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https://www.readbyqxmd.com/read/28934796/decompressive-l5-transverse-processectomy-for-bertolotti-s-syndrome-a-preliminary-study
#1
Chang Il Ju, Seok Won Kim, Jong Gyue Kim, Seung Myung Lee, Ho Shin, Hyeun Young Lee
BACKGROUND: Bertolotti's syndrome is a spinal disorder characterized by abnormal enlargement of the transverse process of the most caudal lumbar vertebra. The L5 transverse process may be enlarged either unilaterally or bilaterally and may articulate or fuse with the sacrum or ilium. Pseudoarticulation between the transverse process of the L5 and the alar of the sacrum can cause buttock pain and leg pain. In addition, the L4 exiting nerve root could be compressed by an enlarged L5 transverse process...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934785/1-year-results-of-a-randomized-controlled-trial-of-conservative-management-vs-minimally-invasive-surgical-treatment-for-sacroiliac-joint-pain
#2
Julius Dengler Dengler, Djaya Kools, Robert Pflugmacher, Alessandro Gasbarrini, Domenico Prestamburgo, Paolo Gaetani, Eddie van Eeckhoven, Daniel Cher, Bengt Sturesson
BACKGROUND: Low back pain (LBP) emanating from the sacroiliac joint (SIJ) is a common finding. Devices to fuse the SIJ are now commercially available, but high-quality evidence supporting their effectiveness is limited. OBJECTIVES: To compare the safety and effectiveness of conservative management (CM) to minimally invasive sacroiliac joint fusion (SIJF) in patients with chronic LBP originating from the SIJ. STUDY DESIGN: Prospective, multicenter randomized controlled trial...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934746/temperature-probe-placement-during-preterm-infant-resuscitation-a-randomised-trial
#3
Brahim Bensouda, Romain Mandel, Abdelwaheb Mejri, Jean Lachapelle, Marie St-Hilaire, Nabeel Ali
BACKGROUND: Hypothermia on admission to intensive care is associated with poor outcomes in preterm infants. The neonatal resuscitation program recommends the use of servo-control thermoregulation during resuscitation. Very little evidence exists to guide optimal temperature probe placement in the delivery room. OBJECTIVE: The aim of this work was to determine, in moderately preterm infants, if temperature probe placement in the dorsal, thoracic, or axillary area during delivery room resuscitation would result in differing temperatures on admission to the neonatal intensive care unit (NICU)...
September 22, 2017: Neonatology
https://www.readbyqxmd.com/read/28934448/cervical-spine-deformity-part-2-management-algorithm-and-anterior-techniques
#4
Lee A Tan, K Daniel Riew, Vincent C Traynelis
A sound operative plan based on solid understanding of the pathology and biomechanics is the most important part of cervical deformity correction. Many different surgical options exist for operative management of cervical spine deformities. However, selecting the correct approach that ensures the optimal clinical outcome can be challenging and often controversial. In Part 2 of this three-part review series, we discuss the pre-operative planning, management algorithm, and anterior surgical techniques for cervical deformity correction...
October 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28934002/estimating-the-optimal-personalized-treatment-strategy-based-on-selected-variables-to-prolong-survival-via-random-survival-forest-with-weighted-bootstrap
#5
Jincheng Shen, Lu Wang, Stephanie Daignault, Daniel E Spratt, Todd M Morgan, Jeremy M G Taylor
A personalized treatment policy requires defining the optimal treatment for each patient based on their clinical and other characteristics. Here we consider a commonly encountered situation in practice, when analyzing data from observational cohorts, that there are auxiliary variables which affect both the treatment and the outcome, yet these variables are not of primary interest to be included in a generalizable treatment strategy. Furthermore, there is not enough prior knowledge of the effect of the treatments or of the importance of the covariates for us to explicitly specify the dependency between the outcome and different covariates, thus we choose a model that is flexible enough to accommodate the possibly complex association of the outcome on the covariates...
September 21, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28933888/identifying-stable-variants-of-callous-unemotional-traits-a-longitudinal-study-of-at-risk-girls
#6
Natalie Goulter, Eva R Kimonis, Samuel W Hawes, Stephanie Stepp, Alison E Hipwell
Callous-unemotional (CU) traits have proven important for designating children and adolescents showing a pattern of particularly severe, stable, and aggressive antisocial behaviors (Frick, Ray, Thornton, & Kahn, 2014). Individuals with secondary CU traits represent a subpopulation that are distinguished from those with primary CU traits by their high anxiety levels and marked histories of social/environmental adversity; however, evidence is largely based on cross-sectional male samples and this study is the first to examine stable trajectories of CU variants among an all-girl population...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28933670/on-enrichment-strategies-for-biomarker-stratified-clinical-trials
#7
Xiaofei Wang, Jingzhu Zhou, Ting Wang, Stephen L George
In the era of precision medicine, drugs are increasingly developed to target subgroups of patients with certain biomarkers. In large all-comer trials using a biomarker stratified design (BSD), the cost of treating and following patients for clinical outcomes may be prohibitive. With a fixed number of randomized patients, the efficiency of testing certain treatments parameters, including the treatment effect among biomarker positive patients and the interaction between treatment and biomarker, can be improved by increasing the proportion of biomarker positives on study, especially when the prevalence rate of biomarker positives is low in the underlying patient population...
September 21, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28933611/optimal-frequency-time-combination-of-whole-body-vibration-training-for-developing-physical-performance-of-people-with-sarcopenia-a-randomized-controlled-trial
#8
Ning Wei, Marco Yc Pang, Shamay Sm Ng, Gabriel Yf Ng
OBJECTIVE: To determine whether frequency and exposure time to whole body vibration influenced its effects on physical performance in seniors with sarcopenia. DESIGN: Randomized controlled trial Setting: A university sports training laboratory. SUBJECTS: Eighty community dwelling seniors with sarcopenia were recruited. INTERVENTIONS: Participants were randomly divided into 4 groups, namely, low-frequency (LG: 20Hz x 720s), medium-frequency (MG: 40Hz x 360s), high-frequency (HG: 60Hz x 240s) and control (CG: no extra training) for 12 weeks of whole body vibration training and 12 weeks of follow-up...
October 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28933570/developing-pictorial-asthma-action-plans-to-promote-self-management-and-health-in-rural-youth-with-asthma-a-qualitative-study
#9
Christina L Duncan, Heather A Walker, Laurel Brabson, Desireé N Williford, Lisa Hynes, Mary Beth Hogan
OBJECTIVE: Asthma action plans (AAPs) provide asthma management instructions to families; however, AAPs typically are written at a 7(th)-9(th) grade reading level, making them less useful in lower literacy families. There is a need to develop simpler AAP formats and content to optimize their utility across all families, including those who are rural and may be at risk for literacy concerns. Because using pictures can simplify and enhance health education, our study aim was to develop a pictorial AAP through a series of focus groups with key stakeholders - youth with asthma, caregivers, and physicians...
September 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28933520/anticoagulation-and-antiplatelet-therapy-in-patients-with-peripheral-arterial-disease-of-the-femoro-popliteal-arteries
#10
Cornelis G Vos, Anco Vahl
Peripheral arterial disease (PAD) is associated with a substantial cardiovascular risk and secondary prevention is recommended for all patients. In this report the literature on anticoagulant and antiplatelet drugs for patients with PAD in the femoro-popliteal segment is reviewed. PubMED/MEDLINE and Cochrane Database was searched for studies published between January 1966 and August 2017. Meta-analyses and randomized controlled trials describing outcome of anticoagulants or antiplatelet drugs for secondary prevention or following vascular interventions in patients with PAD were included...
September 20, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28933516/anti-il5-therapies-for-asthma
#11
REVIEW
Hugo A Farne, Amanda Wilson, Colin Powell, Lynne Bax, Stephen J Milan
BACKGROUND: This review is the first update of a previously published review in The Cochrane Library (Issue 7, 2015). Interleukin-5 (IL-5) is the main cytokine involved in the activation of eosinophils, which cause airway inflammation and are a classic feature of asthma. Monoclonal antibodies targeting IL-5 or its receptor (IL-5R) have been developed, with recent studies suggesting that they reduce asthma exacerbations, improve health-related quality of life (HRQoL) and lung function...
September 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28933237/cross-validation-and-development-of-empirically-derived-adhd-assessment-strategies-insights-from-the-national-longitudinal-study-of-adolescent-health-add-health
#12
Shirag K Shemmassian, Steve S Lee
OBJECTIVE: There is replicated evidence that individual ADHD symptoms differentially predict ADHD diagnostic status, and that non- Diagnostic and Statistical Manual of Mental Disorders (DSM)-based symptom algorithms are superior to DSM criteria for ruling in or ruling out ADHD. However, these findings have been limited to case-control samples, despite the need to replicate them in independent and more representative samples and to increase their generalizability. METHOD: We analyzed the base rates and psychometric properties of ADHD symptoms in the population-based National Longitudinal Study of Adolescent Health (Add Health; http://www...
September 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28933204/healthcare-utilization-and-direct-costs-of-non-infectious-comorbidities-in-hiv-infected-patients-in-the-usa
#13
Joel Gallant, Priscilla Hsue, David Budd, Nicole Meyer
OBJECTIVE: To estimate the incremental healthcare utilization and costs associated with common non-infectious comorbid conditions among commercially and Medicaid-insured HIV-infected patients in the US. METHODS: US administrative claims were used to select adult HIV patients with chronic kidney disease (CKD), cardiovascular disease (CVD) events, or fracture/osteoporosis, three common comorbidities that have been associated with HIV and HIV treatment, between 01/012004 and 06/30/2013...
September 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28932979/tuberculous-meningitis-in-children-and-adults-new-insights-for-an-ancient-foe
#14
REVIEW
Alyssa Mezochow, Kiran Thakur, Christopher Vinnard
PURPOSE OF REVIEW: Tuberculous meningitis is the most devastating manifestation of infection with Mycobacterium tuberculosis and represents a medical emergency. Approximately one half of tuberculous meningitis patients die or suffer severe neurologic disability. The goal of this review will be to review the pathogenic, clinical, and radiologic features of tuberculous meningitis and to highlight recent advancements in translational and clinical science. RECENT FINDINGS: Pharmacologic therapy includes combination anti-tuberculosis drug regimens and adjunctive corticosteroids...
September 20, 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28932975/the-effect-of-a-geriatric-evaluation-on-treatment-decisions-for-older-patients-with-colorectal-cancer
#15
N M Verweij, E T D Souwer, A H W Schiphorst, H A Maas, J E A Portielje, A Pronk, F van den Bos, M E Hamaker
BACKGROUND: Treating elderly colorectal cancer patients can be challenging. It is very important to carefully weigh the risks and benefits of potential treatments in individual patients. This treatment decision making can be guided by geriatric consultation. Our aim was to assess the effect of a geriatric evaluation on treatment decisions for older patients with colorectal cancer. METHODS: Colorectal cancer patients who were referred for a geriatric consultation between 2013 and 2015 in three Dutch teaching hospitals were included in a prospective database...
September 20, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28932287/the-effectiveness-of-ultrasound-guided-hydrodistension-and-physiotherapy-in-the-treatment-of-frozen-shoulder-adhesive-capsulitis-in-primary-care-a-single-centre-service-evaluation
#16
Michael Bryant, Andrew Gough, James Selfe, Jim Richards, Elizabeth Burgess
BACKGROUND: Evidence for optimal non-operative treatment of frozen shoulder is lacking. The present study aimed to evaluate a treatment strategy for stage II to III frozen shoulder provided by the current primary care musculoskeletal service. METHODS: General practioner referrals of shoulder pain to the musculoskeletal service diagnosed with stage II to III frozen shoulder and who opted for a treatment strategy of hydrodistension and guided physiotherapy exercise programme over a 12-month period were evaluated for 6 months...
October 2017: Shoulder & Elbow
https://www.readbyqxmd.com/read/28932118/fabrication-optimization-and-characterization-of-umbelliferone-%C3%AE-d-galactopyranoside-loaded-plga-nanoparticles-in-treatment-of-hepatocellular-carcinoma-in-vitro-and-in-vivo-studies
#17
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Gaurav Kaithwas, Hani Choudhry, Fahad A Al-Abbasi, Firoz Anwar, Amita Verma
Umbelliferone β-D-galactopyranoside (UFG), isolated from plants, exhibits promising inhibitory action on numerous diseases. The present research was initiated to develop a suitable delivery system for UFG with an intention to enhance its therapeutic efficacy against diethyl nitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in Wistar rats. UFG-loaded polymeric nanoparticles prepared by sonication were scrutinized for average size, drug loading capacity, zeta potential, and drug release potency in animals...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28931501/cancer-predisposition-cascade-screening-for-hereditary-breast-ovarian-cancer-and-lynch-syndromes-in-switzerland-study-protocol
#18
Maria C Katapodi, Valeria Viassolo, Maria Caiata-Zufferey, Christos Nikolaidis, Rosmarie Bührer-Landolt, Nicole Buerki, Rossella Graffeo, Henrik Csaba Horváth, Christian Kurzeder, Manuela Rabaglio, Michael Scharfe, Corinne Urech, Tobias E Erlanger, Nicole Probst-Hensch, Karl Heinimann, Viola Heinzelmann-Schwarz, Olivia Pagani, Pierre O Chappuis
BACKGROUND: Breast, colorectal, ovarian, and endometrial cancers constitute approximately 30% of newly diagnosed cancer cases in Switzerland, affecting more than 12,000 individuals annually. Hundreds of these patients are likely to carry germline pathogenic variants associated with hereditary breast ovarian cancer (HBOC) or Lynch syndrome (LS). Genetic services (counseling and testing) for hereditary susceptibility to cancer can prevent many cancer diagnoses and deaths through early identification and risk management...
September 20, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28931260/stereotactic-accuracy-and-surgical-utility-of-the-o-arm-in-deep-brain-stimulation-surgery
#19
Jonathan Dennis Carlson, Kate Elizabeth McLeod, Pamela Sue McLeod, Jamelynn Brooke Mark
BACKGROUND: The stereotactic accuracy of intraoperative imaging is critical to clinical outcome, particularly in "asleep" deep brain stimulation (DBS) surgery that typically forgoes neurophysiological techniques. Different intraoperative imaging modalities and associated accuracies have been reported, including magnetic resonance imaging (MRI), computed tomography (CT), and O-arm. OBJECTIVE: To analyze intraoperative O-arm imaging accuracy and to evaluate the utility of microelectrode mapping...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28931102/-areas-and-challenges-of-oncopsychological-rehabilitation
#20
Péter Kovács, Zsuzsa Koncz, Julianna Peti, Anna Gõdény, Dóra Horváth, Csilla Gerlinger, Katalin Lacsán, Petra Molnár, Ágnes Riskó
Patients with cancer present a number of different difficulties that adversely affect their health care and recovery (e.g. poor communication with physicians, lack of knowledge about their illness and its management, financial problems). Furthermore, mental health problems, such as distress, depression and anxiety, are common amongst patients with cancer. These mental health problems are additional contributors to functional impairment in carrying out family, work, and other social roles, poor adherence to medical treatments, and adverse medical outcomes...
September 20, 2017: Magyar Onkologia
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