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https://www.readbyqxmd.com/read/28106480/radio-pathological-correlation-of-organising-pneumonia-op-a-pictorial-review
#1
Mohammad Zare Mehrjardi, Shahram Kahkouee, Mihan Pourabdollah
Since the description of cryptogenic organising pneumonia (COP) in 1983 by Davison et al. and the subsequent report on bronchiolitis obliterans organising pneumonia (BOOP) by Epler et al., some reports have been published regarding the imaging features of organising pneumonia (OP). In this pictorial review, we aim to describe different manifestations of OP on high-resolution computed tomography (HRCT) accompanied by their histopathological correlations for a better comprehension of the radiological findings pathomechanism...
January 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28104743/active-brown-fat-during-18fdg-pet-ct-imaging-defines-a-patient-group-with-characteristic-traits-and-an-increased-probability-of-brown-fat-redetection
#2
Carlos Gerngroß, Johanna Schretter, Martin Klingenspor, Markus Schwaiger, Tobias Fromme
Brown adipose tissue (BAT) provides a means of non-shivering thermogenesis. In humans, active BAT can be visualized by (18)F-fluoro-desoxyglucose (FDG) uptake as detected by positron emission tomography (PET) combined with computer tomography (CT). The retrospective analysis of clinical scans is a valuable source to identify anthropometric parameters that influence BAT mass and activity and thus the potential efficacy of envisioned drugs targeting this tissue to treat metabolic disease. We analyzed 2854 FDG-PET/CT scans from 1644 patients and identified 98 scans from 81 patients with active BAT...
January 19, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28103116/acute-leukemia-and-concurrent-mediastinal-germ-cell-tumor-case-report-and-literature-review
#3
Luke Maese, K David Li, Xinjie Xu, Zeinab Afify, Christian N Paxton, Angelica Putnam
There is a known association of primary nonseminomatous mediastinal germ cell tumors (NSMGCT) and hematologic malignancy in younger males not linked to treatment. When combined these two rare entities convey a very poor prognosis. Here we report a 16-year-old male with an anterior mediastinal mass diagnosed as a malignant germ cell tumor based on elevation of serologic markers. He was found to have acute leukemia with megakaryocytic differentiation several days later. We focus our report on the pathologic findings, including a review of the literature, and a novel molecular analysis of the germ cell tumor...
January 19, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28086809/primary-mediastinal-clear-cell-sarcoma-a-case-report-and-review-of-the-literature
#4
Long Jin, Yuxia Sui, Haili Zhu, Zhizhong Chen, Shuguang Liu
BACKGROUND: Clear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and rarely presents in the mediastinum. CASE PRESENTATION: We present a case of primary mediastinal CCS in a 57-year-old man. Computer tomography (CT) revealed a 12 × 12 × 7.5 cm mass in the anterior mediastinum. Microscopically, the tumour mainly consisted of epithelioid cells with oval vesicular nuclei and eosinophilic cytoplasm...
January 13, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28073871/benign-cystic-mediastinal-teratoma-presenting-as-a-massive-pleural-effusion-in-a-17-year-old-boy
#5
Annalisa Montebello, Adrian Mizzi, Paul John Cassar, Karen Cassar
Mediastinal teratomas are a rare, albeit an important differential diagnosis of anterior/middle mediastinal masses in young adults and various atypical presentations have been reported. The authors report a case of a 17-year-old boy who presented with a 2-month history of worsening shortness of breath and pleuritic chest pain. A massive left-sided pleural fluid collection was seen on a chest radiograph (CXR). The pleural fluid was drained and a CT Thorax confirmed the presence of a cystic mass. Following re-accumulation of the fluid, thoracotomy was performed and a benign mediastinal teratoma excised...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28057967/massive-thymoma-of-the-mid-posterior-mediastinum-an-unprecedented-case-in-a-young-adult
#6
Karen Fernandes de Oliveira, Marcio Maciel Rodrigues, Gesner Pereira Lopes, Renan Sandoval de Almeida, Juliana Lopes Lusvarghi, João Paulo Vieira Dos Santos
We report an unprecedented case of ectopic thymoma in a young adult. A 33-year-old male presented with a 10-day history of non-productive cough and fever. Investigation revealed mediastinal widening without pulmonary involvement. Computed tomography showed a large mass-14.8 × 10.8 × 8.4 cm-in the mid-posterior mediastinum, and a biopsy obtained by video-assisted thoracoscopy indicated that the mass was a tumor. Immunohistochemistry showed combined thymoma type AB1. Because of the considerable proportions of the tumor and its close proximity to major structures, the patient was treated with chemotherapy...
November 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/28051017/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-increases-the-yield-of-transbronchial-lung-biopsy-for-the-evaluation-of-peribronchial-lesions
#7
Cheng Chen, Chuan-Yong Mu, Mei-Qin Su, Jing-Yu Mao, Ye-Han Zhu, Jian-An Huang
BACKGROUND: Due to absence of visible endobronchial target, the diagnostic yield of flexible bronchoscopy for peribronchial lesions has been unsatisfactory. Convex probe endobronchial ultrasound (CP-EBUS) has allowed for performing real-time transbronchial needle aspiration (TBNA) of enlarged hilar and mediastinal lymph nodes and therefore could also be used as a means of diagnosing proximal peribronchial lesions. METHODS: We retrospectively analyzed the results related to 72 patients who underwent CP-EBUS for peribronchial lesions without endobronchial involvement and adjacent to three-grade bronchi based on chest computed tomography (CT) scan...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28050695/interval-lung-cancer-after-a-negative-ct-screening-examination-ct-findings-and-outcomes-in-national-lung-screening-trial-participants
#8
David S Gierada, Paul F Pinsky, Fenghai Duan, Kavita Garg, Eric M Hart, Ella A Kazerooni, Hrudaya Nath, Jubal R Watts, Denise R Aberle
OBJECTIVES: This study retrospectively analyses the screening CT examinations and outcomes of the National Lung Screening Trial (NLST) participants who had interval lung cancer diagnosed within 1 year after a negative CT screen and before the next annual screen. METHODS: The screening CTs of all 44 participants diagnosed with interval lung cancer (cases) were matched with negative CT screens of participants who did not develop lung cancer (controls). A majority consensus process was used to classify each CT screen as positive or negative according to the NLST criteria and to estimate the likelihood that any abnormalities detected retrospectively were due to lung cancer...
January 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28044305/clinicopathological-analysis-of-mediastinal-masses-a-mixed-bag-of-non-neoplastic-and-neoplastic-etiologies
#9
Preeti Sharma, Vidya Jha, Naveen Kumar, Rohit Kumar, Ashish Mandal
OBJECTIVE: The mediastinum is the central portion of the thoracic cavity, housing numerous organs and harbouring a mixed bag of non-neoplastic and neoplastic lesions. Accurate diagnosis is essential owing to the widely variable therapeutic and prognostic implications. MATERIAL AND METHOD: Cases of mediastinal masses were retrospectively reviewed from January 2011 till January 2016. Clinico-radiological records of these cases were retrieved. Fine needle aspiration cytology (FNAC) was performed wherever feasible...
2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28035284/transcaval-biopsy-of-a-mediastinal-mass-compressing-the-superior-vena-cava
#10
Anthony Logaraj, Philip Edwards
Imaging-guided percutaneous chest biopsy is a commonly performed procedure and considered the minimally invasive gold standard for histopathological investigation of thoracic masses. Recognized complications include pneumothorax, air embolism, and seeding of the biopsy tract. We describe a novel approach to diagnostic sampling of a mediastinal mass in a critically unwell patient using a transjugular hepatic biopsy needle. Transcaval mediastinal biopsy may represent a safer alternative to percutaneous biopsy of mediastinal masses in critically unwell patients...
March 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28033203/outcomes-of-extracorporeal-life-support-during-surgery-for-the-critical-airway-stenosis
#11
Seon Hee Kim, Seunghwan Song, Yeong Dae Kim, Hoseok I, Jeong Su Cho, Hyo Yeong Ahn, Jonggeun Lee, Do Hyung Kim, Bong Soo Son
Anesthetic management of critical airway stenosis is often very challenging. Extracorporeal membrane oxygenation (ECMO) may provide adequate respiratory support when conventional approaches fail. We report our experience of ECMO support for critical airway surgery. Between April 2012 and March 2015, nine patients underwent ECMO-supported airway operation. The reason for surgery was tracheal stenosis in nine patients, and tracheomalacia, tracheal tumor, and external tracheal compression by mediastinal mass in one patient each...
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#12
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28003927/thymic-epidermoid-cyst-clinical-and-imaging-manifestations-of-this-rare-anterior-mediastinal-mass
#13
Jawad M Qureshi, Brian Pagano, Jeffrey Mueller, Lana Schumacher, Claudia Velosa, Matthew S Hartman
Thymic epidermoid cysts are an extremely rare entity. These arise from epidermal cells that migrate to the thymus. The radiologic diagnosis of this rare lesion is challenging. We describe a case of an otherwise healthy 35-year-old woman who presented with an acute onset of chest pain and shortness of breath. She was found to have an anterior mediastinal mass. The imaging findings were, however, not characteristic for any single diagnostic entity. Since the imaging was inconclusive, surgical resection was performed for definitive diagnosis...
2016: Case Reports in Radiology
https://www.readbyqxmd.com/read/28003760/comparison-of-the-clinical-features-and-hematopoietic-stem-cell-transplantation-outcomes-of-mediastinal-malignant-germ-cell-tumors-with-nonmediastinal-extragonadal-placements
#14
Nesrin Ocal, Birol Yildiz, Nuri Karadurmus, Deniz Dogan, Sukru Ozaydin, Ramazan Ocal, Mustafa Ozturk, Fikret Arpaci, Hayati Bilgic
OBJECTIVE: Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantation between mediastinal and nonmediastinal malignant EGCTs. METHOD: Data of the patients with EGCT who were treated and underwent hematopoietic stem cell transplantation at our hospital between 1988 and 2015 were retrieved retrospectively...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28002527/rare-thymic-malignancy-of-b-cell-origin-t-cell%C3%A3-histiocyte-rich-large-b-cell-lymphoma
#15
Ileana Octavia Petrescu, Iancu Emil Pleşea, Maria Camelia Foarfă, Simona Bondari, Cristina Elena Singer, Elena Mădălina Dumitrescu, Răzvan Cosmin Pană, Georgeta Ligia Stănescu, Mircea Ovidiu Ciobanu
AIM: T-cell÷histiocyte-rich B-cell lymphoma is a rare type of diffuse large B-cell lymphoma reported as involving primarily the thymus only by one paper in the English literature. CASE PRESENTATION: A four and a half years old boy was admitted, after a sudden onset in the middle of the night, with superior vena cava syndrome, resuscitated cardiac and respiratory arrest and severe coma with Glasgow Coma Scale rate of 3. In spite of intensive treatment, the patient repeated twice the cardiac arrest and died sixteen hours after admittance...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27999858/frailty-syndrome-visceral-adipose-tissue-and-frailty-in-patients-with-symptomatic-severe-aortic-stenosis
#16
M Pinheiro, J Mancio, G Conceição, W Ferreira, M Carvalho, A Santos, L Vouga, V Gama Ribeiro, A Leite-Moreira, I Falcão-Pires, N Bettencourt
BACKGROUND/OBJECTIVES: In patients with severe aortic stenosis (AS), frailty is a clinically relevant measure of increased vulnerability that should be included in the preoperative risk assessment. Bioelectrical impedance analysis (BIA) derived phase angle (PA) reflects cell membrane integrity and function. Few studies are available on the relative contribution of adiposity distribution on frailty, and about the influences of frailty and visceral obesity in PA value. Therefore, we aimed to evaluate associations among frailty, visceral fat depots and PA in patients with symptomatic severe AS...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27956811/spontaneous-rupture-of-hepatic-metastasis-from-a-thymoma-a-case-report
#17
Ho Jae Kim, Yong Eun Park, Min Seo Ki, Se Ju Lee, Seung Hun Beom, Dai Hoon Han, Young Nyun Park, Jun Yong Park
Bleeding resulting from spontaneous rupture of the liver is an infrequent but potentially life threatening complication that may be associated with an underlying liver disease. A hepatocellular carcinoma or hepatic adenoma is frequently reported is such cases. However, hemoperitoneum resulting from a hepatic metastatic thymoma is extremely rare. Here, we present a case of a 62-year-old man with hypovolemic shock induced by ruptured hepatic metastasis from a thymoma. At the first hospital admission, the patient had a 45-mm anterior mediastinal mass that was eventually diagnosed as a type A thymoma...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27955733/management-of-desmoplastic-small-round-cell-tumor
#18
Andrea Hayes-Jordan, Michael P LaQuaglia, Shakeel Modak
Desmoplastic small round cell tumor (DSRCT) is a soft tissue sarcoma of mesenchymal cell origin that typically presents with multiple intra-abdominal tumors and exhibits a multi-phenotypic pattern of immunohistochemical staining. The specific organ or tissue type of origin has yet to be identified. DSRCT rarely arises as a singular tumor in the abdomen; in most cases, there are dozens to hundreds of abdominal peritoneal tumors that are detected on diagnosis. One very large dominant mass is usually present in the omentum, with an additional one or two large conglomerates of tumors in the pelvis and right peritoneum, respectively...
October 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27929571/an-unusual-mediastinal-mass
#19
J Hardy, A R Jeyabalan, N Bhatt, A R Medford
We report a case of a mediastinal mass indenting the left lateral tracheal wall of a 35-year-old male who presented with weight loss, cough and breathlessness. Flow volume loop and thyroid function tests were normal and thyroid peroxidase antibodies were negative. Technetium scintigraphy and positron emission tomography both showed no uptake. Endobronchial ultrasound-guided fine needle aspiration confirmed ectopic mediastinal thyroid tissue. Mediastinal ectopic thyroid tissue is very rare. Most patients are asymptomatic and euthyroid with positive signals on scintigraphy...
June 2016: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/27915420/extralobar-pulmonary-sequestration-in-the-middle-mediastinum
#20
Takayuki Fukui, Shuhei Hakiri, Kohei Yokoi
We here report a patients with an uncommon extralobar pulmonary sequestration located in the middle mediastinum in a 42-year-old female. Chest computed tomography showed a middle mediastinal mass of 6.5 × 2.7 × 2.0 cm in size, which consisted of some cystic lesions and a solid component. The mass was completely excised via a 3-port video-assisted thoracoscopic approach. Histopathologic examination revealed a cystic cartilaginous wall lined with ciliated columnar epithelium and edematous lung tissue, resulting in an extralobar pulmonary sequestration...
December 3, 2016: General Thoracic and Cardiovascular Surgery
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