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Chronic dehydration

Rômulo Ribeiro do Vale, Nathalia da Silva Conci, Alexandre Pinheiro Santana, Mauricio Baptista Pereira, Natália Yume Hissayasu Menezes, Vilma Takayasu, Lorena Silva Laborda, Aloísio Souza Felipe da Silva
Celiac disease (CD)-also known as gluten-sensitive enteropathy-is a chronic, genetically predisposing and autoimmune entity with a wide range of clinical manifestations triggered by gluten ingestion, which affects 1% of the general population. Currently, up to 60% of the diagnosis of CD is in adults due to the atypical course of the disease. The severe acute onset of CD-also called celiac crisis-is very uncommon and is still not well documented in adults. We report the case of a 58-year-old man who presented a 45-day history of subtle-onset diarrhea followed by malabsorption syndrome with progressive weight loss, anasarca, and electrolyte disturbances...
July 2018: Autopsy & Case Reports
Maria Vanessa Perez-Gomez, Catalina Martin-Cleary, Beatriz Fernandez-Fernandez, Alberto Ortiz
Chronic kidney disease of unknown aetiology (CKDu) refers to the epidemic level of incidence of CKD in several low- and middle-income countries, usually near the equator, for which the aetiology has not been identified. CKDu represents a form of CKD hotspot, defined as a country, region, community or ethnicity with a higher than average incidence of CKD. In terms of the number of persons affected, the so-called hypertensive nephropathy of African Americans probably represents the largest CKD hotspot, which is largely driven by variants of the APOL1 gene, questioning the very existence of hypertensive nephropathy and illustrating how kidney disease driven by genetic predisposition may underlie some forms of hypertension...
August 2018: Clinical Kidney Journal
Gita Kiaee, Pooria Mostafalu, Mohamadmahdi Samandari, Sameer Sonkusale
Topical administration of drugs in a timely manner according to the physiological need at the wound site can enhance the healing rate of chronic wounds. Herein, an electronic wound dressing that enables active topical drug delivery in response to electrically induced pH change is demonstrated for potential treatment of chronic wounds. In this platform, the pH of the dressing is controlled using an electrical field. This allows precise electrical control over the temporal profile of pH-mediated drug release...
August 2, 2018: Advanced Healthcare Materials
José María Peña Porta, Hilda Mercedes Villafuerte Ledesma, Carmen Vicente de Vera Floristán, Ana Ferrer Dufol, Tránsito Salvador Gómez, Rafael Álvarez Lipe
OBJECTIVES: To determine the incidence of metformin-induced lactic acidosis during the period January 2014 to March 2017 in Aragon Healthcare Area III. To analyse the associated clinical and analytical factors and mortality. RESULTS: A total of 31 cases (61.3% males). Incidence: 79.76 cases/100,000 patients-year; mean age 75.39±9.34 years; 23 of them with levels of serum metformin (21.91±15.52 mcg/ ml); milligrams/day of metformin ingested: 1790.32±499; 96.8% of cases in the context of acute kidney failure; 11 cases with a history of chronic kidney disease (35...
July 27, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Simone J C Paulis, Irma H J Everink, Ruud J G Halfens, Christa Lohrmann, Jos M G A Schols
OBJECTIVES: To provide an overview of the prevalence rates and risk factors of dehydration among nursing home residents. DESIGN: Systematic literature review. SETTING: Nursing homes. PARTICIPANTS: Nursing home residents or institutionalized long-term care residents. MEASUREMENTS: A systematic literature review was executed on March 15, 2018, using the databases PubMed, CINAHL, and EMBASE to retrieve all articles focused on the prevalence rates and risk factors for acute and chronic dehydration...
August 2018: Journal of the American Medical Directors Association
Zubaidah Nor Hanipah, Suriya Punchai, Toms Augustin, Stacy A Brethauer, Philip R Schauer, Ali Aminian
BACKGROUND: Bariatric surgery can improve renal dysfunction associated with obesity and diabetes. However, acute kidney injury (AKI) can complicate the early postoperative course after bariatric surgery. The long-term consequences of early postoperative AKI on renal function are unknown. METHODS: Patient undergoing bariatric surgery from 2008 to 2015 who developed AKI within 60 days after surgery were studied. Patients on dialysis before surgery were excluded. RESULTS: Out of 4722 patients, 42 patients (0...
July 24, 2018: Obesity Surgery
Taisuke Shimizu, Masaaki Terao, Hiroaki Hara, Takatsugu Iwashita, Tomonari Ogawa, Koichi Kanozawa, Hajime Hasegawa
Proximal salt reabsorption in the hypertrophied tubules in the early phase of chronic renal failure (CRF) would be diminished according to the inhibited expression of proximal salt-transporting molecules, which may be facilitated by the inhibition of Na-K-ATPase expression. Results from animal models suggest that patients with early-phase CRF would easily develop hyponatremia and, in contrast, patients showing developed CRF would be more likely to show dehydration or hypernatremia. Several large-scale studies of individuals with chronic kidney disease (CKD) revealed that hyponatremia is much more common than hypernatremia in patients with earlier stages of CKD...
2018: Contributions to Nephrology
Julia McNabb-Baltar, Shadeah L Suleiman, Peter A Banks, Darwin L Conwell
OBJECTIVES: Chronic pancreatitis (CP) is a debilitating chronic illness. We sought to assess the most common reasons patients with CP visit the Emergency Department (ED), the disposition of ED visit [admission, discharge, death], and evaluate predictors of admission and discharge. METHODS: Within the Health Care Utilization Project Nationwide Emergency Department Sample (NEDS), we focused on patients, 18 years and older, presenting to the emergency department with CP (ICD-9 code 577...
July 23, 2018: Digestive Diseases and Sciences
Patrick J Moore, Robert Tarran
Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR anion channel. In the absence of functional CFTR, the epithelial Na+ channel is also dysregulated. Airway surface liquid (ASL) hydration is maintained by a balance between epithelial sodium channel (ENaC)-led Na+ absorption and CFTR-dependent anion secretion. This finely tuned homeostatic mechanism is required to maintain sufficient airway hydration to permit the efficient mucus clearance necessary for a sterile lung environment...
August 2018: Expert Opinion on Therapeutic Targets
Nathan Rout-Pitt, Nigel Farrow, David Parsons, Martin Donnelley
Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene, which encodes for a protein responsible for ion transport out of epithelial cells. This leads to a disruption in transepithelial Cl-, Na + and HCO3 - ion transport and the subsequent dehydration of the airway epithelium, resulting in infection, inflammation and development of fibrotic tissue. Unlike in CF, fibrosis in other lung diseases including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis has been well characterised...
July 18, 2018: Respiratory Research
Kathleen T Unroe, Nicole R Fowler, Jennifer L Carnahan, Laura R Holtz, Susan E Hickman, Shannon Effler, Russell Evans, Kathryn I Frank, Monica L Ott, Greg Sachs
Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care (OPTIMISTIC) is a 2-phase Center for Medicare and Medicaid Innovations demonstration project now testing a novel Medicare Part B payment model for nursing facilities and practitioners in 40 Indiana nursing facilities. The new payment codes are intended to promote high-quality care in place for acutely ill long-stay residents. The focus of the initiative is to reduce hospitalizations through the diagnosis and on-site management of 6 common acute clinical conditions (linked to a majority of potentially avoidable hospitalizations of nursing facility residents): pneumonia, urinary tract infection, skin infection, heart failure, chronic obstructive pulmonary disease or asthma, and dehydration...
July 18, 2018: Journal of the American Geriatrics Society
Lawrence A DiDomenico, Dennis P Orgill, Robert D Galiano, Thomas E Serena, Marissa J Carter, Jarrod P Kaufman, Nathan J Young, Allen M Jacobs, Charles M Zelen
Amnion and chorion allografts have shown great promise in healing diabetic foot ulcers (DFUs). Results from an interim analysis of 40 patients have demonstrated the accelerated healing ability of a novel aseptically processed, dehydrated human amnion and chorion allograft (dHACA). The goal of this study was to report on the full trial results of 80 patients where dHACA was compared with standard of care (SOC) in achieving wound closure in non-healing DFUs. After a 2-week screening period, during which patients with DFUs were unsuccessfully treated with SOC, patients were randomised to either SOC alone or SOC with dHACA applied weekly for up to 12 weeks...
July 17, 2018: International Wound Journal
Bruno M Tavares, Paula Fcbc Fernandes, Cláudia Maria C Oliveira, Sônia L Silva, Márcia U Mota, Tacilla Hs Andrade, Samuel F Cunha, Evelyne S Girão
BACKGROUND: Chikungunya virus (CHIKV) infection is an acute febrile illness with polyarthralgia and arthritis. There are few data about CHIKV infection in kidney transplant recipients (KTR). We report the largest case series of CHIKV infection in this population. METHODS: We retrospectively analyzed 32 cases of CHIKV infection in KTR between January 2016 and December 2017 at Hospital Universitário Walter Cantídio of Federal University of Ceará. RESULTS: All patients had been in endemic area before the beginning of the symptoms...
July 13, 2018: Transplantation
Jayaweera Arachchige Asela Sampath Jayaweera, Anpalaham Joseph
OBJECTIVES: Military personnel, because of the unique nature of their duties, are reluctant to face stressors. Living in hot and humid conditions they frequently suffer dehydration. Army soldiers living in dry zone of Sri Lanka, were screened for chronic kidney disease (CKD), common non-communicable diseases and methicillin resistant Staphylococcus aureus (MRSA) colonization. Albumin creatinine ratio > 30 mg/g urine taken as cut-off for detection of CKD. RESULTS: Screened 417 soldiers, all were men and body mass index were 21...
July 13, 2018: BMC Research Notes
Tamara Milagres, Fernando E García-Arroyo, Miguel A Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G Sánchez-Lozada, Richard J Johnson, Carlos Roncal-Jimenez
BACKGROUND: Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have recently reported a model of CKD induced by heat stress. Here we test the hypothesis that rehydration with fructose may induce worse kidney injury than rehydration with equal amounts of water, and we also test if this fructose-induced injury is associated with activation of inflammasomes in the kidney...
July 13, 2018: BMC Nephrology
Brenna L Quinn, Jean C Solodiuk, Dominick Morrill, Sangeeta Mauskar
: Purpose: Children with medical complexity experience frequent pain. But it can be challenging to recognize unexpected behaviors as pain related, especially in the absence of self-report. Often these children undergo extensive workups aimed at diagnosing the sources of pain. This study had three objectives: to describe the signs and symptoms parents of nonverbal children with medical complexity found worrisome, to describe the sources of pain in these children, and to describe nursing pain assessment practices in this population...
August 2018: American Journal of Nursing
A Sala-Cunill, M Lazaro, L Herráez, M D Quiñones, M Moro-Moro, I Sanchez
Atopic dermatitis (AD) is a recurrent and chronic skin disease characterised by dysfunction in the epithelial barrier, skin inflammation and immune dysregulation with changes in the skin microbiota and colonisation of Staphylococcus aureus being common. For this reason, the therapeutic approach to AD is complex and should be directed at restoring skin barrier function, reducing dehydration, maintaining acidic pH and avoiding superinfection and exposure to possible allergens. No curative treatment for AD currently exists...
July 13, 2018: Journal of Investigational Allergology & Clinical Immunology
Renata Porciuncula, Patricia Kelly Wilmsen Dalla Santa Spada, Karen Olivia Bazzo Goulart
OBJECTIVE: To describe the case of a child diagnosed with leukoencephalopathy with vanishing white matter (LVWM), a rare genetic disease with autosomal recessive inheritance pattern. CASE DESCRIPTION: A 5-month-old male child started to refuse breast-feeding, showing somnolence and signs of dehydration,with dry mouth, increasing body temperature and adipsy. As days went by, the symptoms got worse. The infant was very sleepy and was transferred to the intensive care unit, where he stayed for one week...
July 10, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
David C Garrett, Nyssa Rae, Jared R Fletcher, Sasha Zarnke, Sarah Thorson, David B Hogan, Elise C Fear
Dehydration is a common condition characterized by a decrease in total body water. Acute dehydration can cause physical and cognitive impairment, heat stroke and exhaustion, and, if severe and uncorrected, even death. The health effects of chronic mild dehydration are less well studied with urolithiasis (kidney stones) the only condition consistently associated with it. Aside from infants and those with particular medical conditions, athletes, military personnel, manual workers, and older adults are at particular risk of dehydration due to their physical activity, environmental exposure, and/or challenges in maintaining fluid homeostasis...
2018: IEEE Reviews in Biomedical Engineering
Isabela M Lorizola, Cibele P B Furlan, Mariana Portovedo, Marciane Milanski, Patrícia B Botelho, Rosângela M N Bezerra, Beatriz R Sumere, Maurício A Rostagno, Caroline D Capitani
Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were supplemented with dehydrated beet stalks and leaves (SL) or beet stalk and leaf ethanolic extract (EX). In terms of Vitexin-rhaminoside equivalents (VRE), EX groups received ~5.91 mg of VRE·100 g−1 diet, while the SL groups received ~3...
July 5, 2018: Nutrients
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