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Lai San Wong, Yi-Chien Yang
No abstract text is available yet for this article.
November 2018: Indian Journal of Dermatology
Daniel Grace, Mark Gaspar, Rachelle Paquette, Ron Rosenes, Ann N Burchell, Troy Grennan, Irving E Salit
The human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Gay, bisexual, and other men who have sex with men (GBM) living with HIV are disproportionately impacted by HPV-associated anal cancer, with rates about 100-fold that of the general population. Fortunately, HPV vaccination has proven efficacy in preventing both anogenital warts (condyloma) in males and anal pre-cancers (anal intraepithelial neoplasia; AIN) in GBM up to the age of 26. We conducted in-depth, semi-structured interviews with 25 HIV-positive gay men in Toronto to gain an understanding of their knowledge and experiences related to HPV and the HPV vaccine...
2018: PloS One
Halle E Foss, Jacqueline J Blank, Sarah J Lundeen, Carrie Y Peterson, Kirk A Ludwig, Timothy J Ridolfi
BACKGROUND: Human papillomavirus is a common sexually transmitted infection that may affect the oropharynx, genitalia, or anus. Some strains of this virus may cause bulky growths around the anus known as giant anal condylomas. These can become large, disfiguring, and may cause bleeding, as well as difficulty with defecation and hygiene. Surgical management is usually necessary for large condylomas, whereas office-based procedures are common for smaller lesions. It is unclear why some develop large anal margin tumors, whereas others develop limited disease...
December 2018: Journal of Surgical Research
Jiajia Xie, Chunping Ao, Junpeng Li, Lifen Jiang, Hui Liu, Kang Zeng
Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infections. Urethral meatus warts are uncommon. And many treatments are limited by a difficult approach, recurrences, and potential complications. In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4h treatment of 5-aminolevulinic acid (ALA), patients received photodynamic therapy (PDT). Each patient received HPV test before every PDT cycle...
November 14, 2018: Journal of Dermatological Treatment
Stephen K Tyring, Theodore Rosen, Brian Berman, Nathan Stasko, Todd Durham, Tomoko Maeda-Chubachi
BACKGROUND: Nitric oxide (NO), a free radical gas, is endogenously produced in human cells. In high concentration, NO neutralizes many disease-causing microbes. The topical investigational drug SB206 releases NO and has the potential to treat skin diseases caused by viruses. Genital warts (condyloma acuminata) are primarily caused by human papillomavirus (HPV) types 6 and 11. Available treatments have low tolerability and efficacy rates and are inconvenient for the patient. Genital warts can recur if HPV is incompletely eradicated during treatment...
October 1, 2018: Journal of Drugs in Dermatology: JDD
Tina Hsu, Zachary P Nahmias, Ilana S Rosman, David Sheinbein
No abstract text is available yet for this article.
October 2018: JAAD Case Reports
Matthew Hum, Eunice Chow, Nan Schuurmans, Marlene Dytoc
Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. The patient, a 66-year-old female, was referred to Dermatology for large protruding verrucous plaques that covered the entire surface of her external vulva, perineum and perianal area. These lesions developed after being treated for genital warts with cantharidin...
2018: SAGE Open Medical Case Reports
Xianmin Meng, Yongguo Li, Hong Luan, Xiuyan Shi
Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum (CA) was investigated to explore its effect on immune function. A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon α-2b cream. Clinical efficacy and immune function related indicators were compared between the two groups...
November 2018: Experimental and Therapeutic Medicine
Morena Burati, Marco Chiarelli, Sabina Terragni, Fulvio Tagliabue, Lorenzo Ripamonti, Matteo Maternini, Angelo Guttadauro
Giant condyloma acuminatum (GCA) is a rare cauliflower-like lesion, also known as Buschke-L ewenstein tumor (BLT). Although characterized by benign histological features, the local behavior of GCA is extremely aggressive, showing progressive infiltration of the surrounding structures leading to tissue destruction by compression. As the correlation between HPV and GCA development grew stronger, the majority of the Authors came to the conclusion that HPV can not only cause CA but, associated with particular risk factors, it can lead to much more serious conditions such as BLT...
2018: Annali Italiani di Chirurgia
I Hamano, S Hatakeyama, H Yamamoto, T Fujita, R Murakami, M Shimada, A Imai, T Yoneyama, T Yoneyama, Y Hashimoto, T Koie, S Narumi, H Saitoh, T Suzuki, H Tomita, C Ohyama
BACKGROUND: Condyloma acuminatum (CA) is a common sexually transmitted disease associated with human papilloma virus (HPV). CA occurring in the urethra is rare and has not been reported in male renal transplant recipients. In addition, despite immunosuppressive conditions and increased risk of HPV-related malignant neoplasms in transplant recipients, HPV testing in male transplant recipients has been uncommon. Here we report a case of urethral CA in a male deceased donor renal transplantation recipient and discuss the importance of HPV testing in male transplant recipients...
October 2018: Transplantation Proceedings
Martina Z Liu, Yin P Hung, Eric C Huang, Brooke E Howitt, Marisa R Nucci, Christopher P Crum
Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections-3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion-that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma...
October 11, 2018: International Journal of Gynecological Pathology
MeiNian Xu, NaiYu Lin, JunPeng Li, LiFen Jiang, Kang Zeng
No abstract text is available yet for this article.
September 20, 2018: Photodiagnosis and Photodynamic Therapy
Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Ruan
The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell proliferation and apoptosis, to determine a novel therapeutic target for CA recurrence. RT-qPCR was used to validate the lower expression of miR-143 and miR-145 in a larger size of CA samples, and the expression of NRAS in CA samples was significantly higher than self-controls as determined by western blotting assay...
August 2018: Royal Society Open Science
Chunping Ao, Jiajia Xie, Li Wang, Songshan Li, Junpeng Li, Lifen Jiang, Hui Liu, Kang Zeng
BACKGROUND: Anal canal condyloma acuminata are common, sexually transmitted lesions, most often caused by the human papillomavirus. The relatively high recurrence rate of anal canal condyloma acuminata can be attributed to the unsuccessful elimination of viruses in areas of subclinical and latent infection. This study aimed to observe and evaluate the effectiveness of 5-aminolevulinic acid-photodynamic therapy combined with monitoring of human papillomavirus load changes in patients with anal canal condyloma acuminata...
September 2018: Photodiagnosis and Photodynamic Therapy
A Kelati, A Khemis, H Montaudié, J-P Lacour, T Passeron
No abstract text is available yet for this article.
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Nichola Haddad, Rebecca H Allen, Daria Szkwarko, Michelle Forcier, Cherie Paquette
Human papillomavirus (HPV) is a sexually transmitted infection (STI) causing nearly all cases of cervical carcinoma and genital condyloma worldwide. While HPV vaccination rates are higher in Rhode Island compared to other states, still 27% of female adolescents are not fully vaccinated. The requirement for parental consent for vaccination administration poses a barrier to HPV vaccine uptake and hinders adolescent autonomy. This requirement lies in stark contrast to the goals of the Family Planning Title X Program, which provides all adolescents with access to contraception and STI prevention and treatment without parental consent...
September 4, 2018: Rhode Island Medical Journal
Jonathan Wawire, Katrine Hansen, M Ruhul Quddus
No abstract text is available yet for this article.
September 5, 2018: International Journal of Surgical Pathology
Bibhuti B Das, Kristin Anton, Leah Knox, Jason Jarin, Paul K Sue
We report a case of giant condyloma that developed in a pediatric heart transplant recipient. This infection progressed for several months despite reduction in immunosuppression, topical treatment, and oral cimetidine therapy. Complete resolution was observed following seven months of topical cidofovir, without evidence of systemic toxicity or rejection. This article is protected by copyright. All rights reserved.
September 5, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Stina Syrjänen
Papillomaviruses are one of the oldest viruses known, dating back 330 million years. During this long evolution, human papillomaviruses (HPV) have developed into hijackers of human cellular and immune systems in which they replicate and remain silent. Systematic studies on oral HPV infections and their outcomes are still scarce. Oral HPV infections have been linked to sexual behaviour, but recent evidence supports their horizontal, mouth-to-mouth, transmission. Most HPV infections in infants are acquired vertically from the mother during the intrauterine period, during delivery, or later via saliva...
October 2018: European Journal of Oral Sciences
Chunping Ao, Kang Zeng
Human papillomavirus (HPV) is the most common sexually transmitted agent in the world. It can cause condyloma acuminatum, anogenital malignancies, and head and neck cancers. The host immune responses to HPV involve multiple cell types that have regulatory functions, and HPV-mediated changes to regulatory T cells (Tregs) in both the local lesion tissues and the circulatory system of patients have received considerable attention. The role of Tregs in HPV infections ranges from suppression of effector T cell (Teff) responses to protection of tissues from immune-mediated injury in different anatomic subsites...
November 2018: Infection, Genetics and Evolution
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