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Laboratory elderly

Jung Koo Lee, Hak-Cheol Ko, Jin-Gyu Choi, Youn Soo Lee, Byung-Chul Son
Here we report a rare case of diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 62-year-old male patient misdiagnosed as having tuberculous meningitis. Due to its rarity and radiologic findings of leptomeningeal enhancement in the basal cisterns on magnetic resonance imaging (MRI) similar to tuberculous meningitis, DLGNT in this patient was initially diagnosed as communicating hydrocephalus from tuberculous meningitis despite absence of laboratory findings of tuberculosis. The patient's symptoms and signs promptly improved after a ventriculoperitoneal shunting surgery followed by empirical treatment against tuberculosis...
2018: Case Reports in Neurological Medicine
Yorito Yamamoto, Akiko Wakikawa, Akiko Ueno, Ryuhei Nagai, Mitsuhiro Matsumoto, Junko Komatsu, Hiromi Kinoshita, Susumu Minami, Kazutoshi Hayashi
OBJECTIVE: The aim of this study was to clarify the clinical, laboratory, and imaging findings of ovarian cancer in association with endometriotic cysts by detailed comparison of the findings of benign and malignant tumors. METHODS AND MATERIALS: This was a retrospective study of 138 women who had an operation for ovarian tumors at the Department of Obstetrics and Gynecology of Kochi Health Sciences Center between September 1, 2011, and July 30, 2015. The ovarian tumors were divided into two groups: the benign group (endometriotic cysts) and the malignant group (ovarian cancer in association with endometriotic cysts)...
2018: Cancer treatment and research communications
Caner Alparslan, Elif Perihan Öncel, Sinem Akbay, Demet Alaygut, Fatma Mutlubaş, Mansur Tatlı, Martin Konrad, Önder Yavaşcan, Belde Kasap-Demir
Alparslan C, Öncel EP, Akbay S, Alaygut D, Mutlubaş F, Tatlı M, Konrad M, Yavaşcan Ö, Kasap-Demir B. A novel homozygous W99G mutation in CLDN-16 gene causing familial hypomagnesemic hypercalciuric nephrocalcinosis in Turkish siblings. Turk J Pediatr 2018; 60: 76-80. Familial hypomagnesemic hypercalciuric nephrocalcinosis (FHHNC) (OMIM: 248250) is characterized by hypomagnesemia, hypercalciuria and nephrocalcinosis. FHHNC inevitably progresses to end-stage renal disease in decades. Mutations in CLDN-16 and CLDN-19 genes are associated with disrupted magnesium handling in the thick ascending limp of Henle`s loop...
2018: Turkish Journal of Pediatrics
Friedrich Leblhuber, Kostja Steiner, Burkhard Schuetz, Dietmar Fuchs, Johanna M Gostner
BACKGROUND: Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer's disease. OBJECTIVE: The rebalancing of the microbiome could benefically impact on gut inflammation and immune activation. METHODS: In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 77...
August 13, 2018: Current Alzheimer Research
Helena Moreira Silva, Gisela Silva, Emília Costa, Rosa Lima, Fernando Pereira
We describe the case of a previously healthy 8-year-old girl presenting with a 1-year history of iron deficiency anemia. There was no report of hematemesis, abdominal pain or melena. Laboratory work-up excluded iron malabsorption as the underlying cause. Therefore, endoscopic evaluation was performed to exclude gastrointestinal blood loss, which revealed the presence of a 7 mm reddish lesion located within the ampulla of Vater. Capsule endoscopy excluded alternative diagnoses and concomitant lesions. Histopathological examination confirmed the diagnosis of pyogenic granuloma...
August 9, 2018: Clinical Journal of Gastroenterology
Irene Ma, Maggie Guo, Daniel Muruve, Hallgrimur Benediktsson, Christopher Naugler
BACKGROUND: Chronic kidney disease (CKD) is often asymptomatic in its early stages but is indicated and is diagnosed with an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 . Certain sociodemographic groups are known to be at risk for CKD, but it is unclear if there are strong associations between these at risk groups with abnormal eGFR test results in Canada. Using only secondary laboratory and Census data, geospatial variation and sociodemographic associations with abnormal eGFR result rate were investigated in Calgary, Alberta...
August 9, 2018: BMC Nephrology
Silvia Giuliani, Verena Barbieri, Angela Maria Di Pierro, Fabio Rossi, Thomas Widmann, Manuela Lucchiari, Irene Pusceddu, Stefan Pilz, Barbara Obermayer-Pietsch, Markus Herrmann
BACKGROUND: Developed countries have a high prevalence of vitamin D deficiency. In previous studies, 25(OH)D was predominantly measured by immunoassays. The present study assessed serum 25(OH)D in a very large Southern European outpatient cohort by liquid chromatography tandem mass spectrometry (LC-MS/MS). MATERIALS AND METHODS: 74,235 serum 25(OH)D results generated under routine conditions between 2015 and 2016 were extracted from the laboratory information system of the Department of Clinical Pathology at Bolzano Hospital (Italy)...
August 7, 2018: European Journal of Nutrition
Paol Pinti, Ilias Tachtsidis, Antonia Hamilton, Joy Hirsch, Clarisse Aichelburg, Sam Gilbert, Paul W Burgess
The past few decades have seen a rapid increase in the use of functional near-infrared spectroscopy (fNIRS) in cognitive neuroscience. This fast growth is due to the several advances that fNIRS offers over the other neuroimaging modalities such as functional magnetic resonance imaging and electroencephalography/magnetoencephalography. In particular, fNIRS is harmless, tolerant to bodily movements, and highly portable, being suitable for all possible participant populations, from newborns to the elderly and experimental settings, both inside and outside the laboratory...
August 7, 2018: Annals of the New York Academy of Sciences
Kumiko Akashi, Tomoki Ebata, Takashi Mizuno, Yukihiro Yokoyama, Tsuyoshi Igami, Junpei Yamaguchi, Shunsuke Onoe, Masato Nagino
BACKGROUND: Whether operative treatment provides benefits for elderly patients with perihilar cholangiocarcinoma is unknown. The aim of this study was to review resection of perihilar cholangiocarcinoma according to age and to clarify its value for octogenarians. METHODS: Between April 1977 and December 2015, we reviewed consecutive patients who underwent resection for perihilar cholangiocarcinoma with a special focus on patient age. RESULTS: During the study interval, 831 patients underwent resection for perihilar cholangiocarcinoma...
August 3, 2018: Surgery
Tang-Meng Guo, Bei Cheng, Li Ke, Si-Ming Guan, Ben-Ling Qi, Wen-Zhu Li, Bin Yang
Coronary artery disease (CAD) is a multifactorial disease in which inflammation plays a central role. This study aimed to investigate the association of inflammatory markers such as the neutrophil to lymphocyte ratio (NLR), the Global Registry of Acute Coronary Events (GRACE) score with in-hospital mortality of elderly patients with acute myocardial infarction (AMI) in an attempt to explore the prognostic value of these indices for elderly AMI patients. One thousand consecutive CAD patients were divided into two groups based on age 60...
April 2018: Current medical science
Suleyman Emre Kocyigit, Pinar Soysal, Esra Ates Bulut, Ozge Dokuzlar, Ahmet Turan Isik
AIM: The study aimed to evaluate the effect of thiazide diuretics, a first-line antihypertensive therapy, on cognitive function in elderly hypertensive patients with or without cognitive impairment. METHODS: This retrospective and observational study assessed 286 elderly patients with hypertension. Patients were divided based on thiazide diuretic usage and then into dementia and non-dementia groups. The comprehensive geriatric assessment was performed for all patients...
July 30, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
Senol Kobak, Fidan Yildiz, Huseyin Semiz, Mehmet Orman
OBJECTIVES: Sarcoidosis rarely affect patients older than 65 years old. The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset (EOS) and young-onset sarcoidosis (YOS) patients. METHODS: One hundred and thirty one patients diagnosed with sarcoidosis according to clinical, radiologic and histopathological evaluation were included in this study. The patients with initial symptoms started after age 65 were accepted as EOS...
July 24, 2018: Reumatología Clinica
Hoi-Kei Lon, Nuno Mendonca, Sandra Goss, Ahmed A Othman, Charles Locke, Ziyi Jin, Beatrice Rendenbach-Mueller
Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD). Three studies were conducted in healthy subjects (18-55 years), 1 in healthy elderly subjects (≥65 years), and 1 in patients with mild to moderate AD. Four studies assessed pharmacokinetics, 1 study in healthy subjects assessed pharmacodynamics (sleep parameters, particularly rapid eye movement [REM], as a measure of central nervous system [CNS] penetration and activity), and all studies assessed safety...
July 27, 2018: Clinical Pharmacology in Drug Development
Hemda Schmilovitz-Weiss, Rachel Gingold-Belfer, Doron Boltin, Yichayaou Beloosesky, Joseph Meyerovitch, Ruth Tor, Nidal Issa, Alon Grossman, Nira Koren-Morag, Avraham Weiss
BACKGROUND: Serum alanine aminotransferase (ALT) levels below and above the reference range have been found to serve as a marker of liver injury and to predict all-cause mortality. The need to adjust the reference range by age, sex, or other parameters remains unclear. The current reference range of serum ALT in Israel is 0-34 IU/l for women and 0-45 IU/l for men. We aimed to test the applicability of the current reference range values of ALT in specific people - the elderly population...
July 25, 2018: European Journal of Gastroenterology & Hepatology
Elisa Danese, Martina Montagnana, Giuseppe Lippi
Frailty is consequent to age-dependent deregulation of several biological pathways and systems, encompassing namely sarcopenia, age-associated hormonal derangements, inflammation, and nutritional or metabolic deficiencies. Although the prevalence of frailty is usually between 10% and 20% in the general elderly population, its overall burden will increase exponentially along with the predictable prolongation of life expectancy. Risk prediction and early diagnosis will hence become pivotal for mitigating the clinical, social, and economic impact of this condition...
August 1, 2018: Expert Review of Proteomics
Byoung-Gwon Kim, Young-Seoub Hong, Koichi Haraguchi, Mineshi Sakomoto, Hyoun-Ju Lim, Jeong-Wook Seo, Yu-Mi Kim
Methylmercury is widely known to be a toxic substance in the human, especially a nervous system. However, it is difficult to accurately measure the amount of methylmercury in blood, and the form of methylmercury is variously presented. The purpose of study was to compare the total mercury and methylmercury measurements techniques and detection levels between analytical institutions in two countries using the same elderly human blood samples. Total mercury using gold amalgamation direct mercury analysis method (both) and methylmercury using the dithizone extraction and gas chromatography-electron capture detector (GC-ECD) method (N Lab in Japan) and the cold vapor atomic fluorescence spectrophotometer (CVAFS) method (D Lab in Korea) were measured in 47 subjects who agreed to participate in this study...
2018: Computational and Mathematical Methods in Medicine
Gleiciane G Avelar, Wilcelly Machado-Silva, Adriane D Henriques, Jeeser A Almeida, Aparecido P Ferreira, Ciro J Brito, Lucy Gomes, Clayton F Moraes, Otávio T Nóbrega
Nitric oxide (NOx) availability in biological systems is associated with either favorable or unfavorable outcomes. In this sense, several studies bring about evidence that unbalanced NOx production may be underlying to the pathophysiology of vascular disorders. Our study investigated the possible association of clinical, biochemical and inflammatory variables with total circulating levels of NOx in elderly patients devoid of major inflammatory conditions. Clinical (demographics, lifestyle, anthropometry, pressoric traits) and biochemical characteristics (lipemic, glycemic and hormonal profiles) were assessed from 168 geriatrics outpatients eligible for primary care for age-related disorders...
2018: International Journal of Molecular Epidemiology and Genetics
Iryna Kniazkova, Larysa Shapovalova, Maryna Bogun
The presented case report concerns a 62-year-old male patient who was admitted to the rheumatology department with a fever, shoulder and hip joint pain, significant limitation of movement in these joints and general weakness. Laboratory test revealed increase of inflammatory parameters, as ESR and C-reactive protein, rheumatoid factor and ACPA antibodies were absent. In the course of diagnostics, infections and cancer were excluded. The patient met the classification criteria for polymyalgia rheumatica. Polymyalgia rheumatica is not a rare disease, but the number of elderly people in the world continues to increase, and we can assume that the prevalence of this disease will increase in the coming years...
2018: Reumatologia
Alexey Ruzin, Susan T Pastula, Elizabeth Levin-Sparenberg, Xiaohui Jiang, Jon Fryzek, Andrey Tovchigrechko, Bin Lu, Yanping Qi, Hui Liu, Hong Jin, Li Yu, Judith Hackett, Tonya Villafana, Mark T Esser
BACKGROUND: Respiratory syncytial virus (RSV) is an established cause of serious lower respiratory disease in infants, elderly and high-risk populations. The OUTSMART surveillance program aims to characterize patient populations and currently circulating RSV strains, and monitor temporal and geographic evolution of RSV F and G proteins in the U.S. METHODS: The OUTSMART 2016-17 study collected RSV-positive samples from 25 RSVAlert® laboratories from 4 U.S. regions and Puerto Rico during November 2016 through March 2017...
2018: PloS One
Ulla Lepola, Nanco Hefting, Doris Zhang, Mary Hobart
OBJECTIVES: The objective of this study was to evaluate the long-term safety and tolerability of flexible-dose brexpiprazole adjunct to antidepressant treatment (ADT) in elderly patients with major depressive disorder (MDD). METHODS: Elderly patients (≥65 years) with MDD and inadequate response to ≥1 ADT during the current episode were recruited to a 26-week, interventional, open-label study (NCT02400346) at outpatient centers in the USA and Europe. All patients received brexpiprazole 1 to 3 mg/day adjunct to their current ADT...
July 23, 2018: International Journal of Geriatric Psychiatry
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