Xinrui Shi, Loryn Facemire, Sandeep Singh, Shailesh Kumar, Robert Cornelison, Chen Liang, Fujun Qin, Aiqun Liu, Shitong Lin, Yue Tang, Justin Elfman, Thomas Manley, Timothy Bullock, Doris M Haverstick, Peng Wu, Hui Li
RNA processing mechanisms, such as alternative splicing and RNA editing, have been recognized as critical means to expand the transcriptome. Chimeric RNAs formed by intergenic splicing provide another potential layer of RNA diversification. By analyzing a large set of RNA-Seq data and validating results in over 1,200 blood samples, we identified UBA1-CDK16 , a female-specific chimeric transcript. Intriguingly, both parental genes, are expressed in males and females. Mechanistically, UBA1-CDK16 is produced by cis-splicing between the two adjacent X-linked genes, originating from the inactive X chromosome...
February 15, 2024: bioRxiv