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https://www.readbyqxmd.com/read/29976626/drug-refraining-and-seeking-potentiate-synapses-on-distinct-populations-of-accumbens-medium-spiny-neurons
#1
Douglas Roberts-Wolfe, Ana Clara Bobadilla, Jasper Heinsbroek, Daniela Neuhofer, Peter W Kalivas
Cocaine-associated cues and contexts can precipitate drug seeking in humans and experimental animals. Glutamatergic synapses in the core subcompartment of the nucleus accumbens (NAcore) undergo transient potentiation in response to presenting drug-associated cues. The NAcore contains two populations of medium spiny neurons (MSNs) that differentially express D1 or D2 dopamine receptors. By recording the ratio of AMPA and NMDA glutamate receptor currents (AMPA:NMDA) from MSNs in NAcore tissue slices, we endeavored to understand which subpopulation of MSN was undergoing transient potentiation...
July 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29890020/accumbens-brain-derived-neurotrophic-factor-bdnf-transmission-inhibits-cocaine-seeking
#2
Ana-Clara Bobadilla, Constanza Garcia-Keller, Victoria Chareunsouk, Jeffrey Hyde, Daniela Medina Camacho, Jasper A Heinsbroek, Peter W Kalivas
Brain-derived neurotrophic factor (BDNF) regulates a variety of physiological processes, and several studies have explored the role of BDNF in addiction-related brain regions like the nucleus accumbens core (NAcore). We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to self-administer cocaine and extinguished. We then microinjected two inhibitors of BDNF stimulation of tropomyosin receptor kinase B (TrkB), the non-competitive receptor antagonist ANA-12 and TrkB/Fc, a fusion protein that binds BDNF and prevents TrkB stimulation...
June 11, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29861097/a-model-of-%C3%AE-9-tetrahydrocannabinol-self-administration-and-reinstatement-that-alters-synaptic-plasticity-in-nucleus-accumbens
#3
Sade Spencer, Daniela Neuhofer, Vivian C Chioma, Constanza Garcia-Keller, Danielle J Schwartz, Nicholas Allen, Michael D Scofield, Tara Ortiz-Ithier, Peter W Kalivas
BACKGROUND: Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9 -tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in nucleus accumbens core (NAcore) thought to contribute vulnerability to drug reinstatement...
May 3, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29497856/variation-in-frequency-of-intraoperative-arterial-central-venous-and-pulmonary-artery-catheter-placement-during-kidney-transplantation-an-analysis-of-invasive-monitoring-trends
#4
Alexander Nagrebetsky, Richard P Dutton, Jesse M Ehrenfeld, Richard D Urman
The rapidly increasing number of kidney transplantations warrants assessment of anesthesia care in this patient population. We explored the frequency of arterial catheter (AC), central venous catheter (CVC) and pulmonary artery catheter (PAC) placement during kidney transplantation in the USA using data from the National Anesthesia Clinical Outcomes Registry (NACOR) and assessed the between-facility variation in the frequency of catheter placement. We defined cases of kidney transplantation using Agency for Healthcare Research and Quality Clinical Classification Software...
March 2, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29116968/antiemetic-prophylaxis-as-a-marker-of-health-care-disparities-in-the-national-anesthesia-clinical-outcomes-registry
#5
Michael H Andreae, Jonah S Gabry, Ben Goodrich, Robert S White, Charles Hall
BACKGROUND: US health care disparities persist despite repeated countermeasures. Research identified race, ethnicity, gender, and socioeconomic status as factors, mediated through individual provider and/or systemic biases; little research exists in anesthesiology. We investigated antiemetic prophylaxis as a surrogate marker for anesthesia quality by individual providers because antiemetics are universally available, indicated contingent on patient characteristics (gender, age, etc), but independent of comorbidities and not yet impacted by regulatory or financial constraints...
February 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28870523/antagonism-of-mglu2-3-receptors-in-the-nucleus-accumbens-prevents-oxytocin-from-reducing-cued-methamphetamine-seeking-in-male-and-female-rats
#6
Aurelien Bernheim, Kah-Chung Leong, Carole Berini, Carmela M Reichel
Methamphetamine (meth) addiction is a prevalent health concern worldwide, yet remains without approved pharmacological treatments. Preclinical evidence suggests that oxytocin may decrease relapse, but the neuronal underpinnings driving this effect remain unknown. Here we investigate whether oxytocin's effect is dependent on presynaptic glutamatergic regulation in the nucleus accumbens core (NAcore) by blocking metabotropic glutamate receptors 2/3 (mGluR2/3). Male and female Sprague-Dawley rats self-administered meth or sucrose on an escalating fixed ratio, followed by extinction and cue-induced reinstatement sessions...
October 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28726801/accumbens-mechanisms-for-cued-sucrose-seeking
#7
Ana-Clara Bobadilla, Constanza Garcia-Keller, Jasper A Heinsbroek, Michael D Scofield, Victoria Chareunsouk, Cara Monforton, Peter W Kalivas
Many studies support a perspective that addictive drugs usurp brain circuits used by natural rewards, especially for the dopamine-dependent reinforcing qualities of both drugs and natural rewards. Reinstated drug seeking in animal models of relapse relies on glutamate spillover from cortical terminals synapsing in the nucleus accumbens core (NAcore) to stimulate metabotropic glutamate receptor5 (mGluR5) on neuronal nitric oxide synthase (nNOS) interneurons. Contrasting the release of dopamine that is shared by sucrose and drugs of abuse, reinstated sucrose seeking does not induce glutamate spillover...
November 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28386221/deep-brain-stimulation-of-the-nucleus-accumbens-core-affects-trait-impulsivity-in-a-baseline-dependent-manner
#8
Maria C Schippers, Bastiaan Bruinsma, Mathijs Gaastra, Tanja I Mesman, Damiaan Denys, Taco J De Vries, Tommy Pattij
Deep brain stimulation (DBS) of the nucleus accumbens (NA) is explored as a treatment for refractory psychiatric disorders, such as obsessive-compulsive disorder (OCD), depressive disorder (MDD), and substance use disorder (SUD). A common feature of some of these disorders is pathological impulsivity. Here, the effects of NAcore DBS on impulsive choice and impulsive action, two distinct forms of impulsive behavior, were investigated in translational animal tasks, the delayed reward task (DRT) and five-choice serial reaction time task (5-CSRTT), respectively...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28123012/accumbens-nnos-interneurons-regulate-cocaine-relapse
#9
Alexander C W Smith, Michael D Scofield, Jasper A Heinsbroek, Cassandra D Gipson, Daniela Neuhofer, Doug J Roberts-Wolfe, Sade Spencer, Constanza Garcia-Keller, Neringa M Stankeviciute, Rachel J Smith, Nicholas P Allen, Melissa R Lorang, William C Griffin, Heather A Boger, Peter W Kalivas
Relapse to drug use can be initiated by drug-associated cues. The intensity of cue-induced relapse is correlated with the induction of transient synaptic potentiation (t-SP) at glutamatergic synapses on medium spiny neurons (MSNs) in the nucleus accumbens core (NAcore) and requires spillover of glutamate from prefrontal cortical afferents. We used a rodent self-administration/reinstatement model of relapse to show that cue-induced t-SP and reinstated cocaine seeking result from glutamate spillover, initiating a metabotropic glutamate receptor 5 (mGluR5)-dependent increase in nitric oxide (NO) production...
January 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27918331/growth-of-nonoperating-room-anesthesia-care-in-the-united-states-a-contemporary-trends-analysis
#10
Alexander Nagrebetsky, Rodney A Gabriel, Richard P Dutton, Richard D Urman
BACKGROUND: Although previous publications suggest an increasing demand and volume of nonoperating room anesthesia (NORA) cases in the United States, there is little factual information on either volume or characteristics of NORA cases at a national level. Our goal was to assess the available data using the National Anesthesia Clinical Outcomes Registry (NACOR). METHODS: We performed a retrospective analysis of NORA volume and case characteristics using NACOR data for the period 2010-2014...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27611808/diversity-and-similarity-of-anesthesia-procedures-in-the-united-states-during-and-among-regular-work-hours-evenings-and-weekends
#11
COMPARATIVE STUDY
Franklin Dexter, Richard H Epstein, Richard P Dutton, Hubert Kordylewski, Johannes Ledolter, Henry Rosenberg, Bradley J Hindman
BACKGROUND: Anesthesiologists providing care during off hours (ie, weekends or holidays, or cases started during the evening or late afternoon) are more likely to care for patients at greater risk of sustaining major adverse events than when they work during regular hours (eg, Monday through Friday, from 7:00 AM to 2:59 PM). We consider the logical inconsistency of using subspecialty teams during regular hours but not during weekends or evenings. METHODS: We analyzed data from the Anesthesia Quality Institute's National Anesthesia Clinical Outcomes Registry (NACOR)...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27185683/incidence-and-risk-factors-for-early-postoperative-reintubations
#12
Margaret N Tillquist, Rodney A Gabriel, Richard P Dutton, Richard D Urman
STUDY OBJECTIVE: Reintubations are associated with significantly increased morbidity and mortality, increased hospital length of stay, and increased cost. Our aim was to assess the national incidence and associated risk factors for unanticipated early postoperative reintubations. DESIGN: Using the National Anesthesia Clinical Outcomes Registry (NACOR) from 2010 to 2014, multivariate logistic regression was fitted to determine if various patient, surgical, intraoperative, or provider data were associated with unanticipated early postoperative reintubations...
June 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/26721638/analysis-of-unplanned-postoperative-admissions-to-the-intensive-care-unit
#13
Timothy D Quinn, Rodney A Gabriel, Richard P Dutton, Richard D Urman
PURPOSE: To investigate factors associated with unplanned postoperative admissions to the intensive care unit (ICU). METHODS: Data from the National Anesthesia Clinical Outcomes Registry (NACOR) were analyzed. We performed univariate and multivariate logistic regression to identify patient- and surgery-specific characteristics associated with unplanned postoperative ICU admission. We also recorded the prevalence of Current Procedural Terminology (CPT) and International Classification of Diseases, ninth revision ( ICD-9) billing codes and outcomes for unplanned postoperative ICU admissions...
August 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/26708695/rate-of-major-anesthetic-related-outcomes-in-the-intraoperative-and-immediate-postoperative-period-after-cardiac-surgery
#14
Ethan Y Brovman, Rodney A Gabriel, Robert W Lekowski, Richard P Dutton, Richard D Urman
OBJECTIVES: To examine anesthesia-centered outcomes in a large cohort of patients undergoing coronary artery bypass grafting (CABG) or valvular heart surgery. DESIGN: A retrospective study with univariate and multivariate logistic regression to identify independent predictors for mortality. SETTING: Diverse setting including university, small, medium, and large community hospitals. PARTICIPANTS: All patients undergoing CABG or valve surgery in the National Anesthesia Clinical Outcomes Registry (NACOR) from the Anesthesia Quality Institute...
April 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/26606006/national-perioperative-outcomes-for-intrathecal-pump-spinal-cord-stimulator-and-peripheral-nerve-stimulator-procedures
#15
Christopher R Abrecht, Rodney A Gabriel, Richard P Dutton, Alan D Kaye, Edward Michna, Richard D Urman
BACKGROUND: There is abundant literature on the long-term complications of intrathecal pumps (ITP), spinal cord stimulators (SCS), and peripheral nerve stimulators (PNS) used in the treatment of chronic pain. There is less information, however, on the perioperative complications of these procedures. OBJECTIVE: Exploration of the perioperative outcomes of implantable pain devices. STUDY DESIGN: Observational study. SETTING: University hospitals, community hospitals, specialty hospitals, attached surgery centers, and freestanding surgery centers METHODS: Data were obtained from the National Anesthesia Clinical Outcomes Registry (NACOR) of the Anesthesia Quality Institute (AQI)...
November 2015: Pain Physician
https://www.readbyqxmd.com/read/26579661/the-national-anesthesia-clinical-outcomes-registry
#16
REVIEW
Adrian Liau, Jeana E Havidich, Tracy Onega, Richard P Dutton
The Anesthesia Quality Institute (AQI) was chartered in 2008 by the American Society of Anesthesiologists to develop the National Anesthesia Clinical Outcomes Registry (NACOR). In this Technical Communication, we will describe how data enter NACOR, how they are authenticated, and how they are analyzed and reported. NACOR accepts case-level administrative, clinical, and quality capture data from voluntarily participating anesthesia practices and health care facilities in the United States. All data are transmitted to the AQI in summary electronic files generated by billing, quality capture, and electronic health care record software, typically on a monthly basis...
December 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/26418555/large-databases-in-anaesthesiology
#17
REVIEW
Richard P Dutton
PURPOSE OF REVIEW: The purpose of this study is to review the current state of large database research in anaesthesiology and to describe the evolution of the National Anesthesia Clinical Outcomes Registry (NACOR) in the USA. RECENT FINDINGS: The Anesthesia Quality Institute of the American Society of Anesthesiologists was created to develop a national anaesthesia registry for the USA. NACOR and the companion Anesthesia Incident Reporting System are now 5 years old and in daily use by hundreds of US practices...
December 2015: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/26352473/structure-of-the-toxic-core-of-%C3%AE-synuclein-from-invisible-crystals
#18
Jose A Rodriguez, Magdalena I Ivanova, Michael R Sawaya, Duilio Cascio, Francis E Reyes, Dan Shi, Smriti Sangwan, Elizabeth L Guenther, Lisa M Johnson, Meng Zhang, Lin Jiang, Mark A Arbing, Brent L Nannenga, Johan Hattne, Julian Whitelegge, Aaron S Brewster, Marc Messerschmidt, Sébastien Boutet, Nicholas K Sauter, Tamir Gonen, David S Eisenberg
The protein α-synuclein is the main component of Lewy bodies, the neuron-associated aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11-residue segment, which we term NACore, appears to be responsible for amyloid formation and cytotoxicity of human α-synuclein. Here we describe crystals of NACore that have dimensions smaller than the wavelength of visible light and thus are invisible by optical microscopy. As the crystals are thousands of times too small for structure determination by synchrotron X-ray diffraction, we use micro-electron diffraction to determine the structure at atomic resolution...
September 24, 2015: Nature
https://www.readbyqxmd.com/read/25923436/anesthesia-workload-nationally-during-regular-workdays-and-weekends
#19
Franklin Dexter, Richard P Dutton, Hubert Kordylewski, Richard H Epstein
BACKGROUND: We analyze data from the American Society of Anesthesiologist's (ASA) Anesthesia Quality Institute (AQI) to report the U.S. anesthesia workload by time of day and day of the week. We consider the extent to which first case starts, rather than durations of workdays and weekend cases, influence the number of anesthesia providers nationally. METHODS: The ASA AQI data were from all the U.S. anesthesia groups that submitted cases to the National Anesthesia Clinical Outcomes Registry (NACOR) for all 12 months of 2013...
December 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/25861696/gq-dreadd-selectively-initiates-glial-glutamate-release-and-inhibits-cue-induced-cocaine-seeking
#20
Michael D Scofield, Heather A Boger, Rachel J Smith, Hao Li, Philip G Haydon, Peter W Kalivas
BACKGROUND: Glial cells of the central nervous system directly influence neuronal activity by releasing neuroactive small molecules, including glutamate. Long-lasting cocaine-induced reductions in extracellular glutamate in the nucleus accumbens core (NAcore) affect synaptic plasticity responsible for relapse vulnerability. METHODS: We transduced NAcore astrocytes with an adeno-associated virus vector expressing hM3D designer receptor exclusively activated by a designer drug (DREADD) under control of the glial fibrillary acidic protein promoter in 62 male Sprague Dawley rats, 4 dominant-negative soluble N-ethylmaleimide-sensitive factor attachment protein receptor mice, and 4 wild-type littermates...
October 1, 2015: Biological Psychiatry
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