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"Maternal sepsis" OR "neonatal sepsis"

Fábio Gonçalves Coutinho, Edna Maria de Albuquerque Diniz, Ingrid Kandler, Marco Antônio Cianciarullo, Natália Rodrigues Dos Santos
BACKGROUND: To determine the concentration of the Lipid Peroxidation Marker: Malondialdehyde (MDA), and Antioxidant Markers: Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAL) in umbilical cord blood and in unstimulated saliva in the first 24 and 48 hours of life in the PTNB of mothers with and without risk factors for early-onset neonatal sepsis. METHODS: Cross-sectional study with the signing of informed consent by the pregnant women and application of a standard questionnaire classifying the PTNB in Group 1 or 2...
October 2018: Revista da Associação Médica Brasileira
Ufuk Çakır, Cuneyt Tayman
Background It is known that thyroid hormones have effects on bone development. In particular, the effect of thyroid hormones on osteopenia of prematurity (OOP) has not been examined in preterm infants. Our study aimed to examine the relationship between OOP and congenital hypothyroidism (CH) in preterm infants. Methods Very low birth weight infants (VLBW, <1500 g) were included in the study. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were measured on postnatal day 5. Serum calcium, phosphorus and alkaline phosphatase (ALP) levels were studied as standard screening parameters for OOP at postnatal week 4...
December 4, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Li Huang, Lixing Qiao, Huan Zhu, Li Jiang, Liping Yin
BACKGROUND: Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis of the disease. METHODS: The expression profile dataset E-MTAB-4785, which contained 17 sepsis samples and 19 normal samples, was obtained from the ArrayExpress database. The differentially expressed genes (DEGs) were analyzed by the Bayesian testing method in limma package...
November 29, 2018: Italian Journal of Pediatrics
Tatiana Belokrinitskaya, Oleg Filippov, Olesya Chugai
This report presents the relapse and treatment of streptococcal infection in the postpartum period in a patient with severe group A streptococcal sepsis. Maternal sepsis was estimated to cause around 10.7% of maternal deaths worldwide between 2003 and 2009 [1]. Puerperal sepsis caused by group A streptococci (GAS) is associated with 40% of septic deaths among patients with postpartum endometritis, necrotizing fasciitis, and toxic shock syndrome [2,3]. Here we describe a case of recurrent GAS sepsis in the postpartum period...
November 29, 2018: International Journal of Gynaecology and Obstetrics
Masahiro Ishii, Takayuki Hoshina, Shun Ichikawa, Daisuke Shimizu, Shunsuke Araki, Tadamune Kinjo, Eiji Shibata, Toru Hachisuga, Koichi Kusuhara
Neonatal sepsis continues to be a global problem with significant morbidity and mortality, because of the difficulty in predicting its onset with clinical symptoms alone. Thus, the presence of biomarkers is useful for the diagnosis of neonatal sepsis. Presepsin is a 13-kDa truncated form of soluble CD14 that is produced through proteolytic cleavage on activated monocytes. Presepsin, consisting of 64 amino acid residues, has been proposed as a reliable biomarker for the early diagnosis of sepsis in neonates...
2018: Tohoku Journal of Experimental Medicine
Abdolnabi Shabani, Manoochehr Makvandi, Alireza Samarbafzadeh, Ali Teimoori, Mojtaba Rasti, Chiman Karami, Nasteran Rastegarvand, Roya Nikfar, Ahmad Shamsizadeh, Azam Salehi, Kambiz Ahmadi Angali
Background and Objectives: Human enteroviruses (EV) are the most common causes of neonatal sepsis-like disease. The frequencies of EV including coxsackievirus A, coxsackievirus B and Echovirus serotypes have been studied in young infants (younger than three months) with sepsis. So far, the role of enteroviruses among neonates with sepsis was not determined in Ahvaz, Iran. Therefore, this study was aimed to evaluate the frequency of EV among hospitalized young infants with clinical signs and symptoms of sepsis in Ahvaz...
August 2018: Iranian Journal of Microbiology
Diana Olita'a, Roland Barnabas, Gamini Vali Boma, Wendy Pameh, John Vince, Trevor Duke
In low-income and middle-income countries, courses of antibiotics are routinely given to term newborns whose mothers had prolonged rupture of membranes (PROM). Rational antibiotic use is vital given rising rates of antimicrobial resistance and potential adverse effects of antibiotic exposure in newborns. However missing cases of sepsis can be life-threatening.This is a quality improvement evaluation of a protocol for minimal or no antibiotics in term babies born after PROM in Papua New Guinea. Asymptomatic, term babies born to women with PROM >12 hours prior to birth were given a stat dose of antibiotics, or no antibiotics if the mother had received intrapartum antibiotics, reviewed and discharged at 48-72 hours with follow-up...
November 24, 2018: Archives of Disease in Childhood
Dimitrios Patoulias, Maria-Styliani Kalogirou, Ioannis Patoulias
Neonatal sepsis, defined as sepsis occurring within the first 28 days of life, is associated with significant morbidity and mortality. It is undeniable that finding and appliance of biomarkers in clinical practice is of great importance, aiming at the early recognition of the impending clinical deterioration and the prompt and targeted therapeutic intervention. A er systematic and thorough research of the limited relevant literature, we attempt to present a documented point-of-view on the diagnostic value of TREM-1 and its soluble form both in early and late onset neonatal sepsis...
2018: Folia Medica Cracoviensia
Magda Badawy, Dalia S Mosallam, Doaa Saber, Hanan Madani
Background  Mannose-binding lectin (MBL) is a component of innate immunity and is particularly important in neonates, in whom adaptive immunity has not yet completely developed. MBL deficiency and MBL2 gene polymorphisms are associated with an opsonization defect and have been associated with neonatal sepsis. Aim  The aim of our study was to assess serum MBL levels and genotype MBL2 genes to determine whether they can serve as markers for predicting neonatal sepsis in neonatal intensive care units. Patients and Methods  A case-control study was conducted with 114 neonates classified into two groups: the septic group included 64 neonates (41 preterm and 23 full-term infants), and the non-septic control group included 50 neonates (29 preterm and 21 full-term infants)...
December 2018: Journal of Pediatric Genetics
C L Emery, R F Relich, T H Davis, S Young, M Sims, B L Boyanton
Group B Streptococcus (GBS) is the leading cause of neonatal sepsis and meningitis in developed countries. Recommendations for antepartum GBS detection include enriched culture with several options for identifying GBS, some of which are time consuming. To reduce time-to-identification and determination of maternal GBS colonization status, rapid nucleic acid amplification technologies have been developed and commercialized. For rapid detection of GBS, a 3-site clinical study was conducted to evaluate the NeuMoDx™ GBS Assay, a real-time polymerase chain reaction (PCR) test performed for vaginal/rectal swab specimens in Lim broth enrichment culture on the NeuMoDx™ 288 Molecular System (NeuMoDx™ System); this data was used to a support 510(k) submission...
November 21, 2018: Journal of Clinical Microbiology
Lin Ruan, Guan-Yu Chen, Zhen Liu, Yun Zhao, Guang-Yu Xu, Shu-Fang Li, Chun-Ni Li, Lin-Shan Chen, Zheng Tao
BACKGROUND: Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential. METHOD: Our aim was to compare the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP), procalcitonin combined with C-reactive protein (PCT + CRP) and presepsin in the diagnosis of neonatal sepsis. We searched seven databases to identify studies that met the inclusion criteria. Two independent reviewers performed data extraction...
November 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
Xia Qiu, Li Zhang, Yu Tong, Yi Qu, Huiqing Wang, Dezhi Mu
BACKGROUND: Premature rupture of the membranes (PROM) is the principal risk factor for neonatal sepsis. Interleukin-6 (IL-6) has been investigated for early diagnosis of neonatal sepsis, but not for diagnosis of neonatal sepsis with PROM. The objective of this study is to investigate the early diagnostic value of IL-6 for neonatal sepsis with PROM. METHODS: The literature was searched using PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wan Fang, VIP, and CBM databases until March 2018...
November 2018: Medicine (Baltimore)
Ryan S Doster, Jessica A Sutton, Lisa M Rogers, David M Aronoff, Jennifer A Gaddy
Streptococcus agalactiae , or group B Streptococcus (GBS), is a common perinatal pathogen. GBS colonization of the vaginal mucosa during pregnancy is a risk factor for invasive infection of the fetal membranes (chorioamnionitis) and its consequences such as membrane rupture, preterm labor, stillbirth, and neonatal sepsis. Placental macrophages, or Hofbauer cells, are fetally derived macrophages present within placental and fetal membrane tissues that perform vital functions for fetal and placental development, including supporting angiogenesis, tissue remodeling, and regulation of maternal-fetal tolerance...
November 20, 2018: MBio
J Ditai, M Mudoola, M Gladstone, J Abeso, J Dusabe-Richards, M Adengo, P Olupot-Olupot, E D Carrol, J Storr, A Medina-Lara, B Faragher, A D Weeks
BACKGROUND: Neonatal sepsis causes 0.5 million deaths annually, mostly in low resource settings. Babies born in African rural homes without running water or toilet facilities are especially vulnerable. Alcohol-based hand rub (ABHR) may be used by mothers and carers as an alternative to hand washing with soap to prevent neonatal infection. However, no definite study has established the preferred formulation of hand rub for the mothers. This study aimed to assess the effects of addition of bitterants and perfume towards the acceptability of the alcohol-based hand rubs by the mothers in their homes after childbirth...
November 20, 2018: BMC Public Health
Nerea Sarrión-Sos, Marta Morell-García, Laura Martínez-Sebastián, José M Centeno-Rubiano, Elena Montesinos-Sanchis, Nelson Orta-Sibú
Septicemia is the main cause of neonatal mortality. The early-onset neonatal sepsis is usually related to maternal factor risks including recto-vaginal colonization. In the late-onset neonatal septicemia it is more difficult to establish the etiology because the majority of the cases are nosocomial or community related. The Streptococcus agalactiae (beta-hemolytic Streptococcus) is the most frequent germ associated with neonatal sepsis in developed countries. The late-onset form usually occurs with septic symptoms and meningitis and, in a few cases, with osteoarticular, skin and soft tissue infection...
December 1, 2018: Archivos Argentinos de Pediatría
Gambhir Shrestha, Prajwal Paudel, Parashu Ram Shrestha, Shambhu Prasad Jnawali, Deepak Jha, Tek Raj Ojha, Bikash Lamichhane
BACKGROUND: Nepal has made a significant progress in reducing child mortality. However, the annual rate of reduction in neonatal mortality is not satisfactory. As safeguarded by constitution of Nepal and to address neonatal mortality due to poverty and inequity, government has introduced free newborn care (FNC) package. This study aims to assess the status of FNC services in all the public hospitals. METHODS: Child Health Division organized 5 workshops region-wise with the theme of newborn care services in March/April 2018 to cover all the public hospitals in the country...
October 30, 2018: Journal of Nepal Health Research Council
Karen M Puopolo, William E Benitz, Theoklis E Zaoutis
Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically with antibiotics for risk of EOS, often for prolonged periods, in the absence of a culture-confirmed infection. Retrospective studies have revealed that antibiotic exposures after birth are associated with multiple subsequent poor outcomes among preterm infants, making the risk/benefit balance of these antibiotic treatments uncertain...
November 19, 2018: Pediatrics
Karen M Puopolo, William E Benitz, Theoklis E Zaoutis
The incidence of neonatal early-onset sepsis (EOS) has declined substantially over the last 2 decades, primarily because of the implementation of evidence-based intrapartum antimicrobial therapy. However, EOS remains a serious and potentially fatal illness. Laboratory tests alone are neither sensitive nor specific enough to guide EOS management decisions. Maternal and infant clinical characteristics can help identify newborn infants who are at risk and guide the administration of empirical antibiotic therapy...
November 19, 2018: Pediatrics
Violet Okaba Kayom, Jamiir Mugalu, Abel Kakuru, Sarah Kiguli, Charles Karamagi
BACKGROUND: Neonatal sepsis is one of the most important causes of mortality in developing countries and yet the most preventable. In developing countries clinical algorithms are used to diagnose clinical neonatal sepsis because of inadequate microbiological services. Most information on incidence and risk factors of neonatal sepsis are from hospital studies which may not be generalized to communities where a significant proportion of mothers do not deliver from health facilities. This study, conducted in urban Uganda, sought to determine the community based incidence of clinical neonatal sepsis and the factors associated...
November 13, 2018: BMC Pediatrics
Asad Maqbool Ahmad, Zeeshan Ahmed, Arshad Khushdil, Talal Waqar
OBJECTIVE: To observe the duration for normalization of the Total Leucocyte Count (TLC) with adjuvant Granulocyte-Colony Stimulating Factor (G-CSF) treatment in leukopenic neonatal sepsis, and to compare the neutrophilic response to G-CSF in neutropenic vs non-neutropenic subgroups. METHODS: This prospective cohort study was carried out at the Neonatal Intensive Care Unit at Military Hospital Rawalpindi (NICU) from 1st August 2015 to 25th January 2017. Fifty one newborns with sepsis and leucopenia were sampled judgmentally from a population of 5666 admitted to NICU during the study period...
November 2018: JPMA. the Journal of the Pakistan Medical Association
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