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Jason A Trubiano, Olivia Smibert, Abby Douglas, Misha Devchand, Belinda Lambros, Natasha E Holmes, Kyra Y Chua, Elizabeth J Phillips, Monica A Slavin
Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the cancer diagnosis. We demonstrate the successful and safe implementation of a pilot oral penicillin challenge program for cancer patients with low-risk penicillin allergies, increasing the use of penicillin and narrow-spectrum beta-lactams post-testing.
December 2018: Open Forum Infectious Diseases
Cristina Benito-Villalvilla, Irene Soria, José Luis Subiza, Oscar Palomares
Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems related to efficacy, safety, long treatment duration and low patient adherence. There has been intensive research to develop alternative strategies, including novel administration routes, adjuvants or hypoallergenic molecules. Promising results are reported for some of them, but clinical progress is still moderate...
2018: Allergo Journal International
Ludger Klimek, Thomas Kündig, Matthias F Kramer, Sonja Guethoff, Erika Jensen-Jarolim, Carsten B Schmidt-Weber, Oskar Palomares, Mona O Mohsen, Thilo Jakob, Martin Bachmann
Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in various forms and by various routes. Virus-like particles (VLPs) offer a very effective platform for immunization with the allergen and are characterized by high immunogenicity, low allergenicity and high clinical efficacy. Formulations that include Toll-like receptor ligands, T cell stimulatory epitopes and/or depot-forming adjuvants appear to enhance activation of the relevant immune cells...
2018: Allergo Journal International
Robert Pugh, Bryan Wessel, Ashutosh Barve, Martin S Vyleta
Severe reactions to modern iodinated contrasts are uncommon. Breakthrough reactions in the setting of pretreatment with corticosteroids are even rarer. Patients with a history of these refractory reactions can create challenging situations in the diagnostic and therapeutic process. Here, we present a case of an 83-year-old male with hepatocellular carcinoma and a history of multiple severe reactions to iodinated contrast. The patient required a transarterial chemoembolization but the conventional technique was unavailable due to the allergy...
March 2019: Radiology Case Reports
Nannan Yan, Jie Xu, Chuanxiang Zhao, Yi Wu, Fengwei Gao, Ci Li, Wenhui Zhou, Tengfei Xiao, Xiaoming Zhou, Qixiang Shao, Sheng Xia
Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. The current study aimed to investigate potential antiallergic properties of hUC-MSCs in mice with ovalbumin (OVA)-induced food allergy...
December 2018: Experimental and Therapeutic Medicine
Derek Croote, Spyros Darmanis, Kari C Nadeau, Stephen R Quake
Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human health, the cells that produce these antibodies are rarely observed and remain enigmatic. We isolated single IgE B cells from individuals with food allergies and used single-cell RNA sequencing to elucidate the gene expression and splicing patterns unique to these cells. We identified a surprising example of convergent evolution in which IgE antibodies underwent identical gene rearrangements in unrelated individuals...
December 14, 2018: Science
Juliana Madzia, Patrick Ryan, Kimberly Yolton, Zana Percy, Nick Newman, Grace LeMasters, Cole Brokamp
OBJECTIVE: To assess the relationship between greenspace exposure and childhood internalizing and externalizing behaviors. STUDY DESIGN: We analyzed data from the Cincinnati Childhood Allergy and Air Pollution Study, an ongoing prospective birth cohort. Greenspace exposure was estimated based on children's addresses using normalized difference vegetation index (NDVI) images. Neurobehavioral outcomes were assessed using the Behavioral Assessment System for Children, Second Edition...
December 10, 2018: Journal of Pediatrics
Gautam Ramesh, Dana Gerstbacher, Jenna Arruda, Brenda Golianu, John Mark, Ann Ming Yeh
Pediatric integrative medicine is an emerging field which, to date, has not been described in detail in academic medical centers in the United States. Early research of pediatric integrative medicine modalities shows promise for the treatment of common pediatric conditions such as irritable bowel syndrome, acute and chronic pain, headache, and allergy, among others. In light of the growing prevalence of pediatric illnesses and patient complexity, it is crucial to emphasize the patient's overall well-being. As academic centers around the world start to develop pediatric integrative medicine programs, the aim of this manuscript is to briefly highlight evidence of effective integrative treatments in pediatric subspecialties, to describe the establishment of our integrative medicine program, to summarize its early efforts, and to discuss potential barriers and keys to success...
December 12, 2018: Children
Tetsuya Terada, Ryo Kawata
We review current management for allergic rhinitis and possible new treatments for this condition. Management of allergic rhinitis includes promotion of protective factors, avoidance of allergens, and possibly immunotherapy. In recent years, the incidence of allergic rhinitis has increased in many countries. Early intervention at different stages is an important part of management. Allergic disease in infants has been described as the allergic march, commencing with atopic dermatitis accompanied by infantile asthma and progressing to perennial allergic rhinitis induced by house dust mite allergy...
December 11, 2018: Medical Sciences: Open Access Journal
Alisa M Gorbacheva, Dmitry V Kuprash, Nikita A Mitkin
Interleukin 33 (IL-33) is a cytokine constitutively expressed by various cells of barrier tissues that contribute to the development of inflammatory immune responses. According to its function as an alarmin secreted by lung and airway epithelium, IL-33 plays a significant role in pathogenesis of allergic disorders. IL-33 is strongly involved in the pathogenesis of asthma, anaphylaxis, allergy and dermatitis, and genetic variations in IL33 locus are associated with increased susceptibility to asthma. Genome-wide association studies have identified risk "T" allele of the single-nucleotide polymorphism rs4742170 located in putative IL33 enhancer area as susceptible variant for development of specific wheezing phenotype in early childhood...
December 9, 2018: International Journal of Molecular Sciences
Giorgio Ciprandi, Paola Puccinelli, Cristoforo Incorvaia, Simonetta Masieri
Parietaria pollen is the most important cause of pollen allergies in the Mediterranean area, as Parietaria is widespread in this region. Many issues are associated with Parietaria allergy, including the duration of the pollen season (many doctors in fact believe that it lasts throughout the year), pollen load (which seems to be increasing over time), the impact of age (on IgE production and symptom severity), inflammatory changes (after pollen exposure), and the choice of allergen immunotherapy (AIT). In addition, molecular diagnostics allows for the defining of a correct diagnosis, differentiating between mere sensitization and true allergy...
December 7, 2018: Medicina
Erika Yue Lee, Daniel Teitelbaum, Marcus Chiam, Peter Vadas
BACKGROUND: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity. OBJECTIVES: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. METHODS: A retrospective chart review of patients diagnosed with ibuprofen allergy was conducted between 2008 and 2016 in an allergy clinic at a tertiary care academic institution...
December 13, 2018: International Archives of Allergy and Immunology
Akira Shibuya, Kazuko Shibuya
Gut fungal dysbiosis exacerbates colitis and lung allergy. In recent studies published in Science (Leonardi et al., 2018) and Cell Host & Microbe (Li et al., 2018), gut-resident CX3 CR1+ mononuclear phagocytes were found to mediate crosstalk between intestinal fungi and systemic immunity along the lung-gut axis during homeostasis and inflammation.
December 12, 2018: Cell Host & Microbe
Leslie Heathman, Crystal Clark Douglas, Simone P Camel
BACKGROUND: Researchers exploring breastfeeding attitudes and knowledge among women suggest the decision to breastfeed is influenced by the male partner, yet few studies address males. Because collegiate males will soon enter fatherhood, assessment of their attitudes and knowledge may inform interventions aimed at increasing intention to breastfeed. RESEARCH AIM: This study aimed to describe collegiate males' exposure to, attitude toward, and knowledge about breastfeeding...
December 13, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
David J Ponting, Miguel A Ortega, Ida B Niklasson, Isabella Karlsson, Tina Seifert, Johanna Steen, Kristina Luthman, Ann-Therese Karlberg
Epoxy resin monomers (ERMs) are used as building blocks for thermosetting polymers in applications where strong, flexible, and light-weight materials are required. Most epoxy resins are polymers of diglycidyl ether of bisphenol A (DGEBA). It is highly allergenic and causes occupational allergic contact dermatitis and contact allergy in the general population. Thus, measures to prevent exposure by protective clothing and education are not enough. The work describes a continuation of our research aiming at reducing the skin sensitizing potency of ERMs while maintaining the ability to form polymers...
December 13, 2018: Chemical Research in Toxicology
Sebastian Führer, Simone Trimmel, Kathrin Breuker, Martin Tollinger
In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic cross-reactivity of Bet v 1 specific antibodies. Allergic symptoms typically include severe itching, scratching of the throat, and rhino conjunctivitis. So far, experimental structural data for the peach allergen Pru p 1 are not available...
December 12, 2018: Biomolecular NMR Assignments
Michiko Aihara
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
Noriyuki Yanagida
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
Ya-Lan Huang, Da-Na Huang, Wei-Hua Wu, Fan Yang, Xiao-Min Zhang, Miao Wang, Yi-Jun Tang, Qian Zhang, Li-Fei Peng, Ren-Li Zhang
BACKGROUND: Two health concerns primarily related to triatomine bugs are transmission of Trypanosoma cruzi through infective feces, and allergic reactions induced by triatomine bites. In the Southwestern United States, reduviid bugs bites commonly cause insect allergy. In South China, four cases of anaphylactic shock have been reported after this bite exposure. To further classify the species of these bugs and confirm the sensitization of the triatomine saliva, we caught triatomine bugs from the region where the bites occurred and performed phylogenetic and immunohistochemical (IHC) analysis...
December 11, 2018: Infectious Diseases of Poverty
Louise Correia Lima, Gerson de Almeida Queiroz, Ryan Dos Santos Costa, Neuza Maria Alcantara-Neves, Cíntia Rodrigues Marques, Gustavo Nunes de Oliveira Costa, Mauricio Lima Barreto, Camila Alexandrina Viana Figueiredo, Valdirene Leão Carneiro
Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA...
January 2019: Cytokine
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