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Coeliac disease

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https://www.readbyqxmd.com/read/28627089/analysis-of-ptpn22-zfat-and-myo9b-polymorphisms-in-turner-syndrome-and-risk-of-autoimmune-disease
#1
E Villanueva-Ortega, B Ahedo, M A Fonseca-Sánchez, J Pérez-Durán, N Garibay-Nieto, M T Macías-Galavíz, Y Trujillo-Cabrera, E García-Latorre, G Queipo
Turner syndrome (TS) is one of the most common sexual chromosome abnormalities and is clearly associated with an increased risk of autoimmune diseases, particularly thyroid disease and coeliac disease (CD). Single-nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are associated with autoimmune disease. Our aim was to study the functional polymorphic variants of PTPN22 and ZFAT in relation to thyroid disease and those of MYO9B in relation to CD. A cross-sectional comparative analysis was performed on Mexican mestizo patients with TS and age-matched healthy females...
June 18, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28627070/lack-of-immunogenicity-of-hydrolysed-wheat-flour-in-patients-with-coeliac-disease-after-a-short-term-oral-challenge
#2
R Mandile, S Picascia, C Parrella, A Camarca, M Gobbetti, L Greco, R Troncone, C Gianfrani, R Auricchio
BACKGROUND: A gluten-free diet is currently the only reliable therapeutic strategy that is approved for coeliac disease (CD). For many patients, however, compliance remains inadequate. AIM: To investigate the immunogenicity of wheat flour that was pre-treated with selected lactobacilli and fungal proteases (hydrolysed wheat gluten) in coeliac patients. METHODS: The immunogenicity of hydrolysed wheat gluten was evaluated both in vitro in intestinal T cell lines (TCLs) and in vivo in treated CD patients after a short-term gluten challenge...
June 19, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28625740/comparative-proteomic-analysis-of-two-transgenic-low-gliadin-wheat-lines-and-non-transgenic-wheat-control
#3
María Dolores García-Molina, Vera Muccilli, Rosaria Saletti, Salvatore Foti, Stefania Masci, Francisco Barro
Gluten proteins are major determinants of the bread making quality of wheat, but also of important wheat-related disorders, including coeliac disease (CD), and allergies. We carried out a proteomic study using the total grain proteins from two low-gliadin wheat lines, obtained by RNAi, and the untransformed wild type as reference. The impact of silencing on both target and on non-target proteins was evaluated. Because of the great protein complexity, we performed separate analyses of four kernel protein fractions: gliadins and glutenin subunits, and metabolic and CM-like proteins, by using a classical 2D electrophoresis gel based approach followed by RP-HPLC/nESI-MS/MS...
June 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28619356/operative-and-one-year-outcomes-of-the-custom-made-fenestrated-anaconda%C3%A2-aortic-stent-graft-a-uk-multicentre-study
#4
Frances E Colgan, Peter M Bungay, Nicholas Burfitt, Andrew Hatrick, Michael J Clarke, Alun H Davies, Michael Jenkins, David Gerrard, John W Quarmby, Robin Williams
OBJECTIVES: Early and one year outcomes are presented for fenestrated endovascular aneurysm repair (FEVAR) of complex aortic aneurysmal disease with the custom-made Anaconda fenestrated stent graft in 101 patients. METHODS: Retrospective site-reported data from the first 101 elective cases (2010 to 2014) from four UK centres was studied to evaluate patient demographics, aneurysm morphology, clinical success and one year outcomes in patients undergoing fenestrated aneurysm repair with the custom-made Anaconda device...
June 12, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28611068/early-growth-in-children-with-coeliac-disease-a-cohort-study
#5
Christian R Kahrs, Maria C Magnus, Hein Stigum, Knut E A Lundin, Ketil Størdal
OBJECTIVES: We aimed to study growth during the first 2 years of life in children later diagnosed with coeliac disease compared with children without, in a time with changing epidemiology and improved diagnostics. DESIGN: A prospective population-based pregnancy cohort study. SETTING: The nationwide Norwegian Mother and Child Cohort Study. PATIENTS: 58 675 children born between 2000 and 2009 with prospectively collected growth data...
June 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28611066/should-patients-with-coeliac-disease-pay-for-their-treatment
#6
EDITORIAL
John W Puntis, Mark Peter Tighe
No abstract text is available yet for this article.
June 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28606713/rhabdomyolysis-and-coeliac-disease-a-causal-or-casual-association-a-case-report-and-review-of-literature
#7
Claudia Mandato, Alessandro Rossi, Mariano Caldore, Marta Lamba, Michele Rocco, Renata Auricchio, Pietro Vajro, Paolo Siani
BACKGROUND: Rhabdomyolysis is a rare, potentially life-threatening condition, caused by multiple disorders. The association with Coeliac Disease (CD) has been rarely reported and in these cases muscular damage was imputed to hypokalemia. Herein we describe a new case of severe rhabdomyolysis in a child subsequently diagnosed as affected by CD, and review previous reports. CASE PRESENTATION: A 3-year-old boy was referred for diarrhea, brown urine, muscular pain/weakness, and no history of muscular trauma...
June 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28598778/uncommon-presentation-of-granulomatosis-with-polyangiitis-in-association-with-subclinical-coeliac-disease
#8
Paraskevi V Voulgari, Fotini Apostolou, Evangelia Dounousi, George Liapis, Moises Elisaf, Alexandros A Drosos
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June 9, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28589593/editorial-repeat-duodenal-biopsy-for-patients-with-coeliac-disease-physician-heal-thyself-and-dietitian-heal-the-patient
#9
EDITORIAL
N Trott, M Kurien, D S Sanders
No abstract text is available yet for this article.
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28582825/awareness-of-coeliac-disease-among-chefs-and-cooks-depends-on-the-level-and-place-of-training
#10
Michael Schultz, Seong Shin, Kirsten J Coppell
BACKGROUND AND OBJECTIVES: Coeliac disease is triggered by gluten. The only treatment is lifelong avoidance of dietary gluten. Dining out and travelling are particular challenges with a huge impact on quality of life. We examined the knowledge about coeliac disease and gluten-free food preparation among chefs and cooks, and culinary students in Dunedin, New Zealand. METHODS AND STUDY DESIGN: Outlets serving gluten-free food were identified. The head chefs or cooks were invited to complete a questionnaire regarding demographics, education, qualification, experience and knowledge of coeliac disease and gluten-free food preparation...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28581364/positron-emission-tomography-computed-tomography-features-of-monomorphic-epitheliotropic-intestinal-t-cell-lymphoma
#11
Thomas S Y Chan, Elaine Lee, Pek-Lan Khong, Eric W C Tse, Yok-Lam Kwong
OBJECTIVE: To define the positron emission tomography/computed tomography (PET/CT) features of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), a rare malignancy in European and North American populations and the most common form of primary intestinal T-cell lymphoma in Asian populations. METHODS: (18)F-fluorodeoxyglucose (FDG) PET/CT findings of a cohort of MEITL patients were retrospectively analyzed. RESULTS: Eight men and four women with MEITL investigated by PET/CT at diagnosis and relapse were retrospectively analyzed...
June 5, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28572752/chronic-alcohol-overconsumption-may-alter-gut-microbial-metabolism-a-retrospective-study-of-719-13-c-d-xylose-breath-test-results
#12
Steinar Traae Bjørkhaug, Viggo Skar, Asle W Medhus, Anita Tollisen, Jørgen G Bramness, Jørgen Valeur
Objective: Alterations of gut microbiota composition or function may participate in the pathophysiology of several diseases. We aimed to explore the effect of chronic alcohol overconsumption on gut microbial metabolism, as assessed by evaluating (13)C-D-xylose breath test results. Materials and methods: We investigated all (13)C-D-xylose breath tests performed at Lovisenberg Diaconal Hospital during the years 2005 to 2011, using patient files for diagnosing the patients into one of three patient categories: alcohol overconsumption, coeliac disease and functional bowel disorder...
2017: Microbial Ecology in Health and Disease
https://www.readbyqxmd.com/read/28567377/coeliac-disease-and-the-videocapsule-what-have-we-learned-till-now
#13
REVIEW
Edward J Ciaccio, Suzanne K Lewis, Govind Bhagat, Peter H Green
Celiac disease is diagnosed in part by finding areas of pathology in the small bowel (SB) mucosa. This can often be difficult because the pathologic alterations, including atrophy of the small intestinal villi, can often be sparse and subtle. Some of the quantitative methods for detecting and measuring the presence of villous atrophy from videocapsule endoscopy (VCE) images are presented and discussed. These methods consist of static features of measurement including texture, gray level, and presence and abundance of fissures contained within each acquired image...
May 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28567117/commercially-available-glutenases-a-potential-hazard-in-coeliac-disease
#14
Suneeta Krishnareddy, Kenneth Stier, Maya Recanati, Benjamin Lebwohl, Peter Hr Green
BACKGROUND: The only treatment for celiac disease (CD) is a gluten-free diet (GFD). However, there is interest among patients in a medical therapy to replace or help with a GFD. Therapies include gluten-degrading enzymes (glutenases). There are glutenases available marketed as dietary supplements that have not been demonstrated to digest the toxic epitopes of gluten. METHODS: We investigated the contents, claims, and disclaimers of glutenase products and assessed patient interest using Google AdWords to obtain Google search frequencies...
June 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28554285/gluten-free-food
#15
(no author information available yet)
Staple gluten-free (GF) foods have been available on prescription to patients diagnosed with gluten sensitivity enteropathies, such as coeliac disease, since the late 1960s.
May 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28553923/-gluten-free-diet-is-for-some-a-necessity-for-others-a-lifestyle
#16
Iben Møller Jønsson, Gitte Leth Møller, Anders Pærregaard
This review provides a brief overview of the gluten-related conditions coeliac disease (CD), wheat allergy (WA), and non-coeliac gluten sensitivity (NCGS). NCGS is a new entity which includes individuals who report symptoms when exposed to gluten and benefit from gluten-free diet, but do not have CD or WA. The concept NCGS is still controversial and a subject of considerable overdiagnosis, and consensus regarding diagnostic criteria is lacking. Furthermore, the overlap with irritable bowel syndrome is unsettled...
May 29, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28551252/food-for-thought-selecting-the-right-enzyme-for-the-digestion-of-gluten
#17
Michelle L Colgrave, Keren Byrne, Crispin A Howitt
Gluten describes a complex mixture of proteins found in wheat, rye, barley and oats that pose a health risk to people affected by conditions such as coeliac disease and non-coeliac gluten sensitivity. Complete digestion of gluten proteins is of critical importance during quantitative analysis. To this end, chymotrypsin was investigated for its ability to efficiently and reproducibly digest specific classes of gluten in barley. Using proteomics a chymotryptic peptide marker panel was elucidated and subjected to relative quantification using LC-MRM-MS...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28532727/experiences-and-own-management-regarding-residual-symptoms-among-people-with-coeliac-disease
#18
Lisa Ring Jacobsson, Anna Milberg, Katarina Hjelm, Maria Friedrichsen
CONTEXT: Between 7% and 30% of people with treated coeliac disease suffer from residual symptoms, and there is a knowledge gap about their own management of these symptoms. AIM: To explore experiences and management concerning residual symptoms despite a gluten-free diet in people with coeliac disease. METHODS: A qualitative explorative design with semi-structured interviews with 22 adults with coeliac disease in Sweden. Data were analysed using qualitative content analysis...
June 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28512643/diagnostic-and-research-aspects-of-small-intestinal-disaccharidases-in-coeliac-disease
#19
REVIEW
Tanja Šuligoj, Paul J Ciclitira, Borut Božič
Disaccharidases (DS) are brush border enzymes embedded in the microvillous membrane of small intestinal enterocytes. In untreated coeliac disease (CD), a general decrease of DS activities is seen. This manuscript reviews different aspects of DS activities in CD: their utility in the diagnosis and their application to in vitro toxicity testing. The latter has never been established in CD research. However, with the recent advances in small intestinal organoid techniques, DS might be employed as a biomarker for in vitro studies...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28511881/-what-medication-should-be-prescribed-to-a-patient-with-coeliac-disease
#20
C Pérez-Diez, S Guillén-Lorente, P Palomo-Palomo
Coeliac disease is a permanent intolerance to gluten proteins from wheat, rye, barley and triticale. Although strict adherence is complicated, the only effective treatment is a gluten-free diet throughout life. Some drugs contain starch as an excipient, and there is a risk related to the gluten content, which must be avoided in these patients. Current legislation requires the analysis of the protein content of wheat starch, or the absence of starches from another source where rice, maize, or potato starches are used as excipients...
May 13, 2017: Semergen
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