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Nikolaos Douladiris, Victoria Garib, Margit Focke Tejkl, Rudolf Valenta, Nikolaos G Papadopoulos, Birgit Linhart
BACKGROUND: Skin testing represents a commonly used first diagnostic method in clinical practice but allergen extracts may vary in composition and often contain cross-reactive allergens and therefore do not always allow the precise identification of the sensitizing allergen source. Our aim was to investigate the suitability of a single recombinant hybrid molecule, consisting of the four major timothy grass pollen allergens (Phl p 1, Phl p 2, Phl p 5, Phl p 6) for in vivo diagnosis of genuine grass pollen allergy in children suffering from pollinosis...
October 14, 2018: Pediatric Allergy and Immunology
Carmen Rondón, Ibon Eguíluz-Gracia, Mohamed H Shamji, Janice A Layhadi, María Salas, María José Torres, Paloma Campo
PURPOSE OF REVIEW: IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP). RECENT FINDINGS: Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non-atopic phenotypes of rhinitis as demonstrated in LAR...
October 13, 2018: Current Allergy and Asthma Reports
Elizabeth Lippner, Scott H Sicherer, Michael H Land, Michael Schatz, Chitra Dinakar
No abstract text is available yet for this article.
October 11, 2018: Journal of Allergy and Clinical Immunology in Practice
Jan Willem Cohen Tervaert
In the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias, myalgias, pyrexia, dry eyes and dry mouth. During the last few years, it has been postulated that these symptoms in patients with foreign body implants are due to a chronic inflammatory process and an adjuvant effect of the implanted biomaterial. Ultimately, these inflammatory reactions result in (an increase of) allergies, autoimmune diseases, immune deficiency and/or lymphomas...
October 11, 2018: Autoimmunity Reviews
S Miceli Sopo, A Romano, G Bersani, C Fantacci, L Badina, G Longo, G Monti, S Viola, S Tripodi, G Barilaro, I D Iacono, C Caffarelli, C Mastrorilli, S Barni, F Mori, L Liotti, B Cuomo, F Franceschini, D Viggiano, S Monaco
BACKGROUND: Few studies on the age of resolution of Food Protein Induced Enterocolitis Syndrome (FPIES) induced by solid foods are available. In particular, for FPIES induced by egg, the mean age of tolerance acquisition reported in the literature ranges from 42 to 63 months. OBJECTIVE: We have assessed whether the age of tolerance acquisition in acute egg FPIES varies depending on whether the egg is cooked or raw. METHODS: We conducted a retrospective and multicentric study of children with diagnosis of acute egg FPIES seen in 10 Italian allergy units between July 2003 and October 2017...
October 10, 2018: Allergologia et Immunopathologia
Abida Zahirović, Ana Koren, Peter Kopač, Borut Štrukelj, Peter Korošec, Mojca Lunder
Identification of Api m 1 IgE epitopes and characterization of their mimotopes described herein represents an important step towards better understanding of sting anaphylaxis pathogenesis and towards development of alternative immunotherapy for bee venom allergy.
October 10, 2018: Journal of Allergy and Clinical Immunology
Chrysanthi Skevaki, Harald Renz
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; TH 2 lymphocytes; B cells; dendritic cells: microbiome and barrier function; eosinophils, mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH 2) as well as innate (ILC2) effector cells. New pathways of lymphocyte activation, trafficking and recruitment, and effector cell mechanisms have been discovered...
October 10, 2018: Journal of Allergy and Clinical Immunology
María Díaz, Lucía Guadamuro, Irene Espinosa-Martos, Leonardo Mancabelli, Santiago Jiménez, Cristina Molinos-Norniella, David Pérez-Solis, Christian Milani, Juan Miguel Rodríguez, Marco Ventura, Carlos Bousoño, Miguel Gueimonde, Abelardo Margolles, Juan José Díaz, Susana Delgado
Cow's milk protein allergy (CMPA) is the most common food allergy in infancy. Non-IgE mediated (NIM) forms are little studied and the responsible mechanisms of tolerance acquisition remain obscure. Our aim was to study the intestinal microbiota and related parameters in the fecal samples of infants with NIM-CMPA, to establish potential links between type of formula substitutes, microbiota, and desensitization. Seventeen infants between one and two years old, diagnosed with NIM-CMPA, were recruited. They were all on an exclusion diet for six months, consuming different therapeutic protein hydrolysates...
October 11, 2018: Nutrients
Pawel Karpinski, Pawel Skiba, Magdalena Kosinska, Marta Rosiek-Biegus, Emilia Królewicz, Nikolaus Blin, Eckart Meese, Bernard Panaszek, Marita Nittner-Marszalska, Maria Malgorzata Sasiadek
BACKGROUND: Insect venom immunotherapy (VIT) is used to protect patients against Hymenoptera insects' venom allergy (HVA), which can result in severe systemic or even life-threatening conditions. Molecular mechanisms triggered by VIT remain largely unknown. OBJECTIVE: To compare genome-wide gene expression of patients with severe HVA prior to VIT and 12 months after. METHODS: Whole blood RNA samples were analyzed on an expression array. Results from differential expression obtained on a microarray platform were confirmed by quantitative real -time PCR (qRT-PCR)...
October 9, 2018: Immunology Letters
Alisha McGregor, Fred Ashbury, Peter Caputi, Donald Iverson
OBJECTIVE: This study investigates the health and work-environment factors that are associated with presenteeism. METHOD: A self-report survey which measured presenteeism, 13 health conditions (e.g., stress and allergies) and nine work-environment factors (e.g., job strain and leadership) was completed by 229 workers. RESULTS: The most common health condition was stress, while the most common work-environment factor was job strain. Allergies, asthma and high blood pressure along with work-life imbalance, poor leadership and a lack of development opportunities were associated with presenteeism...
October 11, 2018: Journal of Occupational and Environmental Medicine
Heinrich C Weber, Eugene Haydn Walters, Mai Frandsen, Shyamali C Dharmage
OBJECTIVE: Asthma and allergic diseases are poorly described in rural areas. The objective of this study was, therefore, to determine the prevalence of wheezing, asthma, and other allergic disorders among children living in regional and rural Tasmania. METHODOLOGY: Data from a cross-sectional survey using standardized questionnaires of asthma, allergic conditions and food allergies were collected from 39 primary schools across North West Tasmania. We enrolled 1075 children between 6 and 8 years...
October 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Axel Trautmann, Johanna Stoevesandt
BACKGROUND: Anaphylaxis-like reactions developing within a few minutes are the most frequent complications of subcutaneous or submucosal injections of local anaesthetics (LAs), and topically applied LAs are potential contact allergens. In addition, injected LAs have been reported to induce delayed reactions, including local inflammation at the injection site, and various general symptoms. OBJECTIVES: To assess the frequency and symptoms of late-type hypersensitivity occurring several hours after LA injections...
October 11, 2018: Contact Dermatitis
Divya Seth, Deepak Kamat
Drug allergy is commonly encountered in clinical practice. It is an immunological response to a pharmaceutical agent. The clinical presentation can vary from mild cutaneous reactions to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Diagnosis is most often clinical, but investigations such as measurement of immunoglobulin E, patch testing, and skin biopsy may be required. In patients with a known drug allergy, the offending drug should be avoided. [Pediatr Ann. 2018;47(10):e419-e425...
October 1, 2018: Pediatric Annals
Gaston Echaniz, Marcos De Miguel, Glenn Merritt, Plinio Sierra, Pranjal Bora, Nabamallika Borah, Christopher Ciarallo, Miriam de Nadal, Richard J Ing, Adrian Bosenberg
BACKGROUND: Cleft defects are common craniofacial malformations which require early surgical repair. These patients are at high risk of postoperative airway obstruction and respiratory failure. Cleft surgery may require high doses of opioids which may contribute to these complications. OBJECTIVES: To compare the effectiveness of proximal and distal approaches to blocking the maxillary nerve in patients undergoing cleft lip or cleft palate surgery. DESIGN: Randomised, controlled and double-blind study...
October 10, 2018: European Journal of Anaesthesiology
C G Mortz, K E Andersen, L K Poulsen, H F Kjaer, S Broesby-Olsen, C Bindslev-Jensen
BACKGROUND: While much is known on childhood atopic diseases, knowledge about persistence of atopic diseases from childhood to adulthood is limited. We therefore aimed to study the clinical course of atopic diseases and Type I sensitization prospectively in an unselected cohort of adolescents followed into adulthood. METHODS: A cohort of unselected 8th grade school children (mean age 14 years) established in 1995 and followed-up in 2010 were evaluated with questionnaire, clinical examination, skin prick tests and measurements of specific IgE...
October 11, 2018: Allergy
Mi Ae Kim, Dong Kyu Kim, Hyeon Jong Yang, Young Yoo, Youngmin Ahn, Hae Sim Park, Hyun Jong Lee, Yi Yeong Jeong, Bong Seong Kim, Woo Yong Bae, An Soo Jang, Yang Park, Young Il Koh, Jaechun Lee, Dae Hyun Lim, Jeong Hee Kim, Sang Min Lee, Yong Min Kim, Young Joon Jun, Hyo Yeol Kim, Yunsun Kim, Jeong Hee Choi
PURPOSE: Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergy in pollinosis patients caused by raw fruits and vegetables and is the most common food allergy in adults. However, there has been no nationwide study on PFAS in Korea. In this study, we investigated the prevalence and clinical characteristics of PFAS in Korea. METHODS: Twenty-two investigators participated in this study, in which patients with allergic rhinoconjunctivitis and/or bronchial asthma with pollen allergy were enrolled...
November 2018: Allergy, Asthma & Immunology Research
Garima Sharma, Sin Hyeog Im
The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases etc. , dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those as probiotics...
November 2018: Allergy, Asthma & Immunology Research
Andrea Mombelli, Dena Hashim, Norbert Cionca
OBJECTIVES: To compile the current evidence regarding the association between the release of titanium particles and biologic complications of dental implants. MATERIAL AND METHODS: This is a critical review. We searched the literature using the terms "corrosion," "allergy," "hypersensitivity," or "particles" together with "titanium," "Ti," "TiO2. " The bibliographies of identified publications and previously published review articles were scanned to find additional related articles...
October 2018: Clinical Oral Implants Research
Jiří Hrdý, Kateřina Vlasáková, Viktor Černý, Lenka Súkeníková, Olga Novotná, Petra Petrásková, Kristýna Boráková, Rája Lodinová-Žádníková, Libuše Kolářová, Ludmila Prokešová
The growing knowledge of the key role of microbiota in the maturation of neonatal immune system suggests that manipulation of microbiota could be exploited in hampering allergy development. In this study, Escherichia coli O83:K24:H31 (EcO83) was administered to newborns that were followed prospectively. Several immunological characteristics (cytokines, specific IgE, total T regulatory cells (Treg) and subpopulation of natural Treg (nTreg) and induced Treg (iTreg)) were tested in peripheral blood of eight year old children...
October 10, 2018: European Journal of Immunology
Morris Gordon, Elena Biagioli, Miriam Sorrenti, Carla Lingua, Lorenzo Moja, Shel Sc Banks, Simone Ceratto, Francesco Savino
BACKGROUND: Infantile colic is typically defined as full-force crying for at least three hours per day, on at least three days per week, for at least three weeks. This condition appears to be more frequent in the first six weeks of life (prevalence range of 17% to 25%), depending on the specific location reported and definitions used, and it usually resolves by three months of age. The aetiopathogenesis of infantile colic is unclear but most likely multifactorial. A number of psychological, behavioural and biological components (food hypersensitivity, allergy or both; gut microflora and dysmotility) are thought to contribute to its manifestation...
October 10, 2018: Cochrane Database of Systematic Reviews
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