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Morena Burati, Marco Chiarelli, Sabina Terragni, Fulvio Tagliabue, Lorenzo Ripamonti, Matteo Maternini, Angelo Guttadauro
Giant condyloma acuminatum (GCA) is a rare cauliflower-like lesion, also known as Buschke-L ewenstein tumor (BLT). Although characterized by benign histological features, the local behavior of GCA is extremely aggressive, showing progressive infiltration of the surrounding structures leading to tissue destruction by compression. As the correlation between HPV and GCA development grew stronger, the majority of the Authors came to the conclusion that HPV can not only cause CA but, associated with particular risk factors, it can lead to much more serious conditions such as BLT...
2018: Annali Italiani di Chirurgia
I Hamano, S Hatakeyama, H Yamamoto, T Fujita, R Murakami, M Shimada, A Imai, T Yoneyama, T Yoneyama, Y Hashimoto, T Koie, S Narumi, H Saitoh, T Suzuki, H Tomita, C Ohyama
BACKGROUND: Condyloma acuminatum (CA) is a common sexually transmitted disease associated with human papilloma virus (HPV). CA occurring in the urethra is rare and has not been reported in male renal transplant recipients. In addition, despite immunosuppressive conditions and increased risk of HPV-related malignant neoplasms in transplant recipients, HPV testing in male transplant recipients has been uncommon. Here we report a case of urethral CA in a male deceased donor renal transplantation recipient and discuss the importance of HPV testing in male transplant recipients...
October 2018: Transplantation Proceedings
Martina Z Liu, Yin P Hung, Eric C Huang, Brooke E Howitt, Marisa R Nucci, Christopher P Crum
Human papillomavirus (HPV) type 6 is historically classified as low-risk HPV type and associates with low-grade squamous intraepithelial lesions of the anogenital tract. Rare squamous carcinomas have been reported in association with these HPV types but the mechanism(s) behind this carcinogenic sequence have been unclear. We report 4 cases of low risk anogenital HPV infections-3 cervical (immature low-grade squamous intraepithelial lesion with metaplastic phenotype) and one anal (exophytic condyloma) lesion-that manifested with high-grade squamous intraepithelial lesion/squamous cell carcinoma...
October 11, 2018: International Journal of Gynecological Pathology
MeiNian Xu, NaiYu Lin, JunPeng Li, LiFen Jiang, Kang Zeng
No abstract text is available yet for this article.
September 20, 2018: Photodiagnosis and Photodynamic Therapy
Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Ruan
The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell proliferation and apoptosis, to determine a novel therapeutic target for CA recurrence. RT-qPCR was used to validate the lower expression of miR-143 and miR-145 in a larger size of CA samples, and the expression of NRAS in CA samples was significantly higher than self-controls as determined by western blotting assay...
August 2018: Royal Society Open Science
Chunping Ao, Jiajia Xie, Li Wang, Songshan Li, Junpeng Li, Lifen Jiang, Hui Liu, Kang Zeng
BACKGROUND: Anal canal condyloma acuminata are common, sexually transmitted lesions, most often caused by the human papillomavirus. The relatively high recurrence rate of anal canal condyloma acuminata can be attributed to the unsuccessful elimination of viruses in areas of subclinical and latent infection. This study aimed to observe and evaluate the effectiveness of 5-aminolevulinic acid-photodynamic therapy combined with monitoring of human papillomavirus load changes in patients with anal canal condyloma acuminata...
September 2018: Photodiagnosis and Photodynamic Therapy
A Kelati, A Khemis, H Montaudié, J-P Lacour, T Passeron
No abstract text is available yet for this article.
September 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Nichola Haddad, Rebecca H Allen, Daria Szkwarko, Michelle Forcier, Cherie Paquette
Human papillomavirus (HPV) is a sexually transmitted infection (STI) causing nearly all cases of cervical carcinoma and genital condyloma worldwide. While HPV vaccination rates are higher in Rhode Island compared to other states, still 27% of female adolescents are not fully vaccinated. The requirement for parental consent for vaccination administration poses a barrier to HPV vaccine uptake and hinders adolescent autonomy. This requirement lies in stark contrast to the goals of the Family Planning Title X Program, which provides all adolescents with access to contraception and STI prevention and treatment without parental consent...
September 4, 2018: Rhode Island Medical Journal
Jonathan Wawire, Katrine Hansen, M Ruhul Quddus
No abstract text is available yet for this article.
September 5, 2018: International Journal of Surgical Pathology
Bibhuti B Das, Kristin Anton, Leah Knox, Jason Jarin, Paul K Sue
We report a case of giant condyloma that developed in a pediatric heart transplant recipient. This infection progressed for several months despite reduction in immunosuppression, topical treatment, and oral cimetidine therapy. Complete resolution was observed following seven months of topical cidofovir, without evidence of systemic toxicity or rejection. This article is protected by copyright. All rights reserved.
September 5, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Stina Syrjänen
Papillomaviruses are one of the oldest viruses known, dating back 330 million years. During this long evolution, human papillomaviruses (HPV) have developed into hijackers of human cellular and immune systems in which they replicate and remain silent. Systematic studies on oral HPV infections and their outcomes are still scarce. Oral HPV infections have been linked to sexual behaviour, but recent evidence supports their horizontal, mouth-to-mouth, transmission. Most HPV infections in infants are acquired vertically from the mother during the intrauterine period, during delivery, or later via saliva...
October 2018: European Journal of Oral Sciences
Chunping Ao, Kang Zeng
Human papillomavirus (HPV) is the most common sexually transmitted agent in the world. It can cause condyloma acuminatum, anogenital malignancies, and head and neck cancers. The host immune responses to HPV involve multiple cell types that have regulatory functions, and HPV-mediated changes to regulatory T cells (Tregs) in both the local lesion tissues and the circulatory system of patients have received considerable attention. The role of Tregs in HPV infections ranges from suppression of effector T cell (Teff) responses to protection of tissues from immune-mediated injury in different anatomic subsites...
August 29, 2018: Infection, Genetics and Evolution
Philip Zeuschner, Stefan Ueberdiek, Alexey Pryalukhin, Christian Veith, Matthias Saar, Sigrun Smola, Rainer Maria Bohle, Kerstin Junker, Michael Stöckle, Julia Heinzelbecker
Human papilloma virus (HPV) infections are one of the most common sexually transmitted diseases. We present the case of a 77-year-old Caucasian male with enormous genital warts of the penis, scrotum, groins and anus. Lesions were excised by electrosurgery. The histological examination revealed Condylomata gigantea as well as an invasive perianal squamous cell carcinoma. Mucosal "low-risk" HPV type 6 was detected. The patient had a history of an immunosuppressing disease. During the 4-year follow-up, multiple relapses occurred...
August 21, 2018: Urologia Internationalis
Vanessa Combaud, Caroline Verhaeghe, Hady El Hachem, Guillaume Legendre, Philippe Descamps, Ludovic Martin, Pierre-Emmanuel Bouet
No abstract text is available yet for this article.
August 2018: JAAD Case Reports
Shuying Wu, Hong Chen
The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical cancer cells. The overexpression of miRNA-375 significantly increased caspase-3 and caspase-9 activities, induced B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein, tumor protein 53 and cyclin-dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV-18(+) cervical cancer cells...
September 2018: Oncology Letters
Maurice A Recanati, Katherine J Kramer, John J Maggio, Conrad R Chao
Condyloma Acuminatum is a sexually transmitted viral disease caused by the human papilloma virus (HPV). It is the most common viral sexually transmitted disease. In this randomized controlled trial, cantharidin was found to be more effective and better tolerated than trichloroacetic acid for the treatment of these lesions. Patients treated with cantharidin healed with less scarring than those treated with TCA (P<0.034), had less pain during treatment (P<0.01), and required fewer treatments to eradicate warts (P<0...
2018: Clinical and Experimental Obstetrics & Gynecology
Sandra Vela, Sebastian Videla, Arelly Ornelas, Boris Revollo, Bonaventura Clotet, Guillem Sirera, Marta Piñol, Francesc García-Cuyás
BACKGROUND: There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. AIM: To provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice. METHODS: Single-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata...
2018: PloS One
Min-Feng Wu, Bo Wang, Ting Lv, Fei Miao, Jie-Chen Zhang, Hong-Wei Wang
Condyloma acuminata and lichen planus are different cutaneous diseases with disparate etiologies. Simultaneous appearance of two diseases in the same area is rare. This report aims to share the clinical and pathological features of a rare case; introduce the effective and safe therapy of it so as to broaden the therapeutic spectrum of Photodynamic Therapy (PDT) indications.
July 28, 2018: Photodiagnosis and Photodynamic Therapy
Natalie Edgar, Stacey Pilkington, Daniel J Hogan
Imiquimod is a topical immunomodulating medication approved by the US Food and Drug Administration for the treatment of condyloma acuminata, actinic keratoses (AKs), and superficial basal cell carcinoma (BCC). Imiquimod commonly is used off label for its antiviral and antitumoral effects. We present a case of a 51-year-old man with vitiligolike depigmentation following treatment of periungual verruca vulgaris with imiquimod therapy.
June 2018: Cutis; Cutaneous Medicine for the Practitioner
A Lukic, M Di Properzio, E Carico, C De Vitis, S Giglio, G Bordi, D Caserta, R Mancini
OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers. PATIENTS AND METHODS: The expression level of miR-551b was determined in 50 paraffin-embedded cervical specimens (10 normal squamous epithelium, 18 condylomas, 8 CIN1, and 14 CIN2-3) using quantitative Real-time polymerase chain reaction (qRT-PCR)...
July 2018: European Review for Medical and Pharmacological Sciences
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