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Yen-Cheng Chen, Ho-Hsiung Lin, Sheng-Mou Hsiao
OBJECTIVE: To elucidate whether robotic assisted laparoscopic myomectomy (RALM) with barbed sutures is superior to traditional laparoscopic myomectomy (TLM) with barbed sutures. MATERIAL AND METHODS: Medical records of all women with symptomatic uterine myomas who underwent RALM with barbed sutures or TLM with barbed sutures were reviewed. The patients were allocated into the two groups based on their financial considerations. RESULTS: Between July 2012 and March 2016, 78 patients underwent TLM (n = 52) or RALM (n = 26)...
October 2018: Taiwanese Journal of Obstetrics & Gynecology
Jae-Hwan Choi, Eun Hye Oh, Min-Gyu Park, Seung Kug Baik, Han-Jin Cho, Seo Young Choi, Tae-Hong Lee, Ji Soo Kim, Kwang-Dong Choi
The aim of this study was to determine the frequency, clinical and radiological features, and efficacy of clinical evaluation and perfusion-weighted imaging (PWI) for the prediction of final stroke in patients with DWI/MRI-negative posterior circulation stroke (PCS) presenting acute dizziness/vertigo. From our comprehensive prospective stroke registry of acute ischemic stroke during a 7-year period, we identified 1846 consecutive patients with PCS, 850 of whom presented with acute dizziness/vertigo. Of these 850 patients, initial DWI-MRI was negative in 35 (4...
October 19, 2018: Journal of Neurology
Bryce LaFoya, Jordan A Munroe, Xinzhu Pu, Allan R Albig
Notch signaling is a form of intercellular communication which plays pivotal roles at various stages in development and disease. Previous findings have hinted that integrins and extracellular matrix may regulate Notch signaling, although a mechanistic basis for this interaction had not been identified. Here, we reveal that the regulation of Notch by integrins and extracellular matrix is carried out by Src family kinases (SFKs) working downstream of integrins. We identify a physical interaction between the SFK member, c-Src, and the Notch intracellular domain (NICD) that is enhanced by β3 integrin and the integrin binding ECM protein, MAGP2...
October 19, 2018: Scientific Reports
Matthias Port, Francis Hérodin, Marco Valente, Michel Drouet, Patrick Ostheim, Matthäus Majewski, Michael Abend
We examined the transcriptome/post-transcriptome for persistent gene expression changes after radiation exposure in a baboon model. Eighteen baboons were irradiated with a whole body equivalent dose of 2.5 or 5 Gy. Blood samples were taken before, 7, 28 and 75-106 days after radiation exposure. Stage I was a whole genome screening for mRNA combined with a qRT-PCR platform for detection of 667 miRNAs. Candidate mRNAs and miRNAs differentially up- or down-regulated in stage I were chosen for validation in stage II using the remaining samples...
October 18, 2018: Scientific Reports
Katharina Fuchs, Yamel Cardona Gloria, Olaf-Oliver Wolz, Franziska Herster, Lokesh Sharma, Carly A Dillen, Christoph Täumer, Sabine Dickhöfer, Zsofia Bittner, Truong-Minh Dang, Anurag Singh, Daniel Haischer, Maria A Schlöffel, Kirsten J Koymans, Tharmila Sanmuganantham, Milena Krach, Thierry Roger, Didier Le Roy, Nadine A Schilling, Felix Frauhammer, Lloyd S Miller, Thorsten Nürnberger, Salomé LeibundGut-Landmann, Andrea A Gust, Boris Macek, Martin Frank, Cécile Gouttefangeas, Charles S Dela Cruz, Dominik Hartl, Alexander Nr Weber
Chitin is the second most abundant polysaccharide in nature and linked to fungal infection and asthma. However, bona fide immune receptors directly binding chitin and signaling immune activation and inflammation have not been clearly identified because polymeric crude chitin with unknown purity and molecular composition has been used. By using defined chitin (N-acetyl-glucosamine) oligomers, we here identify six-subunit-long chitin chains as the smallest immunologically active motif and the innate immune receptor Toll-like receptor (TLR2) as a primary fungal chitin sensor on human and murine immune cells...
October 18, 2018: EMBO Reports
Amihai Rottenstreich, Shmuel Benenson, Gabriel Levin, Geffen Kleinstern, Allon E Moses, Sharon Amit
OBJECTIVES: To investigate the incidence, risk factors, clinical course and outcomes of pregnancy-related group A streptococcus (GAS) infection. METHODS: A retrospective 13-year cohort study of culture-proven pregnancy-related GAS infection was performed at two university hospitals, serving heterogeneous, multicultural, urban and rural populations. RESULTS: Of 124 women diagnosed with pregnancy-related GAS infection, 115 (93%) were in the puerperium, an incidence of 0...
October 15, 2018: Clinical Microbiology and Infection
Shan Shen, Wei Ji Ma
Given the same sensory stimuli in the same task, human observers do not always make the same response. Well-known sources of behavioral variability are sensory noise and guessing. Visual short-term memory (STM) studies have suggested that the precision of the sensory noise is itself variable. However, it is unknown whether precision is also variable in perceptual tasks without a memory component. We searched for evidence for variable precision in 11 visual perception tasks with a single relevant feature, orientation...
October 18, 2018: Psychological Review
Xiao Luo, Xue Liu, Tao Ding, Zongwei Chen, Lifeng Wang, Kaifeng Wu
Aggregation-induced emission luminogens (termed AIEgens) have emerged as an important class of light-emitting materials with many potential applications. As hinted by their names, AIEgens typically exhibit strong emission in the aggregated form for which the intramolecular motions that dissipate excited state energy are inhibited. Here we demonstrate that AIEgens, using carboxylated te-traphenylethylene (TPE-CA) as an example, can exhibit strong emission in the solution after being grafted onto colloidal nanocrystal (NC) surfaces...
October 18, 2018: Journal of Physical Chemistry Letters
Jacques Dentzer, Dominique Bruel, Matthias Delescluse, Nicolas Chamot-Rooke, Laurent Beccaletto, Simon Lopez, Gabriel Courrioux, Sophie Violette
When modelling onshore sedimentary basins, modellers generally assume that semi-permeable layers (aquitards) greatly restrict vertical flow between aquifers. Aquitards are therefore considered as confining media and vertical flow is assumed to take place mainly within localised permeable faults, if any. In the offshore context, however, interpretation of seismic data frequently provides evidence of fluid flow between sedimentary layers via structurally disrupted formations (pervasive fractures) recognised as zones of reduced seismic amplitude and generically called "chimneys"...
October 17, 2018: Scientific Reports
Jiawen Qian, Chen Wang, Bo Wang, Jiao Yang, Yuedi Wang, Feifei Luo, Junying Xu, Chujun Zhao, Ronghua Liu, Yiwei Chu
BACKGROUND: PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding to its receptor PD-1, which works in braking inflammatory response and conspiring tumor immune evasion. However, in gliomas, the cause of PD-L1 expression in the tumor microenvironment is not yet clear. Besides, auxiliary biomarkers are urgently needed for screening possible responsive glioma patients for anti-PD-1/PD-L1 therapies. METHODS: The distribution of tumor-infiltrating T cells and PD-L1 expression was analyzed via immunofluorescence in orthotopic murine glioma model...
October 17, 2018: Journal of Neuroinflammation
Tamanna Anwar, Gourinath Samudrala
Entamoeba histolytica is an invasive, pathogenic parasite causing amoebiasis. Given that proteins involved in transmembrane (TM) transport are crucial for the adherence, invasion, and nutrition of the parasite, we conducted a genome-wide bioinformatics analysis of encoding proteins to functionally classify and characterize all the TM proteins in E. histolytica . In the present study, 692 TM proteins have been identified, of which 546 are TM transporters. For the first time, we report a set of 141 uncharacterized proteins predicted as TM transporters...
October 16, 2018: Genes
Michael Spagat, Neil F Johnson, Stijn van Weezel
It is still unknown whether there is some deep structure to modern wars and terrorist campaigns that could, for example, enable reliable prediction of future patterns of violent events. Recent war research focuses on size distributions of violent events, with size defined by the number of people killed in each event. Event size distributions within previously available datasets, for both armed conflicts and for global terrorism as a whole, exhibit extraordinary regularities that transcend specifics of time and place...
2018: PloS One
David Leys
Prenylated flavin (prFMN) is a recently discovered cofactor that underpins catalysis in the ubiquitous microbial UbiDX system. UbiX acts as a flavin prenyltransferase while UbiD is a prFMN-dependent reversible (de)carboxylase. The extensive modification of flavin by prenylation, and the consecutive oxidation to the prFMNiminium azomethine ylide, leads to cofactor metamorphosis. While prFMN is no longer able to perform N5-based classical flavin chemistry, it is capable of forming cycloadducts with dipolarophiles, long-lived C4a-based radical species as well as undergoing extensive light driven isomerization...
October 13, 2018: Current Opinion in Chemical Biology
Paraskevi Mavrogiorgou, Björn Enzi, Saskia Steinmann, Christoph Mulert, Georg Juckel
OBJECTIVE: The so-called neuroanatomical hypothesis (with an increased activity of orbitofrontal cortex [OFC]) and the serotonergic hypothesis (with low activity in this system) have been discussed regarding the pathogenesis of obsessive-compulsive disorder (OCD) for decades. This study aimed to look for a relationship between the 2 pathogenetic concepts. METHODS: Nineteen OCD patients (8 female, 11 male, mean ± SD age = 33.37 ± 11.73 years, Yale-Brown Obsessive Compulsive Scale: 21...
October 9, 2018: Journal of Clinical Psychiatry
Qiao Yang, Zihan Xu, Linpeng Zheng, Luping Zhang, Qiai You, Jianguo Sun
Immune checkpoint inhibitor (ICI) therapy had achieved significant clinical benefit in multiple malignant solid tumors, such as non-small cell lung cancer, melanoma and urothelial cancer. ICI therapy not only revolutionarily altered the treatment strategy of malignant solid tumors, but also dramatically prolonged overall survival. However, the objective response rate (ORR) of ICI therapy in second line treatment remains 20% or less. How to find patients eligible for ICI therapy by effective biomarkers became hot nowadays...
2018: American Journal of Cancer Research
Andrew C Katsis, Mzuri H Davies, Katherine L Buchanan, Sonia Kleindorfer, Mark E Hauber, Mylene M Mariette
Songbirds are important models for understanding the mechanisms and fitness consequences of imitative vocal learning. Although the effects of early-life environmental and social conditions on song learning are well-established, the impact of early sound exposure has received surprisingly little attention. Yet recent evidence hints at auditory sensitivity in songbird embryos, including in the zebra finch (Taeniopygia guttata), a classic model species for song learning. Here, we tested whether prenatal exposure to incubation calls-highly rhythmic parental vocalisations produced on the nest-affected song learning in zebra finches...
October 15, 2018: Scientific Reports
Giuseppe Nicola Giordano, Jan Mewes, Alexander Miething
BACKGROUND: Within public health research, generalised trust has been considered an independent predictor of morbidity and mortality for over two decades. However, there are no population-based studies that have scrutinised both contextual-level and individual-level effects of generalised trust on all-cause mortality. We, therefore, aim to investigate such associations by using pooled nationally representative US General Social Survey (GSS) data linked to the National Death Register (NDI)...
October 15, 2018: Journal of Epidemiology and Community Health
Antonella Tramutola, Giulia Abate, Chiara Lanzillotta, Francesca Triani, Eugenio Barone, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Mariagrazia Marziano, Maurizio Memo, Emirena Garrafa, D Allan Butterfield, Marzia Perluigi, Fabio Di Domenico, Daniela Uberti
Alzheimer's disease (AD) is a progressive form of dementia characterized by increased production of amyloid-β plaques and hyperphosphorylated tau protein, mitochondrial dysfunction, elevated oxidative stress, reduced protein clearance, among other. Several studies showed systemic modifications of immune and inflammatory systems due, in part, to decreased levels of CD3+ lymphocytes in peripheral blood in AD. Considering that oxidative stress, both in the brain and in the periphery, can influence the activation and differentiation of T-cells, we investigated the 3-nitrotyrosine (3-NT) proteome of blood T-cells derived from AD patients compared to non-demented (ND) subjects by using a proteomic approach...
October 12, 2018: Free Radical Biology & Medicine
Alexandra C Ley, Jana Nissen, Alexandra Wölk, Martin Röser
In the Alps phylogeographic studies indicate for small insect-pollinated herbs that climatic fluctuations caused significant population migrations and fragmentations into glacial refugia at the periphery of the Alps. Here we investigate whether this holds also for wind-pollinated and -dispersed species. We therefore analysed the phylogeographic pattern (nuclear and chloroplast dataset) of a clade of the four species of the Helictotrichon parlatorei species group (Poaceae) endemic to the Alps. In contrast to earlier findings for small insect-pollinated herbs no clear barriers to gene flow could be detected in this species group...
2018: PloS One
Ruoyu Guo, Yantao Liang, Yu Xin, Long Wang, Shanli Mou, Chunjie Cao, Ruize Xie, Chuanlun Zhang, Jiwei Tian, Yongyu Zhang
As photoautotrophs, phytoplankton are generally present in the euphotic zone of the ocean, however, recently healthy phytoplankton cells were found to be also ubiquitous in the dark deep sea, i.e., at water depths between 2000 and 4000 m. The distributions of phytoplankton communities in much deeper waters, such as the hadal zone, are unclear. In this study, the vertical distribution of the pico- and nano-phytoplankton (PN) communities from the surface to 8320 m, including the epipelagic, mesopelagic, bathypelagic, and hadal zones, were investigated via both 18S and p23S rRNA gene analysis in the Challenger Deep of the Mariana Trench...
2018: Frontiers in Microbiology
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