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"Maternal sepsis" OR "neonatal sepsis"

Eduardo Cuestas, Belén Aguilera, Manuel Cerutti, Alina Rizzotti
OBJECTIVE: To determine whether a sustained neonatal systemic inflammatory response was associated with poor postnatal growth among infants born very preterm during the first year of life. STUDY DESIGN: We studied prospectively 192 infants born preterm (birth weight ≤1.5 kg and gestational age ≤31 weeks). Weight, length, and head circumference were measured at birth, term, 4, and 12 months of corrected age. Serial C-reactive protein and procalcitonin were measured at 1, 3, 7, 14, and 28 days of age and averaged for each infant...
October 16, 2018: Journal of Pediatrics
Ahizechukwu C Eke, Jeanne Sheffield, Ernest M Graham
INTRODUCTION: To evaluate whether there are additional benefits of 17-hydroxyprogesterone caproate (17-OHPC) supplementation in preventing recurrent spontaneous preterm birth in women with a prophylactic cerclage. MATERIAL AND METHODS: Electronic databases (MEDLINE, Scopus, ClinicalTrials gov, PROSPERO, EMBASE, Scielo and the Cochrane Central Register of Controlled Trials) were searched for studies published before June 2018. Keywords included "preterm birth," "prophylactic cerclage," "history-indicated cerclage," "pregnancy" and "17-hydroxyprogesterone caproate...
October 19, 2018: Acta Obstetricia et Gynecologica Scandinavica
Dan Chen, Yalian Ji
BACKGROUND: This study aimed to investigate the clinical features of neonatal sepsis caused by Citrobacter freundii as well as the current status and treatment strategy of multi-drug resistance for infection with this bacterium. METHODS: Nine newborns were diagnosed with C. freundii sepsis between January 2014 and December 2017,we collated and analysed a range of data of the nine patients, including general information,laboratory tests during infection,blood culture and treatments...
October 16, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Devin D Smith, Deepika Sagaram, Russell Miller, Cynthia Gyamfi-Bannerman
OBJECTIVE: Our objective was to describe cerebral palsy (CP) incidence stratified by gestational age (GA) groups within a group at risk for spontaneous preterm birth (sPTB). STUDY DESIGN: This is a secondary analysis of a large study of magnesium for neuroprotection. Nonanomalous, singleton gestations complicated by preterm premature rupture of membranes (PPROM) or preterm labor (PTL) were included. Infants that developed CP were compared to controls that did not...
October 14, 2018: Journal of Maternal-fetal & Neonatal Medicine
Charles R Rosenfeld, Grant Shafer, Lisa M Scheid, L Steven Brown
OBJECTIVE: To determine the validity of screening and serial neutrophil counts in predicting the absence/presence of late-onset sepsis (LOS) in infants with central venous catheters. STUDY DESIGN: Retrospective study of infants admitted to the neonatal intensive care unit (2009-2013) at Parkland Hospital with a central venous catheter and ≥1 LOS evaluations. Infants were categorized as proven or suspect LOS or uninfected based on results of blood cultures, clinical illness, and duration of antibiotics...
October 11, 2018: Journal of Pediatrics
Rocky Wilar
Purpose: To determine the diagnostic value of eosinopenia and neutrophil to lymphocyte ratio (NLR) for diagnosing Early Onset Neonatal Sepsis (EONS). Methods: This is a cross sectional study that conducted in Neonatology Subdivision of Child Health Department of R.D. Kandou General Hospital Manado from July to October 2017. Samples were obtained from all neonates that were met the inclusion criteria as having EONS. Datas were encoded using logistic regression analysis, biserial point correlation, chi square, and ROC curve with p value <0...
October 8, 2018: Korean Journal of Pediatrics
L J Moran, Y Verwiel, M Bahri Khomami, T J Roseboom, R C Painter
Listeriosis is a rare but severe foodborne illness which is more common in populations such as pregnant women, and can result in serious complications including miscarriage, prematurity, maternal and neonatal sepsis, and death in the newborn. Population recommendations exist for specific foods and food preparation practices to reduce listeriosis risk during pregnancy. The aim of the present systematic review was to assess the association between listeriosis and these practices during pregnancy to confirm appropriateness of these recommendations...
2018: Journal of Nutritional Science
Esther M Speer, Elizabet Diago-Navarro, Lukasz S Ozog, David J Dowling, Wei Hou, Mahnoor Raheel, Bettina C Fries, Ofer Levy
Introduction: Neonatal sepsis and its accompanying inflammatory response contribute to substantial morbidity and mortality. Pentoxifylline (PTX), a phosphodiesterase inhibitor which suppresses transcription and production of pro-inflammatory cytokines, is a candidate adjunctive therapy for newborn sepsis. We hypothesized that PTX decreases live microbe-induced inflammatory cytokine production in newborn blood. Methods: Cord blood was stimulated with live microorganisms commonly encountered in newborn sepsis ( Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis , or Candida albicans ), and simultaneously treated with antimicrobial agents (gentamicin, vancomycin, or amphotericin B) and/or clinically relevant concentrations of PTX...
October 1, 2018: Antimicrobial Agents and Chemotherapy
Volkan Özenci, Ulf Schubert
Neonatal sepsis occurs in 1-2/1000 live born neonates and accounts for 3-5% of deaths in term and more than 30% in extremely preterm infants(1). These mortality rates due to neonatal infections are unacceptably high. Immediate and targeted antibiotic treatment is crucial in order to improve survival in this vulnerable population. This article is protected by copyright. All rights reserved.
September 29, 2018: Acta Paediatrica
Michuki Maina, Jalemba Aluvaala, Paul Mwaniki, Olga Tosas-Auguet, Catherine Mutinda, Beth Maina, Constance Schultsz, Mike English
Essential interventions to reduce neonatal deaths that can be effectively delivered in hospitals have been identified. Improving information systems may support routine monitoring of the delivery of these interventions and outcomes at scale. We used cycles of audit and feedback (A&F) coupled with the use of a standardised newborn admission record (NAR) form to explore the potential for creating a common inpatient neonatal data platform and illustrate its potential for monitoring prescribing accuracy. Revised NARs were introduced in a high volume, neonatal unit in Kenya together with 13 A&F meetings over a period of 3  years from January 2014 to November 2016...
2018: BMJ Global Health
Da Hyun Kim, Byoung Jin Min, Eun Jung Jung, Jung Mi Byun, Dae Hoon Jeong, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Young Nam Kim
Objective: The purpose of this study was to evaluate the group B streptococcus (GBS) colonization rate in pregnant Korean women using selective culture media for GBS and to identify obstetrical complications and GBS-induced early-onset neonatal sepsis. Methods: We evaluated 1,014 pregnant women who delivered at Busan Paik Hospital between January 2015 and December 2016. GBS colonization was assessed using chromID Strepto B agar. We evaluated GBS colonization in pregnant women, as well as the obstetrical complication and GBS-induced neonatal sepsis rates...
September 2018: Obstetrics & Gynecology Science
Laura Guerrero-Latorre, Brigette Romero, Edison Bonifaz, Natalia Timoneda, Marta Rusiñol, Rosina Girones, Blanca Rios-Touma
In Quito, the microbiological contamination of surface water represents a public health problem, mainly due to the lack of sewage treatment from urban wastewater. Contaminated water contributes to the transmission of many enteric pathogens through direct consumption, agricultural and recreational use. Among the different pathogens present in urban discharges, viruses play an important role on disease, being causes of gastroenteritis, hepatitis, meningitis, respiratory infections, among others. This study analyzes the presence of viruses in highly impacted surface waters of urban rivers using next-generation sequencing techniques...
December 15, 2018: Science of the Total Environment
Andrew P Brown, Fiona C Denison
Group B streptococcus (GBS) is the most common cause of early-onset neonatal sepsis in many countries and responsible for significant perinatal morbidity and mortality worldwide. Intrapartum antibiotic prophylaxis has been the mainstay of efforts to prevent early-onset GBS disease in recent decades, however it is unclear if women should be targeted based on the presence of clinical risk factors or by screening for GBS colonisation during pregnancy. Universal bacteriological screening of women in late pregnancy has been widely adopted but questions remain regarding its benefits and potential harms...
September 18, 2018: Early Human Development
F Schaltz-Buchholzer, S Biering-Sørensen, N Lund, I Monteiro, P Umbasse, A Bærent Fisker, A Andersen, A Rodrigues, P Aaby, C S Benn
Objective: To examine effects of early Bacille Calmette-Guérin (BCG) vaccination on the risk, cause and severity of infant hospitalizations. Design: Analysis of three trials randomizing low-weight neonates to early-BCG(intervention) versus no-BCG(usual practice in low-weight neonates, control), with hospitalizations as secondary outcome. Methods: Hospitalization data was collected at the pediatric ward of the National Hospital. Effects of BCG on hospitalization risk were assessed in Cox-models providing overall and major disease-group incidence rate ratios(IRRs)...
September 18, 2018: Journal of Infectious Diseases
Yexuzi Li, Junzhong Ke, Chen Peng, Fugen Wu, Yukang Song
AIM: Rapid and accurate diagnosis of neonatal sepsis (NS) is highly warranted because of high associated morbidity and mortality. The study aims to evaluate the effects of miR-300 on inflammatory responses in a septic neonate mouse model. METHODS: A septic mouse model was established by intraperitoneal (i.p.) cecal slurry (CS) injection in order to validate the effect of miR-300 on the inflammatory response in endothelial cells. Bioinformatics tools and luciferase activity were employed to detect the target of miR-300...
September 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yujie Han, Xiaoying Li, Shasha Gao, Xianghong Liu, Lili Kang, Xiaomei Li, Yujie Lang, Xiao Li, Mingying Sun, Zhongtao Gai, Shenglin Yu
OBJECTIVE: Sepsis represents a complex disease with the dysregulated inflammatory response. The purpose of this study is to explore the role of interleukin 17 (IL-17, also known as IL-17A) in the occurrence and development of pediatric sepsis. METHODS: We established the sepsis neonatal rat model with the method of intraperitoneal injection of Escherichia coli (E coli). At each target time point, we got the blood from heart after anesthetizing animals, and the lung and liver tissues were fixed in formalin...
September 14, 2018: Journal of Cellular Biochemistry
Chiara Poggi, Carlo Dani
Sepsis is at present one of the leading causes of morbidity and mortality in the neonatal population. Together with inflammation, oxidative stress is involved in detrimental pathways activated during neonatal sepsis, eventually leading to organ dysfunction and death. The redox cascade during sepsis is mainly initiated by IL-6 and IL-8 stimulation in newborns and includes multiple noxious processes, as direct cell damage induced by reactive oxygen species, activation of gene expression leading to amplification of inflammation and oxidative stress, and impairment of mitochondrial function...
2018: Oxidative Medicine and Cellular Longevity
Aytenew Getabelew, Mihret Aman, Endashaw Fantaye, Tomas Yeheyis
Background: Neonatal sepsis is an important cause of morbidity and mortality among neonates in developing countries accounting for 30-50% of total deaths each year. Childhood mortality is often used as broad indicator of the social development or a specific indicator of health conditions of a country. Objectives: The objective of this study is to assess the prevalence of neonatal sepsis and associated factors among neonates admitted in neonatal intensive care unit at two hospitals in Shashemene town, Ethiopia...
2018: International Journal of Pediatrics
Naveed Durrani, Niels Rochow, Jameel Alghamdi, Anna Pelc, Christoph Fusch, Sourabh Dutta
OBJECTIVES: Neonatologists usually wait 48 hours for blood culture results before deciding to discontinue antibiotics. The objective of the study was to analyze time to positive blood culture in rule out sepsis and estimate the minimum duration of antibiotics. METHODS: Retrospective analysis of blood culture at the Neonatal Intensive Care Unit (NICU), McMaster Children's Hospital (January 2004 to December 2013) using BacT/Alert ®3D microbial system was conducted...
August 30, 2018: Pediatric Infectious Disease Journal
Melissa E Bauer, Michelle Housey, Samuel T Bauer, Sydney Behrmann, Anthony Chau, Caitlin Clancy, Erin A S Clark, Sharon Einav, Elizabeth Langen, Lisa Leffert, Stephanie Lin, Manokanth Madapu, Michael D Maile, Emily McQuaid-Hanson, Kristina Priessnitz, Hen Y Sela, Anuj Shah, Paul Sobolewski, Paloma Toledo, Lawrence C Tsen, Brian T Bateman
BACKGROUND: Given the significant morbidity and mortality of maternal sepsis, early identification is key to improve outcomes. This study aims to evaluate the performance characteristics of the systemic inflammatory response syndrome (SIRS), quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA), and maternal early warning (MEW) criteria for identifying cases of impending sepsis in parturients. The secondary objective of this study is to identify etiologies and risk factors for maternal sepsis and to assess timing of antibiotics in patients diagnosed with sepsis...
August 29, 2018: Anesthesia and Analgesia
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