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https://www.readbyqxmd.com/read/30021630/probabilistic-cost-effectiveness-analysis-of-controlled-ovarian-stimulation-with-recombinant-fsh-plus-recombinant-lh-vs-human-menopausal-gonadotropin-for-women-undergoing-ivf
#1
F S Mennini, A Marcellusi, R Viti, C Bini, A Carosso, A Revelli, C Benedetto
BACKGROUND: The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF. The aim of this analysis was to estimate the cost-effectiveness of Controlled Ovarian Stimulation (COS) with recombinant FSH (rFSH) plus recombinant LH (rLH) in comparison with highly purified human menopausal gonadotropin (HP-hMG) in the woman undergoing in vitro fertilization (IVF) in Italy...
July 18, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/30020823/epigenetic-silencing-of-the-tumor-suppressor-genes-spi1-prdx2-klf4-dlec1-and-dapk1-in-childhood-and-adolescent-lymphomas
#2
İhsan Özdemir, Faruk Güçlü Pınarlı, Ferda Alpaslan Pınarlı, F Nur Baran Aksakal, Arzu Okur, Pınar Uyar Göçün, Ceyda Karadeniz
The aim of the study was to investigate the expression and methylation status of seven distinctive genes with tumor suppressing properties in childhood and adolescent lymphomas. A total of 96 patients with Hodgkin Lymphoma (HL, n = 41), Non-Hodgkin Lymphoma (NHL, n = 15), and reactive lymphoid hyperplasia (RLH, n = 40, as controls) are included in the research. The expression status of CDKN2A, SPI1, PRDX2, DLEC1, FOXO1, KLF4 and DAPK1 genes were measured with QPCR method after the RNA isolation from paraffin blocks of tumor tissue and cDNA conversion...
July 18, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/30018007/seasonal-and-dose-dependent-effects-of-recombinant-gonadotropins-on-sperm-production-and-quality-in-the-flatfish-solea-senegalensis
#3
François Chauvigné, Wendy González, Sandra Ramos, Carla Ducat, Neil Duncan, Ignacio Giménez, Joan Cerdà
Consecutive treatments with recombinant follicle-stimulating and luteinizing hormones (rFsh and rLh, respectively) stimulate spermatogenesis and potentiate sperm production in pubescent specimens of the oligospermic Senegalese sole (Solea senegalensis). However, sperm production in response to the hormones is highly variable, and the steroidogenic potential of the testis may be diminished due to sustained hormone supply. Here, we compared the effectiveness of low (9 μg/kg) and high (18 μg/kg) doses of rFsh and rLh to improve sperm production in adult sole during late winter-early spring (onset of the natural spawning period), and in autumn under a controlled temperature of 12 °C (period of testicular recrudescence)...
July 2, 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29966249/development-and-evaluation-of-raloxifene-hydrochloride-loaded-supersaturatable-smedds-containing-an-acidifier
#4
Jong-Hwa Lee, Hak Hyung Kim, Young Ho Cho, Tae-Sung Koo, Gye Won Lee
Raloxifene hydrochloride (RLH) was formulated into a pH-modified supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) to increase drug solubility and dissolution rate. Optimal formulations of pH-modified S-SMEDDSs were developed by incorporating hydroxypropyl-cellulose-L as a precipitation inhibitor and phosphoric acid as a pH modifier (an acidifier). RLH was dissolved to greater extents by all pH-modified S-SMEDDSs compared with non-pH-modified S-SMEDDSs. In particular, phosphoric acid afforded greater drug dissolution than did the other acidifiers tested, perhaps because phosphoric acid better controlled the pH...
June 29, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29763927/reactive-lymphoid-hyperplasia-or-tubercular-lymphadenitis-can-real-time-pcr-on-fine-needle-aspirates-help-physicians-in-concluding-the-diagnosis
#5
Vivek Gupta, Arvind Bhake
BACKGROUND: Enlarged lymph nodes in adult patients often present a diagnostic challenge. In the absence of granuloma or necrosis, the cytology/tissue findings are misleading and relate the enlarged lymph nodes to reactive lymphoid hyperplasia (RLH), because granuloma formation is an immunological response that usually takes 14-100 days to develop. This study assesses the role of real-time (RT)-PCR in the diagnosis of the Mycobacterium complex (MTBC) in lymph node aspirates compared with culture in cases of RLH...
2018: Acta Cytologica
https://www.readbyqxmd.com/read/29650849/-a-case-of-resected-reactive-lymphoid-hyperplasia-of-liver-suspected-of-hepatocellular-carcinoma
#6
Kei Nakamura, Akira Sougawa, Tomoyuki Nagata, Satoshi Mochizuki, Yuen Nakase, Shozo Kitai, Seishirou Inaba
A 64-year-old woman who had chronic type C viral hepatitis was referred with a liver tumor detected by magnetic resonance imaging(MRI). She had a history of rheumatoid arthritis which was treated by methotrexate. Ethoxybenzyl-MRI(EOBMRI) showed a low signal in the T1-weighted imaging, a high signal in the T2-weighted imaging and a low signal in the hepatobiliary phase. The tumor was 7 millimeters in diameter at S4, and exhibited enhancement in the arterial phase and wash out in the portal phase by contrast enhanced CT...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29543683/eyebrow-shapes-of-chinese-empresses-of-the-ming-and-qing-dynasties
#7
Kun Hwang, Seong Kyung Yoo
The aim of this study was to analyze eyebrow shapes in portraits of Chinese empresses of Ming and Qing dynasties.The frontal portraits of 20 Ming empresses and 24 of Qing in which the eye and eyebrows were identifiable were measured and analyzed. The arch shape did not differ significantly (P > 0.05) between Ming and Qing. The head-up type (66.6%) was significantly more common (P < 0.001), than tail-up (13.6%), horizontal (13.6%), and arched (6.8%). The brow arches of Ming and Qing empresses were classified as 5 arch types: L (Lamas), A (Anastasia), H (Hwang), M (Empress Ma), and D (Empress Du)...
July 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29381940/topical-steroids-eye-drops-in-conjunctival-reactive-lymphoid-hyperplasia-case-report
#8
Bernardo Rodrigues Mendes Moraes, Micael Valtoni Dantas do Nascimento, Epitácio Dias da Silva Neto, Ruth Miyuki Santo
RATIONALE: Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocytic infiltrative disorders. Evidence is scarce regarding appropriate treatment of conjunctival RLH. We report a case treated with topical corticosteroid. PATIENT CONCERNS: A 40 year-old female presented with a 7-month history of a slow growth tumor in the superior conjunctiva of the right eye...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29183794/characterization-of-carp-gonadotropins-structure-annual-profile-and-carp-and-zebrafish-pituitary-topographic-organization
#9
Lian Hollander-Cohen, Matan Golan, Joseph Aizen, Michal Shpilman, Berta Levavi-Sivan
Two gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH), are important players in the hypothalamic-pituitary-gonadal axis of vertebrates. In the present work, we describe the construction of recombinant (r) common carp (Cyprinus carpio; c) FSH (rcFSH) and LH (rcLH) using the Pichia pastoris system, the generation of specific antibodies against their respective β subunits, and their use in the development and validation of specific ELISAs. We produced carp rLH and rFSH as single-chain polypeptides, wherein the GTH subunit α was joined with either cLHβ or cFSHβ mature protein-coding sequences to form a fusion gene that encodes a yoked polypeptide, in which the GTH β-subunit forms the N-terminal part and the α-subunit forms the C-terminal part...
August 1, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29177245/controlled-ovarian-stimulation-with-r-fsh-plus-r-lh-vs-hmg-plus-r-fsh-in-patients-candidate-for-ivf-icsi-cycles-an-rct
#10
Ensieh Shahrokh Tehraninejad, Mina Farshbaf Taghinejad, Batool Hossein Rashidi, Fedyeh Haghollahi
Background: Different combination of gonadotropin preparation has been introduced with no definite superiority of one over others in in vitro fertilization (IVF), but individualized regimens for each patient are needed. Objective: The aim of the present study was to investigate the effect of controlled ovarian stimulation with recombinant- follicle stimulating hormone (r-FSH) plus recombinant-luteinizing hormone (rLH) versus human menopausal gonadotropin (HMG) plus r-FSH on fertility outcomes in IVF patients...
July 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29135567/benign-reactive-lymphoid-hyperplasia-of-the-conjunctiva-treated-with-cyclosporine
#11
Rupin N Parikh, Harpal S Sandhu, Giacomina Massaro-Giordano, Scott M Goldstein, Joan M OʼBrien
PURPOSE: To describe a case of reactive lymphoid hyperplasia (RLH) of the conjunctiva responding to cyclosporine immunosuppressant monotherapy. METHODS: A 66-year-old man with a 2-year history of biopsy-proven bilateral RLH presented for dry eye evaluation with chief complaints of burning, stinging, and irritation in both eyes. After slit-lamp examination and positive findings of matrix metalloproteinase 9 in the patient's tear film, he was diagnosed with meibomian gland dysfunction and tear-insufficiency dry eye disease...
February 2018: Cornea
https://www.readbyqxmd.com/read/28891416/role-of-innate-immunity-in-preeclampsia-a-systematic-review
#12
REVIEW
Ana P Bouças, Bianca M de Souza, Andrea C Bauer, Daisy Crispim
Innate immune system dysfunction has been known to be a key player in preeclampsia (PE). Activation of the maternal innate immunity may be triggered by invading microorganisms or endogenous ligands, which are detected by different pattern recognition receptors (PRRs). Although some studies have linked PRR activation to PE, it is still unclear if dysregulated PRR expression is associated with the development of this complication. Therefore, we conducted a systematic review of the literature, searching articles that evaluated associations of PRRs with PE...
October 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28791335/internalization-of-rat-fsh-and-lh-cg-receptors-by-rec-ecg-in-cho-k1-cells
#13
Jong-Ju Park, Hun-Ki Seong, Jeong-Soo Kim, Byambaragchaa Munkhzaya, Myung-Hwa Kang, Kwan-Sik Min
Equine chorionic gonadotropin (eCG) is a unique molecule that elicits the response characteristics of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in other species. Previous studies from this laboratory had demonstrated that recombinant eCG (rec-eCG) from Chinese hamster ovary (CHO-K1) cells exhibited both FSH- and LH-like activity in rat granulosa and Leydig cells. In this study, we analyzed receptor internalization through rec-eCGs, wild type eCG (eCGβ/α) and mutant eCG (eCGβ/αΔ56) with an N-linked oligosaccharide at Asn(56) of the α-subunit...
June 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28625874/negative-regulation-of-the-rlh-signaling-by-the-e3-ubiquitin-ligase-rnf114
#14
Boren Lin, Qi Ke, Haiying Li, Nichole S Pheifer, David C Velliquette, Douglas W Leaman
The retinoic acid-inducible gene-I (RIG-I)-like helicases (RLH)s are cytoplasmic pattern recognition receptors expressed in both immune and non-immune cells that are essential for detection of intracellular RNA products, primarily of viral origin. Upon binding to viral RNA, RLHs interact with mitochondrial antiviral signaling protein (MAVS) to activate interferon (IFN)-mediated antiviral responses. The RLH/MAVS signaling pathway is regulated by ubiquitination/deubiquitination, in which several ubiquitin-editing proteins play critical roles...
November 2017: Cytokine
https://www.readbyqxmd.com/read/28537052/recombinant-luteinizing-hormone-rlh-and-recombinant-follicle-stimulating-hormone-rfsh-for-ovarian-stimulation-in-ivf-icsi-cycles
#15
REVIEW
Monique H Mochtar, Nora A Danhof, Reuben Olugbenga Ayeleke, Fulco Van der Veen, Madelon van Wely
BACKGROUND: One of the various ovarian stimulation regimens used for in-vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycles is the use of recombinant follicle-stimulating hormone (rFSH) in combination with a gonadotrophin-releasing hormone (GnRH) analogue. GnRH analogues prevent premature luteinizing hormone (LH) surges. Since they deprive the growing follicles of LH, the question arises as to whether supplementation with recombinant LH (rLH) would increase live birth rates...
May 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28416325/involvement-of-the-nuclear-progestin-receptor-in-lh-induced-expression-of-membrane-type-2-matrix-metalloproteinase-required-for-follicle-rupture-during-ovulation-in-the-medaka-oryzias-latipes
#16
Katsueki Ogiwara, Takayuki Takahashi
Hormonal regulation of the expression of Mmp15, a proteolytic enzyme indispensable for ovulation in the teleost medaka, was investigated. In an in vitro culture system using preovulatory follicles, Mmp15 expression and ovulation were induced in the presence of recombinant luteinizing hormone (rLh). Both rLh-induced Mmp15 expression and ovulation were 17α, 20β-dihydroxy-4-pregnen-3-one-dependent, suggesting the involvement of a nuclear progestin receptor (Pgr). In vitro follicle ovulation and Mmp15 expression were reduced by treatment with the Pgr antagonist RU-486...
July 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28329024/toward-developing-recombinant-gonadotropin-based-hormone-therapies-for-increasing-fertility-in-the-flatfish-senegalese-sole
#17
François Chauvigné, Judith Ollé, Wendy González, Neil Duncan, Ignacio Giménez, Joan Cerdà
Captive flatfishes, such as the Senegalese sole, typically produce very low volumes of sperm. This situation is particularly prevalent in the first generation (F1) of reared sole males, which limits the development of artificial fertilization methods and the implementation of selective breeding programs. In this study, we investigated whether combined treatments with homologous recombinant follicle-stimulating (rFsh) and luteinizing (rLh) hormones, produced in a mammalian host system, could stimulate spermatogenesis and enhance sperm production in Senegalese sole F1 males...
2017: PloS One
https://www.readbyqxmd.com/read/28290093/the-effect-of-rlh-supplementation-to-the-gnrh-antagonist-protocol-on-endocrine-dynamics-in-the-advanced-reproductive-age
#18
RANDOMIZED CONTROLLED TRIAL
J S Younis, I Izhaki, M Ben-Ami
PURPOSE: To explore serum endocrine dynamics, specifically LH levels, following rLH supplementation to rFSH following GnRH-antagonist treatment in the advance reproductive age. METHODS: Women were prospectively and similarly treated employing rFSH and the flexible GnRH-antagonist protocol, while rLH was supplemented only to the study group. Serum FSH, LH, E2, and P were evaluated throughout the follicular phase. Three strategies were a priori planned to examine endocrine dynamics among women enrolled...
August 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28128734/microrna-profiling-in-peripheral-t-cell-lymphoma-not-otherwise-specified
#19
Yun Lin, Wei-Ming Chen, Chen Wang, Xiao-Yan Chen
BACKGROUND: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is an obviously heterogeneous and highly invasive malignancy without definite phenotype. MicroRNAs (miRNAs) are powerful gene regulators and have been reported as biomarkers in many malignancies. OBJECTIVE: To discover potential signaling miRNAs in PTCL-NOS distinguished from reactive lymphoid hyperplasia (RLH) and to explore the molecular characteristics based on the discovery. METHODS: We measured the expression profile of miRNAs in PTCL-NOS and RLH from our patients using a panel PCR array...
2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28107729/recombinant-lh-supplementation-in-patients-with-a-relative-reduction-in-lh-levels-during-ivf-icsi-cycles-a-prospective-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Robert Lahoud, John Ryan, Peter Illingworth, Frank Quinn, Michael Costello
PURPOSE: The aim of this study was to assess the use of recombinant luteinizing hormone (rLH) supplementation in patients who experience a reduction in LH concentration during controlled ovarian hyperstimulation (COH) for IVF/ICSI. METHODS: A multi-center prospective randomized controlled trial (RCT) was performed over three years. Two hundred and forty patients aged between 24 and 42 years undergoing IVF/ICSI treatment with a long down regulation (LDR) protocol were recruited...
March 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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