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Coeliac disease

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https://www.readbyqxmd.com/read/29339317/arterial-stenosis-in-antiphospholipid-syndrome-update-on-the-unrevealed-mechanisms-of-an-endothelial-disease
#1
REVIEW
Ghita Harifi, Wared Nour-Eldine, Mohammad Hassan A Noureldine, Mohammad Baker Berjaoui, Romy Kallas, Rita Khoury, Imad Uthman, Jamal Al-Saleh, Munther A Khamashta
First described in 1983, antiphospholipid syndrome (APS) is an autoimmune condition characterized by the occurrence of recurrent arterial and/or venous thrombosis, and/or pregnancy morbidity, in the setting of persistent presence of antiphospholipid antibodies (aPL). While thrombosis is the most well-known pathogenic mechanism in this disorder, the relevance of some other mechanisms such as arterial stenosis is being increasingly recognized. Arterial stenosis has been first described in the renal arteries in patients with APS, however intracranial and coeliac arteries can also be involved with various and treatable clinical manifestations...
January 12, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29325751/a-difficult-diagnosis-of-coeliac-disease-repeat-duodenal-histology-increases-diagnostic-yield-in-patients-with-concomitant-causes-of-villous-atrophy
#2
Gaetano Cristian Morreale, Luigi Maria Montalbano, Maria Cappello, Emanuele Sinagra, Aroldo Rizzo, Antonio Carroccio
Villous atrophy in absence of coeliac disease (CD)-specific antibodies represents a diagnostic dilemma. We report a case of a woman with anaemia, weight loss and diarrhoea with an initial diagnosis of seronegative CD and a histological documented villous atrophy who did not improve on gluten-free diet due to the concomitant presence of common variable immunodeficiency (CVID) and Giardia lamblia infection. This case report confirms that CD diagnosis in CVID patients is difficult; the combination of anti-endomysial antibodies (EmA-IgA), anti-tissue transglutaminase antibodies (tTG-IgAb) antibodies and total IgA is obligatory in basic diagnostic of CD but in CVID are negative...
January 8, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29322540/review-article-coeliac-disease-in-later-life-must-not-be-missed
#3
REVIEW
P Collin, A Vilppula, L Luostarinen, G K T Holmes, K Kaukinen
BACKGROUND: The presenting symptoms of coeliac disease are often subtle and the diagnosis is frequently delayed or overlooked. Therefore, especially elderly patients may be denied the benefits conferred by gluten free diet which can be dramatically life-changing. AIM: To review the occurrence, clinical features, diagnosis and management in coeliac patients detected later in life. METHODS: To review manuscripts concerned with coeliac disease in the elderly and to derive subgroups of elderly people from publications on the disorder...
January 11, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29317440/anorexia-coeliac-and-autoimmune-disease
#4
(no author information available yet)
No abstract text is available yet for this article.
January 9, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29315354/implications-of-guidelines-for-osteoporosis-and-its-treatment
#5
Stephen Tuck, Elizabeth A Little, Terry J Aspray
The development of clinical guidelines is now a more uniform process, with formalised methods to ensure that recommendations are based on current best available evidence from randomised controlled trials and systematic reviews. Over the past 20 years we have seen a growth in guidelines including those relating to osteoporosis, with recommendations varying between and within countries. Some guidelines are concerned with case finding and primary or secondary prevention, such as those produced by the National Institute for Health and Care Excellence (NICE CG146, TA-160, -161, -464), while others focus on specific conditions or risk factors associated with osteoporosis, such as the menopause, coeliac disease and eating disorder...
January 5, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29301808/skin-and-coeliac-disease-a-lot-to-think-about-a-case-series
#6
Sara O Vaz, Catarina Franco, Patrícia Santos, Raquel Amaral
Coeliac disease (CD) is an autoimmune disease, characterised by a permanent sensitivity to gluten. It is being progressively recognised as a multisystemic disease, with multiple extraintestinal manifestations. Skin conditions (eg, dermatitis herpetiformis) are an example of its manifestations; however, its underlying mechanisms are still not well understood. This article presents three cases of uncommon skin conditions in patients with a history of CD. Two of them concern linear IgA bullous dermatosis and erythema nodosum, which have been described in the literature as having potential associations with CD, though only a few cases were reported...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29277903/impact-of-food-processing-and-simulated-gastro-intestinal-digestion-on-gliadin-immunoreactivity-in-rolls
#7
Bartosz Brzozowski
BACKGROUND: Enzymatic modification of wheat proteins during dough fermentation, and its digestion supported by peptidases of microbiological origin can cause degradation of important peptides in the pathogenesis of coeliac disease. However, baking bread and the high temperature associated with could change a physicochemical and immunological properties of proteins. Thermal changes in spatial structure of proteins and its hydrolysis can lead to masking or degrading immunoreactive peptides...
December 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29277481/risk-of-complications-in-coeliac-patients-depends-on-age-at-diagnosis-and-type-of-clinical-presentation
#8
Federico Biagi, Annalisa Schiepatti, Gregorio Maiorano, Giacomo Fraternale, Simona Agazzi, Fabiana Zingone, Carolina Ciacci, Umberto Volta, Giacomo Caio, Raffaella Tortora, Catherine Klersy, Gino R Corazza
BACKGROUND: Coeliac disease is characterised by an increased mortality mostly due to its complications. AIMS: To study the risk of developing complications according to clinical presentation and age at diagnosis, a combined retrospective-prospective longitudinal study was performed in three Italian centres. METHODS: Incidence of complications and mortality rates were calculated using type and age at diagnosis of coeliac disease, sex, and centre of diagnosis as predictors...
December 8, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29238414/oral-manifestations-in-pediatric-patients-with-coeliac-disease-a-review-article
#9
Viviana Marisa Pereira Macho, Ana Sofia Coelho, Diana Maria Veloso E Silva, David José Casimiro de Andrade
Background: Coeliac disease is a chronic enteropathy that remains a challenge for the clinician, due to its atypical manifestations and etiopathogenic complexity. Objective: This article intends to describe the oral characteristics of Coeliac Disease in children in order to facilitate their management in the dental office. Methods: A review of the literature was performed electronically in PubMed (PubMed Central, and MEDLINE) for articles published in English from 2000 to April of 2017...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/29226189/night-sweats-stress-activation-and-coeliac-disease
#10
Dimitrios Cassimos, Katerina Kambouri, Antigoni Mavroudi, Ioannis Xinias, Stavros Thomaidis, Maria Aggelidou, Stefanos Gardikis, Athanasios Chatzimichael
No abstract text is available yet for this article.
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29204673/the-role-of-autoantibodies-in-bone-metabolism-and-bone-loss
#11
REVIEW
Barbara Hauser, Ulrike Harre
Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells...
December 4, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29182792/ex-vivo-culture-of-duodenal-biopsies-from-patients-with-dermatitis-herpetiformis-indicates-that-transglutaminase-3-antibody-production-occurs-in-the-gut
#12
Minna Hietikko, Kaisa Hervonen, Tuire Ilus, Teea Salmi, Heini Huhtala, Kaija Laurila, Tiina Rauhavirta, Timo Reunala, Katri Kaukinen, Katri Lindfors
Coeliac disease and dermatitis herpetiformis (DH) are characterized by autoantibodies targeting transglutaminase (TG)2 and TG3, respectively. Previous studies show that TG2 antibodies are produced in the gut and can be assessed in organ culture of small-intestinal biopsies from patients with coeliac disease. Thus far, no studies have investigated TG3 antibodies in organ culture of biopsies from patients with DH, or exploited the method in DH. The aim of this study was to investigate TG3 and TG2 antibody responses in serum and small-intestinal biopsies from patients with DH with active disease, and from those in remission...
November 28, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29176473/shifting-practice-in-the-diagnosis-of-paediatric-coeliac-disease-in-english-district-general-hospitals
#13
Chai Leng Lee, Morris Gordon
No abstract text is available yet for this article.
November 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29141505/serum-zinc-copper-and-iron-status-of-children-with-coeliac-disease-on-three-months-of-gluten-free-diet-with-or-without-four-weeks-of-zinc-supplements-a-randomised-controlled-trial
#14
K Negi, R Kumar, L Sharma, S P Datta, M Choudhury, P Kumar
Data about the effect of zinc supplementation with gluten-free diet on normalisation of plasma zinc, copper and iron in patients with coeliac disease are scanty. We evaluated the effect of zinc supplementation on serum zinc, copper and iron levels in patients with coeliac disease, by randomising 71 children newly diagnosed with coeliac disease into two groups: Group A = gluten-free diet (GFD); and Group B = gluten-free diet with zinc supplements (GFD +Zn). The rise in iron and zinc was significantly higher in the latter, but the mean rise of copper levels was slightly higher in the former, but the difference was not significant...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29139480/position-paper-the-potential-role-of-optical-biopsy-in-the-study-and-diagnosis-of-environmental-enteric-dysfunction
#15
REVIEW
Alex J Thompson, Michael Hughes, Salzitsa Anastasova, Laurie S Conklin, Tudor Thomas, Cadman Leggett, William A Faubion, Thomas J Miller, Peter Delaney, François Lacombe, Sacha Loiseau, Alexander Meining, Rebecca Richards-Kortum, Guillermo J Tearney, Paul Kelly, Guang-Zhong Yang
Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology...
December 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29127130/eosinophilic-oesophagitis-and-coeliac-disease-is-there-an-association
#16
Ana Margarida Vaz, Antonio Jesus Cadilla, Diamantino Sousa, Horácio Guerreiro
A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29118688/a-tale-of-two-lymphomas
#17
Vikrant Parihar, Paul Crotty, Deidre McNamara
We present a patient with coeliac disease who developed refractory coeliac disease II, which was complicated by the development of metachronous lymphomas.
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29114847/intestinal-anti-transglutaminase-2-immunoglobulin-a-deposits-in-children-at-risk-for-coeliac-disease-cd-data-from-the-preventcd-study
#18
M Borrelli, M Maglio, I R Korponay-Szabó, V Vass, M L Mearin, C Meijer, H Niv-Drori, C Ribes-Koninckx, M Roca, R Shamir, R Troncone, R Auricchio
In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin (Ig)A antibodies (anti-TG2) are produced and deposited in the intestine. PreventCD (www.preventcd.com) is a European multi-centre study, which investigates the influence of infant nutrition and that of genetic, immunological and other environmental factors on the risk of developing CD. The aim of the current study was to evaluate the appearance of intestinal anti-TG2 deposits in very early intestinal biopsies from at-risk infants and their predictive value for villous atrophy...
November 8, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29113008/-drug-therapy-in-coeliac-disease-from-bench-to-bedside
#19
Jürgen Stein, Jörg-Dieter Schulzke, Detlef Schuppan
Coeliac disease is one of the most common diseases worldwide, with an estimated global prevalence of 0.5 - 1 %. The disease is triggered by a combination of environmental (gluten proteins from wheat, rye or barley) and genetic factors (mainly the human leucocyte antigens HLA-DQ2 or -DQ8). At present, a strict gluten-free diet (GFD) represents the only treatment option. However, strict adherence to a GFD is challenging, since even highly motivated patients may be subject to inadvertent or background exposure to gluten...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29105146/the-effect-of-the-gluten-free-diet-on-cardiovascular-risk-factors-in-patients-with-coeliac-disease-a-systematic-review
#20
M D E Potter, S C Brienesse, M M Walker, A Boyle, N J Talley
INTRODUCTION: A gluten free diet (GFD), the mainstay of treatment for celiac disease, is being increasingly adopted by people without this condition. The long-term health effects of this diet, apart from its beneficial effect on enteropathy in celiac disease, are unclear. Concerns exist that the GFD may result in micronutrient deficiencies, increased exposure to toxins such as arsenic, and an increased cardiovascular risk. This systematic review addresses the effect of the GFD on several modifiable cardiovascular risk factors...
November 4, 2017: Journal of Gastroenterology and Hepatology
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