (ceRNAs); the long intergenic non-coding RNA-p21 (lncRNA-p21) and Growth arrest-specific transcript 5 reduce HSC activation as ceRNAs...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/30533423/c-reactive-protein-levels-at-the-midpregnancy-can-predict-gestational-complications
#7
Alessandra Vecchié, Aldo Bonaventura, Federico Carbone, Davide Maggi, Antonella Ferraiolo, Beatrice Carloni, Gabriella Andraghetti, Laura Affinito Bonabello, Luca Liberale, Franco Dallegri, Fabrizio Montecucco, Renzo Cordera
Although essential for a successful pregnancy, a growing body of evidence suggests that maternal inflammation, when dysregulated, may represent a risk factor for both maternal and neonatal outcomes. Here, we assessed the accuracy of maternal C-reactive protein (CRP) concentrations at the middle phase of pregnancy in the identification of maternal adverse outcomes (MAO) until delivery. A correlation between CRP and a complicated pregnancy including both maternal and neonatal adverse outcomes has been investigated, too...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30533297/a-single-spanish-version-of-maternal-and-paternal-postnatal-attachment-scales-validation-and-conceptual-analysis
#8
Anna Riera-Martín, Antonio Oliver-Roig, Ana Martínez-Pampliega, Susana Cormenzana-Redondo, Violeta Clement-Carbonell, Miguel Richart-Martínez
Background: Postnatal bonding constitutes a major process during the postpartum period, and there is evidence that bonding difficulties have negative consequences for parents' mental health and the child's development. However, the conceptualization of postnatal bonding presents inconsistencies, as well as problems in having instruments that encompasses the father figure. The objective was to adapt the maternal postnatal attachment scale (MPAS) and the paternal postnatal attachment scale (PPAS) to Spanish, to evaluate its validity and reliability and to analyze the construct dimensionality of both questionnaires from a gender perspective...
2018: PeerJ
https://www.readbyqxmd.com/read/30533009/maternal-chorioamnionitis-and-neurodevelopmental-outcomes-in-preterm-and-very-preterm-neonates-a-meta-analysis
#9
Dongqiong Xiao, Tingting Zhu, Yi Qu, Xiaoyun Gou, Qun Huang, Xihong Li, Dezhi Mu
CONTEXT: No consensus exists regarding the association between maternal chorioamnionitis and neurodevelopmental outcomes in preterm and very preterm neonates. OBJECTIVES: To investigate whether maternal chorioamnionitis affects neurodevelopmental outcomes and to identify the factors that may explain these effects. DATA SOURCES: We used Ovid Medline, EMBASE and Web of Science to conduct a meta-analysis of studies published in English before August 25, 2017, with titles or abstracts that discussed an association between maternal chorioamnionitis and mental/motor development...
2018: PloS One
https://www.readbyqxmd.com/read/30532319/influence-of-anaesthetic-technique-on-maternal-and-foetal-outcome-in-category-1-caesarean-sections-a-prospective-single-centre-observational-study
#10
Chitra Rajeswari Thangaswamy, Pankaj Kundra, Savitri Velayudhan, Lakshmi Narasimhan Aswini, P Veena
Background and Aims: In category 1 caesarean section (CS), there is limited evidence regarding superior anaesthetic technique. Hence, this study was designed to study the influence of anaesthetic technique on the maternal and foetal outcome. Methods: Patient characteristics, indication for CS, decision-to-delivery interval (DDI), uterine incision-to-delivery time (UIDT), cord blood pH, Apgar scores and neonatal and maternal outcome were noted. Composite endpoint (Apgar score <7, umbilical cord blood pH <7...
November 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/30531707/the-assessment-of-retina-in-pregnant-women-with-myopia
#11
(no author information available yet)
OBJECTIVES: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women. MATERIAL AND METHODS: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina...
October 10, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/30530161/the-early-life-exposome-description-and-patterns-in-six-european-countries
#12
Ibon Tamayo-Uria, Léa Maitre, Cathrine Thomsen, Mark J Nieuwenhuijsen, Leda Chatzi, Valérie Siroux, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Maribel Casas, Montserrat de Castro, Audrius Dedele, Line S Haug, Barbara Heude, Regina Grazuleviciene, Kristine B Gutzkow, Norun H Krog, Dan Mason, Rosemary R C McEachan, Helle M Meltzer, Inga Petraviciene, Oliver Robinson, Theano Roumeliotaki, Amrit K Sakhi, Jose Urquiza, Marina Vafeiadi, Dagmar Waiblinger, Charline Warembourg, John Wright, Rémy Slama, Martine Vrijheid, Xavier Basagaña
Characterization of the "exposome", the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6-11 years in 6 European birth cohorts...
December 6, 2018: Environment International
https://www.readbyqxmd.com/read/30529717/child-s-oxytocin-response-to-mother-child-interaction-the-contribution-of-child-genetics-and-maternal-behavior
#13
Rita Baião, Pasco Fearon, Jay Belsky, Joana Baptista, Alexandra Carneiro, Raquel Pinto, Marlene Nogueira, César Oliveira, Isabel Soares, Ana R Mesquita
The oxytocinergic system is a primary biological system involved in regulating a child's needs for bonding and for protection from threats. It is responsive to social experiences in close relationships, though evidence across studies is not entirely consistent. Guided by previous literature, we investigated individual and environmental factors predicting and presumably affecting children's oxytocin (OT) response during mother-child interaction. by focusing on children's OXTR genotype, and maternal behavior, respectively...
November 16, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/30529234/classification-of-fetal-resilience-to-porcine-reproductive-and-respiratory-syndrome-prrs-based-on-temporal-viral-load-in-late-gestation-maternal-tissues-and-fetuses
#14
Carolina M Malgarin, Roman Nosach, Predrag Novakovic, Muhammad Suleman, Andrea Ladinig, Susan E Detmer, Daniel J MacPhee, John C S Harding
Although porcine reproductive and respiratory syndrome virus (PRRSV) readily crosses the maternal fetal interface (MFI) in third trimester, fetal resilience varies within litters. The aim of this study was to characterize PRRSV-2 concentration in MFI and fetuses at five time points after experimental inoculation of late gestation gilts and use this information to classify potentially resistant, resilient and susceptible fetuses. The secondary objective was to verify the relationship between PRRS viral load and intrauterine growth retardation (IUGR)...
December 5, 2018: Virus Research
https://www.readbyqxmd.com/read/30528520/the-role-of-parent-adolescent-relationships-in-the-development-of-pre-hypertension-in-young-adulthood-in-the-u-s
#15
Hei Wan Mak, Joeun Kim, Senhu Wang
BACKGROUND: Hypertension is a strong factor for stroke and coronary disease, and it has been found that 1 in 4 young adults are experiencing pre-hypertension in the United States This study was designed to examine the role of parent-adolescent relationships in the risk of developing (pre)hypertension in young adulthood, and to explore potential mediator(s). METHODS: Our analysis was based on the data from the National Longitudinal Study of Adolescent to Adult Health, Wave 1 (aged 13-18) and Wave 4 (aged 25-32) (N = 3,350)...
October 24, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/30527988/acceptance-of-flavored-concentrate-premixes-by-young-ruminants-following-a-short-term-exposure
#16
K Nedelkov, M T Harper, A Melgar, X Chen, S Räisänen, C M M R Martins, J Faugeron, E H Wall, A N Hristov
Three cafeteria feeding design experiments were conducted to test whether young ruminants have flavor preferences. Experiment 1 was with 11 Dorset × Suffolk weaned lambs of both sexes, aged 5 mo and averaging 47.5 (standard deviation = 5.8) kg of body weight. The lambs were offered a choice of 5 flavored concentrate premixes (FCP) and an unflavored control for 5 min 4 times over 10 d. The FCP were prepared by mixing 200 to 300 g/t (as-is basis) of synthetic flavors (vanilla, milky, spicy/fenugreek, red summer fruits, and molasses) into a basal diet...
October 24, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30527949/impact-of-exercise-during-pregnancy-on-gestational-weight-gain-and-birth-weight-an-overview
#17
REVIEW
Marina Vargas-Terrones, Taniya S Nagpal, Ruben Barakat
OBJECTIVE: This article presents the state of knowledge related to the impact of exercise on gestational weight gain and birth weight. TRANSCENDENCE OF BABY WEIGHT: Birth weight is an important indicator of intrauterine environment and maternal and newborn health. There are several factors that can affect birth weight including mother's pre-pregnancy Body Mass Index (BMI), gestational weight gain, Gestational Diabetes Mellitus (GDM), chronic diabetes and gestational age at birth...
November 22, 2018: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/30527488/hydrogen-sulfide-donor-gyy4137-acts-through-endothelial-nitric-oxide-to-protect-intestine-in-murine-models-of-necrotizing-enterocolitis-and-intestinal-ischemia
#18
Natalie A Drucker, Amanda R Jensen, Jan P Te Winkel, Troy A Markel
BACKGROUND: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways...
February 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30527122/prospective-biomarkers-in-preterm-preeclampsia-a-review
#19
REVIEW
Fergus P McCarthy, Roisin M Ryan, Lucy C Chappell
Preterm pre-eclampsia (prior to 37 weeks' gestation) remains a major cause of maternal and fetal morbidity and mortality particularly in low to middle income countries. Much research has focused on first and second trimester predictors of pre-eclampsia with the aim of allowing stratification of antenatal care and trialling of potential preventative and therapeutic agents. However, none have been shown to be of benefit in randomised controlled trials. In this literature review we critically evaluate predictive and diagnostic tests for preterm pre-eclampsia and discuss their clinical use and potential value in the management of preterm pre-eclampsia...
October 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/30527116/predictive-value-of-the-sflt-1-and-plgf-in-women-at-risk-for-preeclampsia-in-the-south-of-vietnam
#20
Trung Huu Nguyen, Thanh Cong Bui, Tuan Minh Vo, Quan Minh Tran, Loan Thi-Thanh Luu, Tai Duy Nguyen
BACKGROUND: It has been suggested that soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) play potential roles in preeclampsia diagnosis. Nevertheless, studies on the use of sFlt-1, PlGF, and sFlt-1/PlGF ratio in predicting preeclampsia have found contradictory results. Thus, more studies in different populations are needed. OBJECTIVES: This study aims to (i) examine the associations between sFlt-1, PlGF, or sFlt-1/PlGF ratio at gestational ages of 24-28 weeks and subsequent preeclampsia, and (ii) estimate predictive values of these markers in southern Vietnamese women...
October 2018: Pregnancy Hypertension
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