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https://www.readbyqxmd.com/read/29779297/cardiac-rhythm-management-devices
#1
Irene Stevenson, Alex Voskoboinik
BACKGROUND: The last decade has seen ongoing evolution and use of cardiac rhythm management devices, including pacemakers, cardiac resynchronisation therapy, implantable cardioverter defibrillators and loop recorders. General practitioners are increasingly involved in follow-up and management of patients with these devices. OBJECTIVE: The aim of this article is to provide an overview of different cardiac rhythm management devices, including their role, implant procedure, post-procedural care, potential complications and follow‑up...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29778521/vasculature-on-the-clock-circadian-rhythm-and-vascular-dysfunction
#2
REVIEW
Sandra Crnko, Martin Cour, Linda W Van Laake, Sandrine Lecour
The master mammalian circadian clock (i.e. central clock), located in the suprachiasmatic nucleus of the hypothalamus, orchestrates the synchronization of the daily behavioural and physiological rhythms to better adapt the organism to the external environment in an anticipatory manner. This central clock is entrained by a variety of signals, the best established being light and food. However, circadian cycles are not simply the consequences of these two cues but are generated by endogenous circadian clocks...
May 17, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29778339/lower-risk-of-postoperative-arrhythmias-in-congenital-heart-surgery-following-intraoperative-administration-of-magnesium
#3
Dingchao He, Nimisha Aggarwal, David Zurakowski, Richard A Jonas, Charles I Berul, Sridhar Hanumanthaiah, Jeffrey P Moak
OBJECTIVES: Postoperative arrhythmias are common in children undergoing congenital heart surgery. We evaluated whether intraoperative administration of magnesium was associated with a reduced occurrence of specific postoperative arrhythmias, as has been described previously, or had a broader effect on multiple arrhythmia types, and whether there existed a dose-effect of intraoperative magnesium. METHODS: We used a historical prospective observational cohort study...
April 18, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29778278/new-evidence-of-a-rhythmic-priming-effect-that-enhances-grammaticality-judgments-in-children
#4
Alexander Chern, Barbara Tillmann, Chloe Vaughan, Reyna L Gordon
Musical rhythm and the grammatical structure of language share a surprising number of characteristics that may be intrinsically related in child development. The current study aimed to understand the potential influence of musical rhythmic priming on subsequent spoken grammar task performance in children with typical development who were native speakers of English. Participants (ages 5-8 years) listened to rhythmically regular and irregular musical sequences (within-participants design) followed by blocks of grammatically correct and incorrect sentences upon which they were asked to perform a grammaticality judgment task...
May 16, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29778223/circadian-and-irradiance-effects-on-expression-of-antenna-protein-genes-and-pigment-contents-in-dinoflagellate-prorocentrum-donghaiense-dinophycae
#5
Xinguo Shi, Ling Li, Senjie Lin
PCP and acpPC are the two major antennae proteins that bind pigments in peridinin-containing dinoflagellates. The relationship between antennae proteins and cellular pigments at molecular level is still poorly understood. Here we identified and characterized the two antennae protein genes in dinoflagellate Prorocentrum donghaiense under different light conditions. The mature PCP protein was 32 kDa, while acpPC was a polyprotein each of 19 kDa. Both genes showed higher expression under low light than under high light, suggesting their possible role in a low light adaptation mechanism...
May 2018: Harmful Algae
https://www.readbyqxmd.com/read/29777477/cardiac-and-gait-rhythms-in-healthy-younger-and-older-adults-during-treadmill-walking-tasks
#6
Matthew W Wittstein, Joseph M Starobin, Randy J Schmitz, Sandra J Shulz, Francis Jay Haran, Christopher K Rhea
BACKGROUND: Aging and pathology result in changes in the dynamics of several physiological subsystems. Often, these changes are concurrent, altering the dynamics between subsystems. Cardiac and gait rhythms are one example in which patterns change during physical activity. AIMS: The purpose of this research is to simultaneously monitor changes in cardiac and gait rhythms when participants complete various treadmill walking tasks-normal speed, fast speed, and while synchronizing steps with a blinking metronome...
May 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29777288/time-shifting-effects-of-methylphenidate-on-daily-rhythms-in-the-diurnal-rodent-arvicanthis-ansorgei
#7
Jorge Mendoza, Hester C van Diepen, Rob Rodrigues Pereira, Johanna H Meijer
People suffering of attention-deficit/hyperactivity disorder (ADHD) and treated with the psychostimulant methylphenidate (MPH) show sleep-wake cycle and daily rhythm alterations despite the beneficial effects of MPH on behavioral symptoms (i.e., hyperactivity, attention). In nocturnal rodents (i.e., mice), chronic exposure to MPH alters the neural activity of the circadian clock in the suprachiasmatic nucleus (SCN), behavioral rhythms, and the sleep-wake cycle. Here, we studied the effects of MPH on daily rhythms of behavior and body temperature of the diurnal rodent Arvicanthis ansorgei...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29776959/symptom-burden-of-atrial-fibrillation-and-its-relation-to-interventions-and-outcome-in-europe
#8
Renate B Schnabel, Ladislav Pecen, Nargiz Rzayeva, Markus Lucerna, Yanish Purmah, Francisco M Ojeda, Raffaele De Caterina, Paulus Kirchhof
BACKGROUND: Little is known about the association of atrial fibrillation symptom burden with quality of life and outcomes. METHODS AND RESULTS: In the Prevention of Thromboembolic Events-European Registry in Atrial Fibrillation (n=6196 patients with atrial fibrillation; mean±SD age, 71.8±10.4 years; 39.7% women), we assessed European Heart Rhythm Association score symptoms and calculated correlations with the standardized health status questionnaire (EQ-5D-5L)...
May 18, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29776773/circadian-rhythms-and-mental-health-wearable-sensing-at-scale
#9
Aiden Doherty
No abstract text is available yet for this article.
May 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29776095/optimal-entrainment-of-circadian-clocks-in-the-presence-of-noise
#10
Michele Monti, David K Lubensky, Pieter Rein Ten Wolde
Circadian clocks are biochemical oscillators that allow organisms to estimate the time of the day. These oscillators are inherently noisy due to the discrete nature of the reactants and the stochastic character of their interactions. To keep these oscillators in sync with the daily day-night rhythm in the presence of noise, circadian clocks must be coupled to the dark-light cycle. In this paper, we study the entrainment of phase oscillators as a function of the intrinsic noise in the system. Using stochastic simulations, we compute the optimal coupling strength, intrinsic frequency, and shape of the phase-response curve, that maximize the mutual information between the phase of the clock and time...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775964/time-matters-for-intersex-bodies-between-socio-medical-time-and-somatic-time
#11
Limor Meoded Danon
This article focuses on the dynamic relationships between time and intersex bodies that exist, on the one hand, in medical policy on intersex bodies and, on the other, in intersex people's subjective experiences. Time, from a sociological perspective, is a biosocial agent that establishes diagnostic practices, regulations, and treatment policy regarding intersex bodies. The systematic construction of timeframes by biomedical professionals aims to rapidly diagnose and treat intersex patients and is deeply rooted in the "dimorphic soma-gender order" (DMSGO), the imagined unified relationship of female bodies to femininity and male bodies to masculinity...
May 8, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29775674/the-prognostic-value-of-the-frontal-qrs-t-angle-is-comparable-to-cardiovascular-autonomic-neuropathy-regarding-long-term-mortality-in-people-with-diabetes-a-population-based-study
#12
O May, C B Graversen, M Ø Johansen, H Arildsen
Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. AIM: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. METHODS: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method andan age and gender stratified sample of 240 individuals with diabetes were randomly selected...
May 15, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29775091/chronotherapy-of-maxacalcitol-on-skin-inflammation-induced-by-topical-12-o-tetradecanoylphorbol-13-acetate-in-mice
#13
Daisuke Yoshioka, Hitoshi Ando, Kentaro Ushijima, Masafumi Kumazaki, Akio Fujimura
In general, chronotherapy is desirable for a more effective and/or safe dosage regimen. In this study, a daily rhythm of skin vitamin D receptor (VDR) and chronotherapeutic profiles of maxacalcitol, a vitamin D analogue, were evaluated using mice with skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This study showed that skin nuclear VDR expression in TPA-treated mice has a daily rhythm with the peak at the middle of active period. The effects of maxacalcitol were greater after dosing during early to middle of active period than those after dosing during early to middle of inactive period...
May 18, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29774882/-sleep-wake-rhythm-after-extracorporeal-circulation-in-new-zealand-rabbits
#14
Kaiwei Wang, Jiaqiang Zhang
To evaluate the change of sleep-wake rhythm after extracorporeal circulation (ECC) in New Zealand rabbits, and to explore the role of clock genes in sleep-wake rhythm disorder by ECC.
 Methods: A total of 54 New Zealand rabbits were randomly divided into 3 groups: a normal group (Group N), a sham group (Group S) and a model group (Group ECC). Electrocorticogram (ECOG), electroophthalmogram (EOG) and electromyogram (EMG) were respectively recorded by multipurpose EEG recorder, and the sleep-wake rhythm was also recorded...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29774517/the-acute-effects-of-age-and-particulate-matter-exposure-on-heart-rate-and-heart-rate-variability-in-mice
#15
Blake A Bennett, Ernst W Spannhake, Ana M Rule, Patrick N Breysse, Clarke G Tankersley
Exposure to ambient particulate matter (PM) is associated with increased cardiac morbidity and mortality with the elderly considered to be the most susceptible. The purpose of this study was to determine if exposure to PM would cause a greater impact on heart regulation in older DBA/2 (D2) male mice as determined by changes in heart rate (HR) and heart rate variability (HRV). D2 mice at the ages of 4, 12, and 19 months were instilled with 100 µg of PM or saline by aspiration. Before and after the aspiration, 3-min echocardiogram (ECG) samples for HR and HRV were recorded at 15-min intervals for 3 h along with corresponding measurements of homeostasis, such as temperature, metabolism, and ventilation...
May 17, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29773903/circadian-regulator-nr1d2-regulates-glioblastoma-cell-proliferation-and-motility
#16
Min Yu, Wenjing Li, Qianqian Wang, Yan Wang, Fei Lu
Nuclear receptor NR1D2 is originally characterized as the repressor of genes involved in circadian rhythm. Recently, it is documented that NR1D2 is overexpressed in various cancers. However, the pathways and biological functions that NR1D2 involved in cancers remain poorly understood. Here, we reported that NR1D2 was abundant in human glioblastoma (GBM) tissue and cell lines but not primary human astrocytes. Silencing of NR1D2 changed the morphology of GBM cells, inhibited cell proliferation and motility, whereas had no effects on apoptosis...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29773817/electrical-synapses-between-inhibitory-neurons-shape-the-responses-of-principal-neurons-to-transient-inputs-in-the-thalamus-a-modeling-study
#17
Tuan Pham, Julie S Haas
As multimodal sensory information proceeds to the cortex, it is intercepted and processed by the nuclei of the thalamus. The main source of inhibition within thalamus is the reticular nucleus (TRN), which collects signals both from thalamocortical relay neurons and from thalamocortical feedback. Within the reticular nucleus, neurons are densely interconnected by connexin36-based gap junctions, known as electrical synapses. Electrical synapses have been shown to coordinate neuronal rhythms, including thalamocortical spindle rhythms, but their role in shaping or modulating transient activity is less understood...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773814/melanopsin-mediated-pupil-function-is-impaired-in-parkinson-s-disease
#18
Daniel S Joyce, Beatrix Feigl, Graham Kerr, Luisa Roeder, Andrew J Zele
Parkinson's disease (PD) is characterised by non-motor symptoms including sleep and circadian disruption. Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGC) transmit light signals to brain areas controlling circadian rhythms and the pupil light reflex. To determine if non-motor symptoms observed in PD are linked to ipRGC dysfunction, we evaluated melanopsin and rod/cone contributions to the pupil response in medicated participants with PD (n = 17) and controls (n = 12)...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29772981/treatment-of-recent-onset-atrial-fibrillation-with-quinidine-and-flecainide-in-thoroughbred-racehorses-107-cases-1987-2014
#19
Yuji Takahashi, Yuhiro Ishikawa, Hajime Ohmura
OBJECTIVE To compare the efficacy of quinidine and flecainide in treating naturally occurring, recent-onset atrial fibrillation (AF) in Thoroughbred racehorses. DESIGN Retrospective case series. ANIMALS 107 Thoroughbred racehorses. PROCEDURES Medical records of racehorses with AF that were treated with quinidine or flecainide between 1987 and 2014 were reviewed. Signalment, history, treatments, complications, and outcome data were collected. Horses were allocated to 2 groups according to the initial treatment: initial treatment with quinidine (group 1) or initial treatment with flecainide (group 2)...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29772513/a-transition-to-white-led-increases-ecological-impacts-of-nocturnal-illumination-on-aquatic-primary-producers-in-a-lowland-agricultural-drainage-ditch
#20
Maja Grubisic, Roy H A van Grunsven, Alessandro Manfrin, Michael T Monaghan, Franz Hölker
The increasing use of artificial light at night (ALAN) has led to exposure of freshwater ecosystems to light pollution worldwide. Simultaneously, the spectral composition of nocturnal illumination is changing, following the current shift in outdoor lighting technologies from traditional light sources to light emitting diodes (LED). LEDs emit broad-spectrum white light, with a significant amount of photosynthetically active radiation, and typically a high content of blue light that regulates circadian rhythms in many organisms...
May 14, 2018: Environmental Pollution
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