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https://www.readbyqxmd.com/read/30551142/cytological-and-molecular-aspects-of-the-ageing-sperm
#1
Donatella Paoli, Giulia Pecora, Francesco Pallotti, Fabiana Faja, Marianna Pelloni, Andrea Lenzi, Francesco Lombardo
STUDY QUESTION: Is ageing associated with a decline in semen quality and molecular changes to human sperm? SUMMARY ANSWER: Semen quality declines with advancing age and characteristic molecular changes take place during the ageing process, including increased sperm DNA damage, altered sperm protamination and altered seminal plasma miRNA profile. WHAT IS KNOWN ALREADY: During ageing, the reproductive system is exposed to physiological changes and potentially damaging factors that may impair testicular function...
December 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/30547634/pseudorapidity-dependence-of-particle-production-and-elliptic-flow-in-asymmetric-nuclear-collisions-of-p-al-p-au-d-au-and-3-he-au-at-sqrt-s_-nn-200-gev
#2
A Adare, C Aidala, N N Ajitanand, Y Akiba, M Alfred, V Andrieux, K Aoki, N Apadula, H Asano, C Ayuso, B Azmoun, V Babintsev, M Bai, N S Bandara, B Bannier, K N Barish, S Bathe, A Bazilevsky, M Beaumier, S Beckman, R Belmont, A Berdnikov, Y Berdnikov, D S Blau, M Boer, J S Bok, K Boyle, M L Brooks, J Bryslawskyj, V Bumazhnov, C Butler, S Campbell, V Canoa Roman, R Cervantes, C-H Chen, C Y Chi, M Chiu, I J Choi, J B Choi, T Chujo, Z Citron, M Connors, N Cronin, M Csanád, T Csörgő, T W Danley, A Datta, M S Daugherity, G David, K DeBlasio, K Dehmelt, A Denisov, A Deshpande, E J Desmond, A Dion, P B Diss, D Dixit, J H Do, A Drees, K A Drees, M Dumancic, J M Durham, A Durum, T Elder, A Enokizono, H En'yo, S Esumi, B Fadem, W Fan, N Feege, D E Fields, M Finger, M Finger, S L Fokin, J E Frantz, A Franz, A D Frawley, Y Fukuda, C Gal, P Gallus, P Garg, H Ge, F Giordano, A Glenn, Y Goto, N Grau, S V Greene, M Grosse Perdekamp, T Gunji, H Guragain, T Hachiya, J S Haggerty, K I Hahn, H Hamagaki, H F Hamilton, S Y Han, J Hanks, S Hasegawa, T O S Haseler, K Hashimoto, X He, T K Hemmick, J C Hill, K Hill, A Hodges, R S Hollis, K Homma, B Hong, T Hoshino, N Hotvedt, J Huang, S Huang, K Imai, J Imrek, M Inaba, A Iordanova, D Isenhower, Y Ito, D Ivanishchev, B V Jacak, M Jezghani, Z Ji, J Jia, X Jiang, B M Johnson, V Jorjadze, D Jouan, D S Jumper, S Kanda, J H Kang, D Kapukchyan, S Karthas, D Kawall, A V Kazantsev, J A Key, V Khachatryan, A Khanzadeev, C Kim, D J Kim, E-J Kim, G W Kim, M Kim, M H Kim, B Kimelman, D Kincses, E Kistenev, R Kitamura, J Klatsky, D Kleinjan, P Kline, T Koblesky, B Komkov, D Kotov, S Kudo, B Kurgyis, K Kurita, M Kurosawa, Y Kwon, R Lacey, J G Lajoie, E O Lallow, A Lebedev, S Lee, S H Lee, M J Leitch, Y H Leung, N A Lewis, X Li, X Li, S H Lim, L D Liu, M X Liu, V-R Loggins, S Lökös, K Lovasz, D Lynch, T Majoros, Y I Makdisi, M Makek, M Malaev, A Manion, V I Manko, E Mannel, H Masuda, M McCumber, P L McGaughey, D McGlinchey, C McKinney, A Meles, M Mendoza, W J Metzger, A C Mignerey, D E Mihalik, A Milov, D K Mishra, J T Mitchell, I Mitrankov, G Mitsuka, S Miyasaka, S Mizuno, A K Mohanty, P Montuenga, T Moon, D P Morrison, S I Morrow, T V Moukhanova, T Murakami, J Murata, A Mwai, K Nagai, K Nagashima, T Nagashima, J L Nagle, M I Nagy, I Nakagawa, H Nakagomi, K Nakano, C Nattrass, P K Netrakanti, T Niida, S Nishimura, R Nishitani, R Nouicer, T Novák, N Novitzky, R Novotny, A S Nyanin, E O'Brien, C A Ogilvie, J D Orjuela Koop, J D Osborn, A Oskarsson, G J Ottino, K Ozawa, R Pak, V Pantuev, V Papavassiliou, J S Park, S Park, S F Pate, M Patel, J-C Peng, W Peng, D V Perepelitsa, G D N Perera, D Yu Peressounko, C E PerezLara, J Perry, R Petti, M Phipps, C Pinkenburg, R Pinson, R P Pisani, A Pun, M L Purschke, P V Radzevich, J Rak, B J Ramson, I Ravinovich, K F Read, D Reynolds, V Riabov, Y Riabov, D Richford, T Rinn, S D Rolnick, M Rosati, Z Rowan, J G Rubin, J Runchey, A S Safonov, B Sahlmueller, N Saito, T Sakaguchi, H Sako, V Samsonov, M Sarsour, K Sato, S Sato, B Schaefer, B K Schmoll, K Sedgwick, R Seidl, A Sen, R Seto, P Sett, A Sexton, D Sharma, I Shein, T-A Shibata, K Shigaki, M Shimomura, T Shioya, P Shukla, A Sickles, C L Silva, D Silvermyr, B K Singh, C P Singh, V Singh, M J Skoby, M Slunečka, K L Smith, M Snowball, R A Soltz, W E Sondheim, S P Sorensen, I V Sourikova, P W Stankus, M Stepanov, S P Stoll, T Sugitate, A Sukhanov, T Sumita, J Sun, Z Sun, S Suzuki, S Syed, J Sziklai, A Takeda, A Taketani, K Tanida, M J Tannenbaum, S Tarafdar, A Taranenko, G Tarnai, R Tieulent, A Timilsina, T Todoroki, M Tomášek, C L Towell, R Towell, R S Towell, I Tserruya, Y Ueda, B Ujvari, H W van Hecke, S Vazquez-Carson, J Velkovska, M Virius, V Vrba, N Vukman, X R Wang, Z Wang, Y Watanabe, Y S Watanabe, F Wei, A S White, C P Wong, C L Woody, M Wysocki, B Xia, C Xu, Q Xu, L Xue, S Yalcin, Y L Yamaguchi, H Yamamoto, A Yanovich, P Yin, J H Yoo, I Yoon, H Yu, I E Yushmanov, W A Zajc, A Zelenski, S Zharko, S Zhou, L Zou
Asymmetric nuclear collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at sqrt[s_{NN}]=200  GeV provide an excellent laboratory for understanding particle production, as well as exploring interactions among these particles after their initial creation in the collision. We present measurements of charged hadron production dN_{ch}/dη in all such collision systems over a broad pseudorapidity range and as a function of collision multiplicity. A simple wounded quark model is remarkably successful at describing the full data set...
November 30, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30541681/25-hydroxyvitamin-d-serum-levels-in-rheumatic-female-patients-in-southeast-spain-the-paradigm-of-daily-optimal-sunshine-levels-and-inadequate-vitamin-d-status
#3
Claudia Alejandra Pereda, María Betina Nishishinya, Emilio J A Roldan
BACKGROUND: Almeria is a region in southeast Spain with optimal sunlight levels, along with low pluvial and pollution rates. If exposure to sunlight is sufficient to maintain adequate levels of vitamin D (25OHD), this population should display high serum levels. OBJECTIVES: To describe 25OHD serum status in women from Almeria and evaluate the impact of long sunlight exposure along the seasons on 25OHD. METHODS: Cross-sectional study, performed in women consecutively recruited from an outpatient rheumatology clinic...
December 9, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/30537803/frequency-and-pattern-of-ige-mediated-sensitization-to-aero-and-food-allergens-in-ahvaz-province-of-khuzestan-in-southwestern-iran
#4
Mohammad Shahrooei, Abbas Fayezi, Raheleh Shokouhi Shoormasti, Faramarz Zakavi, Leila Golpasand Hagh, Johan Van Eldere, Xavier Bossuyt, Erna Van Hoeyveld
Efficient diagnosis of allergy and proper treatment need identification of the causative allergens eliciting clinical symptoms. The present study was performed to identify the most common aero- and food allergens and determine the pattern of sensitization among people of Ahvaz (southwestern Iran), one of the most polluted cities worldwide. Based on the physical examination and medical records, patients were referred to the Allergy laboratory for "in vitro" IgE determination. Specific and total IgE was determined by the ImmunoCAP system (Thermo Fisher-Phadia, Uppsala, Sweden)...
August 12, 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/30534141/frailty-significantly-impairs-the-short-term-prognosis-in-elderly-patients-with-heart-failure
#5
Ali Deniz, Caglar Ozmen, Ertugrul Bayram, Gulsah Seydaoglu, Ayhan Usal
Background: Frailty is a condition of elderly characterized by increased vulnerability to stressful events with high risk of adverse outcomes. The purpose of this study was to evaluate the association between frailty and adverse outcomes including death and hospitalization due to heart failure in elderly patients. Methods: We included patients aged ≥ 65 years with the diagnosis of heart failure. The clinical and laboratory data, echocardiography and ECGs were recorded...
November 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/30528147/-treatment-with-oral-anticoagulants-in-older-patients-should-warfarin-still-be-prescribed
#6
Carmelo Lafuente-Lafuente, Christel Oasi, Joël Belmin
Vitamin-K antagonists (VKA) have been the standard for oral anticoagulation. However, they carry several problems in older patients: frequent bleeding complications, complex management, risk of interactions with multiple drugs. Two classes of direct oral anticoagulants (DOA) are currently available in France: (a) direct thrombin inhibitors: dabigatran; and (b) direct factor Xa inhibitors: rivaroxaban, apixaban and others. Their management is easier: quickly effective after administration, they are given at fixed doses and do not need regular laboratory monitoring...
December 7, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/30526732/reemergence-of-west-nile-virus-infections-in-southern-greece-2017
#7
Maria Mavrouli, Georgia Vrioni, Violetta Kapsimali, Costantinos Tsiamis, Spyridon Mavroulis, Danai Pervanidou, Charalambos Billinis, Christos Hadjichristodoulou, Athanassios Tsakris
Greece experienced the largest European West Nile virus (WNV) outbreak in 2010 since the 1996 Romania epidemic. West Nile virus reemerged in southern Greece during 2017, after a 2-year hiatus of recorded human cases, and herein laboratory findings, clinical features, and geographic distribution of WNV cases are presented. Clinical specimens from patients with clinically suspected WNV infection were sent from local hospitals to the Microbiology Department of Medical School, National and Kapodistrian University of Athens, and were tested for the presence of specific anti-WNV antibodies and WNV RNA...
December 10, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30525744/schnitzler-s-syndrome-a-female-elderly-case-presenting-intractable-non-pruritic-febrile-urticarial-rush
#8
Nanae Kimura, Hiromichi Takeshita, Tatsuya Kai, Yasushi Inoue, Masutaka Furue
Schnitzler's syndrome is an acquired autoinflammatory disease characterized by chronic urticarial rash and monoclonal gammopathy (predominantly IgM type). A 75-year-old Japanese woman complained of high fever and non-pruritic urticarial rash appearing almost every day for 3 years. Her abnormal laboratory data included leukocytosis and neutrophilia with elevated erythrocyte sedimentation rate and C-reactive protein level. Hyperglobulinemia of IgA and IgM was also noted. Histological analysis revealed perivascular and interstitial neutrophilic infiltration without any signs of vasculitis...
December 9, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/30508107/antibiotic-resistance-of-enterobacteriaceae-causing-urinary-tract-infections-in-elderly-patients-living-in-the-community-and-in-the-nursing-home-a-retrospective-observational-study
#9
Céline Pulcini, Isabelle Clerc-Urmes, Cossi Angelo Attinsounon, Sébastien Fougnot, Nathalie Thilly
Objectives: Although nursing homes are thought to be significant reservoirs of antibiotic-resistant bacteria, very few large population-based studies comparing antibiotic resistance prevalence in nursing homes and in the community have adjusted for patient characteristics. Our objective was to compare the prevalence of antibiotic resistance of Enterobacteriaceae cultured from urine samples of nursing home residents with that of community-dwelling adults, all aged 65 years or older. Methods: This study analysed around 20 000 positive urine samples sent to a large laboratory in north-eastern France from 2014 to 2017, collected from individuals aged 65 years or older...
November 30, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30499559/-the-efficacy-of-mexidol-for-transient-ischemic-attacks-in-the-vertebrobasilar-system-in-elderly-patients-with-chronic-cerebral-ischemia
#10
Yu V Abramenko
AIM: To evaluate the clinical efficacy, metabolic and membrane protective effects of mexidol for transient ischemic attacks (TIA) in the vertebrobasilar system in elderly patients with chronic cerebral ischemia (CCI). MATERIAL AND METHODS: Fifty-three patients, aged from 60 to 74 years, with the first episode of TIA in the vertebrobasilar system and CCI were examined. Patients of the main group (n=33) received mexidol in the dose of 500 mg for 10 days along with standard therapy, patients of the comparison group (n=20) received only standard therapy...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30498605/fever-of-unknown-origin-as-a-sole-presentation-of-subacute-thyroiditis-in-an-elderly-patient-a-case-report-with-literature-review
#11
Rishi Raj, Srujana Yada, Aasems Jacob, Dileep Unnikrishnan, Wael Ghali
An 80-year-old Caucasian male presented with fever of 3-week duration. Outpatient workup for infectious etiologies was negative and due to persistent fever, he was hospitalized for further evaluation of fever of unknown origin (FUO). Physical examination and laboratory studies remained unremarkable; however a follow-up CT scan of chest, abdomen, and pelvis with contrast done to rule out malignancy as an underlying cause of FUO revealed heterogeneous thyroid gland with surrounding hazy changes suggestive of thyroiditis...
2018: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/30496133/reference-intervals-for-thyroid-stimulating-hormone-free-thyroxine-and-free-triiodothyronine-in-elderly-chinese-persons
#12
Danchen Wang, Songlin Yu, Chaochao Ma, Honglei Li, Ling Qiu, Xinqi Cheng, Xiuzhi Guo, Yicong Yin, Dandan Li, Zhenjie Wang, Yingying Hu, Shuangyu Lu, Guohua Yang, Huaicheng Liu
Background Thyroid hormone levels are essential for diagnosing and monitoring thyroid diseases. However, their reference intervals (RIs) in elderly Chinese individuals remain unclear. We aimed to identify factors affecting thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels using clinical "big data" to establish hormone level RIs for elderly Chinese individuals. Methods We examined 6781, 6772, and 6524 subjects aged ≥65 years who underwent FT3, FT4, and TSH tests, respectively, at the Peking Union Medical College Hospital between September 1, 2013, and August 31, 2016...
November 29, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30477622/-clinical-features-of-children-with-kawasaki-disease-aged-over-5-years
#13
Fang Tian, Jing Zhang, Lan Xiao
OBJECTIVE: To study the clinical and laboratory features of children with Kawasaki disease (KD) aged >5 years. METHODS: A retrospective analysis was performed for the clinical data of 250 elderly children (aged >5 years) who were diagnosed with KD or incomplete KD (divided into 5-9 years and >9 years groups) and 266 KD children aged 1-5 years. Clinical and laboratory features were compared between groups. RESULTS: The >9 years group had the lowest incidence rates of hand and foot swelling and fingertip or perianal desquamation (P<0...
November 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/30456501/cardiac-biomarkers-improve-prediction-performance-of-the-combination-of-american-society-of-anesthesiologists-physical-status-classification-and-americal-college-of-surgeons-national-surgical-quality-improvement-program-calculator-for-postoperative-mortality
#14
Danica Z Markovic, Tatjana Jevtovic-Stoimenov, Milena Stojanovic, Anita Z Vukovic, Vesna Dinic, Bojana Z Markovic-Zivkovic, Radmilo J Jankovic
BACKGROUND: Our previous research has shown American Society of Anaesthesiologists physical status classification (ASA) score and Americal College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) calculator to have the most accuracy in the prediction of postoperative mortality. AIMS: The aim of our research was to define the most reliable combination of cardiac biomarkers with ASA and ACS NSQIP. METHODS: We have included a total of 78 patients...
November 19, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/30453963/association-between-pterygium-sun-exposure-and-serum-25-hydroxyvitamin-in-a-nationally-representative-sample-of-korean-adults
#15
Yoon Hong Chun, Ji-Sun Paik, Ju Heun Oh, Hyun-Seung Kim, Kyung-Sun Na
PURPOSE: Ultraviolet-B (UVB) light exposure is the major risk factor for developing a pterygium, and serum 25-hydroxyvitamin D (25(OH)D) level is an objective measure of UVB light exposure. In this study, we investigated the association between pterygium, sun exposure, and serum 25(OH)D. METHODS: This population-based, cross-sectional study comprised 12,258 adults (aged ≥19 years) participating in the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2012...
November 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/30447689/hypothalamic-hypopituitarism-secondary-to-suprasellar-metastases-from-small-cell-lung-cancer-a-case-report-and-review-of-the-literature
#16
Ryohei Ono, Ryoji Ito, Keiko Nakagawa, Shinichi Teshima, Izumi Kitagawa, Hideyasu Sugimoto
BACKGROUND: Metastasis to the pituitary gland is an infrequent clinical problem, and the symptoms caused by metastases have been reported in only 2.5-18.2% of the cases. However, metastasis to the suprasellar lesion has rarely been reported in the literature. To the best of our knowledge, only nine cases of hypothalamic hypopituitarism due to metastases of solid tumors have been reported in English-language journals. CASE PRESENTATION: A 67-year-old Japanese man presented to our hospital with generalized weakness, lethargy, and weight loss...
November 18, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30446239/sclerochoroidal-calcification-as-casual-finding
#17
A B González Escobar, A Alberte González, A Ibañez García, M Lorenzo Soto, S Gismero Moreno
Sclerochoroidal calcification (SCC) is uncommon and benign. It is usually detected in a routine examination, finding multiple yellow-white lesions in the upper temporal region of the retina in middle-aged and elderly men. A case report is presented of a 79 year-old male patient, who during a routine examination with a pseudoexfoliative glaucoma in the right eye, as well as raised white-yellow subretinal lesions in the upper temporal region in both eyes. After establishing hypotensive treatment and performing autofluorescence, optical coherence tomography (OCT), ultrasound, ocular computed tomography (CT) and complete laboratory analysis, idiopathic SCC was diagnosed...
November 13, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/30445278/cognitive-and-visual-demands-but-not-gross-motor-demand-of-concurrent-smartphone-use-affect-laboratory-and-free-living-gait-among-young-and-older-adults
#18
Paphawee Prupetkaew, Vipul Lugade, Teerawat Kamnardsiri, Patima Silsupadol
BACKGROUND: As smartphones are an integral part of daily activities, understanding the underlying mechanism associated with concurrent cell phone use while walking may help reduce the risks of injury. RESEARCH QUESTION: This study examined the effect of cognitive, visual, and gross motor demands while using a phone during gait among young and older adults in the laboratory and free-living environments. METHODS: Twelve young and twelve older adults walked along a 10-m walkway under five conditions: single-task walking (Walk), walking and bi-manually holding a phone (Walk-Hold), walking while looking at a phone held in front of the participants (Walk-Look), walking while answering questions (Walk-Answer), and walking while texting (Walk-Text)...
November 2, 2018: Gait & Posture
https://www.readbyqxmd.com/read/30444202/pibrentasvir-glecaprevir-induced-cholestatic-jaundice-in-a-hcv-patient-with-renal-failure-a-case-presentation
#19
Benedetto Caroleo, Maria Cristina Caroleo, Antonio Cimellaro, Lidia Colangelo, Maria Perticone, Giulio Di Mizio, Giovambattista De Sarro, Luca Gallelli
Direct-acting a antiviral (DAA) are currently used in the treatment of chronic HCV infection. In patients with renal failure with Elbasvir/Grazoprevir (genotype 1 and 4) or Pibrentasvir/Glecaprevir (genotype 1-6) is advised and these documented both good safety and efficacy. In this manuscript we reported the development of cholestatic jaundice, during Pibrentasvir/Glecaprevir treatment, in a 86-year-old male with chronic HCV (genotype 2) infection and renal failure. At examination patient was jaundiced and suffered of a severe itch...
November 15, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/30443780/outpatient-parenteral-antimicrobial-therapy-and-antibiotic-stewardship-opponents-or-teammates
#20
REVIEW
Ester Steffens, Charlotte Quintens, Inge Derdelinckx, Willy E Peetermans, Johan Van Eldere, Isabel Spriet, Annette Schuermans
PURPOSE: This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS: After a literature review, five authors determined the barriers and facilitators to discuss in this review. RESULTS: Sixty-six publications were included in the narrative review and seven barriers and five facilitators are discussed in this article...
November 15, 2018: Infection
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