keyword
https://read.qxmd.com/read/38529169/effect-of-ketogenic-diet-on-obesity-and-other-metabolic-disorders-narrative-review
#1
REVIEW
Temesgen Baylie, Tiget Ayelgn, Markeshaw Tiruneh, Kibur Hunie Tesfa
Obesity is defined as an abnormal or excessive accumulation of fat that increases the burden of different chronic diseases in the population. It has reached epidemic proportions and is a major risk factor for a variety of diseases, including hypertension, cardiovascular disease, type 2 diabetes, dyslipidaemia, atherosclerosis, and some malignancies. Weight gain is a result of excessive energy intake compared to energy expenditure (energy loss from metabolism and physical exercise). A ketogenic diet has a more useful effect on obesity than other diets...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38523829/the-association-of-low-carbohydrate-diet-and-hectd4-rs11066280-polymorphism-with-risk-of-colorectal-cancer-a-case-control-study-in-korea
#2
JOURNAL ARTICLE
Tao Thi Tran, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
BACKGROUND: Glucose is a main source of energy for tumor cells. Thus, a low-carbohydrate diet (LCD) is thought to make a significant contribution to cancer prevention. In addition, LCD and HECT domain E3 ubiquitin protein ligase 4 (HECTD4) gene may be related to insulin resistance. OBJECTIVES: We explored whether LCD score and HECTD4 rs11066280 are etiological factors for colorectal cancer (CRC) and whether LCD score interacts with HECTD4 rs11066280 to modify CRC risk...
March 2024: Current Developments in Nutrition
https://read.qxmd.com/read/38515467/dietary-intakes-of-hypertensive-patients-in-rural-india-secondary-outcomes-of-a-randomised-double-blind-controlled-trial
#3
JOURNAL ARTICLE
Sudhir Raj Thout, Jie Yu, Joseph Alvin Santos, Md Hameed, Daisy H Coyle
BACKGROUND: Hypertension is highly prevalent in India; however, little is known about the dietary intakes of those living with hypertension, particularly in rural areas. The primary aim was to assess the dietary intakes of individuals living in rural India with self-reported history of hypertension. As secondary analyses, we explored the dietary impact of a salt substitute in this population group. MATERIALS AND METHODS: This study used data from a large randomised controlled trial conducted in seven villages across rural India...
December 2023: Dialogues Health
https://read.qxmd.com/read/38514590/dietary-composition-and-time-in-range-in-population-with-type-2-diabetes-mellitus-exploring-the-association-using-continuous-glucose-monitoring-device
#4
JOURNAL ARTICLE
Aditi R Deshmane, Arti S Muley
AIM: To understand the association between macronutrient composition of a diet with Time in Range (TIR), Time above Range (TAR) and Time below Range (TBR) derived using a Continuous Glucose Monitoring (CGM) device for 14 days. METHODOLOGY: An exploratory analysis on the baseline data of 50 Type 2 Diabetes Mellitus participants with age 25-55 years, HbA1c upto 8% and on Metformin only) enrolled for an interventional clinical trial was performed. RESULTS: Participants consuming adequate carbohydrates (CHO) of 55 to 60% of total calories had better Average Blood Glucose of 142...
March 21, 2024: Endocrine
https://read.qxmd.com/read/38508432/investigating-the-mechanism-of-cornel-iridoid-glycosides-on-type-2-diabetes-mellitus-using-serum-and-urine-metabolites-in-rats
#5
JOURNAL ARTICLE
Yadi Hou, Yanmei Huang, Zihui Shang, Shichao Ma, Tianyi Cui, Ali Chen, Yongxia Cui, Suiqing Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Cornel iridoid glycosides (CIG) are extracted from Corni fructus, a herbal medicine used in traditional Chinese medicine to treat diabetes. However, the antidiabetic effects of CIG and the underlying metabolic mechanisms require further exploration. AIM OF THE STUDY: This study aimed to assess the antidiabetic effects and metabolic mechanism of CIG by performing metabolomic analyses of serum and urine samples of rats. MATERIALS AND METHODS: A rat model of type 2 diabetes mellitus (T2DM) was established by administering a low dose of streptozotocin (30 mg/kg) intraperitoneally after 4 weeks of feeding a high-fat diet...
March 18, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38503330/clinical-landscape-of-citrin-deficiency-a-global-perspective-on-a-multifaceted-condition
#6
JOURNAL ARTICLE
Jun Kido, Georgios Makris, Saikat Santra, Johannes Häberle
Citrin deficiency is an autosomal recessive disorder caused by a defect of citrin resulting from mutations in SLC25A13. The clinical manifestation is very variable and comprises three types: neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD: OMIM 605814), post-NICCD including failure to thrive and dyslipidemia caused by citrin deficiency, and adult-onset type II citrullinemia (CTLN2: OMIM 603471). Frequently, NICCD can run with a mild clinical course and manifestations may resolve in the post-NICCD...
March 19, 2024: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/38494735/ketogenic-diet-alleviates-mechanical-allodynia-in-the-models-of-inflammatory-and-neuropathic-pain-in-male-mice
#7
JOURNAL ARTICLE
Kei Eto, Masanori Ogata, Yoshitaka Toyooka, Toru Hayashi, Hitoshi Ishibashi
Inflammation is involved in the induction of chronic inflammatory and neuropathic pain. Moreover, the ketogenic diet, a high-fat, low-carbohydrate, and adequate protein diet, has an anti-inflammatory effect. Thus, we hypothesized that a ketogenic diet has a therapeutic effect on both types of chronic pain. In the present study, we investigated the effect of a ketogenic diet on mechanical allodynia, a chronic pain symptom, in formalin-induced chronic inflammatory pain and nerve injury-induced neuropathic pain models using adult male mice...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38490533/associations-of-lower-carbohydrate-and-lower-fat-diets-with-mortality-among-people-with-cardiovascular-disease
#8
JOURNAL ARTICLE
Qingying Tian, Lin Li, Zhilei Shan, Qi Lu, Rui Li, Sen Liu, Xiaoyu Lin, Ruyi Li, Xue Chen, Yunjing Ou, An Pan, Gang Liu
BACKGROUND: Although low-carbohydrate and low-fat diets have been shown to have short-term metabolic benefits, the associations of these dietary patterns, particularly different food sources and macronutrient quality, with mortality in people with cardiovascular disease (CVD) remain unclear. OBJECTIVES: To examine the associations of different types of lower-carbohydrate diets (LCDs) and lower-fat diets (LFDs) with mortality among individuals with CVD. METHODS: This study included 3971 adults with CVD from the NHANES 1999-2014...
March 13, 2024: Journal of Nutrition
https://read.qxmd.com/read/38487629/expert-consensus-on-nutrition-and-lower-carbohydrate-diets-an-evidence-and-equity-based-approach-to-dietary-guidance
#9
REVIEW
Jeff S Volek, William S Yancy, Barbara A Gower, Stephen D Phinney, Joanne Slavin, Andrew P Koutnik, Michelle Hurn, Jovonni Spinner, Mark Cucuzzella, Frederick M Hecht
There is a substantial body of clinical evidence supporting the beneficial effects of lower-carbohydrate dietary patterns on multiple established risk factors associated with insulin resistance and cardiovascular diseases in adult populations. Nutrition and health researchers, clinical practitioners, and stakeholders gathered for, "The Scientific Forum on Nutrition, Wellness, and Lower-Carbohydrate Diets: An Evidence- and Equity-Based Approach to Dietary Guidance" to discuss the evidence base around lower-carbohydrate diets, health outcomes, and dietary guidance...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38484979/hepatic-effects-of-low-carbohydrate-diet-associated-with-different-lipid-sources-insights-into-oxidative-stress-cytotoxicity-and-epigenetic-markers-in-a-mice-model-of-obesity
#10
JOURNAL ARTICLE
Aline Boveto Santamarina, Marcela Nascimento Sertorio, Laís Vales Mennitti, Esther Alves de Souza, Daniel Vitor de Souza, Daniel Araki Ribeiro, Luciana Pellegrini Pisani
BACKGROUND: Low-carbohydrate and high-fat diet (LCHF) models have been widely explored as alternatives for treating obesity and promoting weight loss. Their effect is attributed to the change in energy substrate that stimulates ketogenic pathways that can metabolically overload the liver. However, little has been studied about the impact of lipid sources prioritized in the LCHF diet. OBJECTIVE: This study aims to evaluate the impact of different fat sources in the LCHF diet on markers of liver injury, oxidative stress, and epigenetics in obesity...
March 12, 2024: Journal of Nutrition
https://read.qxmd.com/read/38474774/changes-in-macronutrients-during-dieting-lead-to-weight-cycling-and-metabolic-complications-in-mouse-model
#11
JOURNAL ARTICLE
Anouk Charlot, Anthony Bringolf, Léa Debrut, Joris Mallard, Anne-Laure Charles, Emilie Crouchet, Delphine Duteil, Bernard Geny, Joffrey Zoll
Weight cycling is a major challenge in obesity management. Caloric restriction is known to promote this phenomenon, but the impact of macronutrient changes during dieting remains unclear. This study aimed to determine the role of macronutrient changes in weight maintenance without caloric restriction by alternating between two hypercaloric diets: a high-carbohydrate, high-fat Western diet (WD) and a low-carbohydrate, high-fat diet (LCHDF). Obesity was induced in 8-week-old C57BL/6 male mice by 10 weeks of WD feeding...
February 25, 2024: Nutrients
https://read.qxmd.com/read/38458559/design-and-conduct-of-a-randomized-controlled-feeding-trial-in-a-residential-setting-with-mitigation-for-covid-19
#12
JOURNAL ARTICLE
Julia M W Wong, David S Ludwig, David B Allison, Navneet Baidwan, Lisa Bielak, Chia-Ying Chiu, Stephanie L Dickinson, Lilian Golzarri-Arroyo, Steven B Heymsfield, Lauren Holmes, Lisa T Jansen, Donna Lesperance, Tapan Mehta, Megan Sandman, Sarah K Steltz, William W Wong, Shui Yu, Cara B Ebbeling
BACKGROUND: Evaluating effects of different macronutrient diets in randomized trials requires well defined infrastructure and rigorous methods to ensure intervention fidelity and adherence. METHODS: This controlled feeding study comprised two phases. During a Run-in phase (14-15 weeks), study participants (18-50 years, BMI, ≥27 kg/m2 ) consumed a very-low-carbohydrate (VLC) diet, with home delivery of prepared meals, at an energy level to promote 15 ± 3% weight loss...
March 6, 2024: Contemporary Clinical Trials
https://read.qxmd.com/read/38453966/a-ketogenic-diet-rich-in-fish-oil-is-superior-to-other-fats-in-preventing-nnk-induced-lung-cancer-in-a-j-mice
#13
JOURNAL ARTICLE
Ingrid Elisia, Michelle Yeung, Sara Kowalski, Taras Shyp, Jason Tee, Serena Hollman, Amy Wong, Janette King, Roger Dyer, Poul H Sorensen, Gerald Krystal
Given that ketogenic diets (KDs) are extremely high in dietary fat, we compared different fats in KDs to determine which was the best for cancer prevention. Specifically, we compared a Western and a 15% carbohydrate diet to seven different KDs, containing either Western fats or fats enriched in medium chain fatty acids (MCTs), milk fat (MF), palm oil (PO), olive oil (OO), corn oil (CO) or fish oil (FO) for their ability to reduce nicotine-derived nitrosamine ketone (NNK)-induced lung cancer in mice. While all the KDs tested were more effective at reducing lung nodules than the Western or 15% carbohydrate diet, the FO-KD was most effective at reducing lung nodules...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38453270/popular-diets-and-kidney-stones
#14
REVIEW
Sara Zayed, David S Goldfarb, Shivam Joshi
Popular diets often influence dietary patterns, which have different implications for kidney stone risk. Despite the wide variety of popular diets, some general principles can be gleaned from investigating their potential impact on nephrolithiasis. Plant-based diets, including Dietary Approaches to Stop Hypertension, Mediterranean, flexitarian, and vegetarian diets, may protect against nephrolithiasis when they consist largely of unprocessed plant foods, while carbohydrate-restricted diets (including high-protein diets and the ketogenic diet) may raise kidney stone risk...
November 2023: Adv Kidney Dis Health
https://read.qxmd.com/read/38450235/ketogenic-therapy-towards-precision-medicine-for-brain-diseases
#15
REVIEW
Yang Liu, Linlin Fan, Haoying Yang, Danli Wang, Runhan Liu, Tikun Shan, Xue Xia
Precision nutrition and nutrigenomics are emerging in the development of therapies for multiple diseases. The ketogenic diet (KD) is the most widely used clinical diet, providing high fat, low carbohydrate, and adequate protein. KD produces ketones and alters the metabolism of patients. Growing evidence suggests that KD has therapeutic effects in a wide range of neuronal diseases including epilepsy, neurodegeneration, cancer, and metabolic disorders. Although KD is considered to be a low-side-effect diet treatment, its therapeutic mechanism has not yet been fully elucidated...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38428587/effectiveness-of-high-fat-and-high-carbohydrate-diets-on-body-composition-and-maximal-strength-after-15-weeks-of-resistance-training
#16
JOURNAL ARTICLE
Marek Kruszewski, Artur Kruszewski, Rafał Tabęcki, Stanisław Kuźmicki, Krzysztof Stec, Tadeusz Ambroży, Maksim Olegovich Aksenov, Maciej Merchelski, Tomasz Danielik
PURPOSE: The aim of this study was to compare High Carbohydrates Low Fat (HCLF) and Low Carbohydrate High Fat (LCHF) diets in terms of changes in body composition and maximal strength. PATIENTS/METHODS: The study involved 48 men aged 25 ± 2.5, divided into two groups, one of which (n = 23) was following the LCHF diet and the other (n = 25) the HCLF diet. Both groups performed the same resistance training protocol for 15 weeks...
February 28, 2024: Advances in Medical Sciences
https://read.qxmd.com/read/38425445/dietary-sodium-acetate-and-sodium-butyrate-attenuate-intestinal-damage-and-improve-lipid-metabolism-in-juvenile-largemouth-bass-micropterus-salmoides-fed-a-high-carbohydrate-diet-by-reducing-endoplasmic-reticulum-stress
#17
JOURNAL ARTICLE
Liulan Zhao, Liangshun Cheng, Yifang Hu, Xiaohui Li, Yihui Yang, Jin Mu, Lianfeng Shen, Guojun Hu, Kuo He, Haoxiao Yan, Qiao Liu, Song Yang
High-carbohydrate (HC) diets decrease the intestinal levels of sodium acetate (SA) and sodium butyrate (SB) and impair the gut health of largemouth bass; however, SA and SB have been shown to enhance immunity and improve intestinal health in farmed animals. Thus, the present study was to investigate the effects of dietary SA and SB on HC diet-induced intestinal injury and the potential mechanisms in juvenile largemouth bass. The experiment set five isonitrogenous and isolipidic diets, including a low-carbohydrate diet (9% starch) (LC), a high carbohydrate diet (18% starch) (HC), and the HC diet supplemented with 2 g/kg SA (HCSA), 2 g/kg SB (HCSB) or a combination of 1 g/kg SA and 1 g/kg SB (HCSASB)...
March 2024: Animal Nutrition
https://read.qxmd.com/read/38417849/investigation-of-amino-acid-and-fatty-acid-profiles-of-japanese-diets-using-the-food-exchange-lists-for-diabetes-diet
#18
JOURNAL ARTICLE
Ayari Tsumura, Hisami Yamanaka-Okumura, Hana Kawakami, Shiori Yamamoto, Mayu Oura, Hiroshi Tatano, Hirokazu Ohminami, Masashi Masuda, Yutaka Taketani
Dietary Reference Intakes for Japanese provide target values for proteins, fats, and carbohydrates. However, they do not provide information on reference values for amino acids (AAs) and fatty acids (FAs), which determine the quality of foods in detail. Therefore, we evaluated AAs and FAs using the Food Exchange Lists-Dietary Guidance for Persons with Diabetes (in Japanese) Utilization, Second Edition Sample Menus and Practice (FELD) as an ideal Japanese diet. Based on FELD, 15 different daily meal patterns were employed with combinations of three levels of carbohydrates %energy (high carbohydrate [HC], 60%; middle carbohydrate [MC], 55%; and low carbohydrate [LC], 50%) and five levels of energy (1,200-2,000 kcal)...
2024: Journal of Nutritional Science and Vitaminology
https://read.qxmd.com/read/38410637/ketogenic-diet-reduces-a-neurobiological-craving-signature-in-inpatients-with-alcohol-use-disorder
#19
JOURNAL ARTICLE
Corinde E Wiers, Peter Manza, Gene-Jack Wang, Nora D Volkow
BACKGROUND AND AIMS: Increasing evidence suggests that a ketogenic (high-fat, low-carbohydrate) diet (KD) intervention reduces alcohol withdrawal severity and alcohol craving in individuals with alcohol use disorder (AUD) by shifting brain energetics from glucose to ketones. We hypothesized that the KD would reduce a neurobiological craving signature when individuals undergoing alcohol detoxification treatment were exposed to alcohol cues. METHODS: We performed a secondary analysis of functional magnetic resonance data of 33 adults with an AUD who were randomized to a KD ( n  = 19) or a standard American diet (SA; n  = 14) and underwent 3 weeks of inpatient alcohol detoxification treatment...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38410048/the-hedonic-overdrive-model-best-explains-high-fat-diet-induced-obesity-in-c57bl-6-mice
#20
JOURNAL ARTICLE
Lin Gao, Sumei Hu, Dengbao Yang, Lu Wang, Jacques Togo, Yingga Wu, Baoguo Li, Min Li, Guanlin Wang, Xueying Zhang, Li Li, Yanchao Xu, Moshen Mazidi, Elspeth Couper, Andrew Whittington-Davies, Chaoqun Niu, John R Speakman
OBJECTIVE: High-fat diets cause obesity in male mice; however, the underlying mechanisms remain controversial. Here, three contrasting ideas were assessed: hedonic overdrive, reverse causality, and passive overconsumption models. METHODS: A total of 12 groups of 20 individually housed 12-week-old C57BL/6 male mice were exposed to 12 high-fat diets with varying fat content from 40% to 80% (by calories), protein content from 5% to 30%, and carbohydrate content from 8...
February 27, 2024: Obesity
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