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Colistin resistant klebsiella

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https://www.readbyqxmd.com/read/30112189/multiple-mutations-in-lipid-a-modification-pathway-novel-fosa-variants-in-colistin-resistant-klebsiella-pneumoniae
#1
Purva Mathur, Balaji Veeraraghavan, Naveen Kumar Devanga Ragupathi, Francis Yesurajan Inbanathan, Surbhi Khurana, Nidhi Bhardwaj, Subodh Kumar, Sushma Sagar, Amit Gupta
Aim: To investigate antimicrobial resistance mechanisms in a cluster of colistin-resistant Klebsiella pneumoniae . Methods: Antimicrobial susceptibility was tested by disk diffusion and broth microdilution. Whole-genome sequencing and genome analysis were performed. Results: The eight colistin-resistant K. pneumoniae isolates belonged to three different clones (ST11, 14 and 231). The eptA and arnT genes from lipid modification pathway had novel (R157S in arnT and Q319R in eptA ) and rare mutations (V39L, R152H, S260L and A279G in eptA )...
July 2018: Future Science OA
https://www.readbyqxmd.com/read/30109975/in-vitro-bactericidal-activity-of-trimethoprim-sulfamethoxazole-colistin-combination-against-carbapenem-resistant-klebsiella-pneumoniae-clinical-isolates
#2
Jiachun Su, Dan Li, Qinglan Guo, Yan Guo, Yonggui Zheng, Xiaogang Xu
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a formidable health challenge in recent years owing to the shortage of effective antibiotics. Colistin is the last and sometimes the only therapeutic option for CRKP infections. Unfortunately, resistance to colistin monotherapy is likely to develop. CRKP in China reportedly exhibit low rates of resistance to trimethoprim-sulfamethoxazole. The aim of this study was to evaluate the in vitro efficacy of trimethoprim-sulfamethoxazole in combination with colistin against four CRKP clinical isolates...
August 15, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/30100608/tracking-microevolution-events-among-st11-carbapenemase-producing-hypervirulent-klebsiella-pneumoniae-outbreak-strains
#3
Ning Dong, Xuemei Yang, Rong Zhang, Edward Wai-Chi Chan, Sheng Chen
The recent convergence of genetic elements encoding phenotypic carbapenem-resistance and hypervirulence within a single Klebsiella pneumoniae host strain represents a major public concern. To obtain a better understanding of the genetic characteristic of this emerging 'superbug', the complete genomes of 3 isolates of ST11 carbapenemase-producing hypervirulent K. pneumoniae were generated using the Oxford nanopore MinION platform. Comparative whole-genome analysis identified 13 SNPs and 3 major regions of indels in the chromosomes of the clonally disseminated isolates...
August 12, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/30082559/antibiotic-adjuvant-combinations-ceftriaxone-sulbactam-adjuvant-disodium-edetate-as-an-alternative-empiric-therapy-for-the-treatment-of-nosocomial-infections-results-of-a-retrospective-study
#4
Saibal Chakravorty, Prashant Arun
OBJECTIVE: Carbapenems are one of the last therapeutic options to treat various bacterial infections including multidrug resistant (MDR) nosocomial infections. However, excessive and inappropriate prescription of this drug has recently led to an epidemic rise in carbapenem resistance. Optimizing antibiotic utilization and exploring alternate options can be a potential way to control carbapenem resistance. The aim of this study was to assess the clinical efficacy of novel antibiotic adjuvant entity (ceftriaxone + sulbactam + ethylenediaminetetraacetic acid [EDTA] [CSE-1034]) in the treatment of various nosocomial infections...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30076041/molecular-epidemiology-and-risk-factors-for-colistin-or-tigecycline-resistant-carbapenemase-producing-klebsiella-pneumoniae-bloodstream-infection-in-critically-ill-patients-during-a-7-year-period
#5
Matthaios Papadimitriou-Olivgeris, Christina Bartzavali, Aikaterini Spyropoulou, Anastasia Lambropoulou, Nektarios Sioulas, Sophia Vamvakopoulou, Georgios Karpetas, Iris Spiliopoulou, Theofanis Vrettos, Evangelos D Anastassiou, Fotini Fligou, Myrto Christofidou, Markos Marangos
A matched 1:2 case-control study was conducted among critically ill patients in order to identify the risk factors of colistin or tigecycline-resistant carbapenemase-producing Klebsiella pneumoniae (ColR-Kp, TigR-Kp) bacteraemia. MIC to colistin and tigecycline were determined by Etest. From 224 bacteraemic patients, 46.4% and 29.5% were resistant to colistin and tigecycline, respectively. PCR revealed that 199 isolates carried the blaKPC gene. PCR revealed that no isolate carried the mcr-1 gene. Risk factors for ColR-Kp bacteraemia as compared to patients with bacteraemia by a colistin-susceptible isolate or patients without carbapenemase-producing K...
June 7, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/30065720/-in-vitro-vivo-activity-of-potential-mcr-1-inhibitor-in-combination-with-colistin-againsts-mcr-1-positive-klebsiella-pneumonia
#6
Yonglin Zhou, Tingting Wang, Yan Guo, Shui Liu, Jianfeng Wang, Yingbo Shen, Shusheng Tang, Yang Wang, Xuming Deng
Carbapenem resistance among strains of the nosocomial pathogen Klebsiella pneumoniae is increasing worldwide, causing serious clinical infections and higher mortality rates. Polymyxins are some of the few "last resort" options for treatment of carbapenem-resistant Enterobacteriaceae , including K. pneumoniae , however, the emergence of plasmid-mediated colistin resistance gene mcr-1 has largely rendered polymyxin-class antibiotics ineffective in a clinical setting. We previously identified a natural compound, pterostilbene, which has a synergistic effect in combination with polymyxins...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30064544/risk-factors-for-colistin-resistant-enterobacteriaceae-in-a-low-endemicity-setting-for-carbapenem-resistance-a-matched-case-control-study
#7
Andrea C Büchler, Christian Gehringer, Andreas F Widmer, Adrian Egli, Sarah Tschudin-Sutter
BackgroundEmergence of colistin resistance has been related to increased use in clinical settings, following global spread of carbapenem-resistant Gram-negative bacteria. Use of colistin in animal production may constitute a further source of spread of resistant strains to humans. We sought to determine risk factors for human colonisation or infection with colistin-resistant Escherichia coli and Klebsiella pneumoniae in a setting where colistin is mainly used for animal production. Methods: This retrospective matched case-control study was performed during a 5-year period at two university-affiliated hospitals in Basel, Switzerland...
July 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/30061868/molecular-epidemiology-and-virulence-profiles-of-colistin-resistant-klebsiella-pneumoniae-blood-isolates-from-the-hospital-agency-ospedale-dei-colli-naples-italy
#8
Eliana P Esposito, Matteo Cervoni, Mariano Bernardo, Valeria Crivaro, Susanna Cuccurullo, Francesco Imperi, Raffaele Zarrilli
Resistance to colistin is increasingly reported in Klebsiella pneumoniae clinical isolates. The aim of this study was to analyze the molecular epidemiology and virulence profiles of 25 colistin-resistant K. pneumoniae blood isolates from the Hospital Agency "Ospedale dei Colli," Naples, Italy, during 2015 and 2016. Colistin MIC values of isolates ranged from 4 to 256 mg/L. The inactivation of the mgrB gene, encoding a negative regulator of the PhoQ/PhoP signaling system, was the most frequent mechanism of colistin resistance found in 22 out of 25 isolates...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/30060219/occurrence-of-colistin-resistant-hypervirulent-klebsiella-variicola
#9
Yang Lu, Yu Feng, Alan McNally, Zhiyong Zong
Background: A colistin-resistant mucoid Klebsiella strain was recovered from the blood of a patient in China. Hypervirulence has been reported in Klebsiella pneumoniae, but not in other Klebsiella spp. The strain was suspected to be hypervirulent and was therefore characterized. Methods: The strain was subjected to genome sequencing using both the short-read Illumina HiSeq X10 Sequencer and the long-read MinION sequencer. Precise species identification was established using average nucleotide identity based on genome sequences...
July 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30060117/frequency-and-antimicrobial-susceptibility-of-gram-negative-bacteria-isolated-from-patients-with-pneumonia-hospitalized-in-icus-of-us-medical-centres-2015-17
#10
Helio S Sader, Mariana Castanheira, Rodrigo E Mendes, Robert K Flamm
Background: Treatment of infections in the ICU represents a great challenge, especially infections caused by Gram-negative organisms. Rapid introduction of appropriate antimicrobial therapy is crucial to reduce mortality, and resistance rates in the ICU can be elevated due to antimicrobial selection pressure. Objectives: To evaluate the frequency and antimicrobial susceptibility of Gram-negative bacteria isolated from patients with pneumonia hospitalized in ICUs...
July 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30053018/characterization-of-carbapenemase-producing-enterobacteriaceae-from-colonized-patients-in-a-university-hospital-in-madrid-spain-during-the-r-gnosis-project-depicts-increased-clonal-diversity-over-time-with-maintenance-of-high-risk-clones
#11
Marta Hernández-García, Blanca Pérez-Viso, M Carmen Turrientes, Cristina Díaz-Agero, Nieves López-Fresneña, Marc Bonten, Surbhi Malhotra-Kumar, Patricia Ruiz-Garbajosa, Rafael Cantón
Objectives: To describe the incidence and microbiological features of carbapenemase-producing Enterobacteriaceae (CPE) from colonized patients in a Spanish university hospital during a cluster-randomized study [the Resistance of Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS) project] on isolation strategies for faecal ESBL carriers. Methods: From March 2014 to March 2016, 15 556 rectal swabs from 8209 patients admitted in two surgical wards and two medical wards were collected and seeded on ESBL and CPE chromogenic agars...
July 24, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30036693/evaluation-of-comasp%C3%A2-colistin-formerly-sensitest%C3%A2-colistin-a-commercial-broth-microdilution-based-method-to-evaluate-colistin-mic-for-carbapenem-resistant-klebsiella-pneumoniae-isolates
#12
Irene Galani, Panagiota Adamou, Ilias Karaiskos, Helen Giamarellou, Maria Souli
BACKGROUND: Colistin is often the last option to treat infections caused by multidrug-resistant microorganisms, such as carbapenem-resistant K.pneumoniae. Antimicrobial susceptibility testing of colistin has been fraught with difficulties which resulted in the need for updated recommendations from CLSI and EUCAST. Both committees proposed that the ISO 20776-1-2016 standard broth microdilution (BMD) must be the preferred method for colistin MIC testing. The objective of our study was to evaluate the commercial ComASP™ Colistin (Liofilchem® srl, Roseto degli Abruzzi, Italy), a compact panel containing the antibiotic in 7 two-fold dilutions (0...
July 20, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/30034604/meridianin-d-analogues-display-antibiofilm-activity-against-mrsa-and-increase-colistin-efficacy-in-gram-negative-bacteria
#13
William M Huggins, William T Barker, James T Baker, Nicholas A Hahn, Roberta J Melander, Christian Melander
In the last 30 years, development of new classes of antibiotics has slowed, increasing the necessity for new options to treat multidrug resistant bacterial infections. Development of antibiotic adjuvants that increase the effectiveness of currently available antibiotics is a promising alternative approach to classical antibiotic development. Reports of the ability of the natural product meridianin D to modulate bacterial behavior have been rare. Herein, we describe the ability of meridianin D to inhibit biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) and to increase the potency of colistin against colistin-resistant and sensitive Gram-negative bacteria...
July 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/30029899/elucidating-the-antimicrobial-mechanisms-of-colistin-sulfate-on-mycobacterium-tuberculosis-using-metabolomics
#14
Nadia Koen, Shane Vontelin van Breda, Du Toit Loots
Considering the disadvantageous of first line anti-tuberculosis (TB) drugs, including poor patient adherence, drug side effects, the long treatment duration and rapidly increasing microbe resistance, alternative treatment strategies are needed. Colistin sulfate (CS), a polymyxin antibiotic considered a last-resort antibiotics for treating multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter, has antimicrobial activity towards mycobacteria, and could serve as a possible anti-TB drug...
July 2018: Tuberculosis
https://www.readbyqxmd.com/read/30027699/detection-of-mcr-1-plasmids-in-enterobacteriaceae-isolates-from-human-specimens-comparison-with-those-in-escherichia-coli-isolates-from-livestock-in-korea
#15
Eun Jeong Yoon, Jun Sung Hong, Ji Woo Yang, Kwang Jun Lee, Hyukmin Lee, Seok Hoon Jeong
BACKGROUND: The emerging mobile colistin resistance gene, mcr-1, is an ongoing worldwide concern and an evaluation of clinical isolates harboring this gene is required in Korea. We investigated mcr-1-possessing Enterobacteriaceae among Enterobacteriaceae strains isolated in Korea, and compared the genetic details of the plasmids with those in Escherichia coli isolates from livestock. METHODS: Among 9,396 Enterobacteriaceae clinical isolates collected between 2010 and 2015, 1,347 (14...
November 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/30026942/collateral-damage-of-using-colistin-in-hospitalized-patients-on-emergence-of-colistin-resistant-escherichia-coli-and-klebsiella-pneumoniae-colonization-and-infection
#16
W Wangchinda, N Pati, N Maknakhon, C Seenama, S Tiengrim, V Thamlikitkul
Background: Colistin has been used for therapy of carbapenem-resistant Gram-negative infections in Thailand, especially carbapenem-resistant A. baumannii and P. aeruginosa , for more than 10 years. However, the prevalence of colistin-resistant A. baumannii or P. aeruginosa is still less than 5%. Colistin-resistant Enterobacteriaceae has been increasingly reported globally over the past few years and the use of colistin in food animals might be associated with an emergence of colistin resistance in Enterobacteriaceae...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/30014001/emergence-of-resistance-to-colistin-during-the-treatment-of-bloodstream-infection-caused-by-klebsiella-pneumoniae-carbapenemase-producing-klebsiella-pneumoniae
#17
Anubhav Kanwar, Steven H Marshall, Federico Perez, Myreen Tomas, Michael R Jacobs, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Laura J Rojas, Barry N Kreiswirth, Liang Chen, Miguel Quinones-Mateu, David van Duin, Robert A Bonomo
We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/30010911/co-harboring-of-cephalosporin-bla-colistin-mcr-resistance-genes-among-enterobacteriaceae-from-flies-in-thailand
#18
Akira Fukuda, Masaru Usui, Torahiko Okubo, Chie Tagaki, Nop Sukpanyatham, Yutaka Tamura
The spreading of antimicrobial-resistant Enterobacteriaceae, especially those co-harboring plasmid-mediated cephalosporin (bla) and colistin (mcr) resistance genes, is becoming increasingly problematic. As a vector, flies carry antimicrobial-resistant bacteria (ARB) into human and livestock habitats. To investigate ARB in flies, we collected 235 flies from 27 sites (18 urban areas, five pig farms, and four chicken farms) in Thailand during 2013-2015. Cefotaxime-resistant Enterobacteriaceae (CtxRE) and bla-positive CtxRE were isolated from 70 (29...
July 13, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/30010061/a-prospective-comparative-clinical-study-between-high-dose-colistin-monotherapy-and-colistin-meropenem-combined-therapy-for-treatment-of-hospital-acquired-pneumonia-and-ventilator-associated-pneumonia-with-multidrug-resistant-bacterial-klebsiella-pneumoniae
#19
Mohamed Farouk Ahmed Abdelsalam, Maged Salah Abdalla, Hanan Salah El-Din El-Abhar
OBJECTIVES: In clinical practice, colistin is used as a combination therapy to improve its antibacterial activity, despite the consequent increase in toxicity. This pilot prospective study aimed to evaluate the effectiveness and adverse effects of using colistin alone at a loading dose of 9 million international units (MIU), followed by 3 MIU/q8h vs colistin with meropenem 1g/q8h in treating multidrug-resistant (MDR) Klebsiella pneumoniae-induced hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP)...
July 13, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29997745/the-threat-of-colistin-resistance-among-carbapenem-resistant-klebsiella-pneumoniae-isolates-in-iran
#20
EDITORIAL
Mehri Haeili, Mohammad Mehdi Feizabadi
No abstract text is available yet for this article.
April 2018: Iranian Journal of Microbiology
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