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Pyoderma gangrenosum

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https://www.readbyqxmd.com/read/28333874/successful-treatment-of-autoimmune-disease-associated-pyoderma-gangrenosum-with-the-il-1-receptor-antagonist-anakinra-a-case-series-of-3-patients
#1
Celia Beynon, Mei Fong Chin, Prasad Hunasehally, Krishnan Bhagwandas, Martin Bevan, Marisa Taylor, Thomas Lawson
No abstract text is available yet for this article.
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28331898/a-case-of-primarily-facial-pyoderma-gangrenosum-associated-with-takayasu-arteritis
#2
Ken Okamura, Takayuki Konno, Kosuke Onami, Mariko Nikaido, Naoko Okazaki, Yuko Abe, Masahiro Hayashi, Yoriko Yaguchi, Hiroko Sato, Tsuneo Konta, Tamio Suzuki
No abstract text is available yet for this article.
March 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28325754/comparison-of-the-two-most-commonly-used-treatments-for-pyoderma-gangrenosum-results-of-the-stop-gap-randomised-controlled-trial
#3
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28295267/pyoderma-gangrenosum-clinical-characteristics-associated-diseases-and-responses-to-treatment-in-a-retrospective-cohort-study-of-31-patients
#4
Aldana S Vacas, Ana C Torre, María L Bollea-Garlatti, Fernando Warley, Ricardo L Galimberti
OBJECTIVE: The aim of this study was to describe the clinical characteristics of patients with pyoderma gangrenosum (PG) and to evaluate the association between these characteristics, the treatment followed, and the patient responses, relapses, and mortality rates. MATERIAL AND METHODS: This retrospective cohort study identified adults diagnosed with pyoderma gangrenosum over the duration of 10 years. RESULTS: Thirty-one patients were evaluated; 58% were women and 55% were older than 65 years, 87% presented with the ulcerative type, and 77% showed lower limb compromise...
April 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28291538/-pyoderma-gangrenosum-associated-with-anti-proteinase-3%C3%A2-antineutrophil-cytoplasmic-antibodies-pr3-anca-induced-by-propylthiouracil
#5
A Coster, J-L Dargent, N de Visscher, P Levecque, P-P Roquet-Gravy
BACKGROUND: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal...
March 10, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28286096/pyoderma-gangrenosum-or-necrotising-fasciitis-diagnostic-and-therapeutic-wanderings
#6
Mathieu Vaysse-Vic, Pierre-Alain Mathieu, AurélieCharissoux, Jean-Louis Charissoux, Pierre-Sylvain Marcheix
A case of post-traumatic lower-limb pyodermagangrenosum (PG) in a 77-year-old female is reported. The diagnosis of PG is frequently one of exclusion, and it is therefore unsurprising that the condition was initially mistaken for necrotising fasciitis then for necrotising bacterial dermo-hypodermitis. Medical and surgical treatment for those conditionsproved ineffective. This fact, together with the atypical presentation, promoted a re-evaluation of the diagnosis. The clinical findings and investigation results converged to suggest PG, and a therapeutic trial was initiated...
March 9, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28280910/-first-manifestation-of-leg-ulcers-analysis-of-data-from-1000-patients
#7
A Körber, F Jockenhöfer, W Sondermann, M Stoffels-Weindorf, J Dissemond
BACKGROUND: More than 1 million people in Germany suffer from leg ulcers. The diagnosis leg ulcer summarizes many different etiologies. The therapy of leg ulcers is an interdisciplinary and interprofessional challenge. Early identification of the cause of the leg ulcer and initiation of a causal therapy are essential for healing. OBJECTIVES: The aim of this study was to investigate the initial manifestation age of patients with causally associated leg ulcers. Afterwards we calculated the most common etiologies according to decade...
March 9, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28275955/oral-pyoderma-gangrenosum-diagnosis-treatment-and-challenges-a-systematic-review
#8
Caroline Bissonnette, Adel Kauzman, Gisele N Mainville
Pyoderma gangrenosum (PG) is a distinctive ulcerative skin disorder of unknown etiology, associated with an underlying systemic disease in up to 70% of cases. The condition is characterized by the appearance of one or more necrotic ulcers with a ragged undermined violaceous border and surrounding erythema. Lesions are often initiated by minor trauma. The condition can affect any anatomical site, however the head and neck are rarely involved. Although the oral cavity is subject to recurrent minor trauma through everyday activities such as mastication and oral hygiene, as well as during dental treatment, oral lesions appear to be extremely rare...
March 8, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28274350/difficult-and-rare-forms-of-acne
#9
Clio Dessinioti, Andreas Katsambas
Acne is the most common of skin diseases, being characterized as a chronic inflammatory disease of the pilosebaceous unit. Although acne is usually straightforward to diagnose and treat, some patients have difficult or rare forms of acne. What seems to be "nonresponding acne" in a patient may be caused by another acneiform disease that clinically mimics acne, thus misleading the clinician, if not ruled out, with scrutiny. Difficulties in the management of acne may be attributable to patient-related issues (low adherence to treatment or fear for side effects), treatment-related issues (inappropriate treatment, dose, or duration of treatment), or difficult-to-treat acne types (acne conglobata or acne fulminans)...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28272082/er-yag-laser-ablation-an-adjuvant-treatment-for-medically-resistant-pyoderma-gangrenosum
#10
Ercan Çalşkan
No abstract text is available yet for this article.
March 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28267091/bullous-pyoderma-gangrenosum-as-the-presenting-sign-of-acute-myeloid-leukemia-in-a-child
#11
Kamile Arikan, Yasemin Özsürekçi, Mehmet Ceyhan
No abstract text is available yet for this article.
March 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28267089/bullous-pyoderma-gangrenosum-as-the-presenting-sign-of-acute-myeloid-leukemia-in-a-child
#12
Kamile Arikan, Yasemin Özsürekçi, Mehmet Ceyhan
No abstract text is available yet for this article.
March 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28251506/pyogenic-arthritis-pyoderma-gangrenosum-and-acne-papa-syndrome-differential-diagnosis-of-septic-arthritis-by-regular-detection-of-exceedingly-high-synovial-cell-counts
#13
REVIEW
W Löffler, P Lohse, T Weihmayr, W Widenmayer
Pyogenic arthritis, pyoderma gangrenosum and acne syndrome was diagnosed in a 42-year-old patient, after an unusual persistency of high synovial cell counts had been noticed. Clinical peculiarities and problems with diagnosing septic versus non-septic arthritis are discussed.
March 1, 2017: Infection
https://www.readbyqxmd.com/read/28236224/papa-pash-and-papash-syndromes-pathophysiology-presentation-and-treatment
#14
REVIEW
Massimo Cugno, Alessandro Borghi, Angelo V Marzano
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis usually manifesting as skin ulcers with undermined erythematous-violaceous borders. It may be isolated, associated with systemic conditions or occurring in the context of autoinflammatory syndromes such as PAPA (pyogenic arthritis, PG and acne), PASH (PG, acne and suppurative hidradenitis) or PAPASH (pyogenic arthritis, acne, PG and suppurative hidradenitis). From a physiopathological point of view, all these conditions share common mechanisms consisting of over-activation of the innate immune system leading to increased production of the interleukin (IL)-1 family and 'sterile' neutrophil-rich cutaneous inflammation...
February 25, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28225969/exuberant-pyoderma-gangrenosum-in-a-patient-with-autoimmune-hepatitis
#15
Stephanie Galiza Dantas, Leonardo Pereira Quintella, Nurimar Conceição Fernandes
Pyoderma gangrenosum is a rare neutrophilic dermatosis, which usually presents as ulcers with erythematous-violaceous undermined edges and a rough base with purulent or sanguinous exudate. It can be primary or associated with an underlying disease. However, rare cases of its association with autoimmune hepatitis have been described in the literature. Diagnosis is based on a characteristic clinical picture and ruling out other causes of ulcers. This paper aims to discuss the management of corticosteroid therapy and the importance of local treatment...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28224502/pyoderma-gangrenosum-an-update-on-pathophysiology-diagnosis-and-treatment
#16
REVIEW
Afsaneh Alavi, Lars E French, Mark D Davis, Alain Brassard, Robert S Kirsner
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic disorder with prototypical clinical presentations. Its pathophysiology is complex and not fully explained. Recent information regarding the genetic basis of PG and the role of auto-inflammation provides a better understanding of the disease and new therapeutic targets. PG equally affects patients of both sexes and of any age. Uncontrolled cutaneous neutrophilic inflammation is the cornerstone in a genetically predisposed individual. Multimodality management is often required to reduce inflammation, optimize wound healing, and treat underlying disease...
February 21, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28217611/pyoderma-gangrenosum-a-clinician-s-nightmare
#17
Bindhu Bhaskaran, Mittu John Mathew, K N Vijayan, Asha Zacharia
Pyoderma gangrenosum (PG) is a rare disease and that affecting specifically the sole of the foot, is even rarer. Here, we report the case of a 54-year-old female admitted with a painful ulcer on the sole of the right foot which was initially treated with empirical antibiotics and debridement. The disease was found to spread rapidly after each debridement. The culture reports were negative; rheumatology workup and Doppler study were within normal limits. A clinical suspicion of PG was made and was confirmed with tissue biopsy...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28214498/vasculitic-and-autoimmune-wounds
#18
REVIEW
Victoria K Shanmugam, Divya Angra, Hamza Rahimi, Sean McNish
OBJECTIVE: Chronic wounds are a major cause of morbidity and mortality. Approximately 20% to 23% of nonhealing wounds that are refractory to vascular intervention have other causes, including vasculitis, pyoderma gangrenosum, and other autoimmune diseases. The purpose of this article was to review the literature across medical and surgical specialties with regard to refractory chronic wounds associated with vasculitis and autoimmune diseases and to delineate clinical outcomes of these wounds in response to vascular and other interventions...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28213550/rare-case-of-pyoderma-gangrenosum-originating-in-the-spleen
#19
Tatsuya Fujikawa, Takayasu Suzuka
No abstract text is available yet for this article.
February 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28210559/pyoderma-gangrenosum-following-autologous-breast-reconstruction
#20
Prateush Singh, Sami H Tuffaha, Sanford H Robbins, Steven C Bonawitz
Pyoderma gangrenosum (PG) is an uncommon disorder characterized by the development of painful cutaneous ulceration, commonly precipitated by dermal injury at surgical sites. It is a diagnostic challenge as it manifests as necrotizing wounds which are commonly misdiagnosed as postoperative wound infection or ischemia. We discuss the clinical features and histopathological findings that allow for rapid identification of PG following autologous breast reconstruction and suggest an algorithm to aid diagnosis.
February 2017: Gland Surgery
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