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Timo Nyyssönen, Iikka Lantto, Peter Lüthje, Tuomas Selander, Heikki Kröger
The incidence of Achilles tendon (AT) rupture, especially non-sport related rupture, is increasing, while the reasons for this increase are largely unknown. The association between AT rupture and the use of various drug treatments was studied. We collected AT rupture patients from the Finnish Hospital Discharge Register. We also acquired information about all the doctor-prescribed drugs they had purchased within one year before the rupture. For comparison, we randomly selected age- and sex-matched controls from the Finnish Population Register...
August 18, 2018: Scandinavian Journal of Medicine & Science in Sports
Juan Peris-Vicente, Jesús Javier Iborra Millet, Jaume Albiol-Chiva, Samuel Carda-Broch, Josep Esteve-Romero
BACKGROUND: Micellar liquid chromatography - fluorescence detection was used to determine the antibiotics flumequine, marbofloxacin, difloxacin and sarafloxacin in porcine, bovine, poultry, ovine, caprine, rabbit and equine meat, to verify their compliance with the EU Regulation 37/2010 about the occurrence of veterinary drugs in food. RESULTS: The analytes were isolated from matrix by ultrasonication-assisted leaching in a micellar solution, and the supernatant was filtered and directly injected...
August 17, 2018: Journal of the Science of Food and Agriculture
Zewu Zhu, Yu Cui, Feng Zeng, Yang Li, Zhiyong Chen, Chen Hequn
PURPOSE: To compare the efficiency and safety of suctioning ureteral access sheath (UAS) and traditional UAS during flexible ureteroscopy (FURS) for treatment of renal stones. METHODS: Between January 2015 and December 2017, 165 patients who had renal stones successfully underwent FURS with suctioning UAS created by connecting a channel on the tail of the suctioning UAS to a vacuum device. The outcomes of these patients were compared with those of 165 patients undergoing FURS with traditional UAS using a 1:1 scenario matched-pair analysis...
August 17, 2018: World Journal of Urology
Nadeem Muhammad, Abdul Rahman, Muhammad Adnan Younis, Qamar Subhani, Khurram Shehzad, Hairong Cui, Yan Zhu
Nowadays, there are rising concerns about the extensive use of the antibiotics such as chloramphenicol (CAP), has threatened the human life in the form of various vicious diseases. The limited selectivity and sensitivity of confirmatory techniques (UV and electrochemical) and non-fluorescence property of CAP make its determination a challenging task in the modern pharmaceutical analysis. In order to redeem the selective, sensitive and cost-effective fluorescence methodology, here by the dual role of synthesized porous SnO2 nanoparticles were exploited; (i) a porous sorbent in a µ-QuEChERS based sample preparation and as (ii) a stimulant for the transformation of non-fluorescent analytes namely CAP and p-nitrophenol (p-NP) into their respective fluorescent product...
August 17, 2018: Scientific Reports
Jenna Garlock, Leborah Lee, Michaelia Cucci, Lawrence A Frazee, Chanda Mullen
BACKGROUND: In the ED, patients are treated empirically for suspected gonorrhea and/or chlamydia (GC). Limited studies have evaluated the treatment of sexually transmitted diseases (STDs) in conjunction with predictor variables. This study will allow providers to better identify patients with potential GC to streamline antibiotic treatment. OBJECTIVES: The primary objective was to determine the incidence of positive assay in patients that underwent GC screening...
August 7, 2018: American Journal of Emergency Medicine
Karolien Termote, Aaron W Joe, Andrea L Butler, Martin McCarthy, Joseph M Blondeau, Alfonso Iovieno, Simon P Holland, Sonia N Yeung
OBJECTIVE: To report the epidemiology of culture-positive bacterial corneal ulcers in Vancouver, B.C., Canada. DESIGN: Retrospective, observational case series. METHODS: Predetermined search terms were entered into the hospitals' electronic microbiology databases to create a cohort of patients who had undergone corneal scrapings for ulcers from April 2006 to March 2011. All specimens were plated on culture media. Cultured species were identified, and antimicrobial sensitivities were obtained...
August 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Yeshambel Belyhun, Feleke Moges, Mengistu Endris, Banchamlak Asmare, Bemnet Amare, Damtew Bekele, Solomon Tesfaye, Martha Alemayehu, Fantahun Biadgelegne, Andargachew Mulu, Yared Assefa
OBJECTIVES: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. RESULTS: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections...
August 17, 2018: BMC Research Notes
Sidra Zafar, M A Rehman Siddiqui
BACKGROUND: Sub-retinal abscess as the presenting feature in the setting of endogenous fungal endophthalmitis is extremely infrequent. Immunodeficiency states are major predisposing risk factors. To the best of our knowledge, this is the first case report of Candida sub-retinal abscess as initial presentation in an immunocompetent patient. CASE PRESENTATION: A 32-year old, generally fit and well, female presented to us with gradually deteriorating vision in her right eye...
August 17, 2018: BMC Research Notes
Sujittra Taratummarat, Naunpun Sangphech, Chau Tran Bao Vu, Tanapat Palaga, Thunnicha Ondee, Saowapha Surawut, Amornpun Sereemaspun, Patcharee Ritprajak, Asada Leelahavanichkul
BACKGROUND: Gold nanoparticles (AuNP) have several biochemical advantageous properties especially for a candidate of drug carrier. However, the non-conjugated AuNP has a higher rate of cellular uptake than the conjugated ones. Spherical AuNP in a proper size (20-30 nm) is non-toxic to mice and shows anti-inflammatory properties. We tested if the administration of AuNP, as an adjuvant to antibiotics, could attenuate bacterial sepsis in cecal ligation and puncture (CLP) mouse model with antibiotic (imipenem/cilastatin)...
August 17, 2018: BMC Microbiology
Amine Ezzariai, David Riboul, Marlène Z Lacroix, Maialen Barret, Loubna El Fels, Georges Merlina, Alain Bousquet-Melou, Dominique Patureau, Eric Pinelli, Mohamed Hafidi
In this work a fast analytical method for the determination of macrolides, tetracyclines and fluoroquinolones in a compost originating from a mixture of sewage sludge, palm waste and grass was developed by ultra-high performance liquid chromatography coupled to mass spectrometry (U-HPLC/MS). Antibiotics were extracted from compost by using the accelerated solvent extraction (ASE). The chromatographic separation was carried out on a T3 Cortecs C18 column using a mobile phase gradient mixture of water acidified with 1% of formic acid and acetonitrile...
August 7, 2018: Chemosphere
Benjamin M Althouse, Stefan Flasche, Le Nhat Minh, Vu Dinh Thiem, Masahiro Hashizume, Koya Ariyoshi, Dang Duc Anh, Gail L Rodgers, Keith P Klugman, Hao Hu, Lay-Myint Yoshida
BACKGROUND: Acute respiratory infections (ARIs) are the most common causes of death in children under 5 years of age. While the etiology of most pneumonia and ARI episodes is undiagnosed, a broad range of ARI-causing viruses circulate widely in South East Asia. However, the patterns and drivers of the seasonal transmission dynamics are largely unknown. Here we identify the seasonal patterns of multiple circulating viruses associated with hospitalizations for ARIs in Nha Trang, Vietnam...
August 14, 2018: International Journal of Infectious Diseases: IJID
Mairéad C Connor, John W McGrath, Geoff McMullan, Nikki Marks, Derek J Fairley
Clostridium difficile is a spore forming bacterium and the leading cause of colitis and antibiotic associated diarrhoea in the developed world. Effective recovery of spores, particularly in low numbers, is imperative to obtain accurate prevalence data, due to the low number of spores found within non-clinical samples (<20/ml). Through comparison of C. difficile enrichment media, this study showed the importance of selecting an effective enrichment media. Commonly used broths, such as Cooked Meat broth, promote significantly less growth than other available broths such as Brain Heart Infusion broth, BHI...
August 14, 2018: Anaerobe
Saber Yezli, Yara Yassin, Abdulaziz Mushi, Fuad Maashi, Nibras Aljabri, Gamal Mohamed, Kingsley Bieh, Awam Awam, Badriah Alotaibi
BACKGROUND: Overuse and misuse of antibiotics have been reported in Hajj. However, little is known about Knowledge, Attitude and Practice (KAP) of pilgrims themselves in relation to these agents. METHODS: Adult pilgrims from seven countries attending the 2015 Hajj were interviewed using a structured KAP questionnaire. RESULTS: KAP information was collected from 1476 pilgrims. Misconceptions regarding antibiotics included that they: cure all diseases (24...
August 14, 2018: Travel Medicine and Infectious Disease
Nina Bono, Chiara Pennetta, Aurora Sganappa, Elisa Giupponi, Francesco Sansone, Alessandro Volonterio, Gabriele Candiani
A promising strategy to design safer and more effective cationic lipids for gene delivery with inherent antibacterial properties is to covalently tether a lipophilic moiety with oligomeric aminoglycosides (AGs), a large family of Gram-negative-active antibiotics. Herein, we reported the development of a new class of multicationic-head AG-based amphiphiles built on the tetramino-tetrahexyloxycalix[4]arene (4A4Hex-calix-calix[4]) scaffold. Three different conjugates, namely 4A4Hex-calix-calix[4]-neomycin, -neamine, and -paromomycin, were synthesized and characterized...
August 14, 2018: International Journal of Pharmaceutics
Hadis Tavafi, Ahya Abdi Ali, Parinaz Ghadam, Sara Gharavi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen and utilizes several virulence factors for pathogenesis. One of the most important factors is alginate, found in the biofilm which enables P. aeruginosa to establish chronic lung infections. MATERIALS AND METHODS: In this study, 25 clinical alginate-degrading isolates were selected. Biochemical and molecular approach were carried out to identify the isolates by 16S rDNA gene amplification. Growth conditions and enzyme production were the criteria for selection...
August 14, 2018: Microbial Pathogenesis
Praveen Rishi, Shania Vij, Indresh Kumar Maurya, Ujjwal Jit Kaur, Sanjay Bharati, Rupinder Tewari
Fast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the present study, potential of peptides having distinct mechanism of action, if any, was evaluated to improve the efficacy of conventional antibiotics against methicillin-resistant S. aureus (MRSA). After primary screening of six peptides, two peptides namely T3 and T4 showing very high minimum inhibitory concentrations (MICs) were selected to assess their role in altering the MICs of antibiotics to which the pathogen was resistant...
August 14, 2018: Microbial Pathogenesis
Aaron B Caughey, Stephen L Wood, George A Macones, Ian J Wrench, Jeffrey Huang, Mikael Norman, Karin Pettersson, William J Fawcett, Medhat M Shalabi, Amy Metcalfe, Leah Gramlich, Gregg Nelson, R Douglas Wilson
OBJECTIVE: This ERAS Guideline for intraoperative care in Cesarean Delivery (CD) will provide best practice, evidenced-based, recommendations for intra-operative care with primarily, a maternal focus. The 'focused' pathway process for scheduled and unscheduled CD, for this ERAS CD guideline will consider, from decision to operate (starting with the 30 - 60 minutes prior to skin incision) through the conduct of the surgery. METHODS: The literature search (1966-2017) used Embase and PubMed to search medical subject headings including "Cesarean Section", "Cesarean Section", "Cesarean Section Delivery" and all pre- and intra-operative ERAS® items...
August 14, 2018: American Journal of Obstetrics and Gynecology
Emily Marsh, Sylvia M Verhoven, Joseph J Groszek, William H Fissell, Guohua An, Pratish Patel, Buddy Creech, Matthew Shotwell
BACKGROUND: Therapeutic drug monitoring is used for aminoglycosides and vancomycin, and has been proposed for β-lactam antibiotics. Clinical blood samples in the ICU are often obtained via an existing vascular catheter rather than fresh needle phlebotomy. If antibiotics had previously been infused through a vascular catheter then used for blood sampling, carryover of antibiotic from the infusion to the sample might result in misleading assessments of target attainment. To address this concern we conducted a series of in vitro measurements of carryover for three commonly used antibiotics...
August 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
David A Dougan, Ingo Hantke, Kürşad Turgay
In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
August 16, 2018: Cell Chemical Biology
Duygu Gulmez Sevim, Metin Unlu, Cagatay Karaca, Kuddusi Erkilic
A 53-year-old woman with hemiparesis and poor dexterity, underwent cosmetic blepharopigmentation on the both upper eyelids in the dermatology clinic of a private hospital. She was not asked for any information on her medical history and no informed consent was obtained and the procedure was performed without any protective ocular shields. The patient experienced severe lacrimation, discomfort, and increased sensitivity to light during and after the procedure. She also noticed blurred vision after the procedure...
August 17, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
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