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https://www.readbyqxmd.com/read/27913915/age-related-differences-in-clinical-characteristics-and-esophageal-motility-in-patients-with-dysphagia
#1
Rui Nakato, Noriaki Manabe, Tomoari Kamada, Hideo Matsumoto, Akiko Shiotani, Jiro Hata, Ken Haruma
Dysphagia in elderly patients has a major effect on nutrition and quality of life (QOL). Although several studies have shown that aging itself is associated with changes in esophageal motility, the impact of these changes on dysphagia symptoms and QOL is unknown. This study assessed the manometric diagnoses of elderly patients with dysphagia compared with diagnoses in younger counterparts. Participants included 116 consecutive patients examined for dysphagia from 2007 to 2014. We divided patients into three groups by age: Group A, 66 years and older (24 men, 23 women); Group B, 45-65 years (18 men, 24 women); and Group C, 44 years and younger (15 men, 12 women)...
December 2, 2016: Dysphagia
https://www.readbyqxmd.com/read/27910245/anorectal-manometry-should-it-be-performed-in-a-seated-position
#2
G-J Wu, F Xu, L Lin, P J Pasricha, J D Z Chen
BACKGROUND: Anorectal manometry (ARM) is typically preformed in a lateral position. This non-physiological testing position has produced an unexpected negative rectoanal pressure gradient (RAPG, i.e. difference between rectal and anal pressure) with normal defecation. This study was designed (i) to study differences in ARM parameters between water-perfused and solid-state sensors and between lateral and seated positions and (ii) to investigate the roles of ARM parameters in predicting balloon expulsion...
December 1, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27898990/european-paediatric-surgeons-association-survey-on-the-management-of-hirschsprung-disease
#3
Augusto Zani, Simon Eaton, Francesco Morini, Prem Puri, Risto Rintala, Ernest van Heurn, Marija Lukac, Pietro Bagolan, Joachim F Kuebler, Florian Friedmacher, Rene Wijnen, Juan A Tovar, Michael E Hoellwarth, Agostino Pierro
: Aim This study aims to define patterns of Hirschsprung disease (HD) management. Methods An online questionnaire was sent to all European Paediatric Surgeons' Association (EUPSA) members. Results A total of 294 members (61 countries) answered (response rate: 61%). DIAGNOSIS: All respondents perform rectal biopsies (61% rectal suction [RSBs], 39% open full-thickness), 96% contrast enema, and 31% anorectal manometry. At RSB, 17% take the most distal biopsy 1 cm above the dentate line, 34% take 2 cm, 30% take 3 cm, and 19% take > 3 cm...
November 29, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27895430/full-thickness-myotomy-is-associated-with-higher-rate-of-postoperative-gastroesophageal-reflux-disease
#4
Xue-Hong Wang, Yu-Yong Tan, Hong-Yi Zhu, Chen-Jie Li, De-Liang Liu
AIM: To compare long-term occurrence of gastroesophageal reflux disease (GERD) between two different types of peroral endoscopic myotomy (POEM) for achalasia. METHODS: We included all patients with achalasia who underwent POEM at our hospital from August 2011 to October 2012 and had complete GERD evaluation with ≥ 3 years of follow-up. They were divided into circular or full-thickness myotomy groups according to the depth of myotomy. Demographics, Eckardt score, manometry results, 24-h pH monitoring, and GERD symptoms were recorded and compared between the two groups...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27891706/rectal-intussusception-can-high-resolution-three-dimensional-ano-rectal-manometry-compete-with-conventional-defecography
#5
A Benezech, M Cappiello, K Baumstarck, J-C Grimaud, M Bouvier, V Vitton
BACKGROUND: Three-dimensional high-resolution anorectal manometry (3DHRAM), used for exploring anorectal disorders, was recently developed, providing interesting topographic data for the diagnosis of pelvic floor disorders such as excessive perineal descent. The aim of our study was to define a diagnostic strategy based on selected 3DHRAM parameters to identify rectal intussusceptions (RI), considering conventional defecography (CD) as the gold standard. METHODS: All patients referred to our center in the previous 6 months for 3DHRAM to explore fecal incontinence or constipation, and who previously achieved CD, were eligible...
November 27, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27891696/gender-differences-in-chronic-constipation-on-anorectal-motility
#6
M Zakari, J Nee, W Hirsch, B Kuo, A Lembo, K Staller
BACKGROUND: The epidemiology of chronic constipation (CC) skews toward female predominance, yet men make up an important component of those suffering from CC. We sought to determine whether there are sex-specific differences in symptoms and physiologic parameters on anorectal manometry (ARM). METHODS: We performed a case-control analysis of sequential men and age-matched women (2:1 ratio) presenting for ARM as part of the evaluation of CC. We collected physiologic parameters derived from 3D high-resolution ARM in addition to the ROME III constipation module and the Pelvic Floor Distress Inventory 20 (PFDI-20) questionnaires...
November 27, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27891695/downregulation-of-neuronal-vasoactive-intestinal-polypeptide-in-parkinson-s-disease-and-chronic-constipation
#7
F Giancola, F Torresan, R Repossi, F Bianco, R Latorre, A Ioannou, M Guarino, U Volta, P Clavenzani, M Mazzoni, R Chiocchetti, F Bazzoli, R A Travagli, C Sternini, R De Giorgio
BACKGROUND: Chronic constipation (CC) is a common and severe gastrointestinal complaint in Parkinson's disease (PD), but its pathogenesis remains poorly understood. This study evaluated functionally distinct submucosal neurons in relation to colonic motility and anorectal function in PD patients with constipation (PD/CC) vs both CC and controls. METHODS: Twenty-nine PD/CC and 10 Rome III-defined CC patients were enrolled. Twenty asymptomatic age-sex matched subjects served as controls...
November 27, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27888858/novel-findings-in-the-management-of-acute-pancreatitis
#8
Federico Bolado, Enrique de-Madaria
Acute pancreatitis (AP) is a potentially serious disease whose incidence is on the increase. Pancreas divisum does not meet the required criteria to be considered an aetiological factor. Sphincter of Oddi dysfunction may be another cause of idiopathic AP. Less invasive methods cannot replace Sphincter of Oddi manometry in diagnosis. Almost half of patients with systemic inflammatory response syndrome develop organ failure, but the mechanisms involved are not completely understood. Obesity is a risk factor for severity in AP; the cause could be the presence of free unsaturated fatty acids, which have pro-inflammatory activity...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27882697/biomechanical-properties-of-an-implanted-engineered-tubular-gut-sphincter-complex
#9
Elie Zakhem, Mostafa El Bahrawy, Giuseppe Orlando, Khalil N Bitar
Neuromuscular diseases of the gut alter the normal motility patterns. Although surgical intervention remains the standard treatment, preservation of the sphincter attached to the rest of the gut is challenging. The present study aimed to evaluate a bioengineered gut-sphincter complex following its subcutaneous implantation for 4 weeks in rats. Engineered innervated human smooth muscle sheets and innervated human sphincters with a predefined alignment were placed around tubular scaffolds to create a gut-sphincter complex...
November 23, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27874942/breathing-training-on-lower-esophageal-sphincter-as-a-complementary-treatment-of-gastroesophageal-reflux-disease-gerd-a-systematic-review
#10
M Casale, L Sabatino, A Moffa, F Capuano, V Luccarelli, M Vitali, M Ribolsi, M Cicala, F Salvinelli
OBJECTIVE: Gastroesophageal reflux disease (GERD) represents one of the most common gastrointestinal disorders, but is still a challenge to cure. Proton pump inhibitors (PPIs) are currently the GERD's standard treatment, although not successful in all patients; some concerns have been raised regarding their long term consumption. Recently, some studies showed the benefits of inspiratory muscle training in increasing the lower esophageal sphincter pressure in patients affected by GERD, thereby reducing their symptoms...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27865290/pneumatic-dilation-of-the-lower-esophageal-sphincter-can-now-be-successfully-performed-without-morbidity
#11
Yi Jia, Marco Bustamante, Sharareh Moraveji, Richard W McCallum
BACKGROUND: Patients with dysphagia may be diagnosed with impaired lower esophageal sphincter (LES) relaxation and treated with pneumatic dilation (PD), stretching and tearing LES muscle fibers. Esophageal perforation has been reported to be as high as 10%. We conducted a retrospective study to evaluate the perforation rate of PD when used for impaired relaxation of the LES using current techniques. METHODS: A chart review was conducted to identify patients referred for esophageal manometry by high-resolution manometry and later received PD from January 2013 to April 2016...
November 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27864723/pre-treatment-eckardt-score-is-a-simple-factor-for-predicting-one-year-peroral-endoscopic-myotomy-failure-in-patients-with-achalasia
#12
Yutang Ren, Xiaowei Tang, Yanmin Chen, Fengping Chen, Yingying Zou, Zhiliang Deng, Jianuan Wu, Yan Li, Silin Huang, Bo Jiang, Wei Gong
BACKGROUND: Peroral endoscopic myotomy (POEM) is a novel treatment for achalasia with excellent outcomes. But the predictor for treatment failure is not well defined. This study was aimed to prospectively investigate the factors for predicting failed POEM. METHODS: From June 2011 to May 2015, a total of 115 achalasia patients treated by POEM were included for the retrospective cohort study from Nanfang Hospital and the First People's Hospital of Yunnan Province...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27862648/accuracy-of-the-air-flow-sphincter-locator-system-in-identifying-the-lower-esophageal-sphincter-for-placement-of-ph-catheters
#13
Joan W Chen, Jason R Baker, Jessica M Compton, Mark McDermott, Joel H Rubenstein
The Air Flow Sphincter Locator (AFSL) is marketed as an alternative method to manometry for localizing the lower esophageal sphincter (LES) for pH probe placement. Such a system is desirable due to the additional time, cost, and discomfort associated with dual nasal intubation, but its accuracy has never been assessed. To assess the accuracy of the AFSL in localizing the LES. Fifty consecutive outpatients presenting for pH and manometry studies were included. The upper border of the LES was determined using HRM and the AFSL by two technicians independently...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27861223/gastrointestinal-and-urologic-sphincter-dysfunction-in-stiff-person-syndrome
#14
Oana M Dumitrascu, Evgeny I Tsimerinov, Richard A Lewis
OBJECTIVES: Stiff person syndrome is a neurologic disorder characterized by axial rigidity leading to progressive disability, with broad clinical spectrum. METHODS: We report 2 cases with unique clinical presentation. RESULTS: Two young men suffered progressive urinary retention requiring bladder catheterization, anorectal spasms and constipation, complicated subsequently with lower extremity trigger-induced spasms, and gait instability. Associated symptoms revealed brainstem involvement (vertigo, diplopia, and cranial neuropathies) and dysautonomia (abnormal sweating and orthostatic hypotension)...
December 2016: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/27859989/effects-of-high-resolution-esophageal-manometry-on-oxygen-saturation-and-hemodynamic-function
#15
Vicente Ortiz, Esteban Sáez-González, Michel Blé, Francia Carolina Díaz-Jaime, Carmen Vinaixa, Vicente Garrigues
The effect of high-resolution esophageal manometry (HRM) on oxygen saturation (SaO2 ) and hemodynamic function has not been previously evaluated. This was a prospective study of consecutive patients referred for HRM. Demographic and clinical data were collected on all patients. The study variables included SaO2 , heart rate (HR) and blood pressure (BP). SaO2 and HR were measured at baseline, during intubation, during and 5 min after HRM. BP was measured at baseline, during and after HRM. 158 (56% women) patients with a mean age of 56 (SD 15) years were included...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27859421/the-learning-curve-for-interpretation-of-oesophageal-high-resolution-manometry-a-prospective-interventional-cohort-study
#16
S Gaddam, C A Reddy, S Munigala, A Patel, N Kanuri, S Almaskeen, M K Rude, A Abdalla, C P Gyawali
BACKGROUND: High-resolution manometry has become the preferred choice of oesophagologists for oesophageal motor assessment, but the learning curve among trainees remains unclear. AIM: To determine the learning curve of high-resolution manometry interpretation. METHODS: A prospective interventional cohort study was performed on 18 gastroenterology trainees, naïve to high-resolution manometry (median age 32 ± 4.0 years, 44.4% female). An intake questionnaire and a 1-h standardised didactic session were performed at baseline...
November 17, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27856363/rectal-gas-volume-measured-by-computerized-tomography-identifies-evacuation-disorders-in-patients-with-constipation
#17
Seon-Young Park, Disha Khemani, Alfred D Nelson, Deborah Eckert, Michael Camilleri
BACKGROUND & AIMS: Approximately one-third of patients who present with constipation to gastroenterology care have rectal evacuation disorders. We aimed to compare rectal gas volume, measured by computerized tomography (CT), in constipated patients with and without rectal evacuation disorders. METHOD: In a retrospective study, we collected data from 1553 patients with constipation, evaluated over 20 years. We analyzed data from 141 patients evaluated by anorectal manometry, balloon expulsion tests, and colon transit tests, collecting records of abdominal and pelvic CT examinations...
November 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27852554/high-resolution-manometry-versus-conventional-manometry-in-diagnosis-of-patients-with-nonobstructive-dysphagia
#18
Altay Çelebi
No abstract text is available yet for this article.
November 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27852360/-changes-and-implications-of-esophageal-function-in-patients-with-chronic-cough-induced-by-gastroesophageal-reflux
#19
X H Xu, L Yu, Q Chen, Y Huang, H H Sun, L S Yi, S C Xu, H J Lyu, Z M Qiu
Objective: To explore the changes in the esophageal function and their association with the therapeutic outcome in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods: One hundred thirty-five patients with definite GERC consecutively referred to our respiratory clinic were recruited into the study between January 2012 and August 2015.Cough was due to acid reflux in 81 patients and non-acid reflux in 54 patients, with the favorable response to the standard antireflux therapy in 88 patients and to the intensified antireflux treatment in 47 patients...
November 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27846179/real-time-continuous-esophageal-high-resolution-manometry-hrm-during-laparoscopic-heller-myotomy-and-dor-fundoplication-for-the-treatment-of-achalasia-a-promising-novelty-in-regards-of-perfecting-surgical-technique-could-it-guide-surgical-technique-toward-excellent
#20
Tania Triantafyllou, Georgia Doulami, Joanna Papailiou, Apostolos Mantides, Georgios Zografos, Dimitrios Theodorou
High-resolution manometry (HRM) is the gold-standard diagnostic tool for achalasia of the esophagus. Laparoscopic Heller-Dor technique is the preferred surgical approach with success rate estimated 90%. The use of intraoperative HRM provides real-time estimation of intraluminal esophageal pressures and identifies the exact points of esophageal luminal pressure during laparoscopy. Ten patients with achalasia underwent surgery. All patients preoperatively completed 1 manometric study and Quality of Life questionnaires (EORTC QLQ-C30 version 3...
November 14, 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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